Review
Biochemistry & Molecular Biology
Chaithanya Chelakkot, Vipin Shankar Chelakkot, Youngkee Shin, Kyoung Song
Summary: Cancer cells undergo metabolic reprogramming to adopt a glycolysis-dominant metabolic profile, providing them with a survival advantage and contributing to a pro-cancerous tumor environment. This metabolic switch also leads to increased resistance to chemotherapy and radiation. Immune cells in the tumor microenvironment also exhibit a similar metabolic shift, leading to competition with cancer cells for nutrients. Targeting enhanced glycolysis in cancer cells has shown promise in improving treatment efficacy, but effective strategies are still lacking. This review highlights the importance of metabolic reprogramming in cancer cells and the potential of targeting it to enhance conventional cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Sharon Changshan Wu, Karl Munger
Summary: Cancer/testis antigens show potential as therapeutic targets and prognostic biomarkers in head and neck squamous cell carcinoma, warranting further study to elucidate their role in the pathogenesis of these cancers. Their differential expression in HPV-positive HNSCC may mechanistically contribute to the genesis and clinical characteristics of these cancers, making them attractive targets for immunotherapies. These antigens, historically linked to diverse cancers, are increasingly implicated in various hallmarks of cancer, suggesting potential as cancer drivers.
Review
Medicine, Research & Experimental
Sai-li Duan, Min Wu, Zhe-Jia Zhang, Shi Chang
Summary: Although most thyroid cancer patients can be cured with existing treatments, options for patients with poorly differentiated or radioiodine-refractory thyroid cancer are limited. Thyroid cancer cells undergo metabolic reprogramming to meet their energy demands and support malignant behaviors. This review summarizes advances in understanding the reprogramming of glucose metabolism in thyroid cancer cells, aiming to identify new therapeutic approaches for specific types of thyroid cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Tycho de Bakker, Fabrice Journe, Geraldine Descamps, Sven Saussez, Tatiana Dragan, Ghanem Ghanem, Mohammad Krayem, Dirk Van Gestel
Summary: TP53 mutation is a common genetic alteration in head and neck squamous cell carcinoma (HNSCC), and targeting p53 for therapy shows potential. Therapeutic strategies can be categorized into targeting wild-type p53 degradation or inhibition, directly affecting mutated p53, and specifically targeting HPV-positive HNSCC. This review discusses p53 regulation and its targeting in combination with existing therapies, based on the classification of HNSCC according to p53 mutation status and HPV infection.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sara Varatanovic, Stefan Stoiber, Markus Haas, Alexander Lein, Lorenz Kadletz-Wanke, Faris F. Brkic
Summary: MK0752 shows potential as a therapeutic agent for HPV-positive HNSCC by exhibiting antineoplastic effects and inducing apoptosis. Further investigation is needed to validate these findings and understand the underlying mechanisms.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Neil Shende, Jingyue Xu, Wei Tse Li, Jeffrey Liu, Jaideep Chakladar, Kevin T. Brumund, Weg M. Ongkeko
Summary: This study investigated the effects of smoking and HPV infection on eRNA expression in HNSCC tumors. The research found a substantial number of differentially expressed eRNA in each patient cohort, with some dysregulated eRNA correlated to patient survival, clinical variables, immune pathways, and genomic alterations. Additionally, dysregulated eRNA near key HNSCC-related oncogenes were identified, providing potential insights into the relationship between eRNA expression, enhancer activity, and nearby gene dysregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Zhengping Liu, Chunhui Cai, Xiaojun Ma, Jinling Liu, Lujia Chen, Vivian Wai Yan Lui, Gregory F. Cooper, Xinghua Lu
Summary: This study developed a Bayesian framework to infer the activation status of cancer driver proteins and tested its significance by applying it to patient data.
Review
Oncology
Yi Zhang, Qiong Li, Zhao Huang, Bowen Li, Edouard C. Nice, Canhua Huang, Liuya Wei, Bingwen Zou
Summary: Reprogramming glucose metabolism is an important strategy for targeted cancer treatment. Although advanced and effective drugs have been developed, there are still challenges in translating them into clinical applications due to limitations such as short half-life, poor solubility, and multiple side effects. Combining glucose metabolism modulators with conventional anticancer drugs may be a future direction for cancer treatment.
Review
Oncology
Rongfu Tu, Junpeng Ma, Peng Zhang, Ye Kang, Xiaofan Xiong, Junsheng Zhu, Miao Li, Chengsheng Zhang
Summary: This article summarized the significant progress in understanding the key roles of DUBs in cancer cell metabolic rewiring and the opportunities for the application of DUBs inhibitors in cancer treatment.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Reinout H. de Roest, Martijn van der Heijden, Frederik W. R. Wesseling, Emma J. de Ruiter, Martijn W. Heymans, Chris Terhaard, Marije R. Vergeer, Jan Buter, Lot A. Devriese, Jan Paul de Boer, Arash Navran, Ann Hoeben, Conchita Vens, Michiel van den Brekel, Ruud H. Brakenhoff, C. Rene Leemans, Frank Hoebers
Summary: This study collected real-world outcome data from 513 patients with HPV-negative advanced stage HNSCC treated with CRT and found that clinical variables and treatment parameters had a stronger association with overall survival. The association of RT-boost technique with distant metastasis is an important finding that requires further study.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Cell Biology
Linda Hofmann, Tsima Abou Kors, Jasmin Ezic, Beate Niesler, Ralph Roeth, Sonja Ludwig, Simon Laban, Patrick J. Schuler, Thomas K. Hoffmann, Cornelia Brunner, Valentin Medyany, Marie-Nicole Theodoraki
Summary: This study compared the miRNA profiles of exosomes derived from plasma and saliva samples of head and neck squamous cell carcinoma (HNSCC) patients. It identified specific miRNAs that could potentially serve as liquid biomarkers for differentiating cancer patients from healthy individuals, as well as for determining HPV status and disease stage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Qian Cheng, Xiao-Lei Shi, Qi-Lin Li, Lin Wang, Zheng Wang
Summary: Numerous studies have shown that nanomaterials can modulate lactate metabolism to enhance anti-tumor therapy.
Review
Biochemistry & Molecular Biology
Yingming Sun, Zhe Wang, Sufang Qiu, Ruoyu Wang
Summary: HNSCC, the 9th most common malignant tumor worldwide, can be divided into HPV-related and HPV-unrelated subtypes based on etiology. HPV-positive HNSCC is more sensitive to treatment with better survival rates, requiring individualized therapy. EGFR amplification and PI3K/AKT/mTOR pathway aberrant activation are common in HPV-positive HNSCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Food Science & Technology
Lei Huang, Canxia He, Sicong Zheng, Chao Wu, Minghua Ren, Yujuan Shan
Summary: Sulforaphane (SFN) reduces ATP production in bladder cancer cells by inhibiting glycolysis and mitochondrial oxidative phosphorylation. SFN weakens glycolytic flux by suppressing metabolic enzymes such as hexokinase 2 (HK2) and pyruvate dehydrogenase (PDH). Additionally, SFN downregulates the unique glucose transport aberrant-independent aerobic glycolysis in bladder cancer through the AKT1/HK2 axis and PDH expression.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Oncology
N. Ari Wijetunga, Yao Yu, Luc G. Morris, Nancy Lee, Nadeem Riaz
Summary: Recent advances in sequencing technologies have helped unravel the complex interactions between HPV virus, tumor, host factors, and tumor microenvironment (TME) in head and neck squamous cell carcinoma (HNSCC), shedding light on the interaction of the immune system with these malignancies.
Article
Public, Environmental & Occupational Health
Faisal Ismail, Atiya Farag, Soghra Haq, Mohammad A. Kamal
Summary: This study reports the clinical features of suspected COVID-19 patients in Tobruk, Libya, and reflects on the challenges of diagnosis in low-resource settings. The most common symptoms among these patients were fever, cough, and dyspnea. Chest X-ray abnormalities were not observed in all patients.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2023)
Editorial Material
Neurosciences
Abigail R. Bland, John C. Ashton, Mohammad Amjad Kamal, Amirhossein Sahebkar
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Neurosciences
Asim Azhar, Mohammad Akram Wali, Qudsia Rashid, Wajihul Hasan Khan, Khaled Al-hosaini, Mohammad Owais, Mohammad Amjad Kamal
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has become a global concern since March 2020. Initially thought to be limited to the respiratory system, the virus has been found to affect other organs, including the nervous system. Reports indicate that SARS-CoV-2 can penetrate the central nervous system (CNS) and cause neurological symptoms. This comprehensive review examines the entry routes of SARS-CoV-2 into the CNS, the molecular mechanisms involved, clinical symptoms, and associated nervous system diseases.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Neurosciences
Harsh Goel, Keshav Goyal, Avanish Kumar Pandey, Mercilena Benjamin, Fahad Khan, Pratibha Pandey, Sandeep Mittan, Danish Iqbal, Mohammed Alsaweed, Wael Alturaiki, Yahya Madkhali, Mohammad Amjad Kamal, Pranay Tanwar, Tarun Kumar Upadhyay
Summary: Due to environmental contamination, humans are exposed to physical and chemical mutagens, which cause a variety of neurological disorders through neuroinflammation, genetic instability, oxidative stress, and mitochondrial damage. This review summarizes the molecular mechanisms and effects of mutagens in the environment on neurological disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Neurosciences
Md. Mominur Rahman, Sadia Afsana Mim, Md. Rezaul Islam, Nasrin Sultana, Muniruddin Ahmed, Mohammad Amjad Kamal
Summary: G-protein-coupled receptors (GPCRs) are activated by neurotransmitters and play a crucial role in psychiatric and neurological disorders. GPCRs show potential as therapeutic targets for obesity, diabetes, Alzheimer's disease, and other central nervous system disorders. Orphan GPCRs, such as GPR52, GPR6, and GPR8, are of particular interest and may have therapeutic implications for psychiatric disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Materials Science, Paper & Wood
Antti Koistinen, Josphat Phiri, Kavindra Kumar Kesari, Tapani Vuorinen, Thaddeus Maloney
Summary: This study investigates the impact of pulp prehydrolysis conditions on pulp structure, dissolution in a cold NaOH/ZnO solvent, and properties of regenerated cellulose films. The results show that hydrolysis significantly improves the dissolution of pulp and affects the swelling and pore structure of the resulting films. Surprisingly, higher hydrolysis temperature does not lead to increased fiber hornification, and low temperature hydrolysis results in more porous films after drying.
Editorial Material
Biochemistry & Molecular Biology
Tanima Bhattacharya, Nigel H. Greig, Bairong Shen, Mohammad Amjad Kamal
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Neurosciences
Aziz Unnisa, Nigel H. Greig, Mohammad Amjad Kamal
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by underdeveloped brain and impaired social interaction. Recent research suggests that disturbances in neuron-glia interactions play a significant role in the pathophysiology of ASD. Glial cells, in addition to neurons, are essential for mental activities, and a new strategy emphasizing neuron-glia interactions should be applied. Dysfunctional neuron-glia connections result in abnormal neural network formation and neurotransmission, leading to the malfunctioning of brain circuits and behavioral issues. Reactive glial cells and dysfunction in microglia have been associated with autism, and various approaches involving glial cell treatment are being explored.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Sandip Debnath, Devesh Sharma, Somdatta Yashwant Chaudhari, Ritika Sharma, Amir Afzal Shaikh, Rahul Subhash Buchade, Kavindra Kumar Kesari, Abdel-Fattah M. Abdel-Fattah, Mohammad Algahtani, Mayyadah Mheidat, Rawidh Alsaidalani, Tapas Paul, Amany A. A. Sayed, Mohamed M. M. Abdel-Daim
Summary: Alzheimer's disease (AD) is a progressive dementia characterized by cognitive decline and increased inflammation. This study found that patients with AD have higher levels of inflammatory markers and TLR4 activation, leading to neurodegeneration. By using molecular docking and dynamics simulation, 2-Bromoergocryptine Mesylate, an FDA-approved antidiabetic drug, showed strong binding affinity to TLR4 and potential as a lead treatment for AD.
Review
Biochemistry & Molecular Biology
Sayed Sartaj Sohrab, Riya Raj, Amka Nagar, Susan Hawthorne, Ana Claudia Paiva-Santos, Mohammad Amjad Kamal, Mai M. M. El-Daly, Esam I. I. Azhar, Ankur Sharma
Summary: The body's immune response to an invading pathogen that causes infection results in inflammation, which can lead to chronic inflammatory diseases and cancer. Inflammation can be short-term and non-specific, or long-term and specific, causing angiogenesis, fibrosis, tissue destruction, and cancer progression.
Article
Behavioral Sciences
Rajeev K. Singla, Shikha Joon, Baivab Sinha, Mohammad Amjad Kamal, Jesus Simal-Gandara, Jianbo Xiao, Bairong Shen
Summary: The number of studies on natural product-based management of dementia has been increasing steadily, with a significant rise in 2020 and 2021. This article analyzed current trends from 2016 to 2021 to assess the potential growth of natural products in dementia treatment. Common targets and pathways included oxidative stress, NF-kappa B pathway, tau aggregation, AChE inhibition, and A-beta aggregation. The analysis of 33 natural compounds identified 125 sustainable resources distributed among various families, orders, and classes. Certain families and orders, such as Berberidaceae, Zingiberaceae, and Lamiales, were identified as important for further research. Natural products like quercetin, curcumin, icariside II, berberine, and resveratrol were found to have diverse applications. The importance of dietary supplements and natural products is supported by clinical studies and patents, which are also discussed. The article concludes with a discussion on the broad scope, future challenges, and opportunities for field researchers.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Editorial Material
Behavioral Sciences
Rupesh K. Gautam, Aziz Unnisa, Nigel H. Greig, Mohammad Amjad Kamal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Environmental Sciences
Jaspreet Kaur, Gaurav Mudgal, Arvind Negi, Jeewan Tamang, Shambhawi Singh, Gajendra Bahadur Singh, K. Jagadeesh Chandra Bose, Sandip Debnath, Mohammad Ahmad Wadaan, Muhammad Farooq Khan, Janne Ruokolainen, Kavindra Kumar Kesari
Summary: The commercial processing of biomaterials produces wastewater containing azo dyes and hydrolyzed by-products. Current treatment methods lack selectivity and efficiency. Microbial-assisted methods, such as the use of Agrobacterium strain JAS1, have been identified as a potential solution for degrading azo dyes and their by-products.
Review
Polymer Science
Arvind Negi, Kavindra Kumar Kesari
Summary: Cellulose and hemicellulose are the main components of lignocellulosic biomass, and chemical derivatization can produce valuable C5 and C6 organic compounds, which are important for the development of sustainable chemical processes. However, the structural properties of cellulose, such as high crystallinity, abundant hydrogen bonding, and low solubility, limit the success of most depolymerization processes. Various chemical treatments, including acidic treatment and photocatalysis, have been developed to overcome these limitations. Photocatalysts, in particular, show great potential for efficient cellulose biomass conversion without the need for high temperatures.
Review
Biochemistry & Molecular Biology
Muskan Goel, Manish Kumar Mishra, Dhruv Kumar
Summary: In the last two decades, science has made significant progress in cancer treatment methodologies, but the basic backbone of cancer treatment remains surgery, chemotherapy, and radiation therapy. Radiation therapy, used almost a century ago, is still important in the form of radionuclide therapy (RNT) or targeted radionuclide therapy (TRT). TRT has advantages in both micro and macro metastasis, with low dose, high efficacy, and easy targeting. This article reviews different types of radionuclides, vectors, and chelators used in TRT agents, and highlights their therapeutic potential in various types of cancers such as breast cancer, metastatic bone pain, thyroid cancer, neuroendocrine neoplasm, prostate tumors, malignant lymphoma, brain tumors, and hepatocellular carcinoma.
CHEMICAL BIOLOGY LETTERS
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.