Article
Infectious Diseases
Derick Thompson, John A. Watt, Catherine A. Brissette
Summary: The text discusses the host immune and inflammatory response induced by Lyme borreliosis bacterium and how these responses influence the pathology of Lyme disease.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Immunology
Tian-Le Che, Bao-Gui Jiang, Qiang Xu, Yu-Qi Zhang, Chen-Long Lv, Jin-Jin Chen, Ying-Jie Tian, Yang Yang, Simon I. Hay, Wei Liu, Li-Qun Fang
Summary: This study established a nationwide database involving Lyme borreliosis risk factors in China and used a two-stage statistical model to identify the environmental factors influencing its distribution. By mapping the risk distribution, it was found that high-risk areas were not only concentrated in high latitude regions but also distributed in middle and low latitude areas.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Medicine, General & Internal
Vera Maraspin, Franc Strle
Summary: Borrelial lymphocytoma is a rare cutaneous manifestation of early localized European Lyme borreliosis, characterized by solitary nodules or plaques. It is more common in children and males. Tick bites are often associated with later development of Borrelial lymphocytoma, which is frequently observed with erythema migrans. A 14-day antibiotic therapy is usually effective for treatment.
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Infectious Diseases
Mateusz Markowicz, Michael Kundi, Gerold Stanek, Hannes Stockinger
Summary: The relationship between infection with Borrelia burgdorferi sensu lato and nonspecific symptoms is controversial. This study found that individuals infected with B. burgdorferi sl did not develop nonspecific symptoms more frequently compared to non-infected controls.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Parasitology
Zsuzsa Kalmar, Violeta Briciu, Mircea Coroian, Mirela Flonta, Amanda-Lelia Radulescu, Adriana Topan, Andrei Daniel Mihalca, Mihaela Lupse
Summary: The study in Romania found specific IgG and IgM antibodies to Borrelia burgdorferi s.l. among healthy blood donors. Higher seroprevalence was observed in men, older individuals, and those engaged in outdoor work.
PARASITES & VECTORS
(2021)
Article
Infectious Diseases
Aaron M. Brock, Brandon L. Jutras
Summary: Spirochaetes are a unique phylum of bacteria that can cause severe clinical diseases, with Borrelia burgdorferi sensu lato being the primary agent of Lyme borreliosis. However, the basic physiological tasks of B. burgdorferi s.l. are not clearly understood. Recent advances in molecular tools and genetic manipulation have allowed progress in studying these essential cellular processes.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Health Care Sciences & Services
Finja Huendersen, Stefanie Forst, Erich Kasten
Summary: The study found that patients with Lyme disease have lower quality of life and sleep, as well as cognitive impairments in attention and memory. Depressive symptoms are common among Lyme patients, and the disease is often diagnosed late.
Article
Clinical Neurology
Ilse M. Lucke, Amber Vrijlandt, Johan Lim, Anneke J. Kooi, Ivo N. Schaik, Hans L. Zaaijer, Joppe W. Hovius, Filip Eftimov
Summary: This study found that apparent Bbsl seroconversion often occurs in patients receiving IVIg treatment, but antibodies typically disappear post-treatment, with seroreversion observed in a majority of patients within 3 months. The transient presence of anti-Bbsl IgG antibodies after IVIg treatment appears to be dependent on the brand of IVIg, reflecting variations in Bbsl exposure of plasma donors. Lyme borreliosis serological testing during and after IVIg treatment may be of limited utility.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Parasitology
Antje Steinbrink, Katharina Brugger, Gabriele Margos, Peter Kraiczy, Sven Klimpel
Summary: Ticks are vectors of many human pathogens, and Lyme disease is the most commonly occurring vector-borne infectious disease caused by bacteria transmitted by ticks. The incidence of Lyme disease in Europe is relatively high, but epidemiological data are incomplete and standardization of diagnostic and surveillance systems is needed.
PARASITOLOGY RESEARCH
(2022)
Article
Infectious Diseases
Marc Westerholt, Karen Angeliki Krogfelt, Ram Benny Dessau, Lukas Frans Ocias
Summary: Lyme borreliosis (LB) is a common tick-transmitted infection caused by bacteria. This study proposes a method for determining actual changes in IgG and examines antibody reactivity and decay. The results show that both IgG and IgM antibodies persisted for years, with longer seropositivity associated with high initial antibody levels and IgG-type antibodies.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Elisa Kortela, Mari Kanerva, Satu Kurkela, Jarmo Oksi, Asko Jarvinen
Summary: This study evaluated the conditions behind the symptoms in patients with suspected Lyme borreliosis (LB) referred to an infectious diseases clinic. The results showed that LB was unlikely in half of the patients, with most cases having other conditions to explain their symptoms.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Clemence Corre, Guillaume Coiffier, Benoit Le Goff, Marine Ferreyra, Xavier Guennic, Solene Patrat-Delon, Brigitte Degeilh, Jean-David Albert, Pierre Tattevin
Summary: This observational retrospective multicentre study in Western France focused on characterizing Lyme arthritis, management, and outcome. The majority of patients with Lyme arthritis had monoarthritis, primarily affecting the knee. Treatment involved antibiotics, with some patients also receiving intra-articular glucocorticoid injections. Complete resolution of Lyme arthritis was seen in a significant proportion of patients with follow-up data.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Microbiology
Nikola Kasparkova, Eva Bartova, Alena Zakovska, Marie Budikova, Kamil Sedlak
Summary: This study investigated the seropositivity of B. burgdorferi s.l. in horses from the Czech Republic and evaluated the risk factors of infection. The results showed that the positivity rate in clinically healthy horses was 27%, while it was 20% in horses with clinical signs. Pony and Warmblood breeds were the most affected.
Article
Microbiology
Zhihai He, Baogui Jiang, Lin Huang, Zongti Shao, Yun Zhang, Yuqiong Li, Ennian Pu, Xingde Duan, Hang Jiang, Jian Wang, Mingguo Yao, Fan Wang, Shuangshuang Bie, Michael E. von Fricken, Yi Sun, Yi Dong, Jiafu Jiang, Chunhong Du
Summary: This study conducted a comprehensive investigation of Borrelia burgdorferi sensu lato (BBSL) in reservoirs and vectors in Yunnan Province, China. The results revealed a wide distribution of BBSL and multiple endemic genospecies, highlighting the need for expanded surveillance efforts for human in southwestern China.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Parasitology
Nienke Hartemink, Arnold J. H. van Vliet, Gerrit Gort, Fedor Gassner, Frans Jacobs, Manoj Fonville, Willem Takken, Hein Sprong
Summary: In this study, it was found that in the Netherlands, the summer peak in the density of infected nymphs (DIN) is mainly due to peaks in both nymphal infection prevalence (NIP) and density of questing nymphs (DON). There was no significant trend in DIN observed over the years of the study, with variations in DIN between locations mostly resulting from changes in DON. Significant differences in acarological risk were identified between areas in terms of infection prevalence, tick densities, and Borrelia genospecies composition.
PARASITES & VECTORS
(2021)
Article
Infectious Diseases
Monika Jevsnik, Lara Lusa, Tina Ursic, Urska Glinsek Biskup, Miroslav Petrovec
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2020)
Review
Health Care Sciences & Services
Marianne Huebner, Werner Vach, Saskia le Cessie, Carsten Oliver Schmidt, Lara Lusa
BMC MEDICAL RESEARCH METHODOLOGY
(2020)
Article
Medicine, General & Internal
K. Ogrinc, V. Maraspin, L. Lusa, T. Cerar Kisek, E. Ruzic-Sabljic, F. Strle
Summary: Background information on patients with acrodermatitis chronica atrophicans (ACA) is limited. The study assessed clinical and microbiological characteristics of ACA patients at a single medical center, finding that the majority of patients had skin lesions on extremities, showing reddish-blue discoloration, swelling, and thinning of the skin. Most skin samples isolated Borreliae, with the majority being Borrelia afzelii.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Microbiology
Petra Bogovic, Stanka Lotric-Furlan, Tatjana Avsic-Zupanc, Misa Korva, Lara Lusa, Klemen Strle, Franc Strle
Summary: Serum IgG antibody levels against TBEV at the onset of neurologic involvement are crucial for determining the clinical course and long-term outcome of Tick-borne encephalitis (TBE), with low levels associated with more severe clinical manifestations.
Article
Microbiology
Petra Bogovic, Stanka Lotric-Furlan, Tatjana Avsic-Zupanc, Misa Korva, Andrej Kastrin, Lara Lusa, Klemen Strle, Franc Strle
Summary: The monophasic course of tick-borne encephalitis (TBE) presents with distinct clinical features compared to the biphasic course, characterized by older age, higher vaccination rates, more comorbidities, more ICU stays, and higher levels of inflammatory mediators in cerebrospinal fluid. Despite these differences, long-term outcomes 2-7 years post TBE infection are similar.
Article
Environmental Sciences
Lara Lusa, Marianne Huebner
Summary: The SHARE study collects health, lifestyle, and socioeconomic data from individuals ages 50 and older in European countries. This research aims to develop a framework and R code for data management in order to prepare for data analysis and demonstrate its application to a specific research question. The framework significantly reduces the time to initiate research studies, facilitates data extraction, and ensures the validity of modeling results.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Immunology
Misa Pavletic, Misa Korva, Natasa Knap, Petra Bogovic, Lara Lusa, Klemen Strle, Mirijam Nahtigal Klevisar, Tomaz Vovko, Janez Tomazic, Stanka Lotric-Furlan, Franc Strle, Tatjana Avsic-Zupanc
Summary: Vaccinated breakthrough TBE patients display a global inflammatory state with elevated levels of inflammatory cytokines in serum and CSF, indicating localization of immune responses in the CNS. Compared to unvaccinated patients, these breakthrough cases exhibit significantly higher levels of inflammatory mediators and sustained systemic immune activation. Neutrophil-derived inflammation and increased VEGF-A expression could contribute to CNS immune response localization and BBB disruption in breakthrough TBE patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Editorial Material
Biochemical Research Methods
Mark Baillie, Saskia le Cessie, Carsten Oliver Schmidt, Lara Lusa, Marianne Huebner, Topic Grp Initial Data Analysis STRATOS Initiative
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Environmental Sciences
Marianne Huebner, Frank Lawrence, Lara Lusa
Summary: This study quantifies the decline in grip strength with age and body mass and explores whether age affects the decline in grip strength. The results show that the decline in grip strength differs between males and females, with females experiencing an accelerated decline during the menopausal transition while males experience an accelerated decline with increasing age. Higher body mass is associated with an increase in grip strength, but this increase is less pronounced for older males.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Joerg Rahnenfuehrer, Riccardo De Bin, Axel Benner, Federico Ambrogi, Lara Lusa, Anne-Laure Boulesteix, Eugenia Migliavacca, Harald Binder, Stefan Michiels, Willi Sauerbrei, Lisa McShane
Summary: This review provides an overview of key aspects and methods for analyzing high-dimensional data in biomedical research. It addresses the challenges and opportunities of analyzing high-dimensional data, and offers solutions and references for researchers.
Article
Microbiology
Urska Glinsek Biskup, Andrej Steyer, Lara Lusa, Franc Strle, Marko Pokorn, Tatjana Mrvic, Stefan Grosek, Miroslav Petrovec, Monika Jevsnik Virant
Summary: This study determines the frequency of human mastadenovirus (HAdV) in children with acute bronchiolitis, acute gastroenteritis, and febrile seizures, and identifies the types of HAdVs associated with each syndrome. HAdVs were detected in both nasopharyngeal swabs and stool samples, with certain genotypes found exclusively in stool samples. HAdVs were more commonly detected in stool samples, particularly in children with acute bronchiolitis and gastroenteritis.
Article
Immunology
Katarina Ogrinc, Sergio A. Hernandez, Misa Korva, Petra Bogovic, Tereza Rojko, Lara Lusa, Geena Chiumento, Franc Strle, Klemen Strle
Summary: Meningoradiculoneuritis is a distinct clinical entity with unique immune and genetic pathophysiology, characterized by elevated levels of B-cell and T-cell chemokines, as well as increased frequency of TLR1-1805GG polymorphism and constitutional symptoms.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Natasa Kejzar, Lara Lusa
EPIDEMIOLOGIA & PREVENZIONE
(2020)
Article
Public, Environmental & Occupational Health
Lara Lusa
EPIDEMIOLOGIA & PREVENZIONE
(2020)
Article
Multidisciplinary Sciences
Lara Lusa, Crt Ahlin