Article
Biochemistry & Molecular Biology
Wenjing Xu, Jin Ding, Bonan Li, Tiansong Sun, Xujun You, Qinghu He, Wen Sheng
Summary: This study investigates the effects and molecular mechanisms of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism in prostate cancer. The results suggest that these compounds can inhibit cell proliferation and induce apoptosis and ROS production in prostate cancer cells. The miR-7/mTOR/SREBP1 pathway plays a crucial role in mediating the effects of icariin and curcumol.
Article
Chemistry, Medicinal
Juan Wang, Guoxiang Liu, Xiaojuan Li, Mengjie Huangfu, Yisa Liu, Xumei Li, Dan Yu, Luwei Zhou, Xu Chen
Summary: Curcumol induces autophagy through the AMPK/mTOR pathway in NPC cells, and inhibiting autophagy can increase proliferation while attenuating apoptosis and autophagy. Combining curcumol with the autophagy agonist rapamycin and apoptosis inducer MG132 synergizes the apoptotic and autophagic effect of curcumol, suggesting a potential new therapeutic strategy for NPC.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yang Zheng, Tiejian Zhao, Jiaru Wang, Ruizhu Jiang, Jinbiao Huang, Weimin Li, Jiahui Wang
Summary: In this study, it was found that curcumol promotes death of hepatic stellate cells and reduces extracellular matrix deposition. Additionally, curcumol triggers ferroptosis in activated hepatic stellate cells characterized by iron overload, lipid ROS accumulation, glutathione depletion, and lipid peroxidation. Moreover, curcumol promotes autophagy in hepatic stellate cells, which may be mediated by the degradation of NCOA4 and FTH1 complexes, leading to iron overload and induction of ferroptosis.
Article
Cell Biology
Liuhanghang Cheng, Xiaoxuan Lei, Zengjun Yang, Yanan Kong, Pengcheng Xu, Shiya Peng, Jue Wang, Cheng Chen, Yunqing Dong, Xiaohong Hu, Xiaorong Zhang, Tymour Forouzanfar, Gang Wu, Xiaobing Fu
Summary: Histatin 1 has been found to accelerate wound healing and improve the mechanical properties of healed skin by promoting the function of fibroblasts. In vitro experiments showed that fibroblasts stimulated by Hst 1 exhibited enhanced migration ability and transformation into myofibroblasts, leading to improved contraction and collagen secretion functions. Additionally, the study identified activation of the mTOR signaling pathway by Hst 1 in fibroblasts.
CELL PROLIFERATION
(2021)
Article
Dermatology
He-chen Huang, Yan Chen, Jie Hu, Xiu-tian Guo, Shao-rong Zhou, Qi-qi Yang, Yu-qing Du, Yu Jin, Guo-bin Liu, Yun-hua Peng
Summary: This meta-analysis examined the effect of quercetin and its derivatives on wound healing in animal experiments. The results showed that quercetin promoted faster wound closure in animals compared to the control group. The study also found that quercetin inhibited inflammatory response, accelerated angiogenesis, fibroblast proliferation, and collagen deposition. These findings suggest that quercetin and its derivatives can promote the recovery of cutaneous wounds in animals.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Apor Veres-Szekely, Domonkos Pap, Beata Szebeni, Laszlo Orfi, Csenge Szasz, Csenge Pajtok, Eszter Levai, Attila J. Szabo, Adam Vannay
Summary: Fibroblasts play a central role in diseases such as idiopathic pulmonary fibrosis. This study developed a cost-effective method to examine fibroblast migration and discussed the advantages of combining different functional assays in drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sneha Kumari, Rashmi Singh
Summary: The study demonstrated the protective effects of intranasal curcumin on silica-induced lung damage in a mouse model of silicosis, reducing airway inflammation, collagen deposition, and fibrosis markers. Curcumin showed better inhibitory effects compared to dexamethasone in protecting lung structure alterations. Additionally, abnormal mitochondria observed in silicosis were reduced in groups treated with curcumin and dexamethasone.
Article
Biochemistry & Molecular Biology
Sneha Kumari, Rashmi Singh
Summary: Curcumin has protective effects on silica-induced airway inflammation and structural changes in the lungs, making it a potential alternative medication for silicosis.
Article
Biotechnology & Applied Microbiology
Zihan Xu, Wei Shang, Zhiming Zhao, Beibei Zhang, Chunli Liu, Hui Cai
Summary: This study found that curcumin can improve rheumatoid arthritis by inhibiting cell proliferation, migration, invasion, and promoting cell apoptosis. Curcumin also reduces inflammation by decreasing the secretion of inflammatory factors. Therefore, curcumin may be a promising candidate for treating RA.
Article
Nutrition & Dietetics
Jisu Park, Ji Hyeon Ryu, Bo-Young Kim, Hyun Soo Chun, Min Sun Kim, Yong-Il Shin
Summary: Fermented lettuce extract (FLE) has therapeutic effects on collagen-induced arthritis (CIA) and rheumatoid arthritis (RA) by suppressing inflammation and cartilage degradation. FLE inhibits the TGF-beta/Smad signaling pathway and induces autophagy in MH7A cells.
Article
Chemistry, Medicinal
Sumin Sun, Zhanghao Li, Sheng Huan, Jun Kai, Siwei Xia, Ying Su, Shufan Ji, Anping Chen, Shijun Wang, Xuefen Xu, Jiangjuan Shao, Feng Zhang, Biyun Zhang, Zili Zhang, Shizhong Zheng
Summary: This study found that curcumol can alleviate liver fibrosis by regulating necroptosis and autophagy in HSCs. This is achieved by activating Sirt1 to reduce the acetylation level of Atg5 and enhance the interaction between Atg5 and RIP1/RIP3.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Linhai Jiang, Xiaoliang Cai, Sheng Li, Ying Miao, Xiaoyu Yang, Manbian Lin, Liang Chen, Xiaozheng He, Zuquan Weng
Summary: The conjugation of CUR with HES to form HES-CUR NPs enhanced the solubility and drug loading efficiency of CUR. HES-CUR NPs exhibited a stronger antiproliferative effect and better apoptosis induction in HepG2 cells compared to CUR. The efficacy of HES-CUR NPs against HepG2 cells might be related to enhanced mitochondrial damage and autophagy induction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dermatology
Yidan Su, Min Li, Xiqiao Wang, Zhiyong Wang, Lei Yi
Summary: This study investigated the regulatory role of denatured collagen on autophagy and apoptosis in fibroblasts. The results showed that denatured collagen stimulation enhanced autophagy and inhibited apoptosis in fibroblasts. This suggests that denatured collagen promotes cell survival and influences wound healing.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Pharmacology & Pharmacy
Liyuan Gao, Xiang Yang, Baoyu Liang, Yan Jia, Shanzhong Tan, Anping Chen, Peng Cao, Zili Zhang, Shizhong Zheng, Lixia Sun, Feng Zhang, Jiangjuan Shao
Summary: The study found that curcumol regulates pathological angiogenesis in LSECs by modulating autophagy levels and targeting KLF5. Curcumol inhibits autophagy, leading to degradation of KLF5 and suppression of pathological angiogenesis in liver fibrosis models in mice.
Article
Nutrition & Dietetics
Maysa Alves Rodrigues Brandao-Rangel, Carlos Rocha Oliveira, Fabiana Regina da Silva Olimpio, Flavio Aimbire, Jose Roberto Mateus-Silva, Felipe Augusto Chaluppe, Rodolfo P. Vieira
Summary: This study investigated the effects of collagen peptides on the proliferation and activation of fibroblasts and keratinocytes. The results showed that collagen peptides can promote cell proliferation and reduce inflammatory responses caused by lipopolysaccharide.
Article
Neurosciences
Jinyuan Yan, Zhongshan Yang, Ninghui Zhao, Zhiwei Li, Xia Cao
Review
Medicine, Research & Experimental
Yu Jing-Ze, Ying Yi, Liu Yang, Sun Chun-Bin, Dai Chen, Zhao Shan, Tian Shou-Zheng, Peng Jing, Han Ni-Ping, Yuan Jia-Li, Yan Jin-Yuan, Yang Zhong-Shan
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Biochemistry & Molecular Biology
Tian-hao Liu, Chen-yang Zhang, Ahmad Ud Din, Ning Li, Qian Wang, Jing-ze Yu, Zhen-yuan Xu, Chen-xi Li, Xiao-mei Zhang, Jia-li Yuan, Li-guo Chen, Zhong-shan Yang
BIOSCIENCE REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Jinyuan Yan, Ninghui Zhao, Zhongshan Yang, Yuhong Li, Hua Bai, Wei Zou, Keqin Zhang, Xiaowei Huang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Medicine, Research & Experimental
Yi Ying, Chun-bin Sun, Si-qi Zhang, Bo-jun Chen, Jing-ze Yu, Fei-yu Liu, Jing Wen, Jiong Hou, Si-si Han, Jin-yuan Yan, Zhong-shan Yang, Lei Xiong
Summary: ASIV, extracted from Astragalus membranaceus, shows significant anti-inflammatory effects on CSE-exposed cells by promoting autophagy and inhibiting the TLR4/NF-κB signaling pathway, thus alleviating inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Fei-Yu Liu, Jing Wen, Jiong Hou, Si-Qi Zhang, Chun-Bin Sun, Luo-Chuan Zhou, Wen Yin, Wen-Lin Pang, Cui Wang, Yi Ying, Si-Si Han, Jin-Yuan Yan, Chen-Xi Li, Jia-Li Yuan, Hai-Jing Xing, Zhong-Shan Yang
Summary: The study demonstrates that gastrodia extract and gastrodin alleviate lipid deposition and foam cells on the inner membrane of the thoracic aorta in early atherosclerosis mice, regulating blood lipids and reshaping gut microbiota diversity. Additionally, they reverse intestinal mucosal damage, reduce inflammatory cytokines, and potentially act through gut microbe rescue and anti-inflammatory effects to alleviate lipid accumulation in cardiovascular and cerebrovascular diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Geriatrics & Gerontology
Yinying Wang, Rongsha Chen, Zhongshan Yang, Qian Wen, Xia Cao, Ninghui Zhao, Jinyuan Yan
Summary: This review summarizes the role of polysaccharides in neurodegenerative diseases and their mechanisms, and discusses their potential in treatment and future directions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Jing-ze Yu, Jing Wen, Yi Ying, Wen Yin, Si-qi Zhang, Wen-ling Pang, Cui Wang, Yao Bian, Jia-li Yuan, Jin-yuan Yan, Zhong-shan Yang
Summary: Astragaloside (AST) can treat pulmonary fibrosis by modulating the autophagy process and the Ras/Raf/MEK/ERK signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yi Ying, Nannan Li, Shuyuan Wang, Hang Zhang, Yinglin Zuo, Yiwen Tang, Panshuang Qiao, Yazhu Quan, Min Li, Baoxue Yang
Summary: In this study, 25a was found to significantly increase urine output and decrease abdominal circumference in cirrhotic rats without disturbing electrolyte balance. It also reduced the expression of type I collagen in the liver, indicating a potential to slow the progression of cirrhosis. These findings suggest that 25a may serve as a novel diuretic for treating cirrhotic ascites.