Article
Nutrition & Dietetics
Qianqian Wang, Min Guo, Yang Liu, Mengshu Xu, Liuting Shi, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: This study found that certain strains of Bifidobacterium can reduce the production of plasma TMAO and modulate the gut microbiota. These strains may have therapeutic potential for preventing TMAO-related diseases such as atherosclerosis.
Article
Nutrition & Dietetics
Manman Lu, Yuhui Yang, Yuncong Xu, Xiaoyue Wang, Bo Li, Guowei Le, Yanli Xie
Summary: Dietary methionine restriction (MR) can reduce plasma trimethylamine-N-oxide (TMAO) levels by manipulating gut microbiota in mice. MR decreases the ability of gut microbiota to produce trimethylamine (TMA), reduces TMA levels and expression of choline TMA-lyase (CutC) in the intestine, and increases the abundance of SCFA-producing bacteria.
Article
Food Science & Technology
Daoyan Wu, Mei Cao, Jie Zhou, Shiying Yan, Jingshan Peng, Zhihao Yu, Andong Zhang, Jialin Wu, Xin Yan, Jian Zhao
Summary: The study found that L. casei T1 has an inhibitory effect on H. pylori growth and can reduce the expression of inflammatory factors induced by the pathogen, thus preventing gastric inflammation and gut microbiota alteration.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Nutrition & Dietetics
Sa Zhou, Jiamin Xue, Jingbo Shan, Yingxiang Hong, Wenkang Zhu, Zhiyan Nie, Yujie Zhang, Nanxi Ji, Xuegang Luo, Tongcun Zhang, Wenjian Ma
Summary: This study revealed the mechanistic link between TMAO and atherosclerosis risk, showing that TMAO induces vascular inflammation. It was found that TMAO suppresses the expression of AMPK and SIRT1, while AMPK and SIRT1 play important roles in regulating ROS and inflammation. Glutathione and probiotics can relieve TMAO-induced atherosclerosis.
Review
Immunology
Xi Chen, Nanxi Wang, Jiannan Wang, Binyou Liao, Lei Cheng, Biao Ren
Summary: In the human body, different microbial habitats exhibit distinct microbial population patterns and play a crucial role in the development of diseases. The oral cavity and gut are complex and interdependent microbial habitats, with Helicobacter pylori being one of the most important pathogens from the digestive tract. H. pylori infections can disrupt the normal gastric environment and enhance microbial interactions between the oral cavity and gut, thus reshaping the oral and gut microbiomes. The interaction between the oral-gut axis microbiota and H. pylori plays a significant role in H. pylori's colonization, infection, and pathogenicity. The balance of the microecology of the oral-gut axis can be altered by both H. pylori infection and eradication, which can impact the occurrence and progress of related diseases. The shift of oral-gut axis microbiota and their interactions with H. pylori may serve as potential targets for the diagnosis and treatment of H. pylori infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Dengcheng Zhou, Jing Zhang, Chengju Xiao, Chunheng Mo, Bi-Sen Ding
Summary: This study found that the gut microbial metabolite TMAO can reduce the progression of liver fibrosis in a mouse NASH model. Further analysis revealed that TMAO normalizes gut microbiota diversity and preserves liver sinusoidal endothelial cell integrity by inhibiting endothelial beta 1-subunit of Na(+), K(+)-ATPase (ATP1B1) expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Meiqi Zhao, Jiajia Ma, Huiru Liu, Ying Luo, Huiting Deng, Dandan Wang, Fengmei Wang, Peng Zhang
Summary: The gut microbiota plays a crucial role in the development of sepsis, with different enterotypes leading to varying levels of systemic inflammation. The amoxicillin-associated enterotype is characterized by an abundance of opportunistic pathogens, resulting in the most severe inflammation and liver injury in septic mice. These findings highlight the importance of modulating the gut microbiota to prevent or reduce the serious consequences of sepsis, particularly in gut-derived sepsis.
Review
Infectious Diseases
Marcello Fiorani, Ege Tohumcu, Livio Enrico Del Vecchio, Serena Porcari, Giovanni Cammarota, Antonio Gasbarrini, Gianluca Ianiro
Summary: Helicobacter pylori is a bacterium that colonizes the human stomach and is associated with various gastric and extra-gastric disorders. Colonization of H. pylori affects the gastric microenvironment and gastrointestinal microbiota by regulating factors such as acidity, immune responses, antimicrobial peptides, and virulence factors. Eradication therapies for H. pylori can negatively impact the gut microbiota, but integrating probiotics into the treatment has been shown to mitigate these effects and improve eradication rates and patient compliance. This article provides an overview of the complex interaction between H. pylori and the gastrointestinal microbiota, emphasizing the consequences of eradication therapies and the benefits of probiotic supplementation.
Article
Immunology
Qiqi Wang, Yue Sun, Tianyu Zhou, Cong Jiang, A. Lan, Wenzhou Xu
Summary: This study found that intestinal inflammation and periodontitis influence each other through a bidirectional relationship. The intestinal microbiome metabolite, TMAO, may contribute to chronic inflammation in the gut by influencing the gut microbial composition and intestinal immunity. The results suggest that TMAO may influence periodontal immunity and promote periodontal inflammation by affecting the intestinal microenvironment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Lingling Wang, Haobin Yao, Daniel C. Morgan, Kam Shing Lau, Suet Yi Leung, Joshua W. K. Ho, Wai K. Leung
Summary: The study finds that antibiotic treatment for Helicobacter pylori leads to transient alteration in gut microbiota and significantly alters the previously less known gut virome community. Recurrent treatment further leads to lower virus community diversity and altered virus-bacteria interactions, compared with treatment naive patients.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Maria Guerra-Valle, Patricio Orellana-Palma, Guillermo Petzold
Summary: This review discusses the potential impact of plant-based polyphenols on H. pylori and their role in improving gut microbiota.
Review
Physiology
Katongo H. Mutengo, Sepiso K. Masenga, Aggrey Mweemba, Wilbroad Mutale, Annet Kirabo
Summary: The human gut microbiota and its dependant metabolite, trimethylamine N-oxide, play significant roles in the development of hypertension. This review examines the impact of the gut microbiota and trimethylamine N-oxide on hypertension pathogenesis, providing evidence from both human and animal studies. New insights into potential therapies for managing hypertension by altering the gut microbiota are also discussed.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Chikara Iino, Tadashi Shimoyama
Summary: Several studies have shown the association between Helicobacter pylori infection and gut microbiota. Eradication of H. pylori can lead to changes in gut microbiota that may take a long time to revert to the original state. The modification of gastric acidity by long-term H. pylori infection can alter gut microbiota.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Maria Y. Pakharukova, Oxana Zaparina, Sung-Jong Hong, Banchob Sripa, Viatcheslav A. Mordvinov
Summary: The study found that liver flukes are not reservoirs of Helicobacter pylori, but infection significantly increases the prevalence and gene copy number of H. pylori while altering bile and gut microbiota by increasing the abundance of H. pylori. This may be a previously overlooked feature of liver fluke pathogenesis and the findings provide novel insights into the comparative assessment of host microbiota and Helicobacter abundance during epidemiologically important liver fluke infections.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Ting-Ting Chang, Jaw-Wen Chen
Summary: The inhibition of CCL4 was found to improve glucose metabolism, lipid parameters, and inflammatory levels in diet-induced diabetic mice, while also modulating gut microbiota profiles, suppressing proinflammatory metabolites, reducing systemic inflammation, and enhancing insulin resistance.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.