Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

(2019) Shashank Dadsena et al.   Nature Communications

Isoflavone ME-344 disrupts redox homeostasis and mitochondrial function by targeting Heme Oxygenase 1.

(2019) Leilei Zhang et al.   CANCER RESEARCH

Molecular mechanisms of ferroptosis and its role in cancer therapy

(2019) Tao Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells

(2019) Hongqiao Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Redox-dependent gating of VDAC by mitoNEET

(2019) Colin H. Lipper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells

(2019) K.A. Heslop et al.   BIOCHEMICAL PHARMACOLOGY

Abrogation of resistance against bevacizumab (Bev) by mitochondrial inhibition: A phase 0 randomized trial of Bev plus ME344 or placebo in early HER2-negative breast cancer (HERNEBC).

(2018) Miguel Quintela-Fandino et al.   JOURNAL OF CLINICAL ONCOLOGY

The Comparative Toxicogenomics Database: update 2019

(2018) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

VDAC2 enables BAX to mediate apoptosis and limit tumor development

(2018) Hui San Chin et al.   Nature Communications

Phase Ib study of the mitochondrial inhibitor ME-344 plus topotecan in patients with previously treated, locally advanced or metastatic small cell lung, ovarian and cervical cancers

(2017) Jennifer R. Diamond et al.   INVESTIGATIONAL NEW DRUGS

Protein–protein interaction networks as a new perspective to evaluate distinct functional roles of voltage-dependent anion channel isoforms

(2017) Marianna Caterino et al.   Molecular BioSystems

VDAC–Tubulin, an Anti-Warburg Pro-Oxidant Switch

(2017) Eduardo N. Maldonado   Frontiers in Oncology

Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells

(2017) David N. DeHart et al.   SLAS Discovery

Current state of theoretical and experimental studies of the voltage-dependent anion channel (VDAC)

(2016) Sergei Yu. Noskov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction

(2016) Danya Ben-Hail et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics

(2016) Paloma Navarro et al.   Cell Reports

VDAC3 As a Potential Marker of Mitochondrial Status Is Involved in Cancer and Pathology

(2016) Simona Reina et al.   Frontiers in Oncology

VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore

(2015) Masateru Okazaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

NDEx, the Network Data Exchange

(2015) Dexter Pratt et al.   Cell Systems

Phase 1, open-label, dose escalation, safety, and pharmacokinetics study of ME-344 as a single agent in patients with refractory solid tumors

(2014) Johanna C. Bendell et al.   CANCER

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

(2014) S B Ma et al.   CELL DEATH AND DIFFERENTIATION

Voltage-dependent Anion Channels Modulate Mitochondrial Metabolism in Cancer Cells

(2013) Eduardo N. Maldonado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

(2013) Barbara Schellenberg et al.   MOLECULAR CELL

The mitochondrial permeability transition pore (PTP) — An example of multiple molecular exaptation?

(2012) Angelo Vianello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Alpinetin promotes Bax translocation, induces apoptosis through the mitochondrial pathway and arrests human gastric cancer cells at the G2/M phase

(2012) ZHENRAN WANG et al.   Molecular Medicine Reports

Bax Translocation Mediated Mitochondrial Apoptosis and Caspase Dependent Photosensitizing Effect of Ficus religiosa on Cancer Cells

(2012) Jazir Haneef et al.   PLoS One

The role of VDAC in cell death: Friend or foe?

(2011) Kyle S. McCommis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Targeting the Mitochondria Activates Two Independent Cell Death Pathways in Ovarian Cancer Stem Cells

(2011) A. B. Alvero et al.   MOLECULAR CANCER THERAPEUTICS

Characterization of human VDAC isoforms: A peculiar function for VDAC3?

(2010) Vito De Pinto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

NV-128, a novel isoflavone derivative, induces caspase-independent cell death through the Akt/mammalian target of rapamycin pathway

(2009) Ayesha B. Alvero et al.   CANCER

Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis

(2009) Flora Tomasello et al.   CELL RESEARCH

Bax Contains Two Functional Mitochondrial Targeting Sequences and Translocates to Mitochondria in a Conformational Change- and Homo-oligomerization-driven Process

(2009) Nicholas M. George et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis

(2008) Shaopeng Yuan et al.   FASEB JOURNAL

Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death

(2008) N Tajeddine et al.   ONCOGENE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY