Deamidation in Moxetumomab Pasudotox Leading to Conformational Change and Immunotoxin Activity Loss

Title
Deamidation in Moxetumomab Pasudotox Leading to Conformational Change and Immunotoxin Activity Loss
Authors
Keywords
Proteins structure, Protein conformation, Protein stability, Protein folding, Posttranslational modification, Mass spectrometry, Calorimetry, Modeling, Deamidation, Biological activity, Hydrogen-deuterium exchange
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2020-06-11
DOI
10.1016/j.xphs.2020.06.002

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