Journal
METABOLIC BRAIN DISEASE
Volume 35, Issue 7, Pages 1165-1173Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11011-020-00598-z
Keywords
Diabetes; Brain region; Cognitive decline; Metabolomics; Neurotransmitter
Categories
Funding
- National Natural Science Foundation of China [21605115, 81771386]
- Health Foundation for Creative Talents in Zhejiang Province
- Project Foundation for the College Young and Middle-aged Academic Leader of Zhejiang Province
- Wenzhou Bureau of Science and Technology [Y20150087]
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Diabetes at advanced age increases rise of cognitive impairment, but its potential mechanisms are still far from being fully understood. In this study, we analyzed the metabolic alterations in six different brain regions between streptozotocin (STZ)-induced diabetic mice with cognitive decline (DM) and age-matched controls (CON) using a(1)H NMR-based metabolomics approach, to explore potential metabolic mechanisms underlying diabetes-induced cognitive decline. The results show that DM mice had a peculiar metabolic phenotype in all brain regions, mainly involving increased lactate level, decreased choline and energy metabolism as well as disrupted astrocyte-neuron metabolism. Furthermore, these metabolic changes exhibited a brain region-specific pattern. Collectively, our results suggest that brain region-specific metabolic disorders may be responsible for diabetes-induced cognitive dysfunction.
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