Review
Cell Biology
Josefa Alarcon-Apablaza, Ruth Prieto, Mariana Rojas, Ramon Fuentes
Summary: Bone loss often occurs due to trauma, surgery, or congenital malformations. This review examines the potential of mesenchymal stromal cells (MSCs) from the oral cavity for bone regeneration. Different sources of MSCs, such as dental pulp, inflamed dental pulp, exfoliated deciduous teeth, periodontal ligament, periosteal cells, buccal fat pad, and bone-derived MSCs, have been used successfully for repairing bone defects. Additional scaffolds are needed for effective stem cell delivery.
Article
Dentistry, Oral Surgery & Medicine
Ausra Ramanauskaite, Frank Schwarz, Robert Sader, Juergen Becker, Karina Obreja
Summary: Horizontal soft and hard tissue dimensions were similar among different treatment groups, with an inverse correlation between horizontal mucosal thickness and bone thickness observed at sites treated with implantoplasty, while a positive correlation was found at sites treated with regenerative therapy.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Alberto Monje, Andrea Roccuzzo, Daniel Buser, Hom-Lay Wang
Summary: This study evaluated the association between peri-implant bucco-lingual dimension (BLD) and the occurrence of biological and esthetic complications. It found that in scenarios with thin buccal bone wall, major dimensional changes and bone loss are more likely to occur, leading to complications. Therefore, careful assessment of BLD is necessary before implant placement. Additionally, augmenting buccal bone wall defects can enhance tissue stability.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Dusan Holly, Martin Klein, Merita Mazreku, Radoslav Zamborsky, Stefan Polak, L'ubos Danisovic, Maria Csobonyeiova
Summary: Oral and craniofacial bone defects are common, and traditional autologous bone grafting has limitations, making bone tissue engineering combined with stem cell therapy a potential alternative. The number of studies investigating cell-based engineering methods for bone damage reconstruction is increasing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ausra Ramanauskaite, Karina Obreja, Robert Sader, Jurgen Becker, Frank Schwarz
Summary: This study evaluated peri-implant tissue dimensions following different decontamination protocols for treating advanced ligature-induced peri-implantitis in dogs. The results showed similar vertical and horizontal tissue dimensions among different treatment groups.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Review
Medicine, General & Internal
Andrea Roccuzzo, Alexandra Stahli, Alberto Monje, Anton Sculean, Giovanni E. Salvi
Summary: Dental implants are considered a reliable routine procedure for replacing missing teeth, but the presence of peri-implantitis has become a concern due to its negative impact on patients' quality of life. The surgical therapeutic modalities for managing this disorder include indications, contraindications, complexity, predictability, and effectiveness.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Anatomy & Morphology
Antoine Berberi, Mohammad Fayyad-kazan, Sara Ayoub, Rita Bou Assaf, Joseph Sabbagh, Michella Ghassibe-Sabbagh, Bassam Badran
Summary: This paper discusses the use of mesenchymal stem cells obtained from several oral tissues mixed with different types of scaffolds tested in different animal models for bone tissue engineering. It emphasizes the factors that need to be taken into consideration when choosing animals, and highlights the comparisons between human and animal models.
Article
Cell Biology
Sandra Stamnitz, Agnieszka Krawczenko, Urszula Szalaj, Zaneta Gorecka, Agnieszka Antonczyk, Zdzislaw Kielbowicz, Wojciech Swieszkowski, Witold Lojkowski, Aleksandra Klimczak
Summary: FGF-2 and BMP-2 enhance the osteogenic differentiation potential of MSCs grown on a scaffold, making them promising tools for bone regeneration. This was confirmed through in vitro and in vivo experiments.
Review
Cell Biology
Bo Li, Takehito Ouchi, Yubin Cao, Zhihe Zhao, Yi Men
Summary: MSCs can be found in mammalian teeth from various dental sources, with similar multipotent potential and immunomodulatory functions, showing promising applications in injury repair and disease treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Zeqing Zhao, Jin Liu, Michael D. Weir, Abraham Schneider, Tao Ma, Thomas W. Oates, Hockin H. K. Xu, Ke Zhang, Yuxing Bai
Summary: This review article presents the recent advances in PDLSC-based bone regeneration and periodontal tissue regeneration. By combining PDLSCs with various materials and scaffolds, as well as applying different osteoinductive agents and strategies, PDLSCs demonstrate the potential for bone and periodontal tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Rongkai Cao, Beibei Chen, Qianru Li, Piaopiao Qiu, Xiaojie Liang, Yujie Cao
Summary: This study summarizes the characteristics of periosteal cells (PCs) for bone and cartilage regeneration and compares their efficacy with bone marrow stromal cells (BMSCs). The results demonstrate the beneficial effects of PCs in bone regeneration and the need for further research on the cartilage formation capacity of BMSCs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Xiaoying Chen, Wei Xie, Ming Zhang, Yuhan Shi, Shaofen Xu, Haoyu Cheng, Lihong Wu, Janak L. Pathak, Zhichao Zheng
Summary: This review summarizes the regulatory role of non-coding RNAs in the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) and discusses their prospects in clinical bone tissue regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Melis Isik, Ibrahim Vargel, Erdogan Ozgur, Sefa Burak Cam, Petek Korkusuz, Emel Emregul, Sedat Odabas, Burak Derkus
Summary: Advances in bone tissue engineering have been made through the integration of biologically active extracellular nanovesicles with biomaterial platforms. This offers a promising solution for overcoming reduced bone volume and facilitating efficient bone regeneration.
MATERIALS TODAY COMMUNICATIONS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Ausra Ramanauskaite, Kathrin Becker, Emilio A. A. Cafferata, Frank Schwarz
Summary: Guided bone regeneration (GBR) is a method used to treat bone defects at peri-implantitis sites, involving the placement of bone-filler particles and the use of a barrier membrane. The effectiveness of different GBR-supported treatments and their superiority compared to non-GBR treatments remains unclear. This analysis evaluates the long-term clinical efficacy of GBR-supported surgical therapy for peri-implantitis-related bone defects.
PERIODONTOLOGY 2000
(2023)
Article
Engineering, Biomedical
Zain Siddiqui, Amanda M. Acevedo-Jake, Alexandra Griffith, Nurten Kadincesme, Kinga Dabek, Dana Hindi, Ka Kyung Kim, Yoshifumi Kobayashi, Emi Shimizu, Vivek Kumar
Summary: Pulp capping and dental pulp regeneration are evolving techniques to regenerate pulp tissue and maintain tooth vitality, with various methods and materials being used in regenerative endodontics.
BIOACTIVE MATERIALS
(2022)
Article
Physics, Multidisciplinary
Xianjun Wang, Ke Jiang, Xiaojuan Sun, Zi-Hui Zhang, Yuxuan Chen, Bingxiang Wang, Dabing Li
Summary: The profiles of the valence subbands in an AlGaN-based quantum well are studied, considering quantum confinement effect and strain. Increasing the quantum confinement effect and compressive strain raises the relative position of the heavy hole subband to the crystal field splitting hole subband in the valence band. However, the underlying mechanisms of the modulation by the quantum confinement effect and strain are different. In addition, if the energy level between the heavy hole and crystal field splitting hole subbands is close, the subband anti-crossing effect enhances their coupling and leads to dipole moment transformation between the conduction and valence subbands. These findings have important implications for the design of AlGaN-based optoelectronic devices with short wavelength, high carrier injection, or monolithic integration.
Article
Multidisciplinary Sciences
Xingtong Chen, Xiongfeng Lin, Likuan Zhou, Xiaojuan Sun, Rui Li, Mengyu Chen, Yixing Yang, Wenjun Hou, Longjia Wu, Weiran Cao, Xin Zhang, Xiaolin Yan, Song Chen
Summary: This study proposes quantum dots with monmonotonically-graded core/shell/shell structures to improve the performance of devices by reducing the surface-bulk coupling. By exploring the degradation mechanism and improving the operational stability of blue electroluminescence, the researchers have achieved significantly improved lifetimes for the bottom-emitting devices.
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Nan Hu, Weiping Li, Wentao Jiang, Jin Wen, Shensheng Gu
Summary: Dental pulp and periapical diseases cause pain and economic loss for patients. Although root canal therapies provide relief, restoring the nutrition, sensory, and immune functions of dental pulp remains difficult. Tissue engineering and bioactive scaffolds have made significant progress in creating a suitable microenvironment for dental pulp regeneration. This article discusses current challenges and novel perspectives in using bioactive scaffolds to promote dental pulp regeneration.
Article
Nanoscience & Nanotechnology
Yang Chen, Zhiming Shi, Shanli Zhang, Yuanyuan Yue, Hang Zang, Jianwei Ben, Ke Jiang, Yuping Jia, Xiaojuan Sun, Dabing Li
Summary: This study demonstrates the control of interfacial adhesion in III-nitride van der Waals epitaxy (vdWE) by using graded high-temperature nitridation treatment of the graphene insertion layer. Different epitaxial modes were achieved based on the adhesion difference, and the quasi-vdWE enabled by small graphene defects and proper N doping showed the lowest formation energy for AlN nucleation. The successful transfer of III-nitride onto a flexible substrate using a UV resin-assisted bonding technique allows for the fabrication of a flexible photodetector with high device yield and excellent performance after bending cycles. This work offers a promising strategy for controlling vdWE interfacial adhesion and enables the development of future UV foldable and wearable devices.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Physics, Applied
Zhiming Shi, Aiqin Tian, Xiaojuan Sun, Xuan Li, Hang Zang, Xujun Su, Hao Lin, Peng Xu, Hui Yang, Jianping Liu, Dabing Li
Summary: In this study, the atomic formation mechanism of trench defects in InGaN multiple quantum wells (MQWs) was revealed through thermodynamic analysis based on first-principles calculations and experimental confirmation. It was found that the In-rich region induces basal plane stacking faults (BSFs), resulting in low emission efficiency. The presence of trench defects originating from the thick GaN quantum barrier (QB) layer was observed, which had excess indium and poor crystal quality based on cathodoluminescence measurements.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Xiaojuan Sun, Yunfei Tian, Zhiqiang Wang
Summary: A new deep-blue emitting anthracene derivative TBPA was synthesized and characterized. It showed high thermal stability and achieved efficient deep-blue emission in a non-doped electroluminescence device with a maximum external quantum efficiency of 3.13%. It also had low turn-on voltage (3.1 V) and relatively small efficiency roll-off (2.91% at the luminance 100 cd/m(2)).
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
Chunru Fan, Xiaojuan Sun, Zhiming Shi, Bingchen Lu, Yang Chen, Shaojuan Li, Jia-Ming Liu
Summary: In this work, a wafer-scale graphene-Au nanogratings (Gra-Au NGs) plasmonic photodetector array is fabricated via two-beam holographic lithography, which achieves a photosensitive area of 1 mm(2), showing balanced abilities of polarization-sensitive, broadband, and enhanced photoresponse from visible to near-infrared regions.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Neurosciences
Ming Liu, Xiaojuan Sun
Summary: In this study, a multi-compartmental model of fast-spiking basket cells (FS BCs) was constructed to investigate their responses to different spatial dispersion of synaptic inputs. It was found that supralinear dendrites dominate somatic firing, while sublinear dendrites prefer dispersing. It was also revealed that dendritic diameter and Ca2+-permeable AMPA conductance play important roles in this process, while A-type K+ channels and NMDA conductance have little effect. These findings provide valuable insights into dendritic computation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Optics
Xuqing Sun, Hongyao Liu, Liwen Jiang, Ruxue Wei, Chang Wang, Xue Wang, Xiaojuan Sun, Fei Wang, Xinchao Lu, Andrey B. Evlyukhin, Chengjun Huang
Summary: Directionally scattered surface plasmon polaritons (SPPs) have been achieved in low-index dielectric nanoparticles, enhancing the efficiency of plasmonic devices. The excitation mechanism of plasmonic induced electric and magnetic multipole modes and their contributions to the forward scattering of SPPs are numerically illustrated and experimentally visualized.
PHOTONICS RESEARCH
(2023)
Article
Cell Biology
Huisi He, Shuzhen Chen, Zhecai Fan, Yaping Dong, Ying Wang, Shiyao Li, Xiaojuan Sun, Yuting Song, Jinxian Yang, Qiqi Cao, Jie Jiang, Xianming Wang, Wen Wen, Hongyang Wang
Summary: This study aimed to identify the characteristics and potential treatment targets of AFP-negative HCC (ANHC) and AFP-positive HCC (APHC). Single-cell RNA sequencing was used to analyze tumor cells from ANHC, APHC, and adjacent normal tissues. The study found that APHC was associated with immune distortion and the accumulation of tumor-associated macrophages (TAMs) enriched with TAM-SPP1(+). Targeting the Spp1-Cd44 axis improved T cell function and reduced tumor burden in APHC treatment.
Article
Engineering, Biomedical
Xiao Wang, Lisha Pan, Ao Zheng, Lingyan Cao, Jin Wen, Tingshu Su, Xiangkai Zhang, Qingfeng Huang, Xinquan Jiang
Summary: In this study, titanium plasma immersion ion implantation (Ti-PIII) was used to modify carbon fiber reinforced polyetheretherketone (CFRPEEK) and create multi-level nanostructures and active sites on the surface. Hybrid polydopamine (PDA)@ZnO-EDN1 nanoparticles were introduced to enhance the osteogenic and angiogenic properties as well as the antibacterial effect of CFRPEEK. The modified CFRPEEK exhibited excellent stability, cytocompatibility, and enhanced antibacterial, angiogenic, and osteogenic capacities, making it a promising material for orthopedic and dental implants.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Yuxin Yang, Zhiming Shi, Shoufeng Zhang, Xiaobao Ma, Jiangxiao Bai, Dashuo Fan, Hang Zang, Xiaojuan Sun, Dabing Li
Summary: Insightful understanding of defect properties and prevention of defect damage is crucial for the development of photoelectronic devices based on wide-gap III-nitride semiconductors. Through ab initio molecular dynamics and nonadiabatic quantum dynamics simulations, vacancy-induced carrier nonradiative dynamics in wide-gap III-nitrides (GaN, AlN, and Al x Ga1-x N) have been investigated, revealing the impact of V-N on recombination and the influence of increasing x in Al( x )Ga(1-x )N alloys on nonradiative recombination. These findings have significant implications for improving the performance of wide-gap III-nitrides-based photoelectronic devices.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Hang Zang, Zhiming Shi, Jianwei Ben, Ke Jiang, Yang Chen, Shanli Zhang, Mingrui Liu, Tong Wu, Yuping Jia, Xiaojuan Sun, Dabing Li
Summary: III-nitride materials like AlN, GaN, and InN have promising applications in the semiconductor industry, but the high defect densities resulting from the growth process can impact device performance. In this study, a first-principles investigation was conducted to understand the growth and electronic properties of stacking mismatch boundaries (SMBs) in III-nitride materials. The study revealed that SMBs can be categorized into three types based on the terrace edge of the coalescent normal and stacking-fault regions, and the type can be controlled by varying the chemical potential and initial nucleation size during growth. It was also found that SMBs produce in-gap states with various properties, such as itinerant magnetism and optical transition.
Article
Chemistry, Multidisciplinary
Yuxuan Chen, Ke Jiang, Xiaojuan Sun, Zi-Hui Zhang, Shanli Zhang, Jianwei Ben, Bingxiang Wang, Long Guo, Dabing Li
Summary: We proposed an alternative strategy to optimize the metal/n-AlGaN contact by introducing a heterostructure with a polarization effect and by etching a recess structure through the heterostructure beneath the n-contact metal. This strategy could simultaneously decrease the Schottky barrier height as well as provide a better carrier transport channel, enhancing both the thermionic emission and tunneling processes. This investigation provides an alternative approach to obtain a good n-contact, especially for Al-rich AlGaN-based devices, such as diodes and LEDs.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Xiaojuan Sun, Jiaen Sui, Jianwei Ben, Hang Zang, Ke Jiang, Shanli Zhang, Shunpeng Lv, Zhiming Shi, Tong Wu, Dabing Li
Summary: This study investigates the underlying mechanism of the decrease in basal stacking fault density in a nonpolar AlN template. It is found that the elimination of the I-1-type stacking fault involves its transformation into an I-3-type stacking fault, followed by annihilation. The results presented here are significant for the synthesis of high-quality nonpolar AlN materials and nonpolar light-emitting diodes.
