Journal
JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY
Volume 33, Issue 1, Pages 123-127Publisher
TECHNICAL ASSOC PHOTOPOLYMERS,JAPAN
DOI: 10.2494/photopolymer.33.123
Keywords
Surgical glue; Biomimetics; Mussel; Tunicate; Marine organisms
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Funding
- Japan Society for the Promotion of Science (JSPS) through KAKENHI [18K14000, 18K18802]
- Japan Agency for Medical Research and Development (AMED)
- Strategic PRomotion for practical application of INnovative medical Technology (TR-SPRINT)
- Mizuho Foundation for the Promotion of Sciences
- Ogasawara Foundation for the Promotion of Science Engineering
- Grants-in-Aid for Scientific Research [18K14000, 18K18802] Funding Source: KAKEN
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Tissue adhesives are greatly employed as surgical sealants for wound-healing patches and hemostatic dressing. However, achieving strong adhesion of wet tissues is still challenging because the bonding strength of biomedical adhesives is generally weakened by physiological fluids due to their high dielectric and ionic strengths. To overcome this challenge, bioinspired approaches have been adopted to enhance the wet adhesion of biocompatible polymers. Here, we synthesized a series of chitosan functionalized with bioinspired phenolic groups, i.e., phenol, catechol, and gallol, with similar modification rates. The bonding and sealing strengths of wet tissues by this functionalized chitosan were compared under similar conditions. We observed that the gallol group was the most effective in enhancing the tissue adhesion property of chitosan.
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