Article
Neurosciences
Liping Zhao, Shijiang Liu, Xiaobao Zhang, Juan Yang, Mao Mao, Susu Zhang, Shiqin Xu, Shanwu Feng, Xian Wang
Summary: This study investigates the role of satellite glial cell (SGC)-secreted exosomes in the communication between glia and neurons in chemotherapy-induced neuropathic pain (CINP). The results show that SGC-secreted exosomes after oxaliplatin treatment can induce mechanical hypersensitivity in DRG neurons and naive mice, possibly through miRNA cargo.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Markus Leo, Linda-Isabell Schmitt, Andrea Kutritz, Christoph Kleinschnitz, Tim Hagenacker
Summary: Cisplatin has a significant impact on satellite glial cells (SGCs) and dorsal root ganglion (DRG) neurons, affecting the expression of various proteins and potentially contributing to the neurotoxic side effects. Furthermore, SGC-secreted factors play a role in modulating the excitability of sensory neurons, suggesting that targeting SGCs could be a potential strategy in managing chemotherapy-induced neuropathic pain.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Anesthesiology
Zhiyong Chen, Qian Huang, Xiaodan Song, Neil C. Ford, Chi Zhang, Qian Xu, Mark Lay, Shao-Qiu He, Xinzhong Dong, Menachem Hanani, Yun Guan
Summary: This study found that small neurons in the dorsal root ganglia (DRG) are strongly activated by P2R stimulation, likely nociceptors. Large neurons, likely non-nociceptive, are also activated but with a delay. Blocking Pannexin 1 channels weakens the late phase response of DRG neurons, and ganglionic α,β-MeATP treatment sensitizes small neurons and enhances the response of spinal wide-dynamic-range neurons to pain perception.
Article
Cell Biology
Zhiyong Chen, Chi Zhang, Xiaodan Song, Xiang Cui, Jing Liu, Neil C. Ford, Shaoqiu He, Guangwu Zhu, Xinzhong Dong, Menachem Hanani, Yun Guan
Summary: The purinergic system, specifically the P2X7R receptor, plays an important role in pain transmission and the interactions between neuron-satellite glial cells in the dorsal root ganglia (DRG). Activation of P2X7R leads to the release of ATP, which excites neurons and increases DRG neuron excitability. Understanding this signaling pathway could provide insights into pain mechanisms and potential targets for pain management.
Article
Biochemistry & Molecular Biology
Kjeld Morten Mohr, Lone Tjener Pallesen, Mette Richner, Christian Bjerggaard Vaegter
Summary: Satellite glial cells (SGCs) surrounding neuronal somas are sensitive to neuronal stressors and exhibit induced gliosis, however, GFAP may not be a universally suitable marker for SGC reactivity across species and experimental models.
Article
Biochemistry & Molecular Biology
Elena A. Konnova, Alexandru-Florian Deftu, Paul Chu Sin Chung, Marie Pertin, Guylene Kirschmann, Isabelle Decosterd, Marc R. Suter
Summary: This study demonstrates an increased expression of GFAP in two subpopulations of glial cells within the DRG after nerve injury: GFAP+ FABP7+ SGCs and GFAP+ FABP7- nmSCs. This sheds light on the specificity of GFAP as an SGC marker after SNI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jianxiong Wei, Shuyang Chang, Siyi Liu, Lixia Tian, Xuan Zhu, Shuo Wang, Xiaoqiong Zhou, Yuying Wang, Linping Xu, Fu-Quan Huo, Lingli Liang
Summary: In this study, researchers investigated the role of LSD1, a histone demethylase and transcriptional co-repressor, in radicular pain. They found that LSD1 was upregulated in compressed and injured nerve ganglia, suggesting it may contribute to pain hypersensitivities. These findings suggest that LSD1 could serve as a potential target for the treatment of radicular pain and neuropathic pain.
BRAIN RESEARCH BULLETIN
(2022)
Article
Immunology
Wen Chen, Xiaotong Wang, Qingyu Sun, Yurui Zhang, Jing Liu, Tingting Hu, Weihua Wu, Chao Wei, Meng Liu, Yumeng Ding, Dianxin Liu, Yingzi Chong, Peipei Wang, Hongwei Zhu, Weihua Cui, Jiannan Zhang, Qian Li, Fei Yang
Summary: The NLRP3 pathway is activated in the DRG of the DNP model, and TET2 is involved in DNP hypersensitivity by upregulating the TXNIP/NLRP3 pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Bin Wu, Xiaolin Su, Wentong Zhang, Yi-Hong Zhang, Xinghua Feng, Yong-Hua Ji, Zhi-Yong Tan
Summary: This study found that oxaliplatin depolarizes IB4(-) neurons through TRPM8 channels to drive the development of neuropathic pain, and targeting the initial drives of TRPM8 and/or membrane depolarization may prevent oxaliplatin-induced neuropathic pain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Lina Huang, Dilip Sharma, Xiaozhou Feng, Zhiqiang Pan, Shaogen Wu, Daisy Munoz, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao
Summary: The study found that RALY, an RNA-binding protein, plays a role in nerve trauma-induced nociceptive hypersensitivity by regulating the expression of translation initiation factor Eif4g2 in dorsal root ganglion neurons. Interventions targeting RALY expression levels could alleviate the development and maintenance of pain hypersensitivity.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Juping Xing, Hongji Wang, Lisha Chen, Hanxi Wang, Huan Huang, Jiabao Huang, Changshui Xu
Summary: This study investigated the role of Cx43 in neuropathic pain mediated by the P2X4 receptor in rats with chronic constriction injury (CCI). The results showed that blocking Cx43 can alleviate neuropathic pain in CCI rats through the P2X4, p38, ERK, and NF-kB signaling pathways. These findings suggest that Cx43 may be a promising therapeutic target for the development of novel pharmacological agents in the management of neuropathic pain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Anesthesiology
Annemarie Schulte, Hannah Lohner, Johannes Degenbeck, Dennis Segebarth, Heike L. Rittner, Robert Blum, Annemarie Aue
Summary: Pain syndromes lead to molecular and cellular changes in the dorsal root ganglia (DRG). This study introduces a deep learning-based strategy for unbiased analysis of DRG neurons and satellite glial cells (SGCs). The method was validated by analyzing rat DRG sections after nerve injury and comparing known, controversial, and novel changes. The analysis revealed plasticity responses in SGC marker expression but no neuronal death or gliosis.
Article
Anesthesiology
Ling -Jun Xu, Jing Wang, Gui-Dan Li, Kai-Feng Shen, Xing-Hui He, Wei Wu, Cui-Cui Liu
Summary: In this study, it was found that the reduction of SIRT1 and the upregulation of Nav1.7 in the dorsal root ganglion contribute to the development of oxaliplatin-induced neuropathic pain in rats. Activating SIRT1 or blocking Nav1.7 can alleviate pain symptoms.
Article
Clinical Neurology
Li-Ping Xia, Hao Luo, Qiang Ma, Ya-Kai Xie, Wei Li, Hailan Hu, Zhen-Zhong Xu
Summary: GPR151 in nociceptive dorsal root ganglion neurons plays a crucial role in the pathogenesis of neuropathic pain by controlling neuronal hyperexcitability and promoting spinal microglial activation, indicating its potential as a therapeutic target for neuropathic pain treatment.
Article
Medicine, Research & Experimental
Gisele Graca Leite dos Santos, Anna Lethicia Lima Oliveira, Dourivaldo Silva Santos, Renan Fernandes do Espirito Santo, Daniela Nascimento Silva, Paulo Jose Lima Juiz, Milena Botelho Pereira Soares, Cristiane Flora Villarreal
Summary: The study found that MSC can completely reverse the mechanical allodynia and thermal hyperalgesia induced by OXL-induced sensory neuropathy. MSC increased the gene expression of antioxidant factors SOD and Nrf-2, elevated the levels of anti-inflammatory cytokines IL-10 and TGF-beta in the spinal cord of neuropathic mice, and decreased nitrite and MDA levels, possibly inducing the reversal of OXL-induced sensory neuropathy by activating anti-inflammatory and antioxidant pathways.
Article
Immunology
Sven Jarius, Florence Pache, Peter Koertvelyessy, Ilijas Jelcic, Mark Stettner, Diego Franciotta, Emanuela Keller, Bernhard Neumann, Marius Ringelstein, Makbule Senel, Axel Regeniter, Rea Kalantzis, Jan F. Willms, Achim Berthele, Markus Busch, Marco Capobianco, Amanda Eisele, Ina Reichen, Rick Dersch, Sebastian Rauer, Katharina Sandner, Ilya Ayzenberg, Catharina C. Gross, Harald Hegen, Michael Khalil, Ingo Kleiter, Thorsten Lenhard, Juergen Haas, Orhan Aktas, Klemens Angstwurm, Christoph Kleinschnitz, Jan Lewerenz, Hayrettin Tumani, Friedemann Paul, Martin Stangel, Klemens Ruprecht, Brigitte Wildemann
Summary: Comprehensive data on the cerebrospinal fluid (CSF) profile in patients with COVID-19 and neurological involvement are lacking. This study found that neurological symptoms in COVID-19 patients are mainly caused by blood-CSF barrier (BCB) dysfunction rather than intrathecal inflammation. Persistent BCB dysfunction and elevated cytokine levels may contribute to acute symptoms and "long COVID". Direct CNS infection with SARS-CoV-2 is rare in confirmed COVID-19 cases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Environmental Sciences
Marcel Opitz, Sebastian Zensen, Denise Bos, Axel Wetter, Christoph Kleinschnitz, Ellen Uslar, Ramazan Jabbarli, Ulrich Sure, Alexander Radbruch, Yan Li, Nils Dorner, Michael Forsting, Cornelius Deuschl, Nika Guberina
Summary: The study examined the radiation exposure and determined the local diagnostic reference levels (DRLs) of intra-arterial nimodipine therapy for the treatment of cerebral vasospasm. The results showed that the radiation exposure was relatively low for this therapy, but repeated sessions could lead to a cumulative radiation exposure risk.
JOURNAL OF RADIOLOGICAL PROTECTION
(2022)
Article
Cell Biology
Mert Seyhan, Kathrin Ungethum, Michael K. Schuhmann, Daniel Mackenrodt, Viktoria Rucker, Felipe A. Montellano, Silke Wiedmann, Dominik Rath, Tobias Geisler, Bernhard Nieswandt, Peter Kraft, Christoph Kleinschnitz, Peter U. Heuschmann
Summary: This study investigated the feasibility of platelet surface proteins as prognostic markers in ischemic stroke patients, with findings suggesting that elevated CD40 levels may be associated with unfavorable one-year outcomes. Standardized conditions during blood draw and processing in acute stroke units, as well as consideration of patient-related characteristics, are necessary for valid measurements of platelet surface proteins.
Article
Clinical Neurology
Chen Wang, Verena Boerger, Ayan Mohamud Yusuf, Tobias Tertel, Oumaima Stambouli, Florian Murke, Nico Freund, Christoph Kleinschnitz, Josephine Herz, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R. Doeppner, Bernd Giebel, Dirk M. Hermann
Summary: This study demonstrates the neuroprotective and anti-inflammatory effects of MSC-sEVs in aged mice after ischemia, which can reduce neurological deficits, infarct volume, brain edema, neuronal injury, and the infiltration of leukocytes in the brain, as well as decrease the number of monocytes and activated T cells in peripheral blood.
Article
Clinical Neurology
Lucia Beckmann, Stefanie Obst, Nicole Labusek, Hanna Abberger, Christian Koester, Ludger Klein-Hitpass, Sven Schumann, Christoph Kleinschnitz, Dirk M. Hermann, Ursula Felderhoff-Mueser, Ivo Bendix, Wiebke Hansen, Josephine Herz
Summary: Clinical and experimental studies suggest sexual dimorphism in neonatal brain injury and therapy responses caused by hypoxia-ischemia (HI). This study found that regulatory T cells (Tregs) from neonatal female mice provide neuroprotection, while Tregs from male mice increase secondary neurodegeneration, which may be associated with intrinsic transcriptional differences between sexes. There is an urgent need for sex-stratified clinical and preclinical analyses.
Article
Clinical Neurology
Andreas Thimm, Svenja Brakemeier, Kathrin Kizina, Juan Munoz Rosales, Benjamin Stolte, Andreas Totzeck, Cornelius Deuschl, Christoph Kleinschnitz, Tim Hagenacker
Summary: This study investigated the impact of nusinersen on the quality of life of adult SMA patients and found that despite significant improvements in motor function, patients' quality of life did not increase significantly. This highlights the need for novel, disease-specific assessments of quality of life in SMA.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Markus Leo, Linda-Isabell Schmitt, Michael Fleischer, Rebecca Steffen, Cora Osswald, Christoph Kleinschnitz, Tim Hagenacker
Summary: This study investigates the role of spinal astrocytes in the pathogenesis of late-onset SMA forms. Using a mouse model and SMA-like astrocytes, they observed the activation of spinal astrocytes, reduction of certain proteins, and impaired glutamate uptake and potassium uptake. These findings demonstrate the crucial role of spinal astrocytes in the development of late-onset SMA.
Article
Clinical Neurology
Michael Fleischer, Bayram Coskun, Benjamin Stolte, Adela Della-Marina, Heike Koelbel, Hildegard Lax, Michael Nonnemacher, Christoph Kleinschnitz, Ulrike Schara-Schmidt, Tim Hagenacker
Summary: The Essen transition model aims to improve healthcare and quality of life in young adults with neuromuscular diseases. It combines the therapeutic effort of different specialist disciplines through standardized procedures, joint consultations, interdisciplinary conferences, and a transitional database, providing complex care for patients.
Article
Cell Biology
Leoni Rolfes, Steffen Pfeuffer, Jelena Skuljec, Xia He, Chuanxin Su, Sinem-Hilal Oezalp, Marc Pawlitzki, Tobias Ruck, Melanie Korsen, Konstanze Kleinschnitz, Derya Aslan, Tim Hagenacker, Christoph Kleinschnitz, Sven G. Meuth, Refik Pul
Summary: Cladribine-treated MS patients can mount an adequate immune response to influenza independently of treatment duration and time interval to the last cladribine administration. The antibody response against influenza A was comparable between cladribine-treated patients and controls, while the response against influenza B was lower in the cladribine cohort. The increase in geometric mean titers was also lower in the cladribine group compared to controls, but titers increased in both groups for all strains.
Article
Microbiology
Hedda Luise Verhasselt, Elakiya Ramakrishnan, Melina Schlag, Julian R. Marchesi, Jan Buer, Christoph Kleinschnitz, Tim Hagenacker, Andreas Totzeck
Summary: The fungal microbiome in the intestines of patients with myasthenia gravis (MG) was found to be similar to that of patients with non-inflammatory neurological disorders (NIND), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and healthy volunteers. However, due to incomplete data, further analysis and conclusions are limited.
Article
Biochemistry & Molecular Biology
Michael K. Schuhmann, Friederike Langhauser, Lena Zimmermann, Maximilian Bellut, Christoph Kleinschnitz, Felix Fluri
Summary: The study found that DMF treatment can reduce infarct volume and brain edema after stroke, and attenuate lymphocyte infiltration, thus mitigating immune cell-driven damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jonas Feldheim, Teresa Schmidt, Christoph Oster, Julia Feldheim, Martin Stuschke, Walter Stummer, Oliver Grauer, Bjoern Scheffler, Carsten Hagemann, Ulrich Sure, Christoph Kleinschnitz, Lazaros Lazaridis, Sied Kebir, Martin Glas
Summary: To minimize the risk of infections during the COVID-19 pandemic, remote video consultations have become popular in medical fields. However, telemedicine in neuro-oncology presents unique challenges and opportunities. This study analyzed over 3700 neuro-oncological consultations, including more than 300 video consultations, to understand the differences between patient groups and evaluate the benefits and drawbacks of video consultations. Patients who opted for video consultations had worse clinical conditions, higher malignancy grades, were diagnosed more frequently with glioblastoma, and traveled longer distances.
Article
Cell Biology
Markus Leo, Linda-Isabell Schmitt, Fabian Mairinger, Andreas Roos, Christina Hansmann, Stefanie Hezel, Jelena Skuljec, Refik Pul, Ulrike Schara-Schmidt, Christoph Kleinschnitz, Tim Hagenacker
Summary: This study analyzed serum samples of late-onset SMA patients before and after treatment with nusinersen using high-throughput nCounter NanoString technology. Four genes were found to have significantly altered transcript counts in the serum of patients, and these alterations were associated with SMA subtype and treatment response.
Article
Medicine, General & Internal
Jordi Kuehne Escola, Bessime Bozkurt, Bastian Brune, Woon Hyung Chae, Lennart Steffen Milles, Doreen Pommeranz, Lena Brune, Philipp Dammann, Ulrich Sure, Cornelius Deuschl, Michael Forsting, Clemens Kill, Christoph Kleinschnitz, Martin Koehrmann, Benedikt Frank
Summary: Stroke mimics are common in the emergency department, and early detection is crucial for initiating appropriate treatment. This study compared the frequency, clinical characteristics, and predictors of non-neurological and neurological stroke mimics in patients with suspected stroke. The results highlighted the importance of awareness of underlying etiologies and differences in clinical characteristics for optimal care.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Christoph Oster, Teresa Schmidt, Sarina Agkatsev, Lazaros Lazaridis, Christoph Kleinschnitz, Ulrich Sure, Bjorn Scheffler, Sied Kebir, Martin Glas
Summary: This study analyzed phase III clinical trials for glioblastoma conducted since 2005, revealing that the majority of trials did not result in significant improvement in overall survival. Only the EORTC/NCIC, EF-14, and CeTeG studies showed positive outcomes in terms of overall survival in the younger cohort.
NEURO-ONCOLOGY ADVANCES
(2023)