Article
Immunology
Abalinda M. Gorret, Rabbison Muhindo, Emma Baguma, Moses Ntaro, Edgar M. Mulogo, Molly Deutsch-Feldman, Jonathan J. Juliano, Dan Nyehangane, Ross M. Boyce
Summary: A study conducted in western Uganda found that malaria rapid diagnostic tests perform similarly in diagnosing children with Plasmodium falciparum malaria, whether using capillary or venous blood, with high sensitivity, specificity, and agreement between sample types. Only a few tests would have led to a different clinical diagnosis when following the manufacturer's recommended interpretation.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Carson Moore, Thomas Scherr, Japhet Matoba, Caison Sing'anga, Mukuma Lubinda, Phil Thuma, David Wright
Summary: A study was conducted to evaluate the mHAT mobile app for reporting rapid diagnostic test results in low-resource settings. The app demonstrated high sensitivity and specificity compared to visual and laboratory analysis. Analysis of surveillance data revealed challenges in data accuracy and timely submission from satellite clinics.
Article
Biology
Claudia A. Vera-Arias, Aurel Holzschuh, Colins O. Oduma, Kingsley Badu, Mutala Abdul-Hakim, Joshua Yukich, Manuel W. Hetzel, Bakar S. Fakih, Abdullah Ali, Marcelo U. Ferreira, Simone Ladeia-Andrade, Fabian E. Saenz, Yaw Afrane, Endalew Zemene, Delenasaw Yewhalaw, James W. Kazura, Guiyun Yan, Cristian Koepfli
Summary: A novel assay for molecular surveillance of hrp2/hrp3 deletions was developed based on droplet digital PCR (ddPCR). The assay was able to accurately quantify hrp2, hrp3, and a control gene. A comparison with the conventional nested PCR (nPCR) assay showed that ddPCR had a higher accuracy in detecting hrp2 deletions. Screening of 830 samples from different locations revealed pronounced differences in the prevalence of hrp2 and hrp3 deletions.
Article
Public, Environmental & Occupational Health
Atsuyoshi Ishizumi, Roberta Sutton, Anthony Mansaray, Lauren Parmley, Oliver Eleeza, Shibani Kulkarni, Tom Sesay, Laura Conklin, Aaron S. Wallace, Adewale Akinjeji, Mame Toure, Maria Lahuerta, Mohamed F. Jalloh
Summary: The qualitative content analysis identified four main themes: CHWs' work motivation, workload burden, health system and community level barriers, and strategies adopted by CHWs. The findings suggest that focused support is needed for CHWs, coupled with systems-level efforts to address structural barriers and optimize their work contributions.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Microbiology
Fatema Tuj Johora, Mohammad Golam Kibria, Hans-Peter Fuehrer, Mohammad Shafiul Alam
Summary: The article highlights the importance of Plasmodium malariae, points out the limitations and possible failures of rapid diagnostic tests, and emphasizes the necessity to develop analytically sensitive test kits for P. malariae.
Article
Infectious Diseases
Nlandu Roger Ngatu, Basilua Andre Muzembo, Nattadech Choomplang, Sakiko Kanbara, Roger Wumba, Mitsunori Ikeda, Etongola Papy Mbelambela, Sifa Marie-Joelle Muchanga, Tomoko Suzuki, Koji Wada, Hasan Al Mahfuz, Tomohiko Sugishita, Hiroyuki Miyazaki, Shunya Ikeda, Tomohiro Hirao
Summary: Malaria is a prevalent and deadly illness in sub-Saharan Africa, and this study aimed to assess the malaria burden in households in Kongo central province, DRC, and the impact of a community participatory WASH program. The research found high malaria prevalence among participants, but a 6-month WASH intervention significantly reduced household malaria incidence.
Article
Infectious Diseases
Hannah C. Slater, Xavier C. Ding, Sophia Knudson, Daniel J. Bridges, Hawela Moonga, Neil J. Saad, Martin De Smet, Adam Bennett, Sabine Dittrich, Laurence Slutsker, Gonzalo J. Domingo
Summary: This study evaluated the performance of a highly sensitive rapid diagnostic test (HS-RDT) for Plasmodium falciparum malaria. The results showed that the HS-RDT had higher sensitivity compared to conventional malaria rapid diagnostic tests in prevalence surveys, but there was no significant difference in clinical diagnosis and screening pregnant women.
BMC INFECTIOUS DISEASES
(2022)
Article
Biochemical Research Methods
Andrew G. Kantor, Christine F. Markwalter, Armin Nourani, David W. Wright
Summary: Rapid diagnostic tests (RDTs) are crucial for malaria elimination campaigns, but their sensitivity is limited. AnDREW, an Antibody-free Dual-biomarker Rapid Enrichment Workflow, purifies HRP2 and PLDH from larger blood samples, significantly improving detection sensitivity. By utilizing aptamers and optimizing capture and elution processes, AnDREW enhances RDTs by eluting both biomarkers without the need for complexed antibodies.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Immunology
Aaron M. Samuels, Oliver Towett, Brian Seda, Ryan E. Wiegand, Kephas Otieno, Miriam Chomba, Naomi Lucchi, Dragan Ljolje, Kammerle Schneider, Patrick Gt, Titus K. Kwambai, Laurence Slutsker, Feiko O. Ter Kuile, Simon K. Kariuki
Summary: Screening pregnant women for malaria using new point-of-care tests showed moderate improvement in detecting low-density infections compared to conventional rapid diagnostic tests (cRDTs).
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Medicine, General & Internal
Elizabeth N. Allen, Alison Beriliy Wiyeh, Michael McCaul
Summary: This study evaluates the effectiveness of community-based management strategies for treating malaria or fever, and concludes that the use of malaria rapid diagnostic tests by community health workers and drug shop vendors can effectively reduce the prescription of antimalarials to non-malarial patients, but also increases the use of antibiotics.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Medicine, General & Internal
Mathieu Gendrot, Marylin Madamet, Isabelle Fonta, Nicolas Benoit, Remy Amalvict, Joel Mosnier, Bruno Pradines
Summary: Malaria is a common tropical disease encountered by French military members in malaria-endemic areas. This study assessed the sensitivity of ten rapid diagnostic tests (RDTs) in 159 malaria samples. The results showed that some RDTs had low sensitivity for certain types of malaria parasites, but one RDT was considered suitable for military operations in malaria-endemic areas.
Article
Multidisciplinary Sciences
David-A Mendels, Laurent Dortet, Cecile Emeraud, Saoussen Oueslati, Delphine Girlich, Jean-Baptiste Ronat, Sandrine Bernabeu, Silvestre Bahi, Gary J. H. Atkinson, Thierry Naas
Summary: This study developed a smartphone application called xRCovid, which uses machine learning to classify SARS-CoV-2 serological RDT results, improving the accuracy and reliability of RDT testing. The app can replace manual reading, reduce subjectivity in interpretation, and bring more confidence to patient self-testing and clinicians.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Public, Environmental & Occupational Health
Saher Siddiqui, Angelika Morris, Daniel J. Ikeda, Satchit Balsari, Laura Blanke, Miriam Pearsall, Roxanna Rodriguez, Shekhar Saxena, Benjamin F. Miller, Vikram Patel, John A. Naslund
Summary: This article summarizes promising examples of community-initiated care (CIC) projects implemented outside of the research context. Key drivers for scaling up include sustainable financing and human resources, addressing social determinants and stigma, engaging diverse stakeholders, leveraging existing healthcare infrastructure, using sustainable training models, ensuring cultural relevance and appropriateness, and utilizing digital technologies.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Parasitology
Weidong Li, Xinzhou Zhang, Jun Feng, Tao Zhang, Xian Xu, Jingjing Jiang, Shuqi Wang, Xiaofeng Lyu, Shizhu Li, Manman Lu
Summary: The combination of rapid diagnostic tests (RDTs) and microscopy as a malaria surveillance strategy can increase the sensitivity of detecting cases, especially for detecting Plasmodium falciparum infections. However, microscopy showed better specificity and consistency with the gold standard results, indicating the need to consider different diagnostic tools in field practice.
Article
Medicine, General & Internal
Thomas Obadia, Narimane Nekkab, Leanne J. Robinson, Chris Drakeley, Ivo Mueller, Michael T. White
Summary: The PvSeroTAT strategy can effectively identify individuals carrying hypnozoites and target them for radical cure. The benefit and risk of PvSeroTAT strategies are influenced by diagnostic sensitivity and specificity. Higher specificity reduces unnecessary treatment, while higher sensitivity effectively reduces vivax transmission in moderate and low transmission settings.
Article
Health Care Sciences & Services
Oluwatomi Adeoti, Donna Spiegelman, Chinenye Afonne, Catherine O. Falade, Ayodele S. Jegede, Frederick O. Oshiname, Melba Gomes, IkeOluwapo O. Ajayi
IMPLEMENTATION SCIENCE
(2020)
Article
Infectious Diseases
Aliyu Mamman Na'uzo, Dahiru Tukur, Mu'awiyyah Babale Sufiyan, Adebowale Ayo Stephen, IkeOluwapo Ajayi, Eniola Bamgboye, Abdulrazaq Abdullahi Gobir, Chukwuma David Umeokonkwo, Zainab Abdullahi, Olufemi Ajumobi
Article
Infectious Diseases
Ayodele Jegede, Barbara Willey, Prudence Hamade, Fredrick Oshiname, Daniel Chandramohan, IkeOluwa Ajayi, Catherine Falade, Ebenezer Baba, Jayne Webster
Article
Multidisciplinary Sciences
Ayodipupo S. Oguntade, IkeOluwapo O. Ajayi
Summary: This study aimed to characterize the risk factors of HF among patients with hypertension in Africa. It found that poor medication adherence, proteinuria, and alcohol consumption were major adverse risk factors, while calcium channel blockers, daily fruits and vegetable consumption, and eGFR were protective factors against hypertensive heart failure. Public health interventions promoting lifestyle changes and renoprotection are recommended to reduce the risk of HF in hypertensive individuals.
Article
Medicine, General & Internal
Mohamadou Siribie, Andre-Marie Tchouatieu, Issiaka Soulama, Jean Moise Tanga Kabore, Yacouba Nombre, Denise Hien, Alice Kiba Koumare, Nouhoun Barry, Adama Baguiya, Alimatou Hema, Frederic Dianda, Yacouba Savadogo, Seni Kouanda, Alfred Bewendtaore Tiono, Sodiomon Bienvenu Sirima
Summary: This study aims to explore the feasibility and effectiveness of simultaneously deploying three different ACTs for treating malaria, utilizing a four-phase research design and methods to achieve the objectives. The study findings will provide guidance for the development and implementation of future malaria treatment strategies.
Article
Environmental Sciences
Hari S. Iyer, Peter James, Linda Valeri, Francis Bajunirwe, Joan Nankya-Mutyoba, Marina Njelekela, Faraja Chiwanga, Vikash Sewram, IkeOluwapo Ajayi, Clement Adebamowo, Shona Dalal, Todd G. Reid, Timothy R. Rebbeck, Hans-Olov Adami, Michelle D. Holmes
Summary: In SSA, population growth, demographic transitions, and urbanization are expected to increase the burden of NCDs. A multi-country cross-sectional study found a correlation between neighborhood greenness and NCDs, showing that higher NDVI values were associated with lower BMI, lower odds of overweight/obesity, diabetes, and allostatic load components. This suggests that greening strategies could be beneficial as part of broader public health interventions for NCDs.
ENVIRONMENTAL RESEARCH
(2021)
Article
Immunology
Nicolas Nagot, Vinh Vu Hai, Thuy Thi Thu Dong, Oanh Khuat Thi Hai, Delphine Rapoud, Giang Thi Hoang, Catherine Quillet, Khue Pham Minh, Roselyne Vallo, Thanh Tuyet Thi Nham, Joelle Castellani, Jonathan Feelemyer, Don C. Des Jarlais, Lan Phuong Nguyen, Hoi Van Le, Nhung Viet Nguyen, Luan Nguyen Quang Vo, Huong Thi Duong, Jean-Pierre Moles, Didier Laureillard
Summary: This study assessed the prevalence of tuberculosis (TB) and the risk factors associated with TB among people who inject drugs (PWID) in Vietnam. The findings revealed a high TB prevalence among this group and identified smoking methamphetamine and family relationships as factors associated with TB.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Education, Special
Joelle Castellani, Omari Kimbute, Charles Makasi, Zakayo E. Mrango, Aggie T. G. Paulus, Silvia M. A. A. Evers, Pip Hardy, Tony Sumner, Augusta Keiya, Borislava Mihaylova, Mohammad Abul Faiz, Melba Gomes
Summary: Developmental disabilities in children require constant care, reduce autonomy, and may lead to learning difficulties and inability to afford specialized school costs. Parents experience ongoing physical, emotional, and financial stress, with decreased occupational earnings and some families resorting to selling assets or relying on relatives for survival. Understanding the consequences of developmental disabilities helps to identify areas for improved social support.
JOURNAL OF DEVELOPMENTAL AND PHYSICAL DISABILITIES
(2022)
Article
Immunology
Nicolas Nagot, Morgana D'Ottavi, Catherine Quillet, Anne Debellefontaine, Joelle Castellani, Nicolas Langendorfer, Bertrand Hanslik, Sylvain Guichard, Rene Baglioni, Vincent Faucherre, Edouard Tuaillon, Georges-Philippe Pageaux, Didier Laureillard, Helene Donnadieu-Rigole
Summary: Community-based, respondent-driven sampling with peer involvement is a highly efficient strategy for HCV screening among people who use drugs (PWUD). This approach, coupled with same-day treatment initiation, proves to be cost-effective for reaching and curing PWUD with chronic HCV, and may play a key role in achieving HCV elimination.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Olumide Ebenezer Olufayo, Ikeoluwapo Oyeneye Ajayi, Samuel Osobuchi Ngene
Summary: A study conducted at the University of Ibadan, Nigeria, found that modifiable risk factors for cardiovascular disease are prevalent among first-year students, with unhealthy diet and physical inactivity being the main risk factors. The clustering of these risk factors is more pronounced among female students and Muslims.
SAO PAULO MEDICAL JOURNAL
(2023)
Article
Health Care Sciences & Services
Huong Thi Duong, Jean -Pierre Moles, Khue Minh Pham, Roselyne Vallo, Giang Thi Hoang, Vinh Hai Vu, Oanh Thi Hai Khuat, Thanh Tuyet Thi Nham, Duc Quang Nguyen, Catherine Quillet, Delphine Rapoud, Philippe Van de Perre, Joelle Castellani, Jonathan Feelemyer, Laurent Michel, Didier Laureillard, Don Des Jarlais, Nicolas Nagot
Summary: Mass community-based screening using respondent-driven sampling and peer support can rapidly identify untreated HIV-positive people who inject drugs (PWID) in the community and link them to effective care.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Medicine, General & Internal
Osarhiemen Iyare, Ayo Stephen Adebowale, Chukwuma David Umeokonkwo, Eniola Adetola Bamgboye, Abdullahi Abdulrazaq Gobir, Jiwok Joseph Chikan, Tukur Dahiru, IkeOluwapo Oyeneye Ajayi
Summary: Malaria in pregnancy has been on the rise in Plateau State, with the highest prevalence observed in the third quarter of the year. Effective intervention strategies are recommended to combat malaria among pregnant women.
PROCEEDINGS OF SINGAPORE HEALTHCARE
(2021)
Article
Public, Environmental & Occupational Health
Emmanuel Chijioke Obagha, IkeOluwakpo Ajayi, Gobir A. Abdullahi, Chukwuma David Umeokonkwo
Article
Cardiac & Cardiovascular Systems
Ayodipupo S. Oguntade, IkeOluwapo O. Ajayi, Akinyemi Aje, Adewole A. Adebiyi, Okechukwu S. Ogah, Abiodun M. Adeoye
JOURNAL OF THE SAUDI HEART ASSOCIATION
(2020)
Article
Public, Environmental & Occupational Health
IkeOluwapo Oyeneye Ajayi, Olufemi Olamide Ajumobi, Catherine Falade
PAN AFRICAN MEDICAL JOURNAL
(2020)