Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 117, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.111359
Keywords
Dopamine (DOP) grafting; Electrospinning; Poly(L-lactic acid); Silica nanoparticle; Bone regeneration
Categories
Funding
- Rosetrees Trust [A2750/M874, 298582]
- Stoneygate Trust [A2750/M874, 1119976]
- University of Manchester
- Engineering and Physical Sciences Research Council (EPSRC) of the UK
- Global Challenges Research Fund (GCRF) [EP/R01513/1]
- Science and Technology Project of Shaanxi, China [2017JQ2006]
- youth talent promotion plan of Shaanxi Association for Science and Technology [20190305]
- Electron Microscopy Centre in The University of Manchester
- XRD suite in The University of Manchester
- EPSRC [EP/R015139/1] Funding Source: UKRI
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Electrospinning has been widely used to fabricate polymer fibrous scaffolds for bone tissue engineering because of their highly porous structures. In order to improve the biocompatibility of polymer scaffolds, some nano particles have been introduced into electrospun fibres. For example, silica nanoparticles (SiNPs), with high surface area and good biocompatibility, have been used for bone tissue engineering for better bone cell attachment. In this work, porous poly(L-lactic acid) (PLLA) fibrous membrane with high surface area was fabricated by electrospinning and post-treatment process. The membrane can serve as substrates of SiNPs for bone tissue engineering. Dopamine (DOP) was applied to modify the surface of PLLA fibres, which improved the coating strength of SiNPs on PLLA fibres. SiNP coating significantly improved the mechanical properties and hydrophilicity of PLLA/DOP/SiNP composite membranes. As a result of SiNPs coating, PLLA/DOP/SiNP membrane exhibited better cellular biocompatibility, more cell attachment and proliferation. These results demonstrate that porous PLLA/DOP/SiNP composite membrane with high surface area has high potential for periosteum in the field of bone regeneration applications.
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