Article
Nutrition & Dietetics
Karolina Sledzinska, Piotr Landowski, Michal A. Zmijewski, Barbara Kaminska, Konrad Kowalski, Anna Liberek
Summary: The study showed that IBD children have higher levels of vitamin D compared to controls, but a significant portion still lack optimal vitamin D levels. Despite the higher level of vitamin D, IBD children had lower calcium levels compared to healthy controls, with no correlation to disease activity or location of lesions in the gastrointestinal tract.
Article
Nutrition & Dietetics
Danforth A. Newton, John E. Baatz, Katherine E. Chetta, Preston W. Walker, Renee O. Washington, Judy R. Shary, Carol L. Wagner
Summary: The sufficiency of vitamin D in breastfeeding mothers may have different physiological effects compared to the sufficiency of vitamin D in infants. Maternal vitamin D status showed an inverse correlation with infant plasma TNF concentration. The immune response of infants seemed to be more closely related to maternal vitamin D sufficiency, while IL-10 and IL-12 responses were more correlated to infant vitamin D status.
Review
Food Science & Technology
Chao Lu, Weihua Zhou, Xinjue He, Xinxin Zhou, Chaohui Yu
Summary: The study found that patients with celiac disease have lower Vitamin D levels compared to controls, which improve after treatment, but there is no difference in Vitamin D Receptor genotypes between the two groups.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Neurosciences
Randrita Pal, Supriyo Choudhury, Hrishikesh Kumar, Sanjit Dey, Nilansu Das, Barnali Ray Basu
Summary: Parkinson's disease (PD) and vitamin D deficiency (VDD) are closely linked, and understanding the role of vitamin D in PD is crucial for therapeutic strategies. Genetic polymorphisms of vitamin D-related genes, such as VDR and GC, as well as vitamin D metabolising genes, such as CYP2R1 and CYP27A1, may play a role in PD. Literature review shows that certain polymorphisms are associated with PD severity, while others affect vitamin D levels without influencing disease severity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Infectious Diseases
Nanyang Liu, Jiahui Sun, Xiyuan Wang, Tingting Zhang, Ming Zhao, Hao Li
Summary: Low vitamin D status is associated with an increased risk of COVID-19, and COVID-19-positive individuals tend to have lower levels of vitamin D. However, there is significant publication bias in the existing studies.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Transplantation
Anne Schoen, Maren Leifheit-Nestler, Jennifer Deppe, Dagmar-Christiane Fischer, Aysun K. Bayazit, Lukasz Obrycki, Nur Canpolat, Ipek Kaplan Bulut, Karolis Azukaitis, Alev Yilmaz, Sevgi Mir, Fatos Yalcinkaya, Oguz Soylemezoglu, Anette Melk, Gabriele Stangl, Rouven Behnisch, Rukshana Shroff, Justine Bacchetta, Uwe Querfeld, Franz Schaefer, Dieter Haffner
Summary: Uraemic cardiac remodelling is associated with vitamin D and Klotho deficiency, elevated FGF23, and RAS activation. While active vitamin D can ameliorate cardiac remodelling in rats, it does not improve the cardiac phenotype in children with CKD Stages 3-5, possibly due to increased FGF23 and faster CKD progression in treated patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Nutrition & Dietetics
Thurayya ALbuloshi, Ahmed M. Kamel, Jeremy P. E. Spencer
Summary: This study examined the factors associated with vitamin D deficiency in older people in Kuwait and found that lack of vitamin D supplements, low sun exposure duration, dark skin pigmentation, and lower caloric intake were risk factors for deficiency. A significant inverse relationship was also found between vitamin D levels and parathyroid hormone levels.
Article
Nutrition & Dietetics
Haibo Li, Pei Xiao, Hong Cheng, Xiaoyuan Zhao, Yinkun Yan, Junting Liu, Xianghui Xie, Jie Mi
Summary: There is an association between regional fat deposits and vitamin D levels in Chinese school-aged children, especially among boys.
Article
Transplantation
Arpana Iyengar, Nivedita Kamath, Hamsa Reddy, Jyoti Sharma, Jyoti Singhal, Susan Uthup, Sudha Ekambaram, Sumithra Selvam, Anja Rahn, Dagmar-C Fischer, Mandy Wan, Rukshana Shroff
Summary: In children with chronic kidney disease, different dosing regimens of oral cholecalciferol achieved similar 25OHD concentrations without toxicity. Children with glomerular disease required higher doses of cholecalciferol compared to those with non-glomerular disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Neurosciences
Michela Barichella, Federica Garri, Serena Caronni, Carlotta Bolliri, Luciano Zocchi, Maria Carmela Macchione, Valentina Ferri, Daniela Calandrella, Gianni Pezzoli
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor symptoms and various non-motor symptoms. Recent research has suggested a potential correlation between vitamin D and Parkinson's disease, although the mechanisms and efficacy are still unclear.
Article
Pediatrics
Sigal Eilat-Adar, Eias Kassem, Mahmood Sindiani, Sigal Ben-Zaken
Summary: Both the IGF1 axis and hypovitaminosis D are involved in childhood obesity, and genetic scores associated with elevated IGF1 may indicate a tendency towards hypovitaminosis D-related obesity.
Article
Psychiatry
Xiujie Qi, Ting Yang, Jie Chen, Ying Dai, Li Chen, Lijie Wu, Yan Hao, Ling Li, Jie Zhang, Xiaoyan Ke, Mingji Yi, Qi Hong, Jinjin Chen, Shuanfeng Fang, Yichao Wang, Qi Wang, Chunhua Jin, Feiyong Jia, Tingyu Li
Summary: The study investigated the relationship between vitamin D levels and core symptoms and neurodevelopmental levels in children with ASD. The findings showed that children with ASD had lower vitamin D levels and that these levels were primarily associated with core symptoms. Further research is needed to determine the effectiveness of vitamin D supplementation in the treatment of ASD.
PSYCHIATRY RESEARCH
(2022)
Article
Nutrition & Dietetics
Dahyun Park, Juhee Lee, Clara Yongjoo Park, Min-Jeong Shin
Summary: This study found that low levels of vitamin D (<20 ng/mL) were associated with a higher risk of mortality in Korean adults, especially in men and those with hypertension, suggesting an impact of vitamin D on mortality risk.
Article
Nutrition & Dietetics
Debora Melo van Lent, Sarah Egert, Steffen Wolfsgruber, Luca Kleineidam, Leonie Weinhold, Holger Wagner-Thelen, Birgit Stoffel-Wagner, Horst Bickel, Birgitt Wiese, Siegfried Weyerer, Michael Pentzek, Frank Jessen, Matthias Schmid, Wolfgang Maier, Martin Scherer, Steffi G. G. Riedel-Heller, Alfredo Ramirez, Michael Wagner
Summary: Deficiency of vitamin D increases the risk of developing Alzheimer's dementia. It is recommended to monitor vitamin D levels in the elderly and provide supplementation in cases of deficiency.
Article
Nutrition & Dietetics
Zhenzhen Wan, Tingting Geng, Rui Li, Xue Chen, Qi Lu, Xiaoyu Lin, Liangkai Chen, Yanjun Guo, Liegang Liu, Zhilei Shan, An Pan, JoAnn E. Manson, Gang Liu
Summary: This study investigated the association between vitamin D concentration and cardiovascular disease risk in type 2 diabetes patients. The results showed that higher serum vitamin D concentrations were significantly associated with lower risks of total CVD and ischemic heart disease (IHD). Maintaining adequate vitamin D status and avoiding deficiency may help prevent CVD complications in patients with type 2 diabetes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Pediatrics
Vanessa Shaw, Caroline Anderson, An Desloovere, Larry A. Greenbaum, Dieter Haffner, Christina L. Nelms, Fabio Paglialonga, Nonnie Polderman, Leila Qizalbash, Jose Renken-Terhaerdt, Stella Stabouli, Jetta Tuokkola, Johan Vande Walle, Bradley A. Warady, Rukshana Shroff
Summary: Proper nutritional management is crucial for children with chronic kidney disease (CKD) to maintain normal growth and development. Infants with CKD have specific nutritional needs, and inadequate nutrition can lead to growth impairment and abnormal neurodevelopment.
PEDIATRIC NEPHROLOGY
(2023)
Review
Pediatrics
Tugba Tastemel Ozturk, Nur Canpolat, Seha Saygili, Umut Selda Bayrakci, Oguz Soylemezoglu, Fatih Ozaltin, Rezan Topaloglu
Summary: Patients with SGPL1 mutations have a poor prognosis, and may exhibit involvement of various organs/systems beyond adrenal insufficiency.
PEDIATRIC NEPHROLOGY
(2023)
Article
Transplantation
Mehmet S. Sever, Raymond Vanholder, Valerie Luyckx, Kai-Uwe Eckardt, Mykola Kolesnyk, Andrzej Wiecek, Ewa Pawlowicz-Szlarska, Daniel Gallego, Rukshana Shroff, Andrej Skoberne, Ionut Nistor, Mohamed Sekkarie, Dmytro Ivanov, Edita Noruisiene, Serhan Tuglular
Summary: During conflicts, people with kidney disease may face additional threats due to medical and logistical challenges. Acute kidney injury and treatment interruptions can worsen kidney function, and limitations in dialysis and availability of immunosuppressive medications increase the risk of complications. Local preparedness, adjustments in treatment, telemedicine support, and referrals to higher-level hospitals are important measures to address these challenges.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pediatrics
Nivedita Kamath, Arpana Iyengar, Hamsa Reddy, Jyoti Sharma, Jyoti Singhal, Sudha Ekambaram, Susan Uthup, Sumithra Selvam, Mandy Wan, Anja Rahn, Dagmar Christiane-Fischer, Rukshana Shroff
Summary: This study analyzed the effects of different dosing regimens of cholecalciferol supplementation on bone biomarkers. The results showed that cholecalciferol supplementation significantly increased bone formation, and the three dosing regimens had similar effects on bone biomarkers.
PEDIATRIC NEPHROLOGY
(2023)
Review
Pediatrics
Lale Sever, Gulseren Pehlivan, Nur Canpolat, Seha Saygili, Ayse Agbas, Ebru Demirgan, Jun Oh, Elena Levtchenko, Dymtro D. Ivanov, Rukshana Shroff
Summary: Pediatric patients on kidney replacement therapy are highly vulnerable during disasters due to limitations in dialysis treatments and shortage of medical resources. Proper measures and support are crucial to mitigate risks and provide necessary care.
PEDIATRIC NEPHROLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Ezgi Ay, Emre Gurses, Filiz Aslan, Bora Gulhan, Asuman Alniacik, Ali Duzova, Munir Demir Bajin, Levent Sennaroglu, Gulsum Aydan Genc, Fatih Ozaltin, Rezan Topaloglu
Summary: This study aimed to determine the characteristics of hearing loss in patients with dRTA caused by different gene mutations. The results showed that LVAS is common in dRTA patients and may influence the type and severity of hearing loss. Therefore, regular audiological follow-up is essential for early detection of possible late-onset or progressive hearing loss in dRTA patients.
AUDIOLOGY AND NEURO-OTOLOGY
(2023)
Editorial Material
Urology & Nephrology
Sahar Ghasemi, Matthias Wuttke
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Genetics & Heredity
Pascal Schlosser, Nora Scherer, Franziska Grundner-Culemann, Sara Monteiro-Martins, Stefan Haug, Inga Steinbrenner, Burulca Uluvar, Matthias Wuttke, Yurong Cheng, Arif B. Ekici, Gergely Gyimesi, Edward D. Karoly, Fruzsina Kotsis, Johanna Mielke, Maria F. Gomez, Bing Yu, Morgan E. Grams, Josef Coresh, Eric Boerwinkle, Michael Kottgen, Florian Kronenberg, Heike Meiselbach, Robert P. Mohney, Shreeram Akilesh, Miriam Schmidts, Matthias A. Hediger, Ulla T. Schultheiss, Kai-Uwe Eckardt, Peter J. Oefner, Peggy Sekula, Yong Li, Anna Koettgen
Summary: The kidneys play a critical role in removing waste products and retaining valuable solutes in the body. Genetic studies of plasma and urine metabolites have identified important associations and provided insights into kidney function, such as glycerol transport and protein localization. Shared genetic determinants of metabolite-disease combinations offer potential for understanding metabolic diseases. Expanding genetic studies of the metabolome beyond plasma allows for a better understanding of processes at the interface of body compartments.
Article
Pediatrics
Justine Bacchetta, Claus Peter Schmitt, Sevcan A. Bakkaloglu, Shelley Cleghorn, Maren Leifheit-Nestler, Agnieszka Prytula, Bruno Ranchin, Anne Schoen, Stella Stabouli, Johan van de Walle, Enrico Vidal, Dieter Haffner, Rukshana Shroff
Summary: Infants with CKD are highly susceptible to mineral and bone disorders, and this position paper provides guidelines for diagnosing and managing CKD-MBD in infants. The paper includes 34 clinical practice points, such as dietary control of calcium and phosphate, and medication recommendations. The strength of the statements in the paper may vary and should be tailored to individual patient needs by the treating physician.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
Molly R. Wong Vega, Dana Cerminara, An Desloovere, Fabio Paglialonga, Jose Renken-Terhaerdt, Johan Vande Walle, Vanessa Shaw, Stella Stabouli, Caroline Elizabeth Anderson, Dieter Haffner, Christina L. Nelms, Nonnie Polderman, Leila Qizalbash, Jetta Tuokkola, Bradley A. Warady, Rukshana Shroff, Larry A. Greenbaum
Summary: The nutritional management of children with AKI is complex due to the dynamic nature of the condition. The PRNT has developed CPRs to guide dietitians in providing optimal nutrition support in line with AKI medical treatments. Collaboration between dietitians and physicians is crucial in addressing challenges in nutrition assessment and adapting recommendations to individual patient needs.
PEDIATRIC NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Matthias Wuttke, Eva Koenig, Maria-Alexandra Katsara, Holger Kirsten, Saeed Khomeijani Farahani, Alexander Teumer, Yong Li, Martin Lang, Burulca Goecmen, Cristian Pattaro, Dorothee Guenzel, Anna Koettgen, Christian Fuchsberger
Summary: A genotype imputation approach was applied to whole exome sequencing data from the UK Biobank, resulting in the discovery of 158 rare variants and 105 genes significantly associated with kidney function traits. This approach boosts statistical power and provides a comprehensive resource for directing experimental and clinical studies of kidney disease.
NATURE COMMUNICATIONS
(2023)
Article
Transplantation
Pieter Evenepoel, Hanne Skou Jorgensen, Jordi Bover, Andrew Davenport, Justine Bacchetta, Mathias Haarhaus, Ditte Hansen, Carolina Gracia-Iguacel, Markus Ketteler, Louise McAlister, Emily White, Sandro Mazzaferro, Marc Vervloet, Rukshana Shroff, European Renal Osteodystrophy EUROD, European Renal Assoc ERA, European Soc Pediat Nephrology ESPN
Summary: Mineral and bone disorders are commonly seen in patients with chronic kidney disease, which can lead to adverse health outcomes. The management of calcium intake is crucial for maintaining a neutral calcium balance and preventing bone diseases and fractures. However, current clinical practice guidelines lack specific recommendations on calcium intake. Therefore, experts in the field have provided key practice points to assist healthcare professionals, but these recommendations should be individualized based on patient needs.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Rukshana Shroff, Carlo Basile, Frank van der Sande, Sandip Mitra
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pediatrics
Tugba Tastemel Ozturk, Ali Duzova, Pembe Derin Oygar, Demet Baltu, Pelin Ozcilingir Hakverdi, Sibel Lacinel Gurlevik, Eda Didem Kurt-Sukur, Hayrettin Hakan Aykan, Seza Ozen, Ilker Ertugrul, Selman Kesici, Bora Gulhan, Fatih Ozaltin, Yasemin Ozsurekci, Ali Bulent Cengiz, Rezan Topaloglu
Summary: This study investigated the characteristics of acute kidney injury (AKI) in pediatric COVID-19 and MIS-C, and found that the frequency of AKI was 22.7% in COVID-19 and 15.3% in MIS-C. Independent risk factors for AKI in COVID-19 patients were the need for vasoactive/inotropic agents and vomiting/diarrhea, while in MIS-C patients it was the need for vasoactive/inotropic agents and severe inflammation. The study emphasizes the association between AKI and age in MIS-C patients and suggests the need for long-term follow-up for kidney functions.
PEDIATRIC NEPHROLOGY
(2023)
Article
Medicine, Research & Experimental
Anja Pfau, Karen I. Lopez-Cayuqueo, Nora Scherer, Matthias Wuttke, Annekatrin Wernstedt, Daniela Gonzalez Fassrainer, Desiree E. C. Smith, Jiddeke M. van de Kamp, Katharina Ziegeler, Kai-Uwe Eckardt, Friedrich C. Luft, Peter S. Aronson, Anna Koettgen, Thomas J. Jentsch, Felix Knauf
Summary: Sulfate is important for various physiological processes in the human body. The transporter SLC26A1 plays a crucial role in sulfate reabsorption in the kidney. Through genetic analysis and functional experiments, it is confirmed that SLC26A1 is a sulfate transporter in humans. Rare SLC26A1 variants are associated with lower plasma sulfate levels at the population level.
JOURNAL OF CLINICAL INVESTIGATION
(2023)