Article
Oncology
Hongdian Zhang, Peng Ren, Mingquan Ma, Xiaolei Zhu, Kai Zhu, Wanyi Xiao, Lei Gong, Peng Tang, Zhentao Yu
Summary: The study investigated the prognostic value of AFR and AGR in patients with ESCC, finding that AFR may be an independent predictor of overall survival. The predicted nomogram containing AFR showed higher predictive ability with a higher C-index. Calibration curves and DCA analysis supported the conclusion that a low preoperative AFR could be a valuable predictor of poor prognosis in ESCC patients.
Article
Immunology
Qi Li, Jian Zhang, Qi Gao, Jialu Fu, Mengke Li, Hengchao Liu, Chen Chen, Dong Zhang, Zhimin Geng
Summary: This study aimed to explore and screen preoperative serum immune response level-related biomarkers for gallbladder carcinoma (GBC) patients, and develop a prognostic model for clinical decision-making. A total of 427 GBC patients who underwent radical resection were retrospectively analyzed. The preoperative fibrinogen-to-albumin ratio (FAR) was found to have better predictive ability for overall survival. A nomogram model based on independent risk factors was established and validated with good predictive ability compared to FAR and TNM staging system.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Medicine, General & Internal
Xiaofei Chen, Chenyang Zhang, Dingjie Guo, Yashan Wang, Junjun Hu, Jiayi Hu, Song Wang, Xin Liu
Summary: This study aimed to explore the risk factors and prognostic factors of invasive ductal carcinoma (IDC) and predict the survival of IDC patients with metastasis. Risk factors included age, race, marital status, income, geographic region, grade, T stage, N stage, subtype, surgery, and radiotherapy, while prognostic factors included age, race, marital status, income, geographic region, grade, T stage, N stage, subtype, surgery, and chemotherapy. A nomogram was established with a C-index of 0.701, showing good consistency between actual observation and prediction. Survival curves varied significantly among different metastatic patterns.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Shuai Li, Di Zhang, Song Zeng, Tianjun Wu, Yicun Wang, He Zhang, Biao Wang, Xiaopeng Hu
Summary: This study found that albumin-to-fibrinogen ratio (AFR) is an independent prognostic factor in bladder cancer patients and is associated with overall survival and disease-free survival. The developed nomograms incorporating AFR, tumor grade, and tumor multifocality can accurately predict patients' outcomes.
Article
Medicine, Research & Experimental
Yaqun Ding, Xiangyu Qi, Yang Li, Yanni Sun, Jia Wan, Chengxin Luo, Yarui Huang, Qingrong Li, Guixian Wu, Xiaoqing Zhu, Shuangnian Xu
Summary: This study evaluated the effect of albumin-to-fibrinogen ratio (AFR) on survival prognosis in acute myeloid leukemia (AML) patients. The results showed that patients with lower AFR had poorer complete remission rate, shorter time to relapse, higher mortality, shorter overall survival (OS), and disease-free survival (DFS). Multivariate analysis identified AFR as an independent prognostic variable associated with OS. A new prognostic model utilizing AFR showed better predictive performance and net benefits compared to the traditional risk model.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Haitao Yu, Mingxun Wang, Yi Wang, Jinhuan Yang, Liming Deng, Wenming Bao, Bangjie He, Zixia Lin, Ziyan Chen, Kaiyu Chen, Baofu Zhang, Fangting Liu, Zhengping Yu, Longyun Ye, Bin Jin, Gang Chen
Summary: The study found that ICC patients with high FAR and sarcopenia have a poorer prognosis after surgery, and the nomograms developed based on these factors can accurately predict the survival of ICC patients.
Article
Immunology
Aiya Qin, Siqing Wang, Lingqiu Dong, Zheng Jiang, Dandan Yang, Jiaxing Tan, Yi Tang, Wei Qin
Summary: Our study demonstrated that a low albumin-to-fibrinogen ratio (AFR) (<12.44) is an independent prognostic factor of poor renal prognosis in Chinese IgAN patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Surgery
Qinheng Yang, Dong Liang, Yang Yu, Feng Lv
Summary: This study found that fibrinogen-to-albumin ratio (FAR) is a potential prognostic factor for patients with triple-negative breast cancer (TNBC) and can be used in clinical practice.
FRONTIERS IN SURGERY
(2022)
Article
Medicine, General & Internal
Tianshu Jia, Rui Zhang, Fanfei Kong, Qianjiao Zhang, Zhuo Xi
Summary: The study established and validated a point-based nomogram to predict overall survival in LGG patients, showing that the FA score may serve as a potential prognostic biomarker. Age and white blood count were also identified as independent prognostic factors for overall survival in LGG patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Oncology
Chengqing Li, Zhiyao Fan, Wenyi Guo, Feng Liang, Xincheng Mao, Jiahao Wu, Haodong Wang, Jianwei Xu, Dong Wu, Han Liu, Lei Wang, Feng Li
Summary: This study found that the fibrinogen-to-prealbumin ratio (FPR) is a feasible biomarker for predicting prognosis in patients with resectable pancreatic cancer. A nomogram based on FPR was established, which showed better predictive and discriminative ability than the conventional TNM stage.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Baibei Li, Huachu Deng, Ziyan Zhou, Bo Tang
Summary: This study found that a high Fibrinogen to pre-albumin ratio (FPR) is significantly associated with poor overall survival, recurrence-free survival, progression-free survival, complications, disease-free survival, and cancer-specific survival in malignant digestive system tumors. Despite intergroup differences, FPR is strongly associated with overall and relapse-free survival, and sensitivity analysis suggests the stability of the results.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Yang Fu, Yang Yu, Yi Zhou, Tong Li, Yizhou Xie, Yehui Wang, Qiang Ran, Yiming Chen, Xiaohong Fan
Summary: This study analyzed the prognostic value of the fibrinogen-albumin ratio (FAR) in predicting overall survival in elderly osteosarcoma patients. The results showed that FAR was significantly correlated with various clinical-pathological characteristics and an independent risk factor for overall survival. A clinical nomogram was constructed to predict prognosis in elderly patients with osteosarcoma.
Article
Oncology
Mao-Lin Xu, Shu-E Zeng, Fang Li, Xin-Wu Cui, Gui-Feng Liu
Summary: The aim of this study was to develop a radiomics nomogram based on grayscale ultrasound (US) for preoperatively predicting Lymphovascular invasion (LVI) in patients with pathologically confirmed T1 (pT1) breast invasive ductal carcinoma (IDC). The study found that tumor margin, axillary lymph node metastasis status, and radiomics score were independent predictors for predicting LVI, and a radiomics nomogram model was developed. The performance of the nomogram model showed superior discrimination and clinical net benefit compared to the conventional ultrasound model.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zengjie Wu, Qing Lin, Haibo Wang, Guanqun Wang, Guangming Fu, Tiantian Bian
Summary: The study developed a radiomics nomogram based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to accurately differentiate between ductal carcinoma in situ with microinvasion (DCISM) and pure ductal carcinoma in situ (DCIS) breast cancer. The radiomics signature and nomogram model showed better performance in calibration and validation compared to the clinical factor model, indicating good potential for clinical utility.
ACADEMIC RADIOLOGY
(2023)
Article
Immunology
Zhen Wang, Haijun Mao, Guangyue Xu
Summary: This study evaluated the diagnostic potential of novel biomarkers for infected tibial nonunion. The results showed that fibrinogen, albumin-to-globulin ratio (AGR), and fibrinogen-AGR (FAGR) are promising biomarkers for the diagnosis of infected tibial nonunion. These biomarkers have high sensitivity and specificity, and can improve the diagnostic accuracy of infected tibial nonunion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)