Journal
MARINE DRUGS
Volume 18, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/md18060329
Keywords
azole-based peptide; marine sponge; peptide synthesis; cytotoxicity; cyanobacteria; thiazole; bioactivity
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Funding
- Campus Research and Publication Fund Committee of The University of the West Indies, St. Augustine, Trinidad Tobago
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Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. Among broad-ranging pharmacologically active peptides, natural marine-originated thiazole-based oligopeptides possess peculiar structural features along with a wide spectrum of exceptional and potent bioproperties. Because of their complex nature and size divergence, thiazole-based peptides (TBPs) bestow a pivotal chemical platform in drug discovery processes to generate competent scaffolds for regulating allosteric binding sites and peptide-peptide interactions. The present study dissertates on the natural reservoirs and exclusive structural components of marine-originated TBPs, with a special focus on their most pertinent pharmacological profiles, which may impart vital resources for the development of novel peptide-based therapeutic agents.
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