Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 143, Issue 2, Pages 117-121Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1016/j.jphs.2020.02.011
Keywords
Glucocorticoid-induced osteoporosis (GIOP); Scale regeneration; Zebrafish
Categories
Funding
- Api Co., Ltd. (Gifu, Japan)
- Toukai Foundation for Technology
- Gifu Prefectural Promotion Agency for Healthy Longevity and Drug Discovery
Ask authors/readers for more resources
There are several animal models of glucocorticoid-induced osteoporosis (GIOP), but each requires a long time to evaluate drug effects. Zebrafish scales are classified as dermal bone and potentially represent a convenient animal model of GIOP because they rapidly regenerate following their removal. We clarified that dexamethasone-treated regenerating scales showed malformations, decreased size and circularity. Anti-osteoporosis drugs rescued the scale malformation phenotype eight-days following the removal of scales. Hence, the dexamethasone-induced regenerating scale malformation model may be a useful animal model for discovering drugs to treat GIOP. (C) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available