Journal
CLINICAL IMAGING
Volume 40, Issue 3, Pages 506-511Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clinimag.2015.12.001
Keywords
Diffusion; Tensor; Breast; MRI; DTI
Funding
- NIH Core Grant [P30CA008748]
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Objective: To evaluate effects of fibroglandular tissue (FGT) composition and background parenchymal enhancement (BPE) on diffusion tensor imaging (DTI) parameters in normal breast tissue. Methods: DTI analysis was performed on 35 breasts with regions of interest drawn to include only normal tissue. Breasts were dichotomized by FGT composition and by BPE; DTI parameters were compared. Results: The lambda(1) principal diffusion coefficient was lower in breasts with moderate/marked BPE versus those with minimal/mild BPE (P=.039). All other parameters were unaffected. Conclusion: lambda(1) is sensitive to differences in BPE within normal breast tissue that should be taken into account in DTI evaluation. (C) 2016 Elsevier Inc. All rights reserved.
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