P2X3-Receptor Antagonists as Potential Antitussives: Summary of Current Clinical Trials in Chronic Cough

Phenotypic distinctions between the nodose and jugular TRPV1-positive vagal sensory neurons in the cynomolgus monkey

(2019) Marian Kollarik et al.   NEUROREPORT

The Effect of Gefapixant, a P2X3 antagonist, on Cough Reflex Sensitivity: A randomised placebo-controlled study

(2019) Alyn H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration

(2019) Denis Garceau et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children

(2019) Alyn H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials

(2019) Ron Eccles   LUNG

Classification of Cough as a Symptom in Adults and Management Algorithms

(2018) Richard S. Irwin et al.   CHEST

Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?

(2017) Helen Elizabeth Fowles et al.   EUROPEAN RESPIRATORY JOURNAL

Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive/TRPV1-positive neurons detected by low input RNA sequencing

(2017) Jingya Wang et al.   PLoS One

Pregabalin and Speech Pathology Combination Therapy for Refractory Chronic Cough

(2016) Anne E. Vertigan et al.   CHEST

Long-term follow-up of amitriptyline treatment for idiopathic cough

(2016) Marisa A. Ryan et al.   LARYNGOSCOPE

ATP as a cotransmitter in the autonomic nervous system

(2015) Charles Kennedy   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Effects of Aerosolized Adenosine 5′-Triphosphate in Smokers and Patients With COPD

(2015) Ozen K. Basoglu et al.   CHEST

Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice

(2015) Aurelie Vandenbeuch et al.   JOURNAL OF PHYSIOLOGY-LONDON

P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

(2015) Rayid Abdulqawi et al.   LANCET

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

(2014) A. H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

Histamine Induces ATP Release from Human Subcutaneous Fibroblasts, via Pannexin-1 Hemichannels, Leading to Ca2+Mobilization and Cell Proliferation

(2013) Ana Rita Pinheiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres

(2012) Letitia A. Weigand et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7receptors

(2012) Jingsheng Xia et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial

(2012) Nicole M Ryan et al.   LANCET

Sensory Dysfunction of Bladder Mucosa and Bladder Oversensitivity in a Rat Model of Metabolic Syndrome

(2012) Wei-Chia Lee et al.   PLoS One

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Rho Signaling Regulates Pannexin 1-mediated ATP Release from Airway Epithelia

(2011) Lucia Seminario-Vidal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Adenosine Triphosphate and Chronic Obstructive Pulmonary Disease

(2010) Marek Lommatzsch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs

(2010) Christina Nassenstein et al.   JOURNAL OF PHYSIOLOGY-LONDON

Correlation of changes in pain intensity with synovial fluid adenosine triphosphate levels after treatment of patients with osteoarthritis of the knee with high-molecular-weight hyaluronic acid

(2010) Nobuyuki Kumahashi et al.   KNEE

TRPA1 Agonists Evoke Coughing in Guinea Pig and Human Volunteers

(2009) Mark A. Birrell et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Signaling at Purinergic P2X Receptors

(2008) Annmarie Surprenant et al.   Annual Review of Physiology