Article
Multidisciplinary Sciences
Gang Wang, Jianlong Li, Linda Bojmar, Haiyan Chen, Zhong Li, Gabriel C. Tobias, Mengying Hu, Edwin A. Homan, Serena Lucotti, Fengbo Zhao, Valentina Posada, Peter R. Oxley, Michele Cioffi, Han Sang Kim, Huajuan Wang, Pernille Lauritzen, Nancy Boudreau, Zhanjun Shi, Christin E. Burd, Jonathan H. Zippin, James C. Lo, Geoffrey S. Pitt, Jonathan Hernandez, Constantinos P. Zambirinis, Michael A. Hollingsworth, Paul M. Grandgenett, Maneesh Jain, Surinder K. Batra, Dominick J. DiMaio, Jean L. Grem, Kelsey A. Klute, Tanya M. Trippett, Mikala Egeblad, Doru Paul, Jacqueline Bromberg, David Kelsen, Vinagolu K. Rajasekhar, John H. Healey, Irina R. Matei, William R. Jarnagin, Robert E. Schwartz, Haiying Zhang, David Lyden
Summary: Cancer can affect multiple organs beyond those targeted by metastasis. In this study, we found that inflammation, fatty liver, and dysregulated metabolism are characteristics of systemically affected livers in both mouse models and patients with extrahepatic metastasis. Tumour-derived extracellular vesicles and particles (EVPs) play a crucial role in cancer-induced hepatic reprogramming by dysregulating hepatic function. The fatty acid cargo of tumour EVPs, particularly palmitic acid, induces the secretion of TNF by Kupffer cells, leading to a pro-inflammatory microenvironment, suppressing fatty acid metabolism and oxidative phosphorylation, and promoting fatty liver formation.
Article
Biochemistry & Molecular Biology
Xuelin Yao, Hanyuan Liu, Zhen Wang, Fangting Lu, Wenying Chen, Qing Feng, Yahu Miao, Jie Zhang, Yanlei Wang, Ye Chen, Liping Xue, Yehai Liu, Liang Chen, Qiu Zhang
Summary: Circular RNAs (circRNAs) play a crucial role in human cancer development, including papillary thyroid cancer (PTC). The circRNA circEIF3I is found to promote PTC progression by enhancing cell proliferation, cycle, migration, invasion, and in vivo cell proliferation. Mechanistically, circEIF3I interacts with AUF1 to stabilize Cyclin D1 mRNA and increase Cyclin D1 protein production. These findings highlight the significance of circEIF3I as a therapeutic target for PTC.
Article
Oncology
Marte C. C. Liefaard, Kat S. S. Moore, Lennart Mulder, Daan van den Broek, Jelle Wesseling, Gabe S. S. Sonke, Lodewyk F. A. Wessels, Matti Rookus, Esther H. H. Lips
Summary: Studies focused on using blood platelets (TEPs) to detect breast cancer were conducted, but the results were not reproducible in an independent validation cohort. Two classifiers based on TEPs reached an AUC of 0.85 in internal validation, but the AUC dropped to 0.55 and 0.54 in the independent validation set. Post hoc analyses revealed that gene expression variance was associated with the hospital where the samples were collected. The TEP protocol needs revision before it can be reconsidered for breast cancer detection.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
M. Mazzoni, K. Todoerti, L. Agnelli, E. Minna, S. Pagliardini, T. Di Marco, M. G. Borrello, A. Neri, A. Greco
Summary: This study aimed to further understand the regulatory factors of TIMP3 tumor suppressor function in papillary thyroid cancer (PTC). The analysis of genes related to TIMP3 expression revealed an association between TIMP3 expression levels and the regulation of inflammatory functions and immune cell infiltration composition, providing a broader view on the oncosuppressor role of TIMP3 in PTC.
CANCER CELL INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Erik Christensen, Alaine Naidas, David Chen, Mia Husic, Parisa Shooshtari
Summary: The study built a TME scRNA-seq database and developed an R package named TMExplorer for investigating the TME. TMExplorer provides an interface for easy access to all available datasets and their metadata, and allows users to search for datasets based on a wide range of characteristics. The tool streamlines TME examination using scRNA-seq and allows for easy integration into existing scRNAseq analysis pipelines.
Article
Biochemistry & Molecular Biology
Eric L. Bolf, Noelle E. Gillis, Cole D. Davidson, Lauren M. Cozzens, Sophie Kogut, Jennifer A. Tomczak, Seth Frietze, Frances E. Carr
Summary: This study found that restoring TR beta expression in breast cancer cells resulted in more epithelial cell characteristics, reduced expression of mesenchymal cytokeratins, and decreased epithelial to mesenchymal transition pathway activity. Additionally, comparison with thyroid cancer cells revealed shared gene regulation by TR beta in pathways such as lipid metabolism and chromatin remodeling.
MOLECULAR CARCINOGENESIS
(2021)
Article
Genetics & Heredity
Ivan Petrini, Rocio L. Cecchini, Marilina Mascaro, Ignacio Ponzoni, Jessica A. Carballido
Summary: The likelihood of being diagnosed with thyroid cancer has increased in recent years. The aim of this study is to identify potential genes relevant to Papillary Thyroid Carcinoma (PTC) through bioinformatic analysis. Four genes, PTGFR, ZMAT3, GABRB2, and DPP6, were found to be highly relevant and worthy of further investigation.
Article
Medicine, General & Internal
P. G. Vaughan-Shaw, G. Grimes, J. P. Blackmur, M. Timofeeva, M. Walker, L. Y. Ooi, Victoria Svinti, Kevin Donnelly, F. V. N. Din, S. M. Farrington, M. G. Dunlop
Summary: This study found that oral vitamin D supplementation can induce beneficial gene expression effects in human rectal epithelium, leading to anti-tumour effects. However, only a minority of participants showed significant responses to vitamin D supplementation. Changes in HIPK2 and PPP1CC expression serve as blood biomarkers of mucosal transcriptomic response.
Article
Endocrinology & Metabolism
Hongyun Zhao, Da Teng, Lifeng Yang, Xincheng Xu, Jiajia Chen, Tengjia Jiang, Austin Y. Feng, Yaqing Zhang, Dennie T. Frederick, Lei Gu, Li Cai, John M. Asara, Marina Pasca di Magliano, Genevieve M. Boland, Keith T. Flaherty, Kenneth D. Swanson, David Liu, Joshua D. Rabinowitz, Bin Zheng
Summary: This study reveals that itaconate, produced by myeloid-derived suppressor cells (MDSCs), acts as an immune checkpoint metabolite to suppress CD8(+) T cells. Inhibition of IRG1 may enhance anti-tumour immunity and improve the efficacy of immune checkpoint blockade. These findings have implications for understanding immune surveillance and developing new strategies for cancer treatment.
Article
Medicine, Research & Experimental
Sujie Ke, Yan-Yun Liu, Rajendiran Karthikraj, Kurunthachalam Kannan, Jingjing Jiang, Kiyomi Abe, Anna Milanesi, Gregory A. Brent
Summary: The study revealed that SUMOylation of THRB at K146 is essential for normal regulation of thyroid function and synthesis of thyroid hormones. The THRB K146Q mutation resulted in disrupted TSH feedback regulation and altered thyroid hormone production.
Article
Environmental Sciences
Jing Chang, Yifan Pan, Wentao Liu, Peng Xu, Wei Li, Bin Wan
Summary: The study found that lambda-cyhalothrin and its metabolite 3-phenoxybenzoic acid had different effects on the thyroid axis in Chinese lizards, with the former increasing hormone levels and gland height, while the latter caused minor changes. In silico simulations showed that the two substances disrupt the HPT axis in lizards through distinct mechanisms.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Febe van Maldegem, Karishma Valand, Megan Cole, Harshil Patel, Mihaela Angelova, Sareena Rana, Emma Colliver, Katey Enfield, Nourdine Bah, Gavin Kelly, Victoria Siu Kwan Tsang, Edurne Mugarza, Christopher Moore, Philip Hobson, Dina Levi, Miriam Molina-Arcas, Charles Swanton, Julian Downward
Summary: This study introduces a workflow for studying the TME in mouse models using imaging mass cytometry, allowing for optimized image segmentation strategies and automated processes for parallel segmentation of large multi-image datasets.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Davide Di Fusco, Antonio Di Grazia, Giulia Di Maggio, Maria Teresa Segreto, Andrea Iannucci, Claudia Maresca, Alessandro De Stefano, Giuseppe Sica, Carmine Stolfi, Giovanni Monteleone, Ivan Monteleone
Summary: IMP3 is highly expressed in colorectal cancer (CRC) and is associated with poor prognosis. Inhibition of IMP3 enhances caspase-independent cell death in CRC. IMP3 acts as a regulator of the intrinsic apoptotic pathway in CRC through surveillance of anti-apoptotic Bcl mRNA metabolism.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Elisabetta Macerola, Anello Marcello Poma, Fulvio Basolo
Summary: In the field of cancer pathology, molecular characterization of tumors is increasingly important, with the nCounter system showing promise as a solid approach for research in thyroid pathology.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Fengyun Zhong, Yilin Lin, Long Zhao, Changjiang Yang, Yingjiang Ye, Zhanlong Shen
Summary: In recent years, researchers have been paying more attention to the tumour microenvironment (TME) of solid tumours, especially the non-tumour components including immune cells. The infiltration of different immune cells leads to heterogeneity in the tumour immune microenvironment (TIME), resulting in varied therapeutic effects. It has been found that DNA methylation plays a crucial role in remodelling the TIME and is associated with the response to immune checkpoint inhibitors (ICIs). DNA methyltransferase inhibitors (DNMTis) show promise in enhancing the antitumor immune response and have shown synergistic effects when combined with immunotherapies in preclinical studies, offering new strategies for treating refractory solid tumours.
BRITISH JOURNAL OF CANCER
(2023)
Article
Endocrinology & Metabolism
Philip D. Home, Rory J. McCrimmon, Julio Rosenstock, Matthias Bluher, Katrin Pegelow, Lydie Melas-Melt, Khier Djaballah, Francesco Giorgino
Summary: The aim of this study was to investigate the impact of baseline participant characteristics on the outcomes of the SoliMix study. The findings showed that the treatment effects of iGlarLixi were consistent across various baseline characteristics, supporting its use as an effective and well-tolerated treatment option for people with type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Sergio Di Molfetta, Irene Caruso, Angelo Cignarelli, Annalisa Natalicchio, Sebastio Perrini, Luigi Laviola, Francesco Giorgino
Summary: This study aimed to evaluate the effect of professional continuous glucose monitoring (p-CGM)-based care on glucose control in type 1 and type 2 diabetes patients. The use of p-CGM was found to significantly reduce glycated haemoglobin (HbA1c) levels without increasing hypoglycaemia compared to standard care.
DIABETES OBESITY & METABOLISM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Angela Tempesta, Saverio Capodiferro, Simona Di Nanna, Silvia D'Agostino, Marco Dolci, Antonio Scarano, Gianluca Gambarini, Eugenio Maiorano, Gianfranco Favia, Luisa Limongelli
Summary: This study describes the association between endodontic treatment failure and MRONJ in oncologic patients. The results showed that teeth with failed endodontic treatment may be a risk factor for the development of MRONJ before receiving antiresorptive and antiangiogenic drug therapies. Therefore, careful evaluation of these patients is necessary prior to the initiation of drug treatment.
Editorial Material
Endocrinology & Metabolism
G. P. Sorice, M. Caporusso, A. Cignarelli, S. Perrini, A. Natalicchio, F. Giorgino
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Nicola Marrano, Giuseppina Biondi, Anna Borrelli, Martina Rella, Tommaso Zambetta, Ludovico Di Gioia, Mariangela Caporusso, Giancarlo Logroscino, Sebastio Perrini, Francesco Giorgino, Annalisa Natalicchio
Summary: Type 2 diabetes and Alzheimer's disease are major health issues with a close relationship. Lipotoxicity may be the missing link connecting the pathogenesis of these two diseases. Obesity, the main cause of lipotoxicity, is a major risk factor for both conditions. This review provides a comprehensive overview of the common molecular pathways activated by lipotoxicity in type 2 diabetes and Alzheimer's disease, suggesting potential new therapeutic perspectives.
Review
Endocrinology & Metabolism
Matthias Blueher, Mohini Aras, Louis J. Aronne, Rachel L. Batterham, Francesco Giorgino, Linong Ji, Kirsi H. Pietilainen, Oliver Schnell, Elena Tonchevska, John P. H. Wilding
Summary: Obesity is a chronic disease with increasing prevalence worldwide and is associated with various health risks. The treatment of obesity includes behavioral interventions, pharmacotherapy, and bariatric surgery, but long-term weight maintenance is challenging. Recent advances in understanding the pathophysiology of obesity have led to the development of novel and effective therapies, such as semaglutide and tirzepatide, which have shown promising weight loss effects and improvement in cardiometabolic risk factors. These new agents may bridge the gap between traditional treatments and achieve better outcomes in obesity management.
DIABETES OBESITY & METABOLISM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Luisa Limongelli, Gianfranco Favia, Eugenio Maiorano, Antonio D'Amati, Alberto Pispero, Giuseppe Ingravallo, Giuseppe Barile, Angela Tempesta, Fabio Dell'Olio, Rosaria Arianna Siciliani, Saverio Capodiferro
Summary: There is growing evidence of post-COVID condition/syndrome, which occurs in recovered patients and involves various organs/systems, as well as persisting taste dysfunction. The symptoms persist for more than 12 weeks and are related to the persistence of the virus, although the pathogenesis varies by organs or systems.
Review
Genetics & Heredity
Gerardo Cazzato, Teresa Lettini, Anna Colagrande, Irma Trilli, Francesca Ambrogio, Carmelo Laface, Paola Parente, Eugenio Maiorano, Giuseppe Ingravallo
Summary: Programmed death-ligand 1 (PD-L1) is an important ligand for programmed death-1 (PD-1) receptor and is found in myeloid, lymphoid, normal epithelial cells, and cancer. The interaction between PD-1 and PD-L1 is crucial for immunological tolerance development and cancer progression. In the case of malignant melanoma, the immunohistochemical expression of PD-L1 is used to guide therapeutic choices. However, there are various methods used for immunohistochemistry and inconsistent results in the literature. This review aims to discuss the achievements, challenges, and potential solutions in this field.
Review
Medicine, General & Internal
Saverio Capodiferro, Antonio d'Amati, Giuseppe Barile, Fabio Dell'Olio, Luisa Limongelli, Angela Tempesta, Rosaria Arianna Siciliani, Giuseppe Ingravallo, Mauro Mastropasqua, Giuseppe Colella, Ciro Emiliano Boschetti, Chiara Copelli, Eugenio Maiorano, Gianfranco Favia
Summary: Metastases to the oral cavity and head and neck from lung cancer are rare and typically occur in advanced stages of the disease. In even rarer cases, they may be the first indication of metastatic disease. This study retrospectively examined 21 cases of lung cancer metastases to the head and neck and proposed an immunohistochemical panel for identifying the primary tumor. Data from previous studies were also reviewed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Gerardo Cazzato, Eliano Cascardi, Anna Colagrande, Teresa Lettini, Alessandra Filosa, Francesca Arezzo, Carmelo Lupo, Nadia Casatta, Vera Loizzi, Cristina Pellegrini, Maria Concetta Fargnoli, Eugenio Maiorano, Gerolamo Cicco, Roberto Tamma, Giuseppe Ingravallo
Summary: T cell immunoglobulin and mucin domain 3 (TIM-3) is an inhibitory immunocheckpoint that has been investigated for its role in the tumour microenvironment of melanoma. This review provides the most up-to-date knowledge about TIM-3 in melanoma and discusses future prospects and potential applications.
Review
Health Care Sciences & Services
Miriam Dellino, Antonella Vimercati, Antonio D'Amato, Gianluca Raffaello Damiani, Antonio Simone Lagana, Ettore Cicinelli, Vincenzo Pinto, Antonio Malvasi, Salvatore Scacco, Andrea Ballini, Leonardo Resta, Giuseppe Ingravallo, Eugenio Maiorano, Gerardo Cazzato, Eliano Cascardi
Summary: The advent of coronavirus vaccines has alleviated the most serious symptoms of COVID-19, making it no longer an insurmountable global problem. However, there are still many extrapulmonary symptoms, including gynecological alterations, that raise questions about the causal link between COVID-19, vaccines, and gynecological health. The clinical impact of post-COVID-19 gynecological alterations on the female population is mainly determined by their duration, and the extent of these symptoms is still poorly understood.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Francesco Giorgino, Bruno Guerci, Martin Fuechtenbusch, Jeremie Lebrec, Kristina Boye, Marco Orsini Federici, Elke Heitmann, Anne Dib, Maria Yu, Helene Sapin, Luis-Emilio Garcia-Perez
Summary: The TROPHIES study presented the final results, indicating that patients initiating dulaglutide had a longer duration without significant treatment changes and higher treatment persistence compared to those initiating liraglutide. Both drugs showed similar and clinically meaningful reductions in glycated haemoglobin (HbA1c) and weight.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Kristina S. Boye, Jeremie Lebrec, Anne Dib, Elke Heitmann, Marco Orsini Federici, Maria Yu, Helene Sapin, Annabel Barrett, Bruno Guerci, Francesco Giorgino, Martin Fuechtenbusch, Luis-Emilio Garcia-Perez
Summary: This study reports the health-related patient-reported outcomes (PROs) of patients with T2D initiating their first injectable glucose-lowering medication (GLM) with two common GLP-1RAs. The results show that dulaglutide had more significant improvements in PRO scores compared to liraglutide, and patients were more satisfied with the injection device of dulaglutide.
DIABETES OBESITY & METABOLISM
(2023)
Review
Oncology
Valerio Renzelli, Marco Gallo, Lelio Morviducci, Giampiero Marino, Alberto Ragni, Enzo Tuveri, Antongiulio Faggiano, Rossella Mazzilli, Annalisa Natalicchio, Maria Chiara Zatelli, Monica Montagnani, Stefano Fogli, Dario Giuffrida, Antonella Argentiero, Romano Danesi, Stella D'Oronzo, Stefania Gori, Tindara Franchina, Antonio Russo, Matteo Monami, Laura Sciacca, Saverio Cinieri, Annamaria Colao, Angelo Avogaro, Graziano Di Cianni, Francesco Giorgino, Nicola Silvestris
Summary: Endocrine disruptors, such as PBDEs, can interfere with the endocrine system and potentially affect glucose metabolism, endocrine diseases, and cancer risk. However, the evidence regarding their impact is often conflicting. A deeper understanding of the relationship between exposure to endocrine disruptors and obesity, diabetes, metabolic disturbances, and cancer can guide public health interventions.
Article
Oncology
Gerardo Cazzato, Alessandro Massaro, Anna Colagrande, Irma Trilli, Giuseppe Ingravallo, Nadia Casatta, Carmelo Lupo, Andrea Ronchi, Renato Franco, Eugenio Maiorano, Angelo Vacca
Summary: Malignant melanoma, especially the nevoid variant, is difficult to diagnose correctly, even for experienced pathologists. Artificial intelligence has revolutionized the biomedical field and can potentially improve the diagnosis and treatment of nevoid melanoma. This study applies a fast random forest algorithm to naevoid melanomas to develop a clinical protocol aimed at reducing misdiagnosis. The results demonstrate the potential integration of this algorithm into the business process modeling and notation approach.
