Review
Biochemistry & Molecular Biology
Malgorzata Dybowska, Dorota Wyrostkiewicz, Lucyna Opoka, Katarzyna Lewandowska, Malgorzata Sobiecka, Witold Tomkowski, Monika Szturmowicz
Summary: For over two years, the world has been grappling with the COVID-19 pandemic caused by SARS-CoV-2 infection. Post and long-COVID syndromes pose a challenge for the medical and scientific communities. SARS-CoV-2 infection increases the risk of cardiovascular complications, particularly thromboembolic complications, which can be prevented and treated with LMHW. However, there is still controversy surrounding the prevention and treatment of thromboembolic complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medical Laboratory Technology
Giuseppe Lippi, Francois Mullier, Emmanuel J. Favaloro
Summary: D-dimer measurement is important in the diagnosis, exclusion, and prognostication of venous thromboembolism and disseminated intravascular coagulation. Its clinical applications are expanding to include other diseases such as acute aortic dissection, acute intestinal ischemia, and cerebral venous thrombosis, as well as the management of COVID-19.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Virology
Alessandro Perrella, Valentina Orlando, Ugo Trama, Francesca F. Bernardi, Enrica Menditto, Enrico Coscioni
Summary: Researchers analyzed the infection rate of COVID-19 patients before and after treatment with hydroxychloroquine, considering its immunomodulatory and antiviral properties.
Article
Hematology
Damon E. Houghton, Waldemar Wysokinski, Ana Casanegra, Leslie J. Padrnos, Surbhi Shah, Ewa Wysokinska, Rajiv Pruthi, Aneel Ashrani, Meera Sridharan, Lisa Baumann-Kreuziger, Robert McBane, Anand Padmanabhan
Summary: This study analyzed the incidence of VTE before and after COVID-19 vaccination. The results showed that there was no increased risk of acute VTE post-vaccination for the authorized vaccines in the United States.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Hilary Whitworth, Sarah E. Sartain, Riten Kumar, Katherine Armstrong, Lance Ballester, Marisol Betensky, Clay T. Cohen, Rosa Diaz, Caroline Diorio, Neil A. Goldenberg, Julie Jaffray, Jacquelyn Keegan, Kendra Malone, Adrienne G. Randolph, Stacey Rifkin-Zenenberg, Wendy Seto Leung, Anthony Sochet, Lakshmi Srivaths, Ayesha Zia, Leslie Raffini
Summary: This study found that age >= 12 years, cancer, presence of a central venous catheter, and MIS-C were significantly associated with thrombosis in children hospitalized with COVID-19 or MIS-C. It is notable that the majority of thrombotic events occurred in patients aged 12 years and older, and nearly one-third of patients experienced thrombosis despite receiving thromboprophylaxis.
Article
Hematology
Ang Li, Nicole M. Kuderer, Chih-Yuan Hsu, Yu Shyr, Jeremy L. Warner, Dimpy P. Shah, Vaibhav Kumar, Surbhi Shah, Amit A. Kulkarni, Julie Fu, Shuchi Gulati, Rebecca L. Zon, Monica Li, Aakash Desai, Pamela C. Egan, Ziad Bakouny, K. C. Devendra, Clara Hwang, Imo J. Akpan, Rana R. McKay, Jennifer Girard, Andrew L. Schmidt, Balazs Halmos, Michael A. Thompson, Jaymin M. Patel, Nathan A. Pennell, Solange Peters, Amro Elshoury, Gilbero de Lima Lopes, Daniel G. Stover, Petros Grivas, Brian Rini, Corrie A. Painter, Sanjay Mishra, Jean M. Connors, Gary H. Lyman, Rachel P. Rosovsky
Summary: Hospitalized patients with cancer and COVID-19 are at increased risk of VTE and ATE. A simplified RAM model named CoVID-TE was developed to predict VTE in this vulnerable population, showing good performance in stratifying patients into low-risk and high-risk cohorts based on clinical risk factors. The CoVID-TE RAM may aid in real-time data-driven decisions for thrombosis prevention in this population.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Surgery
Jeffrey E. Indes, Issam Koleilat, Ayesha Nzeribe Hatch, Krystina Choinski, Davis Brent Jones, Hasan Aldailami, Henny Billett, John M. Denesopolis, Evan Lipsitz
Summary: Patients with SARS-CoV-2 infection are at risk for acute arterial thrombotic complications despite a lack of conventional risk factors. A hyperinflammatory state may play a role in this phenomenon, especially with a tendency for involvement of the aortoiliac region. This study provides an early characterization of arterial thrombotic disease in SARS-CoV-2 patients.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Silvia Strambi, Agnese Proietti, Christian Galatioto, Federico Coccolini, Camilla Cremonini, Serena Musetti, Fulvio Basolo, Massimo Chiarugi, Dario Tartaglia
Summary: The pathophysiology of gastrointestinal damage in COVID-19 is likely multifactorial, and it is unclear whether the etiology of intestinal ischemia is directly related to viral replication or is caused by hypercoagulability following SARS-CoV-2 infection. Further studies are needed to confirm these preliminary findings and clinicians should monitor COVID-19 patients for the possible presence of SARS-CoV-2 intestinal infection, which can be a potential cause of ischemia and bowel perforation.
Article
Medicine, General & Internal
Yi Lee, Qasim Jehangir, Chun-Hui Lin, Pin Li, Anupam A. Sule, Laila Poisson, Venugopal Balijepally, Abdul R. Halabi, Kiritkumar Patel, Geetha Krishnamoorthy, Girish B. Nair
Summary: Hypercoagulability is a recognized feature in SARS-CoV-2 infection, and there is a need for a risk assessment model to predict venous thromboembolism (VTE) in COVID-19 patients. This study aimed to build a simple clinical model based on commonly available parameters to predict VTE in COVID-19 patients. The model was trained and validated on a large cohort of hospitalized patients and showed a sensitivity of 83% and specificity of 53%. This clinical tool can help personalize thromboprophylaxis for COVID-19 patients based on their VTE risk category.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Francesco Nappi, Adelaide Iervolino, Sanjeet Singh Avtaar Singh
Summary: The SARS-CoV-2 infection has caused a global pandemic, with vaccines offering some restoration. Both infection and vaccination carry the risk of thrombosis, but data on thromboembolism risk in non-hospitalized patients are lacking. The rollout of vaccines has facilitated the easing of lockdown measures and decreased disease spread, emphasizing the essential role of ongoing epidemiological research.
Article
Hematology
Ahmed K. Pasha, Robert D. McBane, Rahul Chaudhary, Leslie J. Padrnos, Ewa Wysokinska, Rajiv Pruthi, Aneel Ashrani, Paul Daniels, Meera Sridharan, Waldemar E. Wysokinski, Damon E. Houghton
Summary: The study found a 29-fold increased rate of VTE within the first week after COVID-19 diagnosis, which then steadily decreased and returned to baseline by the 6th week. Most VTE events occurred during or after hospitalization, with only a small percentage (3.0%) in non-hospitalized patients.
THROMBOSIS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Hematology
Delphine Douillet, Jeremie Riou, Andrea Penaloza, Thomas Moumneh, Caroline Soulie, Dominique Savary, Francois Morin, Rafael Mahieu, Pierre-Marie Roy
Summary: This study assessed the rate and risk factors of symptomatic VTE in patients with mild and moderate COVID-19. It was found that patients with moderate COVID-19 had a higher risk of subsequent VTE after presenting to the emergency department. Age and hospitalization were identified as independent risk factors for symptomatic VTE.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Jun-Ying Li, Hong-Fei Wang, Ping Yin, Di Li, Di-Le Wang, Peng Peng, Wei-Hua Wang, Lan Wang, Xiao-Wei Yuan, Jin-Yuan Xie, Fan Zhou, Nian Xiong, Feng Shao, Chun-Xiu Wang, Xiang Tong, Hao Ye, Wen-Jun Wan, Ben-De Liu, Wen-Zhu Li, Qian Li, Liang V. Tang, Yu Hu, Gregory Y. H. Lip
Summary: The study found that severe and non-severe hospitalized COVID-19 patients have nearly 6 times and 3 times higher odds of developing symptomatic VTE compared to general medical inpatients. VTE commonly develops at a median of 21 days after symptom onset and independent risk factors include advancing age, cancer, longer interval from symptom onset to admission, lower fibrinogen, and higher D-dimer levels.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Engineering, Biomedical
Alexander Supady, Timm Zahn, Marina Rieder, Christoph Benk, Achim Lother, Christoph Bode, Tobias Wengenmayer, Dawid Staudacher, John A. Kellum, Daniel Duerschmied
Summary: This study compared the survival and cardiovascular stabilization outcomes between ECPR patients treated with cytokine adsorption and those without. The results showed no significant differences in ICU survival, lactate clearance, vasopressor need, and fluid demand between the two groups. The study suggests that cytokine adsorption may not improve the outcomes of severely ill patients after ECPR, but larger randomized-controlled trials are needed to confirm these findings.
Article
Cardiac & Cardiovascular Systems
Krystin Krauel, Daniel Duerschmied
Summary: This article summarizes evidence from clinical studies on novel soluble biomarkers in COVID-19, discussing their potential prognostic value and technical details to stimulate further research. A table provides an overview of the biomarkers measured in plasma, serum, or other fluids.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Cardiac & Cardiovascular Systems
Peter Stachon, Klaus Kaier, Philip Hehn, Alexander Peikert, Dennis Wolf, Vera Oettinger, Dawid Staudacher, Daniel Duerschmied, Andreas Zirlik, Manfred Zehender, Christoph Bode, Constantin von zur Muehlen
Summary: In a nationwide registry study in Germany, left main stenting was found to be a safe and effective treatment option for chronic coronary syndrome patients with left main coronary artery disease, showing reduced risks of bleeding, prolonged ventilation time, and postoperative delirium after risk adjustment, along with shorter hospital stay and lower costs.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Marina Rieder, Nadine Gauchel, Klaus Kaier, Carolin Jakob, Stefan Borgmann, Annika Y. Classen, Jochen Schneider, Lukas Eberwein, Martin Lablans, Maria Ruethrich, Sebastian Dolff, Kai Wille, Martina Haselberger, Hanno Heuzeroth, Christoph Bode, Constantin von Zur Muehlen, Siegbert Rieg, Daniel Duerschmied
Summary: The presence of pre-existing oral anticoagulation (OAC) in COVID-19 patients has been shown to have a protective influence on mortality and recovery rates, as well as reduce the frequency of thrombotic events. This effect is independent of the anticoagulation regime during hospital stay and the stage of disease.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Immunology
Juliana de Castilhos, Eli Zamir, Theresa Hippchen, Roman Rohrbach, Sabine Schmidt, Silvana Hengler, Hanna Schumacher, Melanie Neubauer, Sabrina Kunz, Tonia Mueller-Esch, Andreas Hiergeist, Andre Gessner, Dina Khalid, Rogier Gaiser, Nyssa Cullin, Stamatia M. Papagiannarou, Bettina Beuthien-Baumann, Alwin Kraemer, Ralf Bartenschlager, Dirk Jaeger, Michael Mueller, Felix Herth, Daniel Duerschmied, Jochen Schneider, Roland M. Schmid, Johann F. Eberhardt, Yascha Khodamoradi, Maria J. G. T. Vehreschild, Andreas Teufel, Matthias P. Ebert, Peter Hau, Bernd Salzberger, Paul Schnitzler, Hendrik Poeck, Eran Elinav, Uta Merle, Christoph K. Stein-Thoeringer
Summary: The study found that severe cases of COVID-19 can lead to dysbiotic microbial configurations in the oropharyngeal microbiome, particularly in patients treated with broad-spectrum antibiotics, receiving invasive mechanical ventilation, or with prolonged hospitalization. Early specimen collection allowed for the prediction of COVID-19 mortality using machine learning models, with taxonomic signatures outperforming models based on clinical variables, with Neisseria and Haemophilus species abundances being the most important features.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Bengisu Akbil, Tim Meyer, Paula Stubbemann, Charlotte Thibeault, Olga Staudacher, Daniela Niemeyer, Jenny Jansen, Barbara Muehlemann, Jan Doehn, Christoph Tabeling, Christian Nusshag, Cedric Hirzel, David Soekler Sanchez, Alexandra Nieters, Achim Lother, Daniel Duerschmied, Nils Schallner, Jan Nikolaus Lieberum, Dietrich August, Siegbert Rieg, Valeria Falcone, Hartmut Hengel, Uwe Koelsch, Nadine Unterwalder, Ralf-Harto Huebner, Terry C. Jones, Norbert Suttorp, Christian Drosten, Klaus Warnatz, Thibaud Spinetti, Joerg C. Schefold, Thomas Doerner, Leif Erik Sander, Victor M. Corman, Uta Merle, Florian Kurth, Horst von Bernuth, Christian Meisel, Christine Goffinet
Summary: 6-19% of critically ill COVID-19 patients carry auto-antibodies against type I interferons (IFN-AABs), which may serve as early biomarkers for severe COVID-19. This study establishes a clinically applicable strategy for identifying IFN-AAB-positive patients and providing targeted therapies.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Muataz Ali Hamad, Krystin Krauel, Nancy Schanze, Nadine Gauchel, Peter Stachon, Thomas Nuehrenberg, Mark Zurek, Daniel Duerschmied
Summary: In addition to their role in hemostasis and thrombosis, platelets also play a role in modulating inflammatory reactions and immune responses. Circulating platelets can differ within an individual due to their different physical properties and can be categorized into distinct subtypes based on their function or age. Understanding platelet phenotypic variation is important in various physiological and pathological circumstances.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Uzair Ansari, Simone Britsch, Sebastian Rogowski, Daniel Duerschmied, Theano Papavassiliu
Summary: We present a case of acute myocarditis reported after COVID-19 vaccination. CMR is useful for diagnosis and follow-up of myocarditis patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Hematology
Nancy Schanze, Muataz Ali Hamad, Thomas Georg Nuehrenberg, Christoph Bode, Daniel Duerschmied
Summary: Coronary artery disease is a leading cause of global mortality, with ischemia/reperfusion injury (IRI) contributing to cardiac damage. Platelets play an important role in IRI through activation and interaction with other cells. Understanding platelet contributions to IRI is crucial for developing effective treatment strategies.
Article
Biochemistry & Molecular Biology
Xuehui Fan, Lukas Cyganek, Katja Nitschke, Stefanie Uhlig, Philipp Nuhn, Karen Bieback, Daniel Duerschmied, Ibrahim El-Battrawy, Xiaobo Zhou, Ibrahim Akin
Summary: This study compared the electrophysiological and functional properties of endothelial cells derived from human induced pluripotent stem cells with primary human cardiac microvascular endothelial cells. The results demonstrated that the two types of endothelial cells were similar in terms of ion channel function, membrane receptor signaling, and physiological cell functions, although some differences were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Stephanie Luise Rosenkaimer, Laura Winter, Tina Sieburg, Sandra Maier, Athanasios Mavratzas, Wolf-Karsten Hofmann, Ibrahim Akin, Daniel Duerschmied, Ralf-Dieter Hofheinz, Anna Hohneck
Summary: This exploratory study investigated the diagnostic value of inflammatory markers in predicting anti-tumour treatment-related cardiac events in patients with breast cancer. The results showed that markers such as VCAM-1 and sST2 were associated with an increased likelihood of treatment-related events, providing potential for better identification of high-risk patients.
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Article
Cardiac & Cardiovascular Systems
Anna C. Mavromanoli, Stefano Barco, Walter Ageno, Helene Bouvaist, Marianne Brodmann, Claudio Cuccia, Francis Couturaud, Claudia Dellas, Konstantinos Dimopoulos, Daniel Duerschmied, Klaus Empen, Pompilio Faggiano, Emile Ferrari, Nazzareno Galie, Marcello Galvani, Alexandre Ghuysen, George Giannakoulas, Menno Huisman, David Jimenez, Matija Kozak, Irene M. Lang, Nicolas Meneveau, Thomas Muenzel, Massimiliano Palazzini, Antoniu Octavian Petris, Giancarlo Piovaccari, Aldo Salvi, Sebastian Schellong, Kai-Helge Schmidt, Franck Verschuren, Irene Schmidtmann, Gerrit Toenges, Frederikus A. Klok, Stavros Konstantinides
Summary: This study analyzed the changes in RV function in patients with intermediate-risk PE who were switched early to oral anticoagulation. The results showed that the majority of patients had normalized RV function within 6 days and maintained normal RV function throughout the first 6 months. However, almost one in four patients continued to have evidence of RV dysfunction over the long term.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Hematology
Davide Voci, Andrea Gotschi, Ulrike Held, Roland Bingisser, Giuseppe Colucci, Daniel Duerschmied, Riccardo M. Fumagalli, Bernhard Gerber, Barbara Hasse, Dagmar I. Keller, Stavros V. Konstantinides, Francois Mach, Silvana K. Rampini, Marc Righini, Helia Robert-Ebadi, Thomas Rosemann, Stephanie Roth-Zetzsche, Tim Sebastian, Noemi R. Simon, David Spirk, Stefan Stortecky, Lukas Vaisnora, Nils Kucher, Stefano Barco
Summary: The benefits of early thromboprophylaxis in symptomatic COVID-19 outpatients remain unclear. This study presents the 90-day results from the OVID phase III trial, which showed that early thromboprophylaxis with enoxaparin did not improve the course of COVID-19 in terms of hospitalization, death, or resolution of symptoms.
THROMBOSIS RESEARCH
(2023)
Review
Virology
Aydin Huseynov, Ibrahim Akin, Daniel Duerschmied, Ruediger E. Scharf
Summary: An increasing number of post-COVID patients are experiencing long-term complications from the acute COVID-19 infection, posing ongoing challenges for healthcare professionals. It has become clear that COVID-19 not only affects the respiratory system but also other organs, including the cardiovascular system. Cardiopulmonary symptoms such as shortness of breath, palpitations, limited physical capacity, and cardiac arrhythmias can persist in a significant proportion of recovered patients. This article reviews the prevalence and underlying mechanisms of COVID-19-associated arrhythmias and discusses the clinical management of various rhythm disorders in post-COVID patients.
Article
Hematology
Marina Rieder, Niklas Baldus, Daniela Stallmann, Maren Jeserich, Isabella Goller, Luisa Wirth, Luisa Pollmeier, Maike Hofmann, Christoph Bode, Hans-Joerg Busch, Bonaventura Schmid, Nadine Gauchel, Rudiger E. Scharf, Daniel Duerschmied, Achim Lother, Krystin Krauel
Summary: This study aimed to assess platelet reactivity in patients with moderate COVID-19 at early stages. Platelet reactivity was evaluated using whole-blood impedance aggregometry and flow cytometry in 20 COVID-19-positive patients, 55 COVID-19-negative patients (as patient controls), and 15 healthy individuals.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)