Article
Multidisciplinary Sciences
Wanfu Wu, Margaret Warner, Li Wang, Wei-Wei He, Ruipeng Zhao, Xiaoxiang Guan, Cindy Botero, Bo Huang, Charlotte Ion, Charles Coombes, Jan-Ake Gustafsson
Summary: Comparing gene expression profiles of malignant parts and normal adjacent parts of TNBC breasts revealed that CYP-mediated pathways may drive TNBC. However, despite being expressed in TNBC, ER13 is unlikely to be a tumor suppressor as its absence of main tethering partners renders it ineffective on genes related to proliferation and inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Suryendu Saha, Samya Dey, Somsubhra Nath
Summary: This article discusses the role of steroid hormone receptors in cell cycle regulation, with a focus on their interaction with breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Plant Sciences
Peng Zhang, Yuqiang Zhu, Shengjun Zhou
Summary: Cucumber, a widely planted vegetable crop, suffers from powdery mildew caused by Sphaerotheca fuliginea infection. The resistance to powdery mildew involves differential accumulation of metabolites and gene expression changes, especially in flavonoid, hormone, and fatty acid metabolisms. The complex network controlling PM resistance in cucumber includes various hormonal and metabolic pathways.
Article
Oncology
Michelle M. Williams, Nicole S. Spoelstra, Spencer Arnesen, Kathleen O'Neill, Jessica L. Christenson, Jordan Reese, Kathleen C. Torkko, Andrew Goodspeed, Emmanuel Rosas, Toru Hanamura, Sharon B. Sams, Zheqi Li, Steffi Oesterreich, Rebecca B. Riggins, Britta M. Jacobsen, Anthony Elias, Jason Gertz, Jennifer K. Richer
Summary: Mutations in ESR1 are present in over 40% of metastatic breast cancers resistant to adjuvant aromatase inhibitor therapy, leading to constitutive estrogen receptor alpha activity. Metastatic lesions with mutant ER show increased levels of immune-suppressive macrophages, suggesting potential response to immunotherapies. Targeting proteins like AR and CHI3L1 in ER-mutant tumors may provide a therapeutic advantage in estrogen-deprived conditions.
Article
Chemistry, Multidisciplinary
Jia-Zih Dai, Yen-Ju Wang, Cheng-Hsun Chen, I-Lin Tsai, Yi-Chun Chao, Cheng-Wei Lin
Summary: Hormone dysregulation is considered a risk factor for obesity-mediated breast tumorigenesis. However, obesity is associated with poor outcomes among women diagnosed with hormone-independent breast cancer subtype called triple-negative breast cancer (TNBC). This study found that diet-induced obesity (DIO) facilitates tumorigenesis of TNBC cells. Mechanistically, DIO induces a metabolic addiction to fatty acid oxidation (FAO) and activates Yes-associated protein (YAP) signaling. YAP regulates mitochondrial redox homeostasis through transcriptional regulation of antioxidant-related enzymes, therefore protecting tumor cells from FAO-induced mitochondrial oxidative stress. Adipocytes-derived fatty acids are responsible for enhancing the FAO-YAP axis and antioxidative capacity. Additionally, higher expression of an obesity signature in breast cancer patients is positively correlated with YAP signaling and antioxidant genes. The findings reveal the crucial role of YAP in dictating mitochondrial redox homeostasis for obesity-mediated metabolic adaptation and breast tumor progression.
Review
Biochemistry & Molecular Biology
Meng Yang, Feng Ma, Min Guan
Summary: Steroid hormones play a role in regulating lipid homeostasis and may impact the development of nonalcoholic fatty liver disease (NAFLD). Modulating steroid hormone levels or receptor activity could be potential therapeutic strategies for preventing NAFLD.
Article
Medicine, Research & Experimental
Shihui Mao, Qing Ling, Jiajia Pan, Fenglin Li, Shujuan Huang, Wenle Ye, Wenwen Wei, Xiangjie Lin, Yu Qian, Yungui Wang, Xin Huang, Jiansong Huang, Jinghan Wang, Jie Jin
Summary: This study found that high expression of CPT1a in AML patients predicts poor clinical outcome, with downregulation of CPT1a inhibiting cell proliferation. Combining the CPT1a inhibitor ST1326 with Bcl-2 inhibitor ABT199 showed strong synergistic inhibitory effects on AML, suggesting a potential new treatment strategy for the disease.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Shaojie Cheng, Xueying Wan, Liping Yang, Yilu Qin, Shanchun Chen, Yongcan Liu, Yan Sun, Yuxiang Qiu, Luyi Huang, Qizhong Qin, Xiaojiang Cui, Mingjun Wu, Manran Liu
Summary: RGCC overexpression is significantly associated with lung-specific metastasis of TNBC. RGCC activates AMPK alpha 2 and downstream signaling through RGCC-driven PLK1 activity to facilitate TNBC lung metastasis. The study provides implications for RGCC-driven oxidative phosphorylation and fatty acid oxidation as important therapeutic targets for TNBC treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Virginia Solar Fernandez, Marco Fiocchetti, Manuela Cipolletti, Marco Segatto, Paolo Cercola, Annalisa Massari, Sabrina Ghinassi, Francesco Cavaliere, Maria Marino
Summary: The study evaluated the levels and localization of NGB in ER alpha+ breast ductal carcinoma tissue, finding a strong association between NGB accumulation, ER alpha, AKT activation, and the G3 grade, while no association with the menopausal state was evident. Analysis of the data set supported the idea that NGB accumulation could be linked to tumor cell aggressiveness (high grade) and resistance to treatment.
Article
Oncology
Ruipan Zheng, Yurong Wang
Summary: Growing evidence suggests a strong association between decreased lipid catabolism and the development of cancer. In this study, we found that SLC9A5 exhibited significantly higher expression in CRC tumor tissues compared to adjacent paratumor tissues. Knockdown of SLC9A5 resulted in suppressed cell proliferation, migration, and invasion, and further bioinformatics analysis revealed its involvement in the peroxisomal fatty acid oxidation pathway (FAO). The findings suggest that SLC9A5 could serve as a promising therapeutic target for inhibiting the progression of colorectal cancer.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Boya Peng, Yuqi Yang, Zhiyuan Wu, Rachel Tan, Thach Tuan Pham, Eric Yew Meng Yeo, Marco Pirisinu, Migara Kavishka Jayasinghe, Tin Chanh Pham, Kun Liang, Ng Shyh-Chang, Minh T. N. Le
Summary: Cancer cachexia is a syndrome characterized by muscle loss, and inhibiting myostatin has shown promise in preserving muscle mass. However, existing methods of myostatin inhibition have had limited effectiveness and side effects. In this study, a novel method using red blood cell-derived extracellular vesicles to deliver Mstn siRNA to skeletal muscles was tested in a mouse model of cancer cachexia. The results showed that this delivery method was safe, non-inflammatory, and led to increased muscle growth and prevention of cachexia.
Review
Biochemistry & Molecular Biology
Sylwia Szrok-Jurga, Aleksandra Czumaj, Jacek Turyn, Areta Hebanowska, Julian Swierczynski, Tomasz Sledzinski, Ewa Stelmanska
Summary: Fatty acid metabolism, especially beta-oxidation, plays a crucial role in human physiology and pathology. Beta-oxidation is not only involved in energy metabolism but also contributes to the synthesis of various important compounds. This review provides an overview of the importance of mitochondrial and peroxisomal beta-oxidation in different organs and cells and discusses the diseases associated with fatty acid oxidation disturbances. The review also highlights the abnormalities of fatty acid oxidation in cancer cells and diseases caused by mutations in enzymes involved in fatty acid oxidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Eva Dolejsi, Eszter Szanti-Pinter, Nikolai Chetverikov, Dominik Nelic, Alena Randakova, Vladimir Dolezal, Eva Kudova, Jan Jakubik
Summary: The study revealed that membrane cholesterol can modulate the function of muscarinic receptors, with different steroidal compounds showing varying affinity for the receptors. Corticosterone and progesterone were found to allosterically modulate receptor function under physiological conditions.
Article
Cell Biology
Lei Duan, Sarah Calhoun, Daeun Shim, Ricardo E. Perez, Lothar A. Blatter, Carl G. Maki
Summary: The study revealed increased activation of AKT and AMPK in TAM and endoxifen-resistant cells, accompanied by metabolic reprogramming and increased autophagy. Concurrent inhibition of AKT and FAO/autophagy is crucial for sensitizing resistant cells to endoxifen.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Review
Immunology
Duojiao Wu, Yuwen Chen
Summary: Lipids and lipid metabolism play important roles in regulating T cell function and immune memory. Tumor-infiltrating CD8(+) T lymphocytes restore their impaired function by burning fats, while fatty acids and cholesterol in the tumor microenvironment contribute to CD8(+) TILs dysfunction. Understanding the interplay between cellular lipid metabolism and CD8(+) TILs dysfunction is crucial for improving cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Sadaf Noor, Yuliya Semenova, Alexandru Dosa, Joeri J. Pen, Alain Menzel, Salva Piscopo, Nicolas Wirth, Daniel-Ovidiu Costea
Summary: This article discusses alternative treatments for prostate disorders, with a particular focus on the role of nutrients. By providing an overview of the characteristics of the prostate organ and the most prevalent diseases, nutrition-based treatment methods are proposed, with an emphasis on their potential effectiveness in surgery. The article advocates for the recognition of this form of alternative treatment as a fully recognized therapy for prostate disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Medical Informatics
Asma Gasmi Benahmed, Amin Gasmi, Wajiha Anzar, Mehreen Arshad, Geir Bjorklund
Summary: This article summarizes the epidemiology, modes of cross-infection, and recent data on SARS-CoV-2 related to dental practice. It highlights the importance of protecting both dental health care providers and patients from infection transmission, given the dual challenge they face.
HEALTH AND TECHNOLOGY
(2022)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel Ovidiu Costea
Summary: Bariatric surgery is an effective method for significant weight loss in patients who have not achieved weight loss through pharmacological interventions. Post-surgery, sustained weight loss offers metabolic advantages and improves glucose and lipid metabolism. However, bariatric surgery is associated with deficiencies in vitamins and minerals, requiring monitoring and supplementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel-Ovidiu Costea
Summary: Gut microbes play a crucial role in bariatric surgery outcomes, as they can be altered by the surgery and have beneficial effects on therapeutic results.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Boukelia Boukhmis, Geir Bjorklund, Ibrahim H. Elkhidir, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Adekunle Hakeem Temitope, Sadaf Noor, Daniel-Ovidiu Costea
Summary: This systematic review and meta-analysis examined the effect of physical activity on weight loss in adults who underwent bariatric surgery. The study also compared biomarkers between individuals with different levels of physical activity after surgery. The results showed that BMI as a measure of physical activity had a positive impact on the target population. However, further larger-scale studies with stricter criteria are needed to confirm these findings.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Neurosciences
Nagwa A. Meguid, Heba S. Hashem, Mohamed H. Ghanem, Samia A. Helal, Yuliya Semenova, Saher Hashem, Adel Hashish, Salvatore Chirumbolo, Ahmed M. Elwan, Geir Bjorklund
Summary: This study aimed to identify metabolic abnormalities in BCAAs and investigate the presence of epileptiform discharges in ASD patients. Results showed that various types of seizures can occur in ASD children and that ASD children have lower levels of BCAAs compared to neurotypical controls. Further research is needed to better understand ASD and evaluate the association between ASD, EEG changes, seizures, and BCAAs more reliably.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Virology
Anitha D. D. Jayaprakash, Adam J. J. Ronk, Abhishek N. N. Prasad, Michael F. F. Covington, Kathryn R. R. Stein, Toni M. M. Schwarz, Saboor Hekmaty, Karla A. A. Fenton, Thomas W. W. Geisbert, Christopher F. F. Basler, Alexander Bukreyev, Ravi Sachidanandam
Summary: Filoviruses cause severe diseases in humans and nonhuman primates but have subclinical effects in bats. By infecting Egyptian rousette bats with Marburg and Ebola viruses, researchers identified various immune responses and pathways involved in bat resistance to these viruses, providing insights for the development of new strategies to treat and mitigate the diseases caused by these viruses in humans.
Review
Cell Biology
Marina Izmailovich, Yuliya Semenova, Gulzada Abdushukurova, Ainur Mukhamejanova, Azhar Dyussupova, Raida Faizova, Meruert Gazaliyeva, Leila Akhvlediani, Natalya Glushkova, Sundetgali Kalmakhanov, Geir Bjorklund
Summary: A systematic review was conducted to explore the use of component-resolved diagnosis in identifying polysensitization in patients with seasonal allergic rhinitis. A total of 568 publications were identified and 12 were included in the review, with 3302 patients enrolled. The findings showed that component-resolved diagnostics changed the choice of relevant allergens for immunotherapy in at least 50% of cases and sensitization differed based on age, disease type, and disease duration.
Review
Infectious Diseases
Asma Gasmi Benahmed, Amin Gasmi, Torsak Tippairote, Pavan Kumar Mujawdiya, Oleksandr Avdeev, Yurii Shanaida, Geir Bjorklund
Summary: Dental implants are commonly used to replace lost teeth, and titanium implants have a high success rate. However, there is an increasing risk of peri-implantitis, an inflammatory disease that affects the tissues around the implant. This review highlights the impact of different metabolic conditions on peri-implantitis and emphasizes the importance of considering both local and systemic factors in dental implant procedures and treatment.
Review
Chemistry, Medicinal
Amin Gasmi, Pavan Kumar Mujawdiya, Amine Nehaoua, Mariia Shanaida, Yuliya Semenova, Salva Piscopo, Alain Menzel, Volodymyr Voloshyn, Olena Voloshyn, Volodymyr Shanaida, Geir Bjorklund
Summary: The obesity pandemic is a pressing public health concern, with a projected increase in the number of obese or overweight individuals by 2025. Current strategies for treating obesity focus on patient-centered approaches including diet, behavior, medication, and surgery. However, there is a need for novel and more effective pharmaceutical drugs to assist with lifestyle modifications and better manage obesity.
Review
Infectious Diseases
Yernar Amangelsin, Yuliya Semenova, Maryam Dadar, Mohamad Aljofan, Geir Bjorklund
Summary: Tetracycline, a widely used antibiotic, has become a serious threat to the environment due to overuse and weak degradation ability. It accumulates in the food chain, causing toxicity to microbial communities, promoting antibiotic resistance, and disrupting human intestinal flora.
Review
Chemistry, Medicinal
Amin Gasmi, Mariia Shanaida, Oleksandra Oleshchuk, Yuliya Semenova, Pavan Kumar Mujawdiya, Yana Ivankiv, Olena Pokryshko, Sadaf Noor, Salva Piscopo, Stepan Adamiv, Geir Bjorklund
Summary: The immune system protects the body from infectious agents, and a well-balanced immunity is crucial for maintaining human health. Nutritional and micronutrient deficiencies can compromise the immune system, while certain bioactive compounds from plants, fungi, animals, microorganisms, and other natural sources have shown immunomodulatory properties and can enhance the immune response.
Review
Health Care Sciences & Services
Laura Kassym, Assiya Kussainova, Yuliya Semenova, Almas Kussainov, Damir Marapov, Marat Zhanaspayev, Zhanar Urazalina, Almira Akhmetova, Madi Tokanov, Yerbol Smail, Geir Bjorklund
Summary: Drunk driving is a significant risk factor for traffic accidents and their lethality. This meta-analysis provides estimates of the prevalence of drunk driving in non-lethally injured drivers, considering factors such as the world region, blood alcohol concentration, and study quality. The pooled prevalence of drunk driving in injured drivers was found to be 16.6%.
Article
Health Policy & Services
Valeriy Zub, Yuliya Semenova, Oleksandr Tolstanov, Andrii Kotuza, Taras Gutor, Oksana Matsyura, Roman Lysiuk, Geir Bjorklund
Summary: This study assessed the challenges faced by oncologists in providing cancer care in Ukraine after the armed conflict. The findings showed that physicians in regions occupied by the Russian army experienced a significant decline in patient numbers, while most physicians were satisfied with the availability of medicines and equipment.
INTERNATIONAL JOURNAL OF HEALTHCARE MANAGEMENT
(2023)
Article
Neurosciences
Neluwa-Liyanage R. Indika, Udara D. Senarathne, Antonio Malvaso, Dhanushka Darshana, Susan C. Owens, Borhan Mansouri, Yuliya Semenova, Geir Bjorklund
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by early-onset social interaction and communication deficits, along with repetitive and restricted patterns of activities, behavior, and interests. Heavy metal exposure, abnormal metabolism, and genetic susceptibility may play a role in the pathogenesis of ASD. Altered porphyrin metabolism in ASD may be associated with deficiencies in vitamins and minerals, and potential metabolic therapies such as supplementation with vitamins, minerals, cofactors, and antioxidants need to be explored in future research.
MOLECULAR NEUROBIOLOGY
(2023)