Article
Medicine, General & Internal
Marta Bottagisio, Marco Vigano, Antonio Pellegrini, Nicola Logoluso, Luigi Zagra, Andrea Prina, Laura de Girolamo, Elena De Vecchi
Summary: The analysis of synovial fluid is crucial for diagnosing prosthetic joint infections. This study examined the effectiveness of synovial calprotectin, analyzed using a commercial stool test, in accurately predicting PJIs. The study found that synovial calprotectin correlated with established indicators of local infection, suggesting it could be a valuable biomarker for diagnosing PJI.
Article
Orthopedics
Hai Wang, Leilei Qin, Jiawei Wang, Ning Hu, Wei Huang
Summary: The study demonstrates the combination of serum and synovial CRP can be used as an adjunct in the diagnosis of chronic PJI, with significantly higher levels of synovial CRP in the infection group compared to the aseptic group.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Chemistry, Multidisciplinary
Uthpala N. Wijayaratna, Sachindra D. Kiridena, John D. Adams, Caleb J. Behrend, Jeffrey N. Anker
Summary: An implantable sensor has been developed to measure synovial fluid pH for noninvasive early detection and monitoring of hip infections using standard-of-care plain radiography. The sensor shows a linear response and reversibility in the physiologically relevant pH range.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Orthopedics
Dariusz Grzelecki, Aleksandra Grajek, Piotr Walczak, Jacek Kowalczewski
Summary: This study evaluated the usefulness of the rapid D-lactic acid strip test in diagnosing periprosthetic joint infection. The results showed that the test had a sensitivity of 83% and specificity of 100% for diagnosing infection. The two different leukocyte esterase strip tests also had high diagnostic accuracy. However, further investigations are needed to analyze the test's performance in patients with chronic inflammatory diseases and to confirm its clinical utility.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Review
Medicine, General & Internal
Maria Eugenia Portillo, Ignacio Sancho
Summary: The article discusses the use of non-culture techniques in the diagnosis of prosthetic joint infections (PJI). Nucleic acid amplification and sequencing methods are described as useful tools for detecting and identifying pathogens. The new technologies have shown promise in improving the etiological diagnosis of PJI, but rigorous protocols are necessary to avoid contamination.
Article
Orthopedics
Dariusz Grzelecki, Aleksandra Grajek, Maciej Otworowski, Wiktor Paskal, Petr Fulin, Jacek Kowalczewski
Summary: The study evaluated the diagnostic accuracy of different fast point-of-care tests for detecting C-reactive protein (CRP) in synovial fluid for the diagnosis of periprosthetic joint infection (PJI). The cassette test with a minimum cutoff value of >= 8 mg/L demonstrated the best accuracy for the diagnosis of chronic PJI.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Review
Microbiology
Giulia Gatti, Francesca Taddei, Martina Brandolini, Andrea Mancini, Agnese Denicolo, Francesco Congestri, Martina Manera, Valentina Arfilli, Arianna Battisti, Silvia Zannoli, Maria Michela Marino, Anna Marzucco, Manuela Morotti, Laura Grumiro, Agata Scalcione, Giorgio Dirani, Monica Cricca, Vittorio Sambri
Summary: The incidence of total joint arthroplasty is increasing and is expected to exceed 4 million by 2030. As a result, the detection of infections associated with surgical interventions is also increasing, and prosthetic joint infections pose a challenging problem both clinically and economically. In recent years, the implementation of diagnostic methodologies has reduced errors and improved response time.
Article
Orthopedics
Christoph Theil, Thomas Ackmann, Georg Gosheger, Jan Puetzler, Burkhard Moellenbeck, Jan Schwarze, Martin Schulze, Sebastian Klingebiel
Summary: This study analyzed the potential use of synovial pH as a diagnostic marker for chronic prosthetic joint infection (PJI). The results showed that synovial pH could be a useful parameter for diagnosing chronic PJI after hip or knee arthroplasty, but with low sensitivity.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2022)
Article
Infectious Diseases
Zida Huang, Zijie Zhang, Mengqing Li, Wenbo Li, Xinyu Fang, Wenming Zhang
Summary: This study demonstrates that synovial fluid NGAL level can serve as a diagnostic indicator for prosthetic joint infection, with high sensitivity and specificity. In addition, previous antibiotic use does not affect the NGAL level in synovial fluid.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Chiara Baggio, Roberto Luisetto, Carlotta Boscaro, Anna Scanu, Roberta Ramonda, Mattia Albiero, Paolo Sfriso, Francesca Oliviero
Summary: Genomic damage is associated with autoimmune processes, chronic inflammation, and apoptosis. The T cell compartment may exhibit overall genomic instability in certain rheumatological diseases. However, there is limited knowledge regarding leukocyte abnormalities in synovial fluid (SF) and their connection to inflammation. This study aimed to investigate cellular phenotypes in SF from patients with various inflammatory arthropathies. The results showed that inflammatory SF is associated with genomic instability and abnormal cell subsets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Christos Koutserimpas, Ifigeneia Chamakioti, Stylianos Zervakis, Konstantinos Raptis, Kalliopi Alpantaki, Diamantis P. Kofteridis, Georgia Vrioni, George Samonis
Summary: Non-Candida fungal prosthetic joint infections pose a clinical challenge that requires a multidisciplinary approach. The combination of two-stage revision arthroplasty and prolonged antifungal treatment has been shown to be the standard of care in the reviewed cases.
Article
Orthopedics
Lorenzo Drago, Delia Romano, Andrea Fidanza, Alessio Giannetti, Rocco Erasmo, Andreas F. Mavrogenis, Carlo Luca Romano
Summary: Pre-treatment of synovial fluid with Dithiothreitol (DTT) can enhance the sensitivity of microbiological examination in patients with periprosthetic joint infections (PJI), particularly for bacteria in biofilm aggregates.
INTERNATIONAL ORTHOPAEDICS
(2023)
Review
Medicine, General & Internal
Inga Zerr
Summary: The diagnosis of Creutzfeldt-Jakob disease has evolved to include the detection of 14-3-3 protein and abnormally folded prion protein in cerebrospinal fluid, with nearly 100% sensitivity and specificity.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Pathology
Zakareya Gamie, Dileep Karthikappallil, Emane Gamie, Stavros Stamiris, Eustathios Kenanidis, Eleftherios Tsiridis
Summary: Current microbiology culture methods for prosthetic joint infections (PJIs) have a high false-negative rate, prompting investigation into next-generation sequencing (NGS) technology and polymerase chain reaction (PCR). While these technologies show promise in identifying causative organisms, further refinement and addressing cost and complexity issues are necessary before routine clinical use.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Multidisciplinary Sciences
Taiana Cunha Ribeiro, Emerson Kiyoshi Honda, Daniel Daniachi, Ricardo de Paula Leite Cury, Cely Barreto da Silva, Giselle Burlamaqui Klautau, Mauro Jose Salles
Summary: The study compared the sensitivity and specificity of sonication culture and tissue culture in diagnosing prosthetic joint infections (PJI), finding that sonication culture had higher sensitivity rates while tissue culture had better specificity. Combining both methods for diagnosis resulted in the highest sensitivity, indicating that sonication cultures can aid in PJI diagnosis, especially when traditional diagnostic criteria are inconclusive.
Meeting Abstract
Gastroenterology & Hepatology
L. Roncoroni, L. Elli, P. Braidotti, L. Tacchini, V Lombardo, F. Branchi, D. Conte, L. Doneda
DIGESTIVE AND LIVER DISEASE
(2016)
Article
Cardiac & Cardiovascular Systems
E. Vianello, E. Dozio, F. Arnaboldi, M. G. Marazzi, C. Martinelli, J. Lamont, L. Tacchini, A. Sigruener, G. Schmitz, M. M. Corsi Romanelli
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2016)
Article
Gastroenterology & Hepatology
Nicoletta Gagliano, Giuseppe Celesti, Lorenza Tacchini, Stefano Pluchino, Chiarella Sforza, Marco Rasile, Vincenza Valerio, Luigi Laghi, Vincenzo Conte, Patrizia Procacci
WORLD JOURNAL OF GASTROENTEROLOGY
(2016)
Letter
Infectious Diseases
Lorenzo Drago, Roberta De Grandi, Elena De Vecchi, Marco Toscano
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2016)
Article
Infectious Diseases
Kordo Saeed, Matthew Dryden, Matteo Bassetti, Eric Bonnet, Emilio Bouza, Monica Chan, Nick Cortes, Joshua S. Davis, Silvano Esposito, Gerard Giordano, Ian Gould, David Hartwright, David Lye, Mercedes Marin, Rhidian Morgan-Jones, Francisco Lajara-Marco, Elda Righi, Carlo Luca Romano, John Segreti, Serhat Unal, Rhodri Llywelyn Williams, Ata Nevzat Yalcin
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2017)
Article
Dentistry, Oral Surgery & Medicine
Lorenzo Drago, Monica Bortolin, Silvio Taschieri, Elena De Vecchi, Serse Agrappi, Massimo Del Fabbro, Luca Francetti, Roberto Mattina
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2017)
Article
Cell Biology
Elena Vianello, Elena Dozio, Alessandra Barassi, Lorenza Tacchini, John Lamont, Santi Trimarchi, Massimiliano M. Marrocco-Trischitta, Massimiliano M. Corsi Romanelli
MEDIATORS OF INFLAMMATION
(2017)
Article
Multidisciplinary Sciences
Arianna Barbara Lovati, Carlo Luca Romano, Marta Bottagisio, Lorenzo Monti, Elena De Vecchi, Sara Previdi, Riccardo Accetta, Lorenzo Drago
Review
Clinical Neurology
Pedro Berjano, Jorge H. Villafane, Dario Lo Re, Maryem Ismael, Marco Damilano, Lucia Bertozzi, Carlo L. Romano, Lorenzo Drago
JOURNAL OF NEUROSURGICAL SCIENCES
(2019)
Article
Cardiac & Cardiovascular Systems
Elena Dozio, Elena Vianello, Alexis E. Malavazos, Lorenza Tacchini, Gerd Schmitz, Gianluca Iacobellis, Massimiliano M. Corsi Romanelli
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Review
Medicine, General & Internal
Drago Lorenzo, Zuccotti GianVincenzo, Romano Carlo Luca, Goswami Karan, Jorge Hugo Villafane, Mattina Roberto, Parvizi Javad
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Cell Biology
Elena Dozio, Massimiliano Ruscica, Elena Vianello, Chiara Macchi, Clementina Sitzia, Gerd Schmitz, Lorenza Tacchini, Massimiliano M. Corsi Romanelli
MEDIATORS OF INFLAMMATION
(2020)
Article
Medicine, General & Internal
Svetlana Bozhkova, Virginia Suardi, Hemant K. Sharma, Hiroyuki Tsuchiya, Hernan del Sel, Mahmoud A. Hafez, Thami Benzakour, Lorenzo Drago, Carlo Luca Romano
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Microbiology
Vikas M. Agashe, Ashok N. Johari, Mudit Shah, Rashid Anjum, Carlo Romano, Lorenzo Drago, Hemant K. Sharma, Thami Benzakour
Article
Biochemistry & Molecular Biology
Lorenzo Drago, Serse Agrappi, Monica Bortolin, Marco Toscano, Carlo Luca Romano, Elena De Vecchi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)