Article
Clinical Neurology
Ahmed Ismail Kashkoush, Tamia Potter, Jordan C. Petitt, Song Hu, Kyle Hunter, Michael L. Kelly
Summary: This study investigated the clinical and radiological factors that predict intracranial hypertension (ICHTN) in patients with severe traumatic brain injury (TBI). The study found that the Rotterdam CT score (RS) can predict the occurrence of ICHTN, and the diagnostic accuracy of the model was improved with the inclusion of sulcal effacement at the vertex on CT of the head.
JOURNAL OF NEUROSURGERY
(2022)
Review
Critical Care Medicine
Daniel Agustin Godoy, Ali Seifi, Gerald Chi, Lourdes Paredes Saravia, Alejandro A. Rabinstein
Summary: The primary aim of this study is to determine the prevalence of intracranial pressure (ICP) monitoring and intracranial hypertension (IHT) in patients treated for moderate traumatic brain injury (TBI). The results showed that the prevalence rate of ICP monitoring was low, but the proportion of IHT was high among patients undergoing ICP monitoring after moderate TBI. The current literature is limited and does not identify factors associated with ICP monitoring or IHT.
NEUROCRITICAL CARE
(2022)
Article
Computer Science, Information Systems
Hack-Jin Lee, Hakseung Kim, Young-Tak Kim, Kanghee Won, Marek Czosnyka, Dong-Joo Kim
Summary: The study proposed a novel parameter for predicting potentially life-threatening IH events and developed a machine learning model for predicting LTH events. By analyzing the association between LTH parameters and mortality, the model demonstrated reasonable predictive capacity for mortality. The CatBoost model was able to anticipate whether an IH event would progress into an LTH event.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Critical Care Medicine
Frank A. Rasulo, Stefano Calza, Chiara Robba, Fabio Silvio Taccone, Daniele G. Biasucci, Rafael Badenes, Simone Piva, Davide Savo, Giuseppe Citerio, Jamil R. Dibu, Francesco Curto, Martina Merciadri, Paolo Gritti, Paola Fassini, Soojin Park, Massimo Lamperti, Pierre Bouzat, Paolo Malacarne, Arturo Chieregato, Rita Bertuetti, Raffaele Aspide, Alfredo Cantoni, Victoria McCredie, Lucrezia Guadrini, Nicola Latronico
Summary: This study evaluated the reliability of transcranial Doppler (ICPtcd) as a screening test for excluding intracranial hypertension. The results showed that ICPtcd has a high negative predictive value and can accurately exclude intracranial hypertension. It can be useful in situations where invasive methods are not available or cannot be used.
Review
Chemistry, Multidisciplinary
George R. E. Bradley, Maria Roldan, Panayiotis A. Kyriacou
Summary: This systematic review aimed to predict intracranial pressure (ICP) crises in patients with severe traumatic brain injury (TBI) in order to prevent secondary brain injury and improve patient outcomes. The review identified three effective approaches: long short-term memory (LSTM), Gaussian processes (GP), and logistic regression models, with area under the receiver operating characteristics curve (AUC-ROC) ranging from 0.86 to 0.95. The review also highlighted the lack of consensus on the definition of an ICP crisis, the most clinically relevant prediction horizon, and the clinical intelligibility, improvement of patient care, and ethical concerns of algorithms.
APPLIED SCIENCES-BASEL
(2023)
Review
Clinical Neurology
Jetan Badhiwala, Angela Lumba-Brown, Gregory W. J. Hawryluk, Jamshid Ghajar
Summary: External lumbar drainage (ELD) has an immediate significant effect on intracranial pressure (ICP) in patients with traumatic brain injury (TBI), but the durable effect and impact on neurological outcomes are uncertain. ELD appears to be safe with low risk of complications, warranting further high-quality investigation into its potential application in severe TBI with refractory intracranial hypertension.
Article
Cell Biology
Yu-Hsin Chen, Yen-Chou Chen, Yu-Tang Chin, Ching-Chiung Wang, Ling-Ling Hwang, Liang-Yo Yang, Dah-Yuu Lu
Summary: Traumatic brain injury (TBI) is a global health issue that affects at least 10 million people per year. 2, 3, 5, 4'-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG), a compound extracted from the Chinese herb Polygonum multiflorum, has been shown to have protective effects on TBI, reducing injury severity score, promoting motor coordination, improving cognitive performance, and inhibiting apoptosis while promoting neurogenesis.
Article
Critical Care Medicine
Yihua Li, Guoqing Zhang, Yingchi Shan, Xiang Wu, Jiaqi Liu, Yajun Xue, Guoyi Gao
Summary: This study aimed to evaluate intracranial hypertension in patients with traumatic brain injury non-invasively using computed tomography (CT) radiomic features. The study found that second-order features had the most robust ability to predict intracranial hypertension. The findings demonstrate the potential of radiomic feature analysis in clinical practice and further research.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Biochemistry & Molecular Biology
Guangshan Hao, Pinar Eser, Jun Mo
Summary: Intracranial hypertension is a common phenomenon in patients with aneurysmal subarachnoid hemorrhage and is associated with unfavorable outcomes. Recent research suggests that oxidative stress may play a crucial role in the physio-pathological changes leading to increased intracranial pressure.
Article
Medicine, General & Internal
Ki Hong Kim, Young Sun Ro, Hanna Yoon, Stephen Gyung Won Lee, Eujene Jung, Sung Bae Moon, Gwan Jin Park, Sang Do Shin
Summary: This study found that serum zinc levels in acute TBI patients are associated with long-term survival and neurological outcomes, with the low zinc group showing a higher risk of 6-month mortality and disability.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Dmitriy Petrov, Stephen P. Miranda, Ramani Balu, Connor Wathen, Alex Vaz, Vinodh Mohan, Christian Colon, Ramon Diaz-Arrastia
Summary: The objective of this study was to develop an algorithm capable of predicting the onset of intracranial pressure (ICP) crises in patients with severe traumatic brain injury (TBI). The random forest model demonstrated the highest accuracy and area under the curve (AUC) in predicting ICP crises. If implemented in clinical workflows, this algorithm can enable earlier intervention and more effective treatment of intracranial hypertension, potentially leading to improved outcomes for patients with severe TBI.
JOURNAL OF NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Tamas Kovacs-Oller, Renata Zempleni, Boglarka Balogh, Gergely Szarka, Balint Fazekas, Adam J. Tengolics, Krisztina Amrein, Endre Czeiter, Istvan Hernadi, Andras Buki, Bela Volgyi
Summary: Traumatic brain injury (TBI) is a major cause of sudden death after head trauma. The retina, as part of the brain, can also be affected by TBI, both in severe and mild-repetitive cases. Our study found that the level of inflammation and cell death in the retina differs between sTBI and rmTBI, indicating different response mechanisms. Therefore, the retina may serve as a model for studying head injuries and developing new diagnostic procedures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Brittany M. Stansbury, Caitlin J. Kelley, Robert F. Rudy, Sophia S. Bonnin, Kristina M. Chapple, Laura A. Snyder, Jordan A. Weinberg, Dih-Dih Huang
Summary: Traumatic brain injury (TBI) often leads to death or permanent disability, mainly due to secondary brain injury from intracranial hypertension (ICH). This study evaluated the efficacy of pentobarbital coma therapy in managing ICH and long-term functional outcomes. The results indicated that patients who did not respond immediately to pentobarbital coma therapy had poor outcomes, suggesting the need for alternative treatments or early intervention. In contrast, patients who responded quickly to pentobarbital coma therapy had excellent long-term outcomes.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Pharmacology & Pharmacy
Ting-Ting Li, Tian Sun, Yue-Zhen Wang, Qiang Wan, Wen-Zhi Li, Wan-Chao Yang
Summary: Inhalation of high-concentration hydrogen gas can improve traumatic brain injury (TBI)-induced acute lung injury (ALI) by reducing pulmonary edema, inflammation, and apoptosis. This study provides evidence for the potential use of hydrogen gas as a treatment for TBI-ALI patients in the ICU.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Kelly A. Fair, David H. Farrell, Belinda H. McCully, Elizabeth A. Rick, Elizabeth N. Dewey, Cole Hilliard, Rondi Dean, Amber Lin, Holly Hinson, Ronald Barbosa, Martin A. Schreiber, Susan E. Rowell
Summary: Traumatic intracranial hemorrhage is a significant cause of secondary brain injury in patients with traumatic brain injury. The severity of injury and D-dimer levels significantly differ between patients with and without PICH.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Critical Care Medicine
Jessica L. Nielson, Shelly R. Cooper, Seth A. Seabury, Davide Luciani, Anthony Fabio, Nancy R. Temkin, Adam R. Ferguson
Summary: Missing data is a significant challenge in TBI clinical research, with patterns arising from various factors. This review examines common missing data types in TBI research and evaluates statistical approaches, with a focus on recent innovations in missing values analysis. Real-world examples from TRACK-TBI pilot study and clinical trials demonstrate the application of statistical techniques to mitigate the impact of missing data and draw sound conclusions.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Critical Care Medicine
Lindsay D. Nelson, Jason K. Barber, Nancy R. Temkin, Kristen Dams-O'Connor, Sureyya Dikmen, Joseph T. Giacino, Mark D. Kramer, Harvey S. Levin, Michael A. McCrea, John Whyte, Yelena G. Bodien, John K. Yue, Geoffrey T. Manley
Summary: The study aimed to examine the construct validity of the BTACT in assessing TBI patients of different severities. Results showed that the BTACT is a promising, brief, phone-based cognitive screening tool for TBI patients, but its sensitivity to TBI severity is lower compared to comprehensive neuropsychological tests, suggesting it should not be used as a substitute for comprehensive, in-person cognitive tests.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Critical Care Medicine
Linda B. Xu, John K. Yue, Frederick Korley, Ava M. Puccio, Esther L. Yuh, Xiaoying Sun, Miri Rabinowitz, Mary J. Vassar, Sabrina R. Taylor, Ethan A. Winkler, Ross C. Puffer, Hansen Deng, Michael McCrea, Murray B. Stein, Claudia S. Robertson, Harvey S. Levin, Sureyya Dikmen, Nancy R. Temkin, Joseph T. Giacino, Pratik Mukherjee, Kevin K. W. Wang, David O. Okonkwo, Amy J. Markowitz, Sonia Jain, Geoffrey T. Manley, Ramon Diaz-Arrastia
Summary: The study found that hsCRP levels in TBI patients and orthopedic trauma controls rose between days 1 and 5, then fell within 2 weeks but remained higher compared to healthy controls. Within the first two weeks, hsCRP was significantly higher in patients with death/severe disability compared to those with moderate disability/good recovery, with the highest AUC at 2 weeks.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
John K. Yue, Diana Chang, Kasey J. Han, Albert S. Wang, Taemin Oh, Peter P. Sun
Summary: This article presents the challenges and nuances of managing multiple migrating intracranial fragments after a pediatric gunshot wound to the head. The case report describes a successful retrieval of fragments using adjustments in head of bed elevation and gravity assistance. The patient recovered well after the surgery.
Article
Clinical Neurology
John K. Yue, Diana Chang, Michael Travis Caton, Alexander F. Haddad, Cecilia L. Dalle Ore, Thomas A. Wozny, Taemin Oh, Albert S. Wang, Daniel A. Tonetti, Kurtis Auguste, Peter P. Sun, Daniel L. Cooke, Steven W. Hetts, Adib A. Abla, Nalin Gupta, Jarod L. Roland
Summary: This retrospective study reviewed the experience of using a hybrid neuroangiography surgical suite in pediatric facilities, demonstrating its safety and efficacy in reducing the number of procedures and improving the efficiency of care.
PEDIATRIC NEUROSURGERY
(2022)
Article
Clinical Neurology
Hansen Deng, Enyinna L. Nwachuku, Tiffany E. Wilkins, John K. Yue, Anita Fetzick, Yue-Fang Chang, Sue R. Beers, David O. Okonkwo, Ava M. Puccio
Summary: This study examined severe traumatic brain injury (TBI) survivors with favorable outcomes and found that the time to follow commands varied widely. Diffuse axonal injury, intraventricular hemorrhage, and infections may delay cognitive improvement. Patients showed considerable recovery up to 2 years after their injury.
Article
Critical Care Medicine
Yelena G. Bodien, Jason Barber, Sabrina R. Taylor, Kim Boase, John D. Corrigan, Sureyya Dikmen, Raquel C. Gardner, Joel H. Kramer, Harvey Levin, Joan Machamer, Thomas McAllister, Lindsay D. Nelson, Laura B. Ngwenya, Mark Sherer, Murray B. Stein, Mary Vassar, John Whyte, John K. Yue, Amy Markowitz, Michael A. McCrea, Geoffrey T. Manley, Nancy Temkin, Joseph T. Giacino
Summary: To assess the effects of traumatic brain injury (TBI), a multi-dimensional Flexible Outcome Assessment Battery (FAB) was designed, which assigns participants to different assessment groups based on a decision-making algorithm and guides test selection throughout recovery. The feasibility of FAB was demonstrated by a high proportion of participants completing the assessment and receiving valid scores. Furthermore, the level of function assessed by FAB at 2 weeks post-injury was associated with the GOSE scores at 6 and 12 months.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Andrew I. R. Maas, David K. Menon, Geoffrey T. Manley, Mathew Abrams, Cecilia Akerlund, Nada Andelic, Marcel Aries, Tom Bashford, Michael J. Bell, Yelena G. Bodien, Benjamin L. Brett, Andras Buki, Randall M. Chesnut, Giuseppe Citerio, David Clark, Betony Clasby, D. Jamie Cooper, Endre Czeiter, Marek Czosnyka, Kristen Dams-O'Connor, Veronique De Keyser, Ramon Diaz-Arrastia, Ari Ercole, Thomas A. van Essen, Eanna Falvey, Adam R. Ferguson, Anthony Figaji, Melinda Fitzgerald, Brandon Foreman, Dashiell Gantner, Guoyi Gao, Joseph Giacino, Benjamin Gravesteijn, Fabian Guiza, Deepak Gupta, Mark Gurnell, Juanita A. Haagsma, Flora M. Hammond, Gregory Hawryluk, Peter Hutchinson, Mathieu van der Jagt, Sonia Jain, Swati Jain, Ji-Yao Jiang, Hope Kent, Angelos Kolias, Erwin J. O. Kompanje, Fiona Lecky, Hester F. Lingsma, Marc Maegele, Marek Majdan, Amy Markowitz, Michael McCrea, Geert Meyfroidt, Ana Mikoli, Stefania Mondello, Pratik Mukherjee, David Nelson, Lindsay D. Nelson, Virginia Newcombe, David Okonkwo, Matej Oresic, Wilco Peul, Dana Pisica, Suzanne Polinder, Jennie Ponsford, Louis Puybasset, Rahul Raj, Chiara Robba, Cecilie Roe, Jonathan Rosand, Peter Schueler, David J. Sharp, Peter Smielewski, Murray B. Stein, Nicole von Steinbuchel, William Stewart, Ewout W. Steyerberg, Nino Stocchetti, Nancy Temkin, Olli Tenovuo, Alice Theadom, Ilias Thomas, Abel Torres Espin, Alexis F. Turgeon, Andreas Unterberg, Dominique Van Praag, Ernest van Veen, Jan Verheyden, Thijs Vande Vyvere, Kevin K. W. Wang, Eveline J. A. Wiegers, W. Huw Williams, Lindsay Wilson, Stephen R. Wisniewski, Alexander Younsi, John K. Yue, Esther L. Yuh, Frederick A. Zeiler, Marina Zeldovich, Roger Zemek
Article
Clinical Neurology
John K. Yue, Nishanth Krishnan, Lawrence Chyall, Alexander F. Haddad, Paloma Vega, David J. Caldwell, Gray Umbach, Evelyne Tantry, Phiroz E. Tarapore, Michael C. Huang, Geoffrey T. Manley, Anthony M. DiGiorgio
Summary: This study examined the relationship between hospital length of stay in traumatic brain injury (TBI) patients and risk factors, finding that prolonged stay was associated with younger age, severe injuries, low socioeconomic status, and type of health insurance.
WORLD NEUROSURGERY
(2022)
Article
Medicine, General & Internal
John K. Yue, Nishanth Krishnan, John H. Kanter, Hansen Deng, David O. Okonkwo, Ava M. Puccio, Debbie Y. Madhok, Patrick J. Belton, Britta E. Lindquist, Gabriela G. Satris, Young M. Lee, Gray Umbach, Ann-Christine Duhaime, Pratik Mukherjee, Esther L. Yuh, Alex B. Valadka, Anthony M. DiGiorgio, Phiroz E. Tarapore, Michael C. Huang, Geoffrey T. Manley
Summary: Neuroworsening is an early indicator of traumatic brain injury severity and a predictor of neurosurgical intervention and unfavorable outcome. Clinicians should be vigilant in detecting neuroworsening to provide immediate therapeutic interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Raquel C. Gardner, Ava M. Puccio, Frederick K. Korley, Kevin K. W. Wang, Ramon Diaz-Arrastia, David O. Okonkwo, Ross C. Puffer, Esther L. Yuh, John K. Yue, Xiaoying Sun, Sabrina R. Taylor, Pratik Mukherjee, Sonia Jain, Geoffrey T. Manley
Summary: Accurate blood-based biomarkers are needed for the diagnosis of traumatic brain injury in older adults. This study found that the blood-based biomarker glial fibrillary acidic protein has good to excellent performance in diagnosing traumatic brain injury until at least 3 days post-injury in all age groups. The addition of a blood-based diagnostic has the potential to streamline the diagnosis of traumatic brain injury.
BRAIN COMMUNICATIONS
(2022)
Meeting Abstract
Clinical Neurology
John K. Yue, Ryan R. L. Phelps, Debra P. Hemmerle, Pavan S. Upadhyayula, Ethan A. Winkler, Hansen Deng, Diana Chang, Mary Vassar, Sabrina Taylor, David Schnyer, Hester F. Lingsma, Ava Puccio, Esther Yuh, Pratik Mukherjee, Michael C. Huang, Laura B. Ngwenya, Alex B. Valadka, Amy Markowitz, David O. Okonkwo, Geoffrey T. Manley
Meeting Abstract
Clinical Neurology
John K. Yue, Firas Kobeissy, Zhihui Yang, Haiyan Xu, Hansen Deng, Kasey Han, Ava Puccio, Xiaoying Sun, Miri Rabinowitz, Amy Markowitz, David O. Okonkwo, Ramon Diaz-Arrastia, Geoffrey T. Manley, Kevin Wang
Meeting Abstract
Clinical Neurology
Hansen Deng, Enyinna Nwachuku, Tiffany Wilkins, John K. Yue, Anita L. Fetzick, Yue-Fang Chang, Sue Beers, David O. Okonkwo, Ava Puccio