Article
Hematology
Alessandra Iurlo, Nicole Galli, Cristina Bucelli, Silvia Artuso, Dario Consonni, Daniele Cattaneo
Summary: This study evaluated the changes in CD34(+) cells in MF patients and examined their association with spleen response. The results showed a progressive reduction in CD34(+) cell count during ruxolitinib therapy. The increase in CD34(+) cell count was found to be associated with an increase in spleen length, according to multivariable regression analysis.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Yunfan Yang, Hongmei Luo, Yuhuan Zheng, Zhongqing Zou, Ting Niu, Yongqian Jia, Huanling Zhu, Ting Liu, Yu Wu, Hong Chang, Jie Ji, Jian Li, Ling Pan
Summary: The study aimed to investigate the effect of low-dose ruxolitinib treatment on myelofibrosis (MF), revealing that low-dose treatment resulted in gradual spleen response and significant improvement in bone marrow fibrosis.
ANNALS OF HEMATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Douglas Tremblay, John Mascarenhas
Summary: Myelofibrosis is a hematologic malignancy characterized by splenomegaly in 80% of newly diagnosed patients. JAK inhibitors are the main pharmacologic treatment for splenomegaly, but their efficacy in reducing spleen size is variable and the duration of benefit is limited.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Oncology
Alessandro Malara, Cristian Gruppi, Margherita Massa, Maria Enrica Tira, Vittorio Rosti, Alessandra Balduini, Giovanni Barosi
Summary: The level of circulating EDA-FN in plasma is associated with disease severity and progression in primary myelofibrosis, and may serve as a marker for disease progression and a novel target for treating splenomegaly.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Vikas Gupta, Martin Griesshammer, Bruno Martino, Lynda Foltz, Renato Tavares, Haifa Kathrin Al-Ali, Pilar Giraldo, Paola Guglielmelli, Elza Lomaia, Catherine Bouard, Carole Paley, Ranjan Tiwari, Evren Zor, Pia Raanani
Summary: The large JUMP study analyzed factors predictive of spleen and symptom responses in myelofibrosis patients receiving ruxolitinib. Results showed that lower IPSS risk, earlier treatment initiation, and higher ruxolitinib doses were associated with increased spleen response rates, but not symptom improvement.
LEUKEMIA & LYMPHOMA
(2021)
Article
Hematology
Timothy Devos, Dominik Selleslag, Nikki Granacher, Violaine Havelange, Fleur Samantha Benghiat
Summary: This article provides recommendations for the use of ruxolitinib in Belgian myelofibrosis patients, including dose optimization/monitoring, adverse events, and interruption/rechallenge management.
Article
Surgery
Mauro Santarelli, Giacomo Lo Secco, Daniele Celi, Gitana Scozzari, Patrick Pautasso, Paolo De Paolis
Summary: The study aimed to evaluate the feasibility and safety of laparoscopic splenectomy for massive spleens. Results showed that patients with splenomegaly had significantly longer operative time and higher conversion rate compared to those with normal-weight spleens.
UPDATES IN SURGERY
(2021)
Article
Materials Science, Multidisciplinary
Sarah Hesham Rashed, A. Abd-Elhamid, Somia Yassin Hussain Abdalkarim, Rabah H. El-Sayed, Ali A. El-Bardan, Hesham M. A. Soliman, A. A. Nayl
Summary: In this study, LDH and GO-LDH nanoparticles were prepared using coprecipitation method followed by sonochemical treatment. The adsorption performance of LDH and GO-LDH for Methyl Orange dye was evaluated, and it was found that GO-LDH exhibited improved adsorption capacity and diffusion rate compared to LDH. Additionally, GO-LDH showed excellent reusability behavior. The findings suggest that GO-LDH could be a cost-effective alternative to LDH as an adsorbent.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Review
Hematology
Francesco Passamonti, Barbara Mora
Summary: The clinical phenotype of myelofibrosis is characterized by splenomegaly, symptomatology, blood cell alterations, and vascular complications. Diagnosis requires evaluations of blood counts, bone marrow morphology, genetic mutations, and disease history. Treatment options include anemia-oriented therapies and JAK inhibitors, with stem cell transplant being the only curative option. New paradigms for evaluating efficacy and translational studies show promise for future strategies in MF patients.
Article
Energy & Fuels
Yi Jiang, Bin Cai, Ying Yang, Fei Yu, Yilai Sun, Xin Qi, Liying Wang, Xuesong Li, Xijia Yang
Summary: Supercapacitors, as efficient energy storage devices, have demonstrated excellent charge storage capacity and stable cycling performance. In this study, a core-shell structure of NiCoSe2@NiCo-LDH was synthesized and used as electrode material for supercapacitors, showing significantly improved specific capacitance and cycling stability. Furthermore, the NiCoSe2@NiCo-LDH composite and activated carbon materials were assembled into an asymmetric supercapacitor, confirming its potential for practical applications.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Chemistry, Physical
Chongsei Yoon, Swathi Ippili, Venkatraju Jella, Alphi Maria Thomas, Jang-Su Jung, Yire Han, Tae-Youl Yang, Soon-Gil Yoon, Giwan Yoon
Summary: This study demonstrates an eco-friendly and stretchable flexoelectricity-enhanced piezoelectric nanogenerator based on zinc-aluminum layered double hydroxide nanosheets-ZnO heterostructure, showing enhanced output performance attributed to flexoelectric and piezoelectric effects, with high mechanical durability.
Article
Hematology
Myung-Won Lee, Sang-Hoon Yeon, Hyewon Ryu, Ik-Chan Song, Hyo-Jin Lee, Hwan-Jung Yun, Seon Young Kim, Jeong Eun Lee, Kyung Sook Shin, Deog-Yeon Jo
Summary: The study compared spleen volume in patients with essential thrombocythemia (ET) and prefibrotic/early primary myelofibrosis (pre-PMF), finding that pre-PMF patients had significantly larger spleen volume than ET patients. All pre-PMF patients had splenomegaly at diagnosis, while only half of ET patients had normal-sized spleens initially.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Chengwen Bin, Xu Hou, Keyi Wang, Luocheng Liao, Yadan Xie, Han Yang, Hua Wei, Yunya Liu, Jie Wang
Summary: This study proposes a novel approach of interlayer coupling to develop high-performance ferroelectric capacitors. The interlayer electrostatic coupling between the ferroelectric layers leads to excellent energy storage density and efficiency, and the performance remains stable under various conditions. This method offers a new avenue to enhance energy storage performance in flexible ferroelectric capacitors.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Yuxin Li, Guolang Zhou, Jingzhou Yin, Feixiang Li, Qing Zou, Wen Chen, Wenjie Yan, Qiaoqi Li, Cheng Liu, Alireza Khataee, Lili Zhang
Summary: Two-dimensional catalysts with photothermal effect are being researched to catalyze the release of H2 from NaBH4 in energy saving systems. This study explores oxygen vacancy enriched CoFe-LDH derivatives for NaBH4 hydrolysis catalyzed by photo-thermal synergy. The CoFe-300 degrees C with the highest concentration of oxygen vacancy shows the best photo-thermal synergistic catalytic performance, achieving a hydrogen production rate of 1877.5 mmol g-1 h-1 and maintaining high efficiency after 5 cycles. This study reveals an enhanced photo-thermal synergistic catalytic mechanism for the hydrolysis of NaBH4.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Chemistry, Physical
Shucheng Liu, Ming Li, Yi Tang, Xiaogang Wen
Summary: A novel Fe3O4/MgAl-TA LDH nanocomposites with tartrate anion-intercalation was synthesized by a one-step hydrothermal process. The synthesized FTLDH are flower-like hollow micro-spheres composed of nanosheets with an average thickness of 25 nm. The calcined FTLDH (FTLDH-C) has a specific surface area of 120 m2/g, resulting in high adsorption capacities for various dyes.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Multidisciplinary Sciences
Anna S. Nam, Kyu-Tae Kim, Ronan Chaligne, Franco Izzo, Chelston Ang, Justin Taylor, Robert M. Myers, Ghaith Abu-Zeinah, Ryan Brand, Nathaniel D. Omans, Alicia Alonso, Caroline Sheridan, Marisa Mariani, Xiaoguang Dai, Eoghan Harrington, Alessandro Pastore, Juan R. Cubillos-Ruiz, Wayne Tam, Ronald Hoffman, Raul Rabadan, Joseph M. Scandura, Omar Abdel-Wahab, Peter Smibert, Dan A. Landau
Letter
Hematology
Julia T. Geyer, Elizabeth Margolskee, Spencer A. Krichevsky, Daniele Cattaneo, Leonardo Boiocchi, Paola Ronchi, Francesca Lunghi, Joseph M. Scandura, Maurilio Ponzoni, Robert P. Hasserjian, Umberto Gianelli, Alessandra Iurlo, Attilio Orazi
Article
Hematology
Nicole Molle, Spencer Krichevsky, Pouneh Kermani, Richard T. Silver, Ellen Ritchie, Joseph M. Scandura
Article
Cardiac & Cardiovascular Systems
Jiwon Kim, Spencer Krichevsky, Lola Xie, Maria Chiara Palumbo, Sara Rodriguez-Diego, Brian Yum, Lillian Brouwer, Richard T. Silver, Andrew I. Schafer, Ellen K. Ritchie, Maria Mia Yabut, Claudia Sosner, Evelyn M. Horn, Richard B. Devereux, Joseph M. Scandura, Jonathan W. Weinsaft
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2019)
Article
Immunology
Elizabeth Perez, Jonathan R. Baker, Silvana Di Giandomenico, Pouneh Kermani, Jacqueline Parker, Kihwan Kim, Jianjun Yang, Peter J. Barnes, Sophie Vaulont, Joseph M. Scandura, Louise E. Donnelly, Heather Stout-Delgado, Suzanne M. Cloonan
JOURNAL OF IMMUNOLOGY
(2020)
Article
Oncology
Ghaith Abu-Zeinah, Spencer Krichevsky, Tatiana Cruz, Gabriela Hoberman, Diana Jaber, Niamh Savage, Claudia Sosner, Ellen K. Ritchie, Joseph M. Scandura, Richard T. Silver
Summary: The study suggests that treatment of PV with rIFN alpha can reduce the risk of myelofibrosis and mortality, especially in high-risk patients.
Article
Oncology
Ghaith Abu-Zeinah, Richard T. Silver, Khalid Abu-Zeinah, Joseph M. Scandura
Review
Oncology
Naveen Pemmaraju, Srdan Verstovsek, Ruben Mesa, Vikas Gupta, Jacqueline S. Garcia, Joseph M. Scandura, Stephen T. Oh, Francesco Passamonti, Konstanze Dohner, Adam J. Mead
Summary: This article discusses the definition of disease modification in myelofibrosis and the recent clinical trials of developing therapeutic drugs, emphasizing the need for surrogate measures of survival in early-stage trials.
Article
Physiology
Gustavo Frindt, Joel R. Meyerson, Alexandra Satty, Joseph M. Scandura, Lawrence G. Palmer
Summary: The study investigated the expression of individual subunits of ENaC in rat kidneys and colon. The results showed a large excess of β and γ subunits relative to the requirement for channel activity, suggesting a potential mechanism for rapid regulation of channels at the cell surface.
JOURNAL OF GENERAL PHYSIOLOGY
(2022)
Letter
Hematology
Ghaith Abu-Zeinah, Silvana Di Giandomenico, Daniel Choi, Tatiana Cruz, Katie Erdos, Elwood Taylor, Ellen K. Ritchie, Richard T. Silver, Joseph M. Scandura
Letter
Oncology
Richard T. T. Silver, Katie Erdos, Elwood Taylor III, Joseph M. M. Scandura, Ghaith Abu-Zeinah
Letter
Biophysics
Alexandra Gomez-Arteaga, Nina Orfali, Michelle Pasciolla, Ayanna Baptiste, Inna Guindine, Jingmei Hsu, Jonathan Lin, Sebastian A. Mayer, Adrienne A. Phillips, Tsiporah B. Shore, Paul D. Simonson, Edward DiCarlo, Sung Yoon, Thangamani Muthukumar, Koen van Besien
BONE MARROW TRANSPLANTATION
(2023)
Letter
Biophysics
Mohammad Alhomoud, Cynthia Magro, Surya Seshan, Taotao Zhang, Alexandra Gomez-Arteaga, Nora Chokr, Samuel Yamshon, Adrienne Phillips, Sebastian Mayer, Tsiporah Shore, Jeffrey Laurence
BONE MARROW TRANSPLANTATION
(2023)
Article
Hematology
Ok-kyong Chaekal, Alexandra Gomez-Arteaga, Zhengming Chen, Rosemary Soave, Tsiporah Shore, Sebastian Mayer, Adrienne Phillips, Jing Mei Hsu, Alexander Drelick, Rosy Priya L. Kodiyanplakkal, Markus Plate, Michael J. Satlin, Koen van Besien
Summary: This study investigated serologic responses in 145 allogeneic transplant recipients following Covid-19 vaccination, showing a high response rate in most patients with certain factors like vaccination timing, lymphocyte count, and chronic GVHD potentially influencing the vaccine efficacy.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Hematology
Koen van Besien, Andrew Artz, Richard E. Champlin, Danielle Guarneri, Michael R. Bishop, Julianne Chen, Usama Gergis, Tsiporah Shore, Hongtao Liu, Gabriela Rondon, Sebastian A. Mayer, Samer A. Srour, Wendy Stock, Stefan O. Ciurea