Antidepressant-Like Effects of CX717, a Positive Allosteric Modulator of AMPA Receptors

Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function

(2019) Ronald S. Duman et al.   MOLECULAR PSYCHIATRY

Effects of chronic systemic low-impact ampakine treatment on neurotrophin expression in rat brain

(2018) Daniel P. Radin et al.   BIOMEDICINE & PHARMACOTHERAPY

Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist

(2018) Marta Gordillo-Salas et al.   Translational Psychiatry

TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window

(2018) Akiyoshi Kunugi et al.   NEUROPSYCHOPHARMACOLOGY

Identifying fast-onset antidepressants using rodent models

(2017) M J Ramaker et al.   MOLECULAR PSYCHIATRY

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex

(2015) Laura Jiménez-Sánchez et al.   CEREBRAL CORTEX

The role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in depression: Central mediators of pathophysiology and antidepressant activity?

(2015) Florian Freudenberg et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Coadministration of the AMPAKINE CX717 with Propofol Reduces Respiratory Depression and Fatal Apneas

(2013) Jun Ren et al.   ANESTHESIOLOGY

p11 and its role in depression and therapeutic responses to antidepressants

(2013) Per Svenningsson et al.   NATURE REVIEWS NEUROSCIENCE

Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests

(2013) Jesper T. Andreasen et al.   NEUROSCIENCE LETTERS

Antidepressant effects of AMPA and ketamine combination: role of hippocampal BDNF, synapsin, and mTOR

(2013) Luli Akinfiresoye et al.   PSYCHOPHARMACOLOGY

Identification of the Cortical Neurons that Mediate Antidepressant Responses

(2012) Eric F. Schmidt et al.   CELL

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

(2012) Vanja Duric et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Respiratory depression in rats induced by alcohol and barbiturate and rescue by ampakine CX717

(2012) Jun Ren et al.   JOURNAL OF APPLIED PHYSIOLOGY

A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

(2012) Melissa R. Warden et al.   NATURE

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

(2012) Dipesh Chaudhury et al.   NATURE

Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior

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Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

(2011) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep

(2011) Julia Boyle et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects

(2011) A Bortolozzi et al.   MOLECULAR PSYCHIATRY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Chronic antidepressant treatments induce a time-dependent up-regulation of AMPA receptor subunit protein levels

(2011) Alessandro Barbon et al.   NEUROCHEMISTRY INTERNATIONAL

A Role for p11 in the Antidepressant Action of Brain-Derived Neurotrophic Factor

(2010) Jennifer L. Warner-Schmidt et al.   BIOLOGICAL PSYCHIATRY

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

(2010) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Repeated rat-forced swim test: Reducing the number of animals to evaluate gradual effects of antidepressants

(2010) T.J. Mezadri et al.   JOURNAL OF NEUROSCIENCE METHODS

5-HT1A Autoreceptor Levels Determine Vulnerability to Stress and Response to Antidepressants

(2010) Jesse W. Richardson-Jones et al.   NEURON

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Selective Antagonism of Opioid-Induced Ventilatory Depression by an Ampakine Molecule in Humans Without Loss of Opioid Analgesia

(2009) B G Oertel et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Positive AMPA Receptor Modulation Rapidly Stimulates BDNF Release and Increases Dendritic mRNA Translation

(2009) H. Jourdi et al.   JOURNAL OF NEUROSCIENCE

PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling

(2008) Irina Nikonenko et al.   JOURNAL OF CELL BIOLOGY

Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717

(2008) R. E. Hampson et al.   PSYCHOPHARMACOLOGY

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY