Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 112, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2020.110941
Keywords
Pectin; Nanofiber mat; Crosslinking; Gelatin; Cell infiltration
Categories
Funding
- Fundamental Research Funds for the Central Universities [2412019FZ041, 2412019FZ024]
- National Natural Science Foundation of China [51503027, 51732003]
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Pectin nanofiber mats are promising tissue engineering scaffolds but suffer from poor cell infiltration. In this study, gelatin, a collagen derived cell adhesive protein, was used to crosslink the electrospun nanofibers of periodate oxidized pectin. Cell culture experiment results demonstrated that cells were able to grow into the gelatin-crosslinked pectin nanofiber mats rather than only spread on mat surface. The nanofiber mats showed moderate mechanical strength, with a maximum tensile strength of up to 2.3 MPa, an ultimate tensile strain of up to 15%, and were capable of degrading gradually over 4 weeks or even longer periods in simulated body fluids. Thus, gelatin-crosslinked pectin nanofiber mats hold a great potential for soft tissue regeneration.
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