Article
Nutrition & Dietetics
Haofeng Hong, Longting Chen, Yiming Zhong, Zihuan Yang, Weishi Li, Chunli Song, Huijie Leng
Summary: This study used a Mendelian randomization approach to investigate the potential causal effects of homocysteine, folate, and vitamin B12 on site- and gender-specific osteoarthritis (OA). The results showed that genetically predicted homocysteine had adverse effects on OA, while genetically predicted folate and vitamin B12 had protective effects on OA.
Article
Nutrition & Dietetics
Ziva Lavrisa, Hristo Hristov, Masa Hribar, Katja Zmitek, Anita Kusar, Barbara Korousic Seljak, Matej Gregoric, Urska Blaznik, Nadan Gregoric, Katja Zaletel, Adrijana Oblak, Josko Osredkar, Igor Pravst
Summary: Vitamin B12 deficiency is a common issue in the Slovenian population, especially among the elderly. Lower intake is observed in females, and meat and milk are the main contributors to vitamin B12 intake across all age groups. Serum vitamin B12 levels have a significant impact on the health of the elderly.
Review
Medicine, General & Internal
Johan Frostegard
Summary: The prognosis in systemic lupus erythematosus (SLE) has improved, but cardiovascular disease (CVD) still remains a significant clinical problem. Atherosclerosis and antiphospholipid antibody syndrome are the main underlying causes of CVD in SLE. Inflammation and low levels of anti-phosphorylcholine also contribute to the increased risk of CVD in SLE. Close monitoring and treatment of both traditional and non-traditional risk factors are important.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Rheumatology
Christine Chew, John A. Reynolds, Apinya Lertratanakul, Peggy Wu, Murray Urowitz, Dafna D. Gladman, Paul R. Fortin, Sang-Cheol Bae, Caroline Gordon, Ann E. Clarke, Sasha Bernatsky, John G. Hanly, David Isenberg, Anisur Rahman, Jorge Sanchez-Guerrero, Juanita Romero-Diaz, Joan Merrill, Daniel Wallace, Ellen Ginzler, Munther Khamashta, Ola Nived, Andreas Jonsen, Kristjan Steinsson, Susan Manzi, Ken Kalunian, Mary Anne Dooley, Michelle Petri, Cynthia Aranow, Ronald van Vollenhoven, Thomas Stoll, Graciela S. Alarcon, S. Sam Lim, Guillermo Ruiz-Irastorza, Christine A. Peschken, Anca D. Askanase, Diane L. Kamen, Murat Inanc, Rosalind Ramsey-Goldman, Ian N. Bruce
Summary: Vitamin D deficiency and MetS may increase cardiovascular risk in SLE patients. Lower 25(OH)D levels were associated with a higher likelihood of MetS and insulin resistance, as well as components of MetS such as hypertension, hypertriglyceridemia, and decreased HDL levels.
Article
Cardiac & Cardiovascular Systems
Jiamin Huang, Pipasha Khatun, Yuqing Xiong, Bingrui Liu, Yisu Zhao, Quanjun Lyu
Summary: This study found that higher dietary intake of vitamin B6 may be associated with a lower prevalence of cardiovascular disease (CVD) in the United States population. Conversely, there was no significant association between dietary intake of folate and vitamin B12 and the odds of CVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Endocrinology & Metabolism
Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Cordova, Juan C. Cabrera-Guzman, Percy Herrera-Anazco, Vicente A. Benites-Zapata
Summary: This systematic review and meta-analysis assessed the association of vitamin B12, folic acid, and homocysteine (Hcy) levels with MetS. The results showed that higher vitamin B12 levels were inversely associated with MetS, whereas higher Hcy levels were positively associated with MetS. Folate levels were not associated with MetS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Winner Kucha, Daniel Seifu, Abenezer Tirsit, Mahlet Yigeremu, Markos Abebe, Dawit Hailu, Dareskedar Tsehay, Solomon Genet
Summary: The study found that deficiency in folate and vitamin B12 in the blood of pregnant women may be associated with neural tube defects. There is a correlation between the use of folate/multivitamins and neural tube defects.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Li Li, Qi Huang, Linjian Yang, Rui Zhang, Leili Gao, Xueyao Han, Linong Ji, Xiantong Zou
Summary: There is an association between non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) with levels of vitamin B12 and associated metabolites, while MMA and HCY may be associated with an increased risk for advanced fibrosis.
Review
Geriatrics & Gerontology
Yuxin Quan, Jisen Xu, Qing Xu, Zhiqing Guo, Ruwei Ou, Huifang Shang, Qianqian Wei
Summary: This meta-analysis summarizes the relationship between homocysteine, vitamin B12, folate, and Parkinson's disease (PD). The results show that PD patients have lower folate and vitamin B12 levels, but higher homocysteine levels compared to healthy individuals. PD is also significantly associated with hyperhomocysteinemia. Various factors are linked to homocysteine levels in PD patients. Further research is needed to fully understand their roles in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Ji-Won Kim, Wook-Young Baek, Ju-Yang Jung, Hyoun-Ah Kim, Cheong In Yang, Seung-Ju Kim, Chang-Hee Suh
Summary: This study found that seasonal vitamin D levels are correlated with clinical manifestations and disease activity in lupus patients. Adequate vitamin D levels are important for achieving a low disease activity state in both winter and summer.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Giulietta S. Monasso, Janine F. Felix, Sandra G. Heil, Yolanda B. de Rijke, Romy Gaillard, Vincent W. V. Jaddoe
Summary: The study found associations between circulating vitamin B12, folate, and homocysteine concentrations during fetal life and early signs of atherosclerosis in school-age children, but only certain biochemical markers showed impact.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Panpan Zhang, Xia Xie, Yurong Zhang
Summary: This study investigated the associations between plasma homocysteine (Hcy), vitamin B12, and folate levels and the risk of all-cause mortality in American adults with stroke. The results showed a significant positive association between plasma Hcy levels and all-cause mortality in stroke patients, while no significant associations were found between plasma folate and vitamin B12 levels and all-cause mortality.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Julien Levy, Rosa-Maria Rodriguez-Gueant, Abderrahim Oussalah, Elise Jeannesson, Denis Wahl, Stephane Ziuly, Jean-Louis Gueant
Summary: The study found an association between intermediate/severe HHcy and cardiovascular diseases outcomes, highlighting the importance of diagnosing and treating nutritional deficiencies and inherited disorders.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Immunology
Gabriela Guzman-Martinez, Concepcion Maranon
Summary: Patients with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease (CVD), which is becoming one of the most relevant complications and a significant factor causing morbidity and mortality in SLE. Immune constituents, including specific circulating cell populations, autoantibodies, and inflammatory mediators, play a role in the pathogenesis of atherosclerosis and endothelial damage in SLE patients. This review summarizes the presentation of CVD in SLE, the role of autoimmune responses in inducing atherogenesis, endothelial impairment, and cardiac disease, and discusses the utility of immune mediators as early CVD biomarkers and targets for clinical intervention in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Xiaohong Lu, YanHua Wang, Jing Zhang, Dan Pu, Nan Hu, Jing Luo, Qi An, Lan He
Summary: The systematic review and meta-analysis found that patients with systemic lupus erythematosus (SLE) have a higher risk of developing cardiovascular disease (CVD) compared to the general or healthy population, and the risk of CVD in lupus nephritis (LN) patients is significantly higher than in SLE patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)