Article
Clinical Neurology
Hatice Tankisi, Bulent Cengiz, James Howells, Gintaute Samusyte, Martin Koltzenburg, Hugh Bostock
Summary: The study compared different estimation methods of SICI in healthy control subjects, finding that the serial tracking protocol did not accurately show the dependence of inhibition on ISI. Additionally, there were differences in SICI variability between different estimation methods.
Article
Neurosciences
Christina S-Z Nielsen, Gintaute Samusyte, Kirsten Pugdahl, Jakob U. Blicher, Anders Fuglsang-Frederiksen, Bulent Cengiz, Hatice Tankisi
Summary: The study investigated the test-retest reliability of two novel SICI protocols in healthy subjects, finding moderate-to-good interobserver and intraday reliability but poor individual repeatability. Both protocols showed no significant systematic bias across sessions and had comparable test-retest reliability profiles. Further studies in patient cohorts are needed to explore the clinical utility of these protocols.
Article
Clinical Neurology
Hatice Tankisi, Bulent Cengiz, Gintaute Samusyte, James Howells, Martin Koltzenburg, Hugh Bostock
Summary: By reducing the number of stimuli in SICI experiments, time and resources can be saved without significant loss of accuracy.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Hatice Tankisi, Hossein Pia, Kristine Strunge, James Howells, Bulent Cengiz, Gintaute Samusyte, Martin Koltzenburg, Anders Fuglsang-Frederiksen, Hugh Bostock
Summary: This study compares the utility of different threshold-tracking methods in the early diagnosis of ALS and finds that T-SICIp has higher sensitivity and specificity, particularly in patients without upper motor neuron signs.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Neurosciences
Nathan Pavey, Parvathi Menon, Mehdi A. J. van den Bos, Matthew C. Kiernan, Steve Vucic
Summary: A complex interaction of inhibitory and facilitatory interneuronal processes may underlie the development of cortical excitability. The study utilized threshold tracking transcranial magnetic stimulation to assess cortical excitability with different coil orientations. Significant effects of coil orientation were observed on short interval intracortical inhibition (SICI) and facilitation (SICF). The results suggest that distinct interneuronal processes are recruited with variable cortical orientation and thresholds.
NEUROSCIENCE LETTERS
(2023)
Article
Clinical Neurology
Hatice Tankisi, Christina S-Z Nielsen, James Howells, Bulent Cengiz, Gintaute Samusyte, Martin Koltzenburg, Jakob U. Blicher, Anette T. Moller, Kirsten Pugdahl, Anders Fuglsang-Frederiksen, Mamede de Carvalho, Hugh Bostock
Summary: This study found that both amplitude-based measure of cortical inhibition and T-SICI are sensitive measures for detecting cortical involvement in MND patients and may aid in early diagnosis of ALS, with T-SICI showing the most abnormalities before the development of upper motor neuron signs.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Kodai Miyara, Seiji Etoh, Kentaro Kawamura, Atsuo Maruyama, Takehiro Kuronita, Akihiko Ohwatashi, Megumi Shimodozono
Summary: The study examined the effects of lower limb segmental muscle vibration on intracortical and spinal excitability in healthy participants. It was found that muscle vibration led to a gradual decrease in short-interval intracortical inhibition over time, possibly due to long-term potentiation. These results may have implications for the treatment of spasticity.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Onno van der Groen, Christopher Latella, Kazunori Nosaka, Dylan Edwards, Wei-Peng Teo, Janet L. Taylor
Summary: Cross-education is the phenomenon of neuromuscular adaptations in the untrained limb after training the opposite limb. This study compared the effects of eccentric and concentric exercise on motor cortex responses using transcranial magnetic stimulation (TMS). The results showed that both eccentric and concentric exercise decreased maximal voluntary isometric contraction (MVIC) torque in the exercised arm. However, the non-exercised biceps brachii showed decreased resting motor threshold (RMT) after concentric exercise and decreased intracortical facilitation (ICF) after eccentric exercise. The findings suggest that unilateral eccentric and concentric exercise have different effects on excitability in the non-exercised hemisphere.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Min Hu, Ningning Zeng, Zhongke Gu, Yuqing Zheng, Kai Xu, Lian Xue, Lu Leng, Xi Lu, Ying Shen, Junhao Huang
Summary: The study found that short-term HIIT may enhance brain activity by modulating motor cortical plasticity and executive function at the neural level.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Psychiatry
Parmis Fatih, M. Utku Kucuker, Jennifer L. Vande Voort, Deniz Doruk Camsari, Faranak Farzan, Paul E. Croarkin
Summary: Based on 113 articles, it is suggested that LICI may serve as a biomarker of GABA(B) functioning, but more rigorous research is required. The existing LICI literature shows methodological heterogeneity and inconsistencies in findings, which are also non-specific to diseases. Future studies should address these weaknesses and focus on high-quality test-retest reliability.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Yoshitaka Okamoto, Daisuke Ishii, Satoshi Yamamoto, Kiyoshige Ishibashi, Yutaka Kohno, Kenji Numata
Summary: This study investigated the effects of upper limb immobilization on sensory information processing and motor-related areas. It was found that upper limb immobilization reduced the excitability of the corticospinal tract, while having minimal effects on the excitability of the primary motor cortex. Additionally, upper limb immobilization resulted in decreased pinch force, but had no effect on visual reaction time.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Yo-Ichi Suzuki, Yan Ma, Kazumoto Shibuya, Sonoko Misawa, Tomoki Suichi, Atsuko Tsuneyama, Keigo Nakamura, Jose Manuel Matamala, Thanuja Dharmadasa, Steve Vucic, Dongsheng Fan, Matthew C. Kiernan, Satoshi Kuwabara
Summary: TT-TMS was used to study Caucasians, Han Chinese, and Japanese, revealing no significant differences in TMS excitability indexes among races. This suggests that racial differences minimally affect motor cortical excitability and function when measured by TT-TMS.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Bulent Cengiz, H. Evren Boran, Halil Can Alaydin, Hatice Tankisi, Gintaute Samusyte, James Howells, Martin Koltzenburg, Hugh Bostock
Summary: Short-latency afferent inhibition (SAI), measured as a reduction in motor evoked potential amplitude (A-SAI), is of clinical interest as a potential biomarker for cognitive impairment. This study compared A-SAI with a threshold-tracking alternative method (T-SAI) and found that A-SAI and T-SAI were closely related when A-SAI was normalized by log conversion. However, within-subject variability was significantly smaller for normalized A-SAI.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Clinical Neurology
Andrea Guerra, Francesco Asci, Alessandro Zampogna, Valentina D'Onofrio, Antonio Suppa, Giovanni Fabbrini, Alfredo Berardelli
Summary: The study demonstrates that long-term treatment with safinamide benefits SICF and M1 plasticity in PD patients, potentially preventing worsening of LID severity over time.
Article
Neuroimaging
Stephanie M. Hare, Xiaoming Du, Bhim M. Adhikari, Shuo Chen, Chen Mo, Ann Summerfelt, Mark D. Kvarta, Laura Garcia, Peter Kochunov, L. Elliot Hong
Summary: Short interval intracortical inhibition (SICI) is a biomarker for altered motor inhibition in schizophrenia. The study found that higher SICI ratios in patients were associated with lower regional homogeneity in the right insula, and reduced connectivity between the right insula and hubs of the corticospinal pathway. Mediation analysis supported a model in which the direct effect of local insular connectivity strength on SICI is mediated by interhemispheric connectivity between the insula and left sensorimotor cortex.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
