Review
Endocrinology & Metabolism
Annemarie Balasko, Karin Zibar Tomsic, Darko Kastelan, Tina Dusek
Summary: Secondary adrenal insufficiency develops after successful treatment for Cushing's syndrome. Glucocorticoid replacement therapy is necessary until the recovery of the HPA axis. Patients often experience symptoms of glucocorticoid withdrawal syndrome after cure. Individualized treatment is needed to avoid overtreatment or undertreatment.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Chemistry, Physical
Ferhat Can Piskin, Gamze Akkus, Sevinc Puren Yucel, Bisar Akbas, Fulya Odabasi
Summary: This study aimed to develop a radiomics signature-based MRI method for diagnosing adrenal Cushing's syndrome in adrenal incidentalomas. By studying 50 patients with adrenal incidentalomas, it was found that MRI-based radiomic scores can be used to predict adrenal Cushing's syndrome.
ENERGY STORAGE MATERIALS
(2023)
Letter
Endocrinology & Metabolism
Frederic Castinetti, Vincent Amodru, Thierry Brue
Summary: This short manuscript reports three cases of atypical adrenal insufficiency with osilodrostat, which is highly effective in blocking cortisol secretion but also carries the risk of adrenal insufficiency.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yasir S. Elhassan, Cristina L. Ronchi, Piyumi Wijewickrama, Stephanie E. Baldeweg
Summary: Adrenal hemorrhage is a rare and underestimated condition with nonspecific clinical features. It can occur in various clinical contexts, including abdominal trauma, adrenal tumors, sepsis, and COVID-19 infection. Prompt recognition is crucial to prevent adrenal crisis and insufficiency.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Nada Younes, Matthieu St-Jean, Isabelle Bourdeau, Andre Lacroix
Summary: Endogenous Cushing's syndrome during pregnancy is rare, commonly caused by adrenal adenomas and pregnancy-induced CS. Diagnosis is challenging due to physiologic hypercortisolism in pregnancy. Careful interpretation of cortisol production tests and limited imaging options are required. Surgical resection of lesions before 24 weeks of gestation is the optimal treatment, with metabolic complications managed in mild cases.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Endocrinology & Metabolism
Iza F. R. Machado, Isabel Q. Menezes, Sabrina R. Figueiredo, Fernando M. A. Coelho, Debora R. B. Terrabuio, Davi Ramos, Gustavo F. C. Fagundes, Ana Alice W. Maciel, Ana Claudia Latronico, Maria Candida B. Fragoso, Eduardo L. R. Cancado, Berenice B. Mendonca, Madson Q. Almeida
Summary: COVID-19 may cause bilateral adrenal infarction, which is associated with positive antiphospholipid antibodies. Therefore, patients with positive antiphospholipid antibodies should be closely monitored for symptoms or signs of acute adrenal insufficiency during COVID-19.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Ruxandra-Cristina Marin, Simona Gabriela Bungau, Delia Mirela Tit, Paul Andrei Negru, Andrei-Flavius Radu, Radu Dumitru Moleriu
Summary: Approximately two-thirds of Romanian HIV patients were parenterally infected with the F subtype of HIV in early childhood. They are now facing immunological aging, with immunosuppression posing an additional challenge in developing effective and well-tolerated regimens. A retrospective study compared the immune recovery of 462 HIV-infected patients who received different treatment regimens, showing normal immune response but a significant difference between groups. The study also assessed the relationship between immune and virological responses to therapy, finding an association at the final visit.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Ruxandra-Cristina Marin, Tapan Behl, Nicoleta Negrut, Simona Bungau
Summary: Management of antiretroviral therapy in HIV+ patients faces challenges in improving patient adherence by selecting appropriate treatment regimens to reduce viremia, enhance immune response, and minimize adverse reactions. The use of protease inhibitor darunavir with enzyme inhibitors cobicistat or ritonavir has shown effectiveness in reducing HIV mortality and morbidity by impacting drug interactions and pharmacokinetics.
Article
Surgery
Praachi Raje, Jordan M. Broekhuis, Barry A. Sacks, Benjamin C. James
Summary: Adrenal vein sampling (AVS) provides valuable information for determining appropriate management of adrenal Cushing's syndrome, especially in distinguishing unilateral from bilateral disease. Even in cases of bilateral disease, AVS may identify a dominant gland, allowing for staged unilateral adrenalectomy before considering complete adrenalectomy or medical management. Larger studies are needed to further establish the significant benefit of AVS for this population.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Microbiology
Katy Moore, Nilay Thakkar, Mindy Magee, Heather Sevinsky, Blisse Vakkalagadda, Susan Lubin, Cyril Llamoso, Peter Ackerman
Summary: Fostemsavir is a new drug that effectively prevents HIV-1 from entering host cells. Its metabolism is influenced by certain enzymes, and coadministration with other drugs may affect its concentration. This study evaluates the impact of combining fostemsavir with different antiretroviral drugs, showing that some combinations increase temsavir concentrations while others decrease them. Overall, fostemsavir is well tolerated in various combination regimens and does not require dosage adjustments.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Vania Benido Silva, Joana Cardoso, Maria Esteves Brandao, Isabel Mesquita, Maria Teresa Pereira
Summary: This is a case report about a patient who developed iatrogenic Cushing's syndrome (ICS) due to an interaction between Cobicistat and glucocorticoids. The patient had HIV-hepatitis C co-infection and underwent sleeve gastrectomy for obesity. The presence of morbid obesity and rarity of this pharmacological complication made the diagnosis challenging.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Infectious Diseases
Dongxu Yu, Leilei Shi, Xinrui Zhang, Huifen Yang, Jing Feng, Yubao Wang
Summary: We reported a case of a 68-year-old man who presented with recurrent fever and multiorgan dysfunction. His significantly elevated procalcitonin and C-reactive protein levels indicated recurrent sepsis. However, no focus of infection and no pathogens were identified through a variety of examinations and tests. Although the increase of creatine kinase was less than five times the upper limit of normal value, the diagnosis of rhabdomyolysis secondary to adrenal insufficiency resulting from primary empty sella syndrome was finally made, as supported by serum myoglobin elevation, serum cortisol, and adrenocorticotropic hormone deficiency, bilateral adrenal atrophy on computed tomography, and empty sella on magnetic resonance imaging. After the glucocorticoid replacement treatment, the patient's myoglobin gradually returned to normal range, and his condition continued to improve. Rhabdomyolysis resulting from a rare cause may be misdiagnosed as sepsis in patients who present with increased procalcitonin levels.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Ruxandra-Cristina Marin, Delia Mirela Tit, Oana Sandulescu, Adrian Streinu-Cercel, Simona Gabriela Bungau
Summary: The study found that in HIV-infected subjects, the use of DRV/c in combination with other antiretroviral drugs was better tolerated and had a lower impact on metabolic profiles compared to DRV/r. Specifically, patients in the DRV/c group were at lower risk of developing side effects and metabolic impairments in all body functions studied.
Article
Endocrinology & Metabolism
Leamarie Meloche-Dumas, Frederic Mercier, Andre Lacroix
Summary: Primary bilateral adrenocortical hyperplasias are rare forms of pituitary ACTH-independent Cushing's syndrome, with treatment options including bilateral adrenalectomy and unilateral adrenalectomy, as well as medical therapies.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Genetics & Heredity
Giacomo Bitetto, Gianluca Lopez, Dario Ronchi, Alessandra Pittaro, Valentina Melzi, Erika Peverelli, Fulvia Milena Cribiu, Giacomo P. P. Comi, Giovanna Mantovani, Alessio Di Fonzo
Summary: Allgrove disease is a rare genetic syndrome characterized by multiple symptoms. The study found downregulation of Aladin transcript and protein, as well as impairment in the nucleocytoplasmic transport. These findings suggest a potential link between ACTH resistance, SCARB1 impairment, and defective nucleocytoplasmic transport.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Meeting Abstract
Clinical Neurology
S. Keddie, D. Foldes, F. Caimari, S. E. Baldeweg, S. D'Sa, M. Lunn
NEUROMUSCULAR DISORDERS
(2018)
Article
Endocrinology & Metabolism
S. E. Baldeweg, S. Ball, A. Brooke, H. K. Gleeson, M. J. Levy, M. Prentice, J. Wass
ENDOCRINE CONNECTIONS
(2018)
Letter
Geriatrics & Gerontology
Suzanne Reeves, Erica Sugita, Stephanie E. Baldeweg, Robert Howard
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2018)
Article
Endocrinology & Metabolism
Francisca Caimari, Stephen Keddie, Michael P. Lunn, Shirley D'Sa, Stephanie E. Baldeweg
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Article
Endocrinology & Metabolism
Wiebke Arlt, Stephanie E. Baldeweg, Simon H. S. Pearce, Helen L. Simpson
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Anneke Graf, Hani J. Marcus, Stephanie E. Baldeweg
Summary: The study found that while only a small percentage of patients had confirmed or suspected COVID-19 infection, over half were still indirectly impacted by the pandemic through delays or changes to their planned care.
Article
Clinical Neurology
Ziad Hussein, Ploutarchos Tzoulis, Hani J. Marcus, Joan Grieve, Neil Dorward, Pierre Marc Bouloux, Stephanie E. Baldeweg
Summary: This study aims to evaluate the management and outcome of hyponatraemia following transsphenoidal surgery. The findings show that hyponatraemia is a relatively common occurrence in postoperative patients, associated with longer hospital stay and risk of readmission, and the effectiveness of fluid restriction is limited.
ACTA NEUROCHIRURGICA
(2022)
Article
Endocrinology & Metabolism
Phillip Yeoh, Andrew A. Dwyer, Ella Anghel, Pierre M. Bouloux, Bernard Khoo, Shern Chew, Florian Wernig, Paul Carroll, Simon J. B. Aylwin, Stephanie E. Baldeweg, William Drake, Jeannie Todd, Lindiwe Mangena, Ashley Grossman
Summary: This study compared the effects of a standard dose and a low dose of insulin tolerance test (ITT) on glucose, cortisol, and growth hormone (GH) responses. The results showed that the low-dose ITT produced comparable glucose, cortisol, and GH responses to the standard dose. Given the risks associated with hypoglycaemia, the low dose appears to be preferable to the standard dose ITT in most circumstances.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Haitham Hamoda, Annice Mukherjee, Edward Morris, Stephanie E. Baldeweg, Channa N. Jayasena, Paula Briggs, Sara Moger
CLINICAL ENDOCRINOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Haitham Hamoda, Sara Moger, Edward Morris, Stephanie E. Baldeweg, Asha Kasliwal, Flic Gabbay
CLINICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yasir S. Elhassan, Cristina L. Ronchi, Piyumi Wijewickrama, Stephanie E. Baldeweg
Summary: Adrenal hemorrhage is a rare and underestimated condition with nonspecific clinical features. It can occur in various clinical contexts, including abdominal trauma, adrenal tumors, sepsis, and COVID-19 infection. Prompt recognition is crucial to prevent adrenal crisis and insufficiency.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Danyal Z. Khan, John G. Hanrahan, Stephanie E. Baldeweg, Neil L. Dorward, Danail Stoyanov, Hani J. Marcus
Summary: The pituitary gland plays a vital role in the body and its proximity to critical neurovascular structures means that pituitary adenomas can have serious consequences. Advances in surgical care have been made, but challenges such as treatment failure and recurrence remain. Novel medical technologies, such as endoscopy and artificial intelligence, have the potential to improve outcomes and benefit patients.
Article
Medicine, General & Internal
Anneke Graf, Chan Hee Koh, Gordon Caldwell, Joan Grieve, Melissa Tan, Jasmine Hassan, Kaushiki Bakaya, Hani J. Marcus, Stephanie E. Baldeweg
Summary: This study assessed the quality of outpatient consultations and found that the shift to telemedicine during the pandemic has negatively impacted consultation quality. High-quality consultations were associated with greater satisfaction and definitive consultation outcome decisions.
CLINICS AND PRACTICE
(2022)
Article
Clinical Neurology
R. Bhargava, Z. Hussein, N. L. Dorward, J. P. Grieve, Z. Jaunmuktane, H. J. Marcus, I Proctor, S. E. Baldeweg
Summary: IgG4-related hypophysitis is a rare chronic inflammatory condition of the pituitary gland, with clinical presentation similar to other forms of hypophysitis. Pituitary biopsy should be considered for diagnosis, followed by further workup and follow-up.
ACTA NEUROCHIRURGICA
(2022)
Meeting Abstract
Clinical Neurology
Stephen Keddie, David Foldes, Francisca Caimari, Stephanie Baldeweg, Michael Chou, Kwee Yong, Aisling Carr, Mary Reilly, Shirley D'Sa, Michael Lunn
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2018)