Article
Clinical Neurology
Carolin Hoyer, Christian Kahlert, Resul Guney, Frank Schlichtenbrede, Michael Platten, Kristina Szabo
Summary: This retrospective study analyzed the medical records of patients with CRAO treated in a stroke unit, revealing an increasing trend in admission rate and thrombolysis rate. However, a large proportion of patients did not receive timely treatment within the optimal time window, predominantly due to prehospital delay to presentation.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Florian Philipp Raber, Florian Vincent Gmeiner, Jens Dreyhaupt, Armin Wolf, Albert Christian Ludolph, Jens Ulrich Werner, Jan Kassubek, Katharina Althaus
Summary: This study aimed to investigate the feasibility, efficacy, and safety of intravenous thrombolysis (IVT) in functionally blind patients with non-arteritic central retinal artery occlusion (NA-CRAO). The results showed that early IVT therapy within 4.5 hours of symptom onset might be a potential treatment option for NA-CRAO. MRI should be performed in all patients for optimized treatment and secondary stroke prevention.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Wesley Chan, Alexis M. Flowers, Benjamin Meyer, Beau B. Bruce, Nancy J. Newman, Valerie Biousse
Summary: Patients with acute central retinal artery occlusion (CRAO) often present late, leading to delayed diagnosis. Those presenting within 24 hours are more likely to be admitted and receive comprehensive stroke work-up. Only a small number of patients received intravenous thrombolysis.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Review
Clinical Neurology
Lele Huang, Yujie Wang, Ruijun Zhang
Summary: Intravenous thrombolysis with alteplase may be effective and safe for patients with central retinal artery occlusion (CRAO), leading to improved best-corrected visual acuity. However, ocular-specific complications unrelated to thrombolysis may affect final visual outcomes.
JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Daniel A. Wenzel, Sven Poli, Maria Casagrande, Vasyl Druchkiv, Martin S. Spitzer, Karl Ulrich Bartz-Schmidt, Carsten Grohmann, Maximilian Schultheiss
Summary: This study investigated the correlation between inner retinal hyperreflectivity and acute central retinal artery occlusion (CRAO) using optical coherence tomography (OCT). The results showed a strong correlation between inner retinal hyperreflectivity and CRAO, suggesting that it could serve as a potential biomarker for prompt diagnosis of CRAO.
FRONTIERS IN MEDICINE
(2022)
Article
Neuroimaging
Jongshin Kim, Seunguk Jung, Kyu Hyung Park, Se Joon Woo, Cheolkyu Jung
Summary: The study found a significant correlation in the severity of steno-occlusive lesions between the OphA and the ipsilateral CA in patients with CRAO. Patients with less severe angiographic features in the CA showed improved retinal reperfusion after IAT. The angiographic findings in the CA may serve as a predictive marker for vessel integrity of the OphA and recanalization outcome after IAT.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Medicine, General & Internal
Maria Casagrande, Nils Alexander Steinhorst, Susanne Kathrin Dippel, Fabian Kueck, Carsten Grohmann, Martin S. Spitzer, Sven Poli, Nicolas Feltgen, Maximilian Schultheiss
Summary: This study investigates the sensitivity and specificity of the CRAO-Detection Score in diagnosing CRAO without requiring fundoscopy. The questionnaire can be used as a screening tool to detect CRAO patients, which is crucial for prompt diagnosis and treatment of CRAO.
FRONTIERS IN MEDICINE
(2023)
Article
Clinical Neurology
Brian Mac Grory, Sean R. Landman, Paul D. Ziegler, Chantal J. Boisvert, Shane P. Flood, Christoph Stretz, Tracy E. Madsen, Michael E. Reznik, Shawna Cutting, Elizabeth E. Moore, Hunter Hewitt, James B. Closser, Jose Torres, Patrick J. Lavin, Karen L. Furie, Ying Xian, Wayne Feng, Valerie Biousse, Matthew Schrag, Shadi Yaghi
Summary: The study found that the cumulative incidence of new atrial fibrillation (AF) after central retinal artery occlusion (CRAO) was approximately 49.6% at 2 years. Patients with CRAO had a higher risk of developing AF compared to controls and a similar risk to patients with stroke. CRAO was also associated with an increased incidence of new stroke.
Article
Clinical Neurology
Laura Donaldson, Patrick Nicholson, Edward Margolin
Summary: Central retinal artery occlusion (CRAO) leads to rapid vision loss and poor visual outcomes. Two cases of CRAO occurring after cataract surgery were reported, with significant improvement in vision after intra-ophthalmic artery fibrinolysis administered within a few hours of symptom onset.
JOURNAL OF NEURO-OPHTHALMOLOGY
(2023)
Article
Clinical Neurology
Dong-Wan Kang, Keun-Hwa Jung, Wookjin Yang, Hyeong Min Kim, Youngjoon Kim, Matthew Chung, Jiyeon Ha, Monique Therese Punsalan, Eung-Joon Lee, Han-Yeong Jeong, Jeong-Min Kim, Sang-Bae Ko, Seung-Hoon Lee
Summary: This study investigated the impact of embolic sources on outcomes in central retinal artery occlusion (CRAO) patients, finding that patients with embolic sources were more likely to experience visual improvement.
Article
Clinical Neurology
Jay B. B. Lusk, Ailin Song, Shakthi Unnithan, Hussein R. R. Al-Khalidi, Alen Delic, Adam de Havenon, Valerie Biousse, Matthew Schrag, Sven Poli, Jonathan P. P. Piccini, Ying Xian, Emily C. C. O'Brien, Brian Mac Grory
Summary: This retrospective observational cohort study found an inverse association between atrial fibrillation (AF) and central retinal artery occlusion (CRAO) in a large representative sample of hospitalized patients. This study contributes to our understanding of the relationship between AF and CRAO.
Article
Medicine, General & Internal
Jerzy Dropinski, Radoslaw Dziedzic, Agnieszka Kubicka-Trzaska, Bozena Romanowska-Dixon, Teresa Iwaniec, Lech Zareba, Jan G. Bazan, Agnieszka Padjas, Stanislawa Bazan-Socha
Summary: This study investigated vascular endothelial dysfunction, arterial wall atherosclerotic alterations, and cardiac function in CRAO patients and found that these markers were associated with CRAO. Therefore, non-invasive ultrasound assessments may be helpful for patients with increased risk of CRAO.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Shima Shahjouei, Reza Bavarsad Shahripour, Oana M. Dumitrascu
Summary: Thrombolytic therapy with tissue plasminogen activator (tPA) can improve visual recovery in non-arteritic central retinal artery occlusion (naCRAO) patients. The efficacy of intravenous thrombolysis (IVT) or intra-arterial thrombolysis (IAT) in naCRAO is still uncertain. Early treatment with tPA is associated with enhanced visual outcomes in naCRAO.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Haitao Hu, Bing Zhang, Yuqi Zhao, Huan Zhou, Hongfang Chen, Shenqiang Yan
Summary: The meta-analysis showed that intra-arterial thrombolysis (IAT) can be an effective treatment option for patients with acute nonarteritic central retinal artery occlusion (CRAO) within 6 hours from symptom onset, leading to improved visual outcomes.
EUROPEAN NEUROLOGY
(2022)
Review
Medicine, General & Internal
J. C. Lin, S. Song, S. M. Ng, I. U. Scott, P. B. Greenberg
Summary: This study aimed to assess the effects of treatments for acute non-arteritic CRAO. By analyzing six randomized controlled trials, the study found that there is no generally agreed upon treatment regimen for CRAO, and large, well-designed clinical trials are needed to determine the most effective treatment.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)