Article
Multidisciplinary Sciences
Hyo Jin Kang, Soo Young Moon, Baek-Kyu Kim, Yujin Myung, Ju-Hee Lee, Jae Hoon Jeong
Summary: To overcome the limitations of lymphedema treatment, human adipose-derived stem cells (hADSCs) were injected into decellularized lymph nodes to produce a recellularized lymph node-scaffold, and the effect of lymphangiogenesis was investigated in lymphedema animal models.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Lincoln Biswas, Junyu Chen, Jessica De Angelis, Amit Singh, Charlotte Owen-Woods, Zhangfan Ding, Joan Mane Pujol, Naveen Kumar, Fanxin Zeng, Saravana K. Ramasamy, Anjali P. Kusumbe
Summary: Blood and lymphatic vessels play important roles in regulating tissue-specific functions. In this study, the presence of lymphatic vessels in mouse and human bones is demonstrated using advanced imaging techniques. The expansion of lymphatic vessels during genotoxic stress and the signaling pathways involved are identified. Lymphangiogenesis is found to stimulate hematopoietic and bone regeneration by promoting the secretion of CXCL12 and the expansion of Myh11-positive cells. However, this response is impaired in aged animals. These findings suggest that targeting lymphangiogenesis could be a potential therapeutic approach for promoting tissue regeneration.
Article
Oncology
Shannon Green, Victoria D. Vuong, Paritosh C. Khanna, John R. Crawford
Summary: This study demonstrates the feasibility of using pre-diagnostic neuroimaging to predict the growth velocity of pediatric brain tumors. It also indicates that high-grade tumors have a faster growth rate than low-grade tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Jia Wang, Xiange Huang, Hegen Li, Deyue Yan, Wei Huang
Summary: In this study, two Zn(ii) coordination polymers were synthesized and transformed into stable nanoparticles for drug delivery. These nanoparticles showed good anticancer activity by entering cancer cells and inhibiting their proliferation, while exhibiting low toxicity to normal cells.
DALTON TRANSACTIONS
(2022)
Article
Gastroenterology & Hepatology
Guido Carpino, Vincenzo Cardinale, Alessandra Di Giamberardino, Diletta Overi, Samantha Donsante, Tania Colasanti, Gaia Amato, Gianluca Mennini, Matteo Franchitto, Fabrizio Conti, Massimo Rossi, Mara Riminucci, Eugenio Gaudio, Domenico Alvaro, Carmine Mancone
Summary: The study identified THBS1, THBS2, and PEDF released in iCCA inhibit vessel growth and promote tumor-associated lymphangiogenesis, offering potential targets for interventions to counteract the dissemination process in iCCA.
JOURNAL OF HEPATOLOGY
(2021)
Article
Oncology
Stanley Ly, Vivek Anand, Fouad El-Dana, Khoa Nguyen, Yiming Cai, Shirong Cai, Helen Piwnica-Worms, Debasish Tripathy, Aysegul A. Sahin, Michael Andreeff, Venkata Lokesh Battula
Summary: GD2 is expressed in around 60% of primary TNBC tumors at variable levels and is associated with worse overall survival of patients with TNBC. Treatment with dinutuximab significantly decreased adhesion and migration of TNBC cells, inhibited mTOR signaling, and reduced tumor growth in both cell-line xenografts and PDX models. Our data provide proof-of-concept for the critical role of GD2 in BCSCs and demonstrate the potential of dinutuximab as a novel therapeutic approach for TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Zohra Benyahia, Caroline Gaudy-Marqueste, Caroline Berenguer-Daize, Norhimane Chabane, Nadege Dussault, Mylene Cayol, Christine Vellutini, Amina Djemli, Isabelle Nanni, Nathalie Beaufils, Kamel Mabrouk, Jean-Jacques Grob, L'Houcine Ouafik
Summary: This study found that adrenomedullin promotes melanoma tumor growth and neovascularization, affecting the tumor microenvironment. This discovery provides an important therapeutic target for future melanoma treatments.
Article
Multidisciplinary Sciences
Munekazu Yamakuchi, Masashi Okawa, Kazunori Takenouchi, Aryal Bibek, Shingo Yamada, Keiichi Inoue, Kazuhiko Higurashi, Akito Tabaru, Kiyonori Tanoue, Yoko Oyama, Sadayuki Higashi, Chieko Fujisaki, Hideaki Kanda, Hiroto Terasaki, Taiji Sakamoto, Yoshiharu Soga, Teruto Hashiguchi
Summary: In this study, antibodies against human VEGF-A121 and VEGF-A165 were produced and ELISA assays for hVEGF-A121 and hVEGF-A165 were created. The levels of VEGF-A121 and VEGF-A165 were measured in serum, plasma, and platelets from healthy volunteers, and the results showed different ratios of VEGF isoforms. The newly developed ELISAs provide useful biomarkers for diseases involving VEGF-A121 and VEGF-A165.
Article
Multidisciplinary Sciences
Beatrice Malacrida, Sam Nichols, Eleni Maniati, Roanne Jones, Robin Delanie-Smith, Reza Roozitalab, Eleanor J. Tyler, Morgan Thomas, Gina Boot, Jonas Mackerodt, Michelle Lockley, Martin M. Knight, Frances R. Balkwill, Oliver M. T. Pearce
Summary: The team developed a four-cell culture model to investigate the role of platelets in malignant cell invasion and extracellular matrix production, revealing their promotion of factors associated with poor prognosis. They found that platelet activation is critical in stimulating malignant cell invasion and successfully dissected the roles of malignant cells and mesothelial cells.
Review
Medicine, General & Internal
Baptiste Camus, Anne-Segolene Cottereau, Lola-Jade Palmieri, Solene Dermine, Florence Tenenbaum, Catherine Brezault, Romain Coriat
Summary: Radionuclide therapy for neuroendocrine tumors, targeting tumor cells with a large quantity of somatostatin receptors, is effective and has shown significant efficacy in metastatic midgut neuroendocrine tumors. Besides midgut tumors, pancreatic and pulmonary neuroendocrine tumors also seem to benefit from this treatment approach.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benedikt M. Schaarschmidt, Moritz Wildgruber, Roman Kloeckner, James Nie, Verena Steinle, Arthur J. A. T. Braat, Fabian Lohoefer, Hyun S. Kim, Harald Lahner, Manuel Weber, Jens Theysohn
Summary: Y-90 radioembolization (Y-90 RE) could be an important alternative treatment option for neuroendocrine neoplasms (NENs) patients with hepatic metastases, but more clinical evidence is needed.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Syeda Mahak Zahra Bokhari, Peter Hamar
Summary: Vascular endothelial growth factors (VEGFs) play a crucial role in regulating blood vessel formation in both normal and cancer development. VEGF-A is the most well-studied angiogenic factor secreted by tumor cells, making it a rational target for anticancer therapy. However, inhibiting VEGF-A can lead to the upregulation of VEGF-D, which has been shown to have comparable blood angiogenic potential and may facilitate tumor growth. This review focuses on summarizing the angiogenic role of VEGF-D in blood vessel formation and its potential as a therapeutic target for antiangiogenic therapy in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Richard J. Beck, Sander Sloot, Hirokazu Matsushita, Kazuhiro Kakimi, Joost B. Beltman
Summary: In this study, the importance of cytolytic versus IFNG-mediated cytostatic effects in a murine melanoma model was compared. The contribution of immune checkpoints HAVCR2, LAG3, and PDCD1/CD274 to CTL exhaustion was also investigated. The results showed that the cytostatic effects of IFNG were more important in tumor control, and HAVCR2 and LAG3 better characterized the development of a dysfunctional CTL phenotype than the PDCD1/CD274 axis.
Article
Surgery
Daniel Kaemmerer, Matthias Twrznik, Harshad R. Kulkarni, Dieter Horsch, Susanne Sehner, Richard P. Baum, Merten Hommann
Summary: Resection of primary tumors before PRRT significantly improves the survival rate of patients with stage IV neuroendocrine neoplasms.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jong Keon Jang, Jae Ho Byun, Ji Hun Kang, Jung Hee Son, Jin Hee Kim, Seung Soo Lee, Hyoung Jung Kim, Changhoon Yoo, Kyu-pyo Kim, Seung-Mo Hong, Dong-Wan Seo, Song Cheol Kim, Moon-Gyu Lee
Summary: The study evaluated the ability of CT-determined resectability to predict R0 resection in patients with PDAC after neoadjuvant FOLFIRINOX chemotherapy, finding a relatively low sensitivity and specificity. Low-contrast enhancement of soft tissue contacting artery may enhance the ability of CT to predict R0 resection.
EUROPEAN RADIOLOGY
(2021)