Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yumei Cao, Su'an Tang, Xiaoyu Nie, Zuoqing Zhou, Guangfeng Ruan, Weiyu Han, Zhaohua Zhu, Changhai Ding
Summary: The study identified miR-214-3p as a key regulator in osteoarthritis, impacting ECM metabolism and cell apoptosis in cartilage by modulating the NF-kappa B signaling pathway. Targeting IKKP, decreased miR-214-3p exacerbates OA development, suggesting it as a potential novel therapeutic target for OA.
Article
Cell Biology
Ruiqin Hu, Yanna Xu, Bingshe Han, Yi Chen, Wenhao Li, Guijun Guan, Peng Hu, Yan Zhou, Qianghua Xu, Liangbiao Chen
Summary: Developmental growth is a complex process that involves the coordinated regulation of gene expression. This study identifies miR-202-3p as a key factor in determining embryonic fate during the mid-blastula transition (MBT) in zebrafish. miR-202-3p regulates the expression of a trio of genes involved in cell proliferation and survival, and is crucial for embryonic viability and development during MBT.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Binghui Li, Shiping Niu, Hongli Geng, Changkun Yang, Changliang Zhao
Summary: This study evaluated the effects of berberine, a functional component in traditional Chinese medicine, on neonatal sepsis (NS) and found that berberine increased survival rates, attenuated intestinal injuries, and inhibited inflammatory responses by upregulating miR-132-3p. The protective effects of berberine against NS-induced symptoms in newborn mice were dependent on the upregulation of miR-132-3p.
Article
Gastroenterology & Hepatology
Jie Zhao, Honggang Wang, Jin Zhou, Jun Qian, Haojun Yang, Yan Zhou, Hao Ding, Yu Gong, Xiaoyang Qi, Yuwen Jiao, Pu Ying, Liming Tang, Ye Sun, Weiming Zhu
Summary: The study reveals that miR-130a-3p promotes the progression of Crohn's disease through the ATG16L1/NF-kappa B pathway and serves as a potential preclinical therapeutic target in Crohn's disease.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Immunology
Qiao Zhou, Ding-Xiu He, Yi-Ling Deng, Chun-Li Wang, Lan-Lan Zhang, Fa-Ming Jiang, Laurent Irakoze, Zong-An Liang
Summary: This study found that miR-124-3p has a protective effect on acute lung injury (ALI) by inhibiting the TLR4/NF-kappa B signaling pathway, and miR-124-3p directly targets PDE4B to suppress this signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Ling Feng, Ru Wang, Yifan Yang, Xixi Shen, Qian Shi, Meng Lian, Hongzhi Ma, Jugao Fang
Summary: The study found that KPNA4 is upregulated in PTC tissues and cells, and its overexpression promotes cell proliferation and invasion, while silencing KPNA4 has the opposite effects and induces apoptosis in PTC cells. Additionally, KPNA4 is negatively regulated by miR-548b-3p, which inhibits cell proliferation and invasion but promotes apoptosis in PTC cells. Overexpression of miR-548b-3p and downregulation of KPNA4 both inhibit tumor growth in mouse models.
Article
Cell & Tissue Engineering
Jiahui Mao, Lingxia Wang, Junying Wu, Yichun Wang, Huiyan Wen, Xueming Zhu, Bo Wang, Huan Yang
Summary: miR-370-3p plays a role in promoting breast cancer progression by inhibiting FBLN5 expression and activating the NF-kappa B signaling pathway. High expression of serum exosomal miR-370-3p in breast cancer patients may serve as a potential biomarker for diagnosis.
STEM CELLS INTERNATIONAL
(2021)
Article
Immunology
Lei Xu, Hongxia Cao, Peng Xu, Mingxi Nie, Chun Zhao
Summary: In patients with septic acute kidney injury (AKI), levels of miR-495-3p were decreased while levels of circ_0114427 and TRAF6 were increased. Circ_0114427 modulates cell apoptosis and inflammatory response in AKI through the miR-495-3p/TRAF6 axis.
Article
Medicine, General & Internal
Shuai Deng, Bin Gu, Zheng Yu, Zhen Shen, Houwei Ren
Summary: The study indicates that MIR210HG plays a crucial role in sepsis-induced acute kidney injury by activating the NF-kappa B signaling pathway to promote inflammatory response. Silencing of MIR210HG can counteract AKI-induced histological changes in the kidneys.
YONSEI MEDICAL JOURNAL
(2021)
Article
Cell Biology
Theodomir Dusabimana, Jihyun Je, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: This study revealed the crucial role of GOLPH3 in the development and progression of acute liver and kidney injury induced by endotoxemia. Upregulation of GOLPH3 was associated with high morbidity and mortality. Knockdown of GOLPH3 alleviated cellular stress response and inflammatory reaction, leading to the recovery of Golgi morphology and function. These findings suggest GOLPH3 as a potential therapeutic target for endotoxemia-induced tissue injury.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Liang He, Zhuoran Wang, Rui Zhou, Wei Xiong, Yuqiao Yang, Ning Song, Jinqiao Qian
Summary: Myocardial ischemia/reperfusion (I/R) injury is a common cause of mortality. Cardiac miR-146a is emerging as a potent regulator of myocardial function. Dexmedetomidine preconditioning provides cardioprotective effects, of which mechanisms related to miR-146a-3p targeting IRAK1 and TRAF6 through inhibition of NF-kappa B signaling pathway and ROS emission.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Eileen Dahlke, Toni Engmann, Yaman Anan, Robert Haesler, Giovanni Solinas, Franziska Theilig
Summary: Acute kidney injury (AKI) is a common renal injury with significant morbidity and mortality worldwide. This study investigated the role of NF-kappa B in AKI and found that its deletion improved renal function, reduced tissue damage and fibrosis, and enhanced vascularization, metabolism, reactive species disposal, and fine-tuned cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yan-yan Yu, Xiang-qian Li, Wen-peng Hu, Shi-chao Cu, Jia-jia Dai, Ya-nan Gao, Yi-ting Zhang, Xiao-yi Bai, Da-yong Shi
Summary: The NF-kappa B inhibitor 270 showed anti-inflammatory effects in LPS-induced AKI and ALI, improving pathological changes, reducing pro-inflammation gene expression, blocking NF-kappa B and JNK pathway activation, attenuating oxidative stress and autophagy inhibition, and reducing inflammation markers in plasma.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Pan Pan, Xudong Liu, LingLing Wu, Xiaogang Li, Kaifei Wang, Xiaoting Wang, Xiang Zhou, Yun Long, Dawei Liu, Lixin Xie, Longxiang Su
Summary: TREM-1 acts as an amplifier of inflammatory responses triggered by bacterial or fungal infection. It promotes apoptosis and inhibits autophagy in HK-2 cells exposed to LPS potentially through the NF-kappa B pathway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)