Article
Endocrinology & Metabolism
Xiaolin Ye, Yang Liu, Jiajin Hu, Yanyan Gao, Yanan Ma, Deliang Wen
Summary: This study investigated the effects of chlorogenic acid (CGA) found in coffee on obesity and metabolic endotoxemia. CGA was found to prevent weight gain, improve intestinal barrier function, and prevent metabolic disorders and endotoxemia through altering the gut microbiota composition. The study concludes that CGA-induced changes in the gut microbiota play a key role in inhibiting metabolic endotoxemia in high-fat diet-fed mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiroyuki Hoshiko, Edith J. M. Feskens, Els Oosterink, Renata M. C. Ariens, Jurriaan J. Mes, Nicole J. W. de Wit
Summary: This study identified biomarkers linking a leaky gut and subsequent bacterial translocation to metabolic health, with zonulin potentially aiding in monitoring a leaky gut and detecting individuals at risk for developing chronic metabolic diseases.
Article
Microbiology
Yaqing Chen, Huanchan Zhou, Yushan Lai, Qi Chen, Xiao-Qiang Yu, Xiaoyun Wang
Summary: Insect gut microbiota plays crucial roles in insects, and can be influenced by external factors such as food and antibiotics. This study revealed that antibiotic-induced dysbiosis of gut microbiota affects energy and metabolic homeostasis in Spodoptera frugiperda.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, Harika Nalluri, Thomas Kaiser, Shernan G. Holtan, Alexander Khoruts, Daniel J. Weisdorf, Christopher Staley
Summary: Our study found that despite heavy and sustained antibiotic pressure, microbial communities within the same patient remained more similar to each other than to those from other patients. We identified 6 taxa within the pre-treatment microbiota that predicted the extent of antibiotic-induced perturbations. Our results suggest that specific species in the pre-treatment microbiota play a key role in determining personalized microbiota responses to antibiotics in humans, which could lead to precision interventions to prevent antibiotic-induced dysbiosis and its adverse clinical consequences.
Article
Multidisciplinary Sciences
Sakshi Khanna, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Geeta Shukla
Summary: The study demonstrates the protective potential of a synbiotic in attenuating metabolic complications induced by a high fat diet, improving various morphometric parameters and influencing gut microbiota and metabolic markers positively.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Iram Liaqat, Arjumand Iqbal Durrani, Urooj Zafar, Saima Rubab, Mehwish Faheem, Muhammad Mubin, Chand Raza, Nauman Aftab
Summary: The study investigated the impact of cultured gut microbiota from obese humans combined with a high-fat diet on inducing metabolic endotoxemia in humanized mice. The results showed that this intervention led to significant changes in body weight, BMI, and plasma endotoxin levels, indicating the onset of metabolic endotoxemia. Additionally, the microbial diversity in the cecal contents of the experimental mice shifted towards Firmicutes and Bacteroidetes phyla, highlighting the importance of gut microbiota composition in the development of metabolic disorders.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Plant Sciences
Rongrong Zhou, Dan He, Haichao Zhang, Jing Xie, Shuihan Zhang, Xuefei Tian, Hongliang Zeng, Yuhui Qin, Luqi Huang
Summary: This study aimed to explore the insulin-sensitizing and anti-diabetic effects of ginsenoside Rb1 and its underlying mechanisms. Using a diabetes model, the study found that ginsenoside Rb1 reduces blood glucose and insulin levels, and improves gut microbiota dysbiosis and fecal metabolites. Antibiotic intervention showed that ginsenoside Rb1 fails to improve high-fat diet-induced diabetes.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Microbiology
Madeleine Spatz, Gregory Da Costa, Rebecka Ventin-Holmberg, Julien Planchais, Chloe Michaudel, Yazhou Wang, Camille Danne, Alexia Lapiere, Marie-Laure Michel, Kaija-Leena Kolho, Philippe Langella, Harry Sokol, Mathias L. Richard
Summary: This study investigated the effects of antibiotic treatment on the fungal microbiota in the gut. It was found that amoxicillin-clavulanic acid treatment led to a decrease in the overall fungal population in mouse feces and a remodeling of the fungal community. Certain bacterial strains were shown to inhibit fungal growth. This study provides new insights into the interactions between fungi and bacteria in the gut and may offer new strategies for modulating gut microbiota equilibrium.
Article
Nutrition & Dietetics
Zuchen Wei, Nong Zhou, Liang Zou, Zhenxing Shi, Baoqing Dun, Guixing Ren, Yang Yao
Summary: Dietary intervention with soy protein improved the growth of undernourished weaning rats by regulating gut microbiota and metabolites, leading to increased body weight gain and influencing amino acid levels and vitamin B-6 metabolism.
FRONTIERS IN NUTRITION
(2021)
Article
Chemistry, Medicinal
Honglei Zhao, Hongyan Wu, Meitao Duan, Ruixuan Liu, Quanhong Zhu, Kai Zhang, Lili Wang
Summary: The study demonstrated the protective effects of cinnamaldehyde on type 1 diabetes mellitus in mice, potentially through modulating glycogen synthesis in the liver, gut microbiota, and serum metabolomics to lower blood glucose levels and reduce insulin resistance.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Immunology
Joseph Kai Man Li, Lynn Lin Wang, Becky Su Yan Lau, Ryan Tsz Hei Tse, Carol Ka Lo Cheng, Steven Chi Ho Leung, Christine Yim Ping Wong, Stephen Kwok Wing Tsui, Jeremy Yuen Chun Teoh, Peter Ka Fung Chiu, Chi Fai Ng
Summary: This study investigated the impact of a single dose of oral co-amoxiclav on the gut microbiota before transrectal ultrasound-guided transperineal prostate biopsy (TPPBx) in the following five weeks. The results showed that the gut microbiota experienced irreversible changes after the administration of oral co-amoxiclav.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ben A. Kappel, Lorenzo De Angelis, Andreas Puetz, Marta Ballanti, Rossella Menghini, Nikolaus Marx, Massimo Federici
Summary: There is a link between gut microbiota and host cholesterol metabolism, and changes in gut microbiota may contribute to hypercholesterolemia. Treatment with antibiotics can increase serum cholesterol levels and potentially impact cardiovascular disease.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Pediatrics
Sofia Ainonen, Mysore Tejesvi, Md. Rayhan Mahmud, Niko Paalanne, Tytti Pokka, Weizhong Li, Karen E. Nelson, Jarmo Salo, Marjo Renko, Petri Vanni, Anna Maria Pirttila, Terhi Tapiainen
Summary: Perinatal antibiotic exposure had a significant impact on the gut microbiota of 1-year-old infants, with a greater effect than exposure to later courses of antibiotics. The composition of the gut microbiota was found to be influenced by the timing of antibiotic exposure.
PEDIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Siyuan Feng, Chen Meng, Zikai Hao, Hong Liu
Summary: The gut microbiota is closely associated with subhealth. B. licheniformis has the potential in regulating subhealth by remodeling the gut microbiota, reducing inflammation, regulating neurotransmitter levels, and easing a negative mood.
Article
Nutrition & Dietetics
Shujuan Zheng, Yanan Wang, Jingjing Fang, Ruixuan Geng, Mengjie Li, Yuhan Zhao, Seong-Gook Kang, Kunlun Huang, Tao Tong
Summary: The study found that oleuropein may ameliorate the advanced stage of type 2 diabetes through modulating the composition and function of gut microbiota, providing a promising therapeutic approach for the treatment of advanced stage type 2 diabetes.
Article
Food Science & Technology
Sarai Vasquez-Reyes, Ariana Vargas-Castillo, Lilia G. Noriega, Laura A. Velazquez-Villegas, Berenice Perez, Monica Sanchez-Tapia, Guillermo Ordaz, Renato Suarez-Monroy, Alfredo Ulloa-Aguirre, Halina Offner, Nimbe Torres, Armando R. Tovar
Summary: This study aims to determine whether genistein activates thermogenesis and mitochondrial activity in white adipose tissue (WAT) through the G-coupled receptor GPR30. The results show that GPR30 partially mediates genistein stimulation of WAT thermogenesis and the improvement of glucose tolerance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Nutrition & Dietetics
Tauqeerunnisa Syeda, Monica Sanchez-Tapia, Itzel Orta, Omar Granados-Portillo, Lizbeth Perez-Jimenez, Juan-de-Dios Rodriguez-Callejas, Samuel Toribio, Maria-del-Carmen Silva-Lucero, Ana-Leonor Rivera, Armando R. Tovar, Nimbe Torres, Claudia Perez-Cruz
Summary: Ingestion of bioactive foods can improve gut microbiota dysbiosis, reduce fatty liver, and cognitive damage in obese rats, and also has anti-inflammatory and neuroprotective effects.
Article
Pediatrics
Ana Laura de la Garza, Bianca Romero-Delgado, Alejandra Mayela Martinez-Tamez, Marcela Cardenas-Tueme, Bianka Dianey Camacho-Zamora, Daniel Matta-Yee-Chig, Monica Sanchez-Tapia, Nimbe Torres, Alberto Camacho-Morales
Summary: This study found that maternal high-sweeteners intake during gestation and lactation can alter gut microbiota diversity in adult male offspring rats and lead to cognitive dysfunction.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cell Biology
Daniel Cuervo-Zanatta, Tauqeerunnisa Syeda, Vicente Sanchez-Valle, Mariangel Irene-Fierro, Pablo Torres-Aguilar, Monica Adriana Torres-Ramos, Mineko Shibayama-Salas, Angelica Silva-Olivares, Lilia G. Noriega, Nimbe Torres, Armando R. Tovar, Ivan Ruminot, L. Felipe Barros, Jaime Garcia-Mena, Claudia Perez-Cruz
Summary: Fiber intake is associated with a lower risk for Alzheimer's disease in older adults. The neuroprotective effects of fiber intake may depend on the modulation of gut microbiota dysbiosis and specific actions of short-chain fatty acids in brain cells.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Luis E. Gonzalez-Salazar, Aurora E. Serralde-Zuniga, Adriana Flores-Lopez, Juan P. Diaz-Sanchez, Isabel Medina-Vera, Edgar Pichardo-Ontiveros, Rocio Guizar-Heredia, Karla G. Hernandez-Gomez, Ana Vigil-Martinez, Liliana Arteaga-Sanchez, Azalia Avila-Nava, Natalia Vazquez-Manjarrez, Nimbe Torres, Armando R. Tovar, Martha Guevara-Cruz
Summary: The present study aimed to determine the prevalence of adiposity-based chronic disease (ABCD) and its association with anthropometric indices in the Mexican population. The results showed that the prevalence of ABCD was 87.4%, increasing with age. This suggests that obesity-related complications are common in this population.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Oncology
Daniela Shveid Gerson, Raquel Gerson-Cwilich, Cesar Octavio Lara Torres, Alberto Chousleb de Kalach, Jose Luis Ventura Gallegos, Luis Ernesto Badillo-Garcia, Juan Enrique Bargallo Rocha, Antonio Maffuz-Aziz, Ernesto Roberto Sanchez Forgach, Gerardo Castorena Roji, Carlos D. Robles Vidal, Ariana Vargas-Castillo, Nimbe Torres, Armando R. Tovar, Mariela Contreras Jarquin, Jesus Tenahuatzin Gomez Osnaya, Alejandro Zentella-Dehesa
Summary: Obesity is associated with an increased risk of aggressive breast cancer variants. Current breast cancer cell lines do not represent different BMI populations. Establishing breast cancer cell lines from patients with different BMIs will help to understand the functional changes associated with these comorbidities.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Rocio Guizar-Heredia, Lilia G. Noriega, Ana Leonor Rivera, Osbaldo Resendis-Antonio, Martha Guevara-Cruz, Nimbe Torres, Armando R. Tovar
Summary: A prolonged and elevated postprandial glucose response (PPGR) is a key factor in the development of metabolic syndrome and type 2 diabetes, and can be prevented through dietary interventions. However, dietary recommendations alone have not always been successful in preventing alterations in PPGR, as it is also influenced by genetics, body composition, gut microbiota, and other factors. Recent advancements in continuous glucose monitoring and machine learning have made it possible to predict the effects of different dietary foods on PPGRs, allowing for personalized dietary recommendations. Additional components such as nutrigenomics, nutrigenetics, and metabolomics can further enhance the predictive algorithms. This review summarizes the evidence and future prospects of personalized nutrition in preventing PPGR and improving metabolic diseases.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Sofia Moran-Ramos, Daniel Cerqueda-Garcia, Blanca Lopez-Contreras, Elena Larrieta-Carrasco, Hugo Villamil-Ramirez, Selene Molina-Cruz, Nimbe Torres, Monica Sanchez-Tapia, Rogelio Hernandez-Pando, Carlos Aguilar-Salinas, Teresa Villarreal-Molina, Samuel Canizales-Quinteros
Summary: This study aimed to characterize the gut microbiome composition of patients with obesity and biopsy-proven NAFLD. The study found that Parabacteroides distasonis and Alistipes putredenis were enriched in fatty liver patients but not in NASH patients. Furthermore, individuals with a Prevotella copri dominant bacterial community were more likely to develop NASH, possibly due to higher intestinal permeability and lower capacity for butyrate production.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Maria E. Meneses, Daniel Martinez-Carrera, Laura Gonzalez-Ibanez, Nimbe Torres, Monica Sanchez-Tapia, Claudia C. Marquez-Mota, Gilmar Rendon, Vladimir Mitzi, Alfredo Morales, Isaac Tello-Salgado, Armando R. Tovar
Summary: Well-characterized and standardized extracts of a Mexican genotype of Ganoderma lucidum cultivated on oak sawdust (Gl-1) or oak sawdust plus acetylsalicylic acid (Gl-2, ASA) were administered to rats for 14 days to assess toxicity. The extracts showed no significant adverse effects on the rats, including on the liver, kidney, biochemical parameters, inflammatory responses, and gut microbiota.
Article
Nutrition & Dietetics
Monica Sanchez-Tapia, Alberto Mimenza-Alvarado, Lizbeth Granados-Dominguez, Adriana Flores-Lopez, Adriana Lopez-Barradas, Victor Ortiz, Claudia Perez-Cruz, Hilda Sanchez-Vidal, Julieta Hernandez-Acosta, Jose Alberto Avila-Funes, Martha Guevara-Cruz, Armando R. Tovar, Nimbe Torres
Summary: Currently, the number of individuals with mild cognitive impairment (MCI) and dementia (D) is increasing. This study investigated the role of tau protein, beta-amyloid, LPS, and curli protein in elderly individuals with MCI or D, as well as the contribution of gut microbiota. The results showed that as individuals aged, tau protein, beta-amyloid, and LPS increased significantly in serum during MCI and D. This was associated with an increase in the abundance of E. coli that synthesize the amyloid protein curli, leading to the aggregation of amyloid proteins. Rats also exhibited an increase in curli protein abundance in the brain with aging. Thus, an alteration in the gut microbiota-brain axis, characterized by an increase in curli protein and LPS, contributes to cognitive impairment and dementia through the increase in tau and beta-amyloid protein.
Article
Plant Sciences
Azalia Avila-Nava, Joshua Ayork Acevedo-Carabantes, Itzayana Alamilla-Martinez, Sandra Tobon-Cornejo, Ivan Torre-Villalvazo, Armando R. Tovar, Nimbe Torres, Lilia G. Noriega
Summary: The aim of this study was to evaluate the effects of Chaya leaf extracts on mitochondrial bioenergetics and fatty acid oxidation in muscle cells and liver cells. The results showed that Chaya leaf extracts have antioxidant activity and can increase mitochondrial function and fatty acid oxidation in liver cells, indicating their potential in treating metabolic diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laura Gonzalez-Ibanez, Maria E. Meneses, Monica Sanchez-Tapia, Daniel Perez-Luna, Nimbe Torres, Ivan Torre-Villalvazo, Myrna Bonilla, Beatriz Petlacalco, Ivan Castillo, Adriana Lopez-Barradas, Antonio Macias, Armando R. Tovar, Daniel Martinez-Carrera
Summary: Obesity is a global public health problem, and functional foods, such as edible and medicinal mushrooms, can be used as a strategy to treat obesity. In a study with Wistar rats, the consumption of these mushrooms showed significant effects in reducing weight gain, fat mass, serum lipid parameters, and preventing adipocyte hypertrophy and collagen deposition. Mushroom consumption also reduced endoplasmic reticulum stress and inflammation while increasing adiponectin expression in subcutaneous adipose tissue, surpassing the effects of the commercial drug atorvastatin. Thus, bioactive compounds from edible, functional, and medicinal mushrooms represent promising natural therapies for obesity treatments.
Article
Biochemistry & Molecular Biology
Rebeca Fuentes-Romero, Laura A. A. Velazquez-Villegas, Sarai Vasquez-Reyes, Berenice Perez-Jimenez, Zuleima N. Dominguez N. Velazquez, Monica Sanchez-Tapia, Ariana Vargas-Castillo, Sandra Tobon-Cornejo, Adriana M. M. Lopez-Barradas, Valentin Mendoza, Nimbe Torres, Fernando Lopez-Casillas, Armando R. R. Tovar
Summary: Genistein, an isoflavone found in soybeans, has been shown to activate the thermogenic program in subcutaneous white adipose tissue (scWAT) in mice, leading to increased UCP1 expression. This effect is mediated through the interaction of genistein with estrogen and cAMP response elements on the UCP1 promoter. These findings provide mechanistic insights into genistein's role in thermogenesis and suggest its potential therapeutic applications for metabolic disorders.
Meeting Abstract
Endocrinology & Metabolism
N. Torres
ANNALS OF NUTRITION AND METABOLISM
(2023)