Article
Clinical Neurology
Aleksandre Dvalishvili, Mirza Khinikadze, Giorgi Gegia, Lali Khutsishvili
Summary: The study observed the outcomes of the neuroendoscopic method for treating early-stage posthemorrhagic hydrocephalus and found that it is a safe and effective treatment option, reducing hospital stay and complications.
CHILDS NERVOUS SYSTEM
(2022)
Article
Clinical Neurology
Sruthi Ramagiri, Shelei Pan, Dakota DeFreitas, Peter H. Yang, Dhvanii K. Raval, David F. Wozniak, Prabagaran Esakky, Jennifer M. Strahle
Summary: Posthemorrhagic hydrocephalus is a common complication of intraventricular hemorrhage in infants. This study develops an animal model of intraventricular hemorrhage and demonstrates that administration of the iron chelator deferoxamine at the time of hemorrhage can prevent hydrocephalus and reduce iron levels in the choroid plexus. This treatment strategy may be clinically relevant for preventing neurological sequelae after intraventricular hemorrhage.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Andreas Schaumann, Christoph Buhrer, Matthias Schulz, Ulrich-Wilhelm Thomale
Summary: Neuroendoscopic procedures for neonatal hydrocephalus have gained popularity, with this study documenting 153 procedures in 116 infants over a 10-year period. Complications such as secondary infection, CSF fistula, and shunt dysfunction were observed, with a shunt survival rate of 74% within the first year of life. Ongoing studies are needed to assess the long-term benefits of neuroendoscopic techniques.
CHILDS NERVOUS SYSTEM
(2021)
Article
Neurosciences
Sara Diana Lolansen, Nina Rostgaard, Dagne Barbuskaite, Tenna Capion, Markus Harboe Olsen, Nicolas H. Norager, Frederik Vilhardt, Soren Norge Andreassen, Trine L. Toft-Bertelsen, Fenghui Ye, Marianne Juhler, Richard F. Keep, Nanna MacAulay
Summary: This study aimed to elucidate the molecular coupling between hemorrhagic events and the development of posthemorrhagic hydrocephalus (PHH), as well as the inflammatory profile of PHH pathogenesis. The findings suggest that excessive cerebrospinal fluid (CSF) secretion may contribute to PHH development, likely due to hyperactivity of choroid plexus transporters. Hemorrhage-induced inflammation detected in CSF and choroid plexus tissue may represent the underlying pathology of PHH.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Biochemistry & Molecular Biology
Sara Diana Lolansen, Nina Rostgaard, Tenna Capion, Nicolas H. Norager, Markus Harboe Olsen, Marianne Juhler, Tiit Illimar Mathiesen, Nanna MacAulay
Summary: The molecular mechanisms underlying the development of posthemorrhagic hydrocephalus (PHH) remain unclear, but elevated cerebrospinal fluid (CSF) osmolality is not the cause of PHH. The pathological CSF accumulation observed in these patients is instead attributed to other pathological alterations associated with the abnormal presence of blood within the CSF compartments following subarachnoid hemorrhage (SAH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Victor Garcia-Navarro, Carlos Perez-Vega, Pilar Robles-Lomelin, Paola Valdez-Sandoval, Paola M. Garnica Vazquez, Yazmin Lemus Rodriguez, Silvia G. Leon Cortes, Eva Chavana Naranjo
Summary: The study found that half of the patients with PHH who received early neurosurgical interventions had average or above average neurodevelopmental scores in all three areas. This suggests promising results for the implementation of this type of intervention based on current literature and ongoing clinical trials.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Clinical Neurology
Susan Honeyman, Alexandros Boukas, Jayaratnam Jayamohan, Shailendra Magdum
Summary: Neuroendoscopic lavage (NEL) is a safe and potentially effective treatment for neonatal IVH, reducing shunt dependence and potentially improving shunt survival for those requiring CSF diversion. Good motor and cognitive outcomes can be achieved neurodevelopmentally.
CHILDS NERVOUS SYSTEM
(2022)
Article
Clinical Neurology
Diego M. Morales, Christopher D. Smyser, Rowland H. Han, Jeanette K. Kenley, Joshua S. Shimony, Tara A. Smyser, Jennifer M. Strahle, Terrie E. Inder, David D. Limbrick
Summary: The study examined the relationship between diffusion magnetic resonance imaging (dMRI) and cerebrospinal fluid (CSF) biomarkers in preterm infants with posthemorrhagic hydrocephalus (PHH), finding elevated CSF biomarkers and differences in dMRI measures between PHH infants and controls. Specific associations were observed between dMRI and CSF biomarkers at the initiation of PHH treatment, suggesting potential for innovative methods to examine PHH-related white matter injury and developmental sequelae.
Article
Clinical Neurology
Miguel Saez-Alegre, Rocio Martin, Alexis Palpan, Fernando Carceller, Jesus Saez-Alegre, Guillermo Servera, Rudolf Bauer, Pablo Garcia Feijoo, Javier Saceda
Summary: This study developed a predictive algorithm using artificial intelligence techniques and classical statistics to predict the conversion of an Ommaya reservoir to a permanent shunt, achieving an accuracy of 86%.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Fenghui Ye, Ya Hua, Richard F. Keep, Guohua Xi, Hugh J. L. Garton
Summary: Blocking CD47 in the hematoma accelerated hematoma clearance and alleviated hemolysis and hydrocephalus development after intraventricular hemorrhage, suggesting CD47 might be valuable in the future treatment for IVH. Erythrophagocytosis was observed as soon as 4 h after IVH and was enhanced on day 3. CD47 blockade also upregulated intra-hematoma infiltration of CD68, heme oxygenase-1 and ferritin positive phagocytes by day 3.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Clinical Neurology
Yi Cao, Chang Liu, Gaowei Li, Weina Gao, Hui Tang, Shuanmin Fan, Xin Tang, Long Zhao, Haoxiang Wang, Aijun Peng, Chao You, Aiping Tong, Liangxue Zhou
Summary: Metformin has been found to attenuate neuroinflammation and subsequent fibrosis after intraventricular hemorrhage, thereby reducing the occurrence of delayed hydrocephalus. It exerts its effects through regulating the AMPK/SIRT1/NF-kappa B pathways.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Assem Shakeyeva, Vasilyi Kuzmin, Vasilyi Lozovoy
Summary: This study aimed to improve the diagnosis and treatment methods for posthemorrhagic hydrocephalus in infants. Through clinical and laboratory examinations and statistical analysis, it was found that complications were more common in premature and low birth weight infants, and multiple puncture drainage procedures had a higher risk of complications such as infection and catheter occlusion. The proposed diagnostic and treatment algorithm significantly reduced complications, shortened hospital stays, and improved the quality of life.
PEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Kelly B. Mahaney, Chandana Buddhala, Mounica Paturu, Diego M. Morales, Christopher D. Smyser, David D. Limbrick, Santosh E. Gummidipundi, Summer S. Han, Jennifer M. Strahle
Summary: This study found that neonates with severe initial ventriculomegaly had higher initial levels and prolonged clearance of cerebrospinal fluid hemoglobin and hemoglobin degradation products compared to those with moderate initial ventriculomegaly, indicating a more severe early ventricular enlargement.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2022)
Review
Clinical Neurology
Atsuko Harada
Summary: In recent years, there has been an increasing trend in performing endoscopic third ventriculostomy with or without choroid plexus cauterization as a permanent treatment for posthemorrhagic hydrocephalus (PHH). This paper provides a review of the latest evidence on the permanent treatment options for PHH.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2023)
Article
Neurosciences
Miriam Zamorano, Scott D. Olson, Candice Haase, Juan J. Herrera, Shuning Huang, David J. Sequeira, Charles S. Cox Jr, Brandon A. Miller
Summary: Inflammation and white matter injury are consequences of neonatal intraventricular hemorrhage (IVH). The effects of IVH occurring at different developmental time points in the same model have not been examined. Understanding how the timing of IVH affects outcome may provide important insights into both IVH pathophysiology and innate immune development.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Maria R. Mang de la Rosa, Ayse Safaltin, Paul -Georg Jost-Brinkmann, Annette Aigner, Petra Julia Koch
Summary: The study aimed to compare the transfer accuracy of five different surgical guides (SGs) for orthodontic mini-implants (OMIs) in the anterior palate. Ten maxillary patient models and corresponding lateral cephalograms were virtually matched to plan the OMI position. Three 3D-printed and two conventional SGs were manufactured, and a total of 96 OMIs were transferred and compared. The results showed that conventional SGs had higher accuracy compared to 3D-printed SGs, but the latter can still provide sufficient accuracy for palatal OMI placement.
ANGLE ORTHODONTIST
(2023)
Review
Pharmacology & Pharmacy
Priyanga Ranasinghe, Melisande L. Addison, James W. Dear, David J. Webb
Summary: Post-transcriptional gene silencing can be achieved through siRNA therapy, which uses synthetic short double-stranded RNA molecules to specifically target and degrade mRNA transcripts. This technology offers advantages such as broad targeting capabilities and long-lasting effects. However, challenges in terms of pharmacokinetics and pharmacodynamics have been addressed through chemical modification and delivery systems. Several siRNA therapies have been approved for clinical use, but further advancements are needed to target organs beyond the liver and reach special sites.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Michael Karimov, Marlene Scherer, Heike Franke, Alexander Ewe, Achim Aigner
Summary: A three-dimensional tissue slice air-liquid interface (ALI) culture model was developed for nanoparticle testing, which showed clearer differences in transfection efficacy and cytotoxicity compared to 2D cell culture. This model allows for the evaluation of biological nanoparticle efficacy and biocompatibility in an intact tissue environment, providing a cost-effective and time-saving alternative.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Chemistry, Medicinal
Lukas Heyder, Phil M. M. Hochban, Corey Taylor, Florent Chevillard, Christof Siefker, Christian Iking, Hannes Borchardt, Achim Aigner, Gerhard Klebe, Andreas Heine, Peter Kolb, Wibke E. Diederich
Summary: In this study, fragment-sized hits binding to Pim-1 kinase were optimized using a combination of computational, synthetic, and crystallographic expertise. The resulting potent ligands target rarely-targeted regions of Pim-1 kinase with affinities in the nanomolar range. The combination of computational and experimental approaches successfully developed a novel molecular scaffold for inhibition of Pim-1 kinase, targeting specific surface regions that have been less frequently investigated.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Entomology
Nagalapura Ramakrishnappa Prasannakumar, Vala Keshava Rao, Nagendraiah Jyothi, Sarikonda Saroja, Ankanahalli Naranayanashetty Lokesha, Govindaraju Ramkumar
Summary: Aphids, thrips, whiteflies, mealy bugs, and mites can cause significant crop losses. This study found that extracts from the seeds of Annona squamosa and Sapindus mukorossi have insecticidal properties against these pests, making them potential botanicals for safe pest management in organic farming.
JOURNAL OF APPLIED ENTOMOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shinan Geng, Mengqin Guo, Guiting Zhan, Dingwen Shi, Liyun Shi, Lu Gan, Yanbing Zhao, Xiangliang Yang
Summary: A NIR light-triggered dePEGylation/ligand-presenting strategy based on thermal decomposition of azo bonds is developed in this study. It overcomes the PEG dilemma and improves tumor targeting and drug delivery by enhancing cellular uptake and tumor accumulation.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Analytical
Maria Sokol, Ivan Gulyaev, Mariia Mollaeva, Sergey Kuznetsov, Vladimir Zenin, Maksim Klimenko, Nikita Yabbarov, Margarita Chirkina, Elena Nikolskaya
Summary: The combinatorial administration of vorinostat and genotoxic agents enhances their antitumoral action against tumors. To support this, a high-performance liquid chromatography method was developed for the simultaneous determination of doxorubicin and vorinostat in polymeric nanoparticles. The method was precise and accurate, and could be adopted for routine analysis of the drugs in nanoparticles.
JOURNAL OF SEPARATION SCIENCE
(2023)
Review
Urology & Nephrology
Verena Sailer, Gunhild von Amsberg, Stefan Duensing, Jutta Kirfel, Verena Lieb, Eric Metzger, Anne Offermann, Klaus Pantel, Roland Schuele, Helge Taubert, Sven Wach, Sven Perner, Stefan Werner, Achim Aigner
Summary: Androgen deprivation therapy is important in treating advanced prostate cancer, but there is a need for novel treatment approaches. It is crucial to critically assess current preclinical models in order to understand tumor progression and resistance better.
NATURE REVIEWS UROLOGY
(2023)
Review
Chemistry, Multidisciplinary
Anisha D'Souza, Saeideh Nozohouri, Benjamin S. Bleier, Mansoor M. Amiji
Summary: Nucleic acid-based therapeutic molecules have great potential for treating diseases in the CNS, but delivering them to the brain's target cells and sub-cellular compartments is a challenge. This review discusses the challenges and recent advances in cellular and sub-cellular delivery using various mechanisms and routes of administration.
PHARMACEUTICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Thomas Foster, Michael Lewkowicz, Christina Quintas, Corina Mihaela Ionescu, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Elaine Y. M. Wong, Armin Mooranian, Hani Al-Salami
Summary: Hearing loss is a significant issue worldwide, and gene delivery and nanoencapsulation technology may provide effective means for treatment.
Article
Oncology
Luis Alberto Bravo-Vazquez, Natalia Frias-Reid, Ana Gabriela Ramos-Delgado, Sofia Madeline Osorio-Perez, Hania Ruth Zlotnik-Chavez, Surajit Pathak, Antara Banerjee, Anindya Bandyopadhyay, Asim K. Duttaroy, Sujay Paul
Summary: MicroRNAs and long non-coding RNAs play a crucial role in the development and progression of pancreatic cancer. Their dysregulation is associated with chemoresistance and tumor growth, and they have the potential to be used as biomarkers for accurate diagnosis and as therapeutic targets.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Madlen Schranz, T. Sonia Boender, Timo Greiner, Theresa Kocher, Birte Wagner, Felix Greiner, Jonas Bienzeisler, Michaela Diercke, Linus Grabenhenrich, Annette Aigner, Alexander Ullrich
Summary: During the COVID-19 pandemic in Germany, there was a significant decrease in the number of patients seeking emergency care, especially during the first and second waves. The decrease was more prominent among younger age groups and less severe cases. This decrease in emergency department consultations is important to understand in order to ensure that patients receive the necessary care during future pandemics or public health crises.
Article
Clinical Neurology
Frederik Bartels, Birgit Baumgartner, Annette Aigner, Graham Cooper, Astrid Blaschek, Eva Maria Wendel, Annikki Bertolini, Michael Karenfort, Matthias Baumann, Robert Cleaveland, Andreas Wegener-Panzer, Steffen Leiz, Michela Salandin, Peter Krieg, Tobias Reindl, Markus Reindl, Carsten Finke, Kevin Rostasy
Summary: This observational cohort study found that patients with acute disseminated encephalomyelitis (ADEM) showed reduced brain volume at onset and over time, with a more pronounced reduction in brain volume for MOG-negative patients compared to MOG-positive patients, and relapsing MOG-positive patients showed additional brain volume loss.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Medicine, Research & Experimental
Laure Bosquillon de Jarcy, Bengisu Akbil, Baxolele Mhlekude, Johanna Leyens, Dylan Postmus, Greta Harnisch, Jenny Jansen, Marie L. Schmidt, Annette Aigner, Fabian Pott, Robert Lorenz Chua, Lilian Krist, Roberta Gentile, Barbara Muehlemann, Terence C. Jones, Daniela Niemeyer, Julia Fricke, Thomas Keil, Tobias Pischon, Juergen Janke, Christian Conrad, Stefano Iacobelli, Christian Drosten, Victor M. Corman, Markus Ralser, Roland Eils, Florian Kurth, Leif Sander, Christine Goffinet
Summary: The expression levels of 90K/LGALS3BP protein were found to be elevated in COVID-19 patients. The SARS-CoV-2 infection inhibited the levels of PBMC-associated 90K protein, suggesting increased release into the extracellular space. Monocyte-specific induction of LGALS3BP mRNA expression was also observed in COVID-19 patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Winna Lim, Elisa Birgit Sodemann, Laura Buettner, Martin Jonczyk, Willie Magnus Luedemann, Johannes Kahn, Dominik Geisel, Henning Jann, Annette Aigner, Georg Boening
Summary: SCT-derived iodine content was found to be associated with tumor response in metastasized NETs, with patients having higher iodine content in lymphonodular metastases having lower odds for disease progression. However, the opposite trend was observed in hepatic and pancreatic metastases.