Can Vitamin D and L-Cysteine Co-Supplementation Reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans?

Targeted 25-hydroxyvitamin D concentration measurements and vitamin D3 supplementation can have important patient and public health benefits

(2020) William B. Grant et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is linked with cardiovascular disease

(2020) Rajesh Parsanathan et al.   HYPERTENSION RESEARCH

Obesity and COVID-19: Immune and metabolic derangement as a possible link to adverse clinical outcomes

(2020) Emmanouil Korakas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Recovery from COVID-19 in a patient with spondyloarthritis treated with TNF-alpha inhibitor etanercept

(2020) Pierre-Marie Duret et al.   ANNALS OF THE RHEUMATIC DISEASES

‘Scientific Strabismus’ or Two Related Pandemics: COVID-19 & Vitamin D Deficiency

(2020) Murat Kara et al.   BRITISH JOURNAL OF NUTRITION

Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

(2020) Mehmet Soy et al.   CLINICAL RHEUMATOLOGY

Reduced 25(OH) Vitamin D Association with Lower Alpha-1-Antitrypsin Blood Levels in Type 2 Diabetic Patients

(2020) Virginia M. Lindley et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2

(2020) Antonio D’Avolio et al.   Nutrients

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

(2020) William B. Grant et al.   Nutrients

G6PD deficiency shifts polarization of monocytes/macrophages towards a proinflammatory and profibrotic phenotype

(2020) Rajesh Parsanathan et al.   Cellular & Molecular Immunology

Cytokine storm and leukocyte changes in mild versus severe SARS‐CoV‐2 infection: Review of 3939 COVID‐19 patients in China and emerging pathogenesis and therapy concepts

(2020) Jin Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Circulating levels of IL‐2, IL‐4, TNF‐α, IFN‐γ, and C‐reactive protein are not associated with severity of COVID‐19 symptoms

(2020) Wen Luo et al.   JOURNAL OF MEDICAL VIROLOGY

Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10

(2019) Sarah Dimeloe et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Vitamin D Supplementation and Prevention of Type 2 Diabetes

(2019) Anastassios G. Pittas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of N-acetyl-cysteine and β-mercaptoethylamine

(2019) Rita Crinelli et al.   Nutrients

Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high-fat diet-fed obese mice

(2019) Rajesh Parsanathan et al.   Scientific Reports

Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort

(2018) Sanjeev Budhathoki et al.   BMJ-British Medical Journal

Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort

(2018) Sanjeev Budhathoki et al.   BMJ-British Medical Journal

Glutathione stimulates vitamin D regulatory genes, and lowers inflammation and increases 25-hydroxy-vitamin D levels in blood: A novel approach to treat 25-hydroxy-vitamin D-deficiency

(2018) Sushil K. Jain et al.   ANTIOXIDANTS & REDOX SIGNALING

Vitamin D and Influenza—Prevention or Therapy?

(2018) Beata M. Gruber–Bzura   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vivo transcriptome changes of human white blood cells in response to vitamin D

(2018) Antonio Neme et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

(2018) JoAnn E. Manson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD-fed mice

(2018) Rajesh Parsanathan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain

(2017) Katarzyna Dzik et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Impact of Three Doses of Vitamin D3 on Serum 25(OH)D Deficiency and Insufficiency in At-Risk Schoolchildren

(2017) Jennifer M Sacheck et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention

(2017) Michael F. Holick   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

L-cysteine supplementation upregulates glutathione (GSH) and vitamin D binding protein (VDBP) in hepatocytes cultured in high glucose and in vivo in liver, and increases blood levels of GSH, VDBP, and 25-hydroxy-vitamin D in Zucker diabetic fatty rats

(2016) Sushil K. Jain et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Vitamin D and cardiovascular disease prevention

(2016) Stefan Pilz et al.   Nature Reviews Cardiology

Elevated peripheral blood mononuclear cell-derived superoxide production in healthy young black men

(2015) Shekhar H. Deo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inability to Maintain GSH Pool in G6PD-Deficient Red Cells Causes Futile AMPK Activation and Irreversible Metabolic Disturbance

(2015) Hsiang-yu Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Conflicting reports on vitamin D supplementation: Evidence from randomized controlled trials

(2015) Richard D. Lewis et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults

(2014) Jessica A. Alvarez et al.   CLINICAL ENDOCRINOLOGY

Vitamin D and L-cysteine levels correlate positively with GSH and negatively with insulin resistance levels in the blood of type 2 diabetic patients

(2014) S K Jain et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials

(2014) E. Theodoratou et al.   BMJ-British Medical Journal

Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes

(2013) Sushil K. Jain et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Association of racial disparities in the prevalence of insulin resistance with racial disparities in vitamin D levels: National Health and Nutrition Examination Survey (2001-2006)

(2013) Stephen K. Williams et al.   NUTRITION RESEARCH

Modeling the influence of vitamin D deficiency on cigarette smoke-induced emphysema

(2013) Mardi A. Crane-Godreau et al.   Frontiers in Physiology

Vitamin D3 supplementation (4000 IU/d for 1 y) eliminates differences in circulating 25-hydroxyvitamin D between African American and white men

(2012) Elizabeth Garrett-Mayer et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Circulating 25-Hydroxy-Vitamin D and Risk of Cardiovascular Disease

(2012) Lu Wang et al.  

Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria

(2012) Kai Soo Tan et al.   JOURNAL OF CLINICAL INVESTIGATION

Intracellular glutathione redox status in human dendritic cells regulates IL-27 production and T-cell polarization

(2011) Y. Kamide et al.   ALLERGY

Vitamin D and type 2 diabetes: a systematic review

(2011) J Mitri et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Vitamin D Status, Adiposity, and Lipids in Black American and Caucasian Children

(2011) Kumaravel Rajakumar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Vitamin D and the anti-viral state

(2011) Jeremy A. Beard et al.   JOURNAL OF CLINICAL VIROLOGY

Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine

(2010) R. V. Sekhar et al.   DIABETES CARE

Vitamin D Insufficiency

(2010) Tom D. Thacher et al.   MAYO CLINIC PROCEEDINGS

Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey

(2009) Adit A. Ginde et al.   ARCHIVES OF INTERNAL MEDICINE

The vitamin D–antimicrobial peptide pathway and its role in protection against infection

(2009) Adrian F Gombart   Future Microbiology