Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 8, Pages 2416-2424Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c00291
Keywords
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Funding
- National Natural Science Foundation [21532007]
- Drug Innovation Major Project, MOST [2018ZX09711001-001-005]
- Biological Resources Program, CAS, of People's Republic of China [KFJ-BRP-008]
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An ethanol extract of the powdered twigs of Podocarpus imbricatus afforded 14 new diterpenoids (1-14), which all share an aromatized C ring. These isolates belong to five diterpenoid types that include abietanes (1-3), semperviranes (4-9), totaranes (10-12), a C-17 norabietane (13), and an icetexane (14). Their structures were assigned mainly by analysis of the spectroscopic data, and the absolute configuration of 1 was determined by X-ray crystallography. A biosynthetic pathway for five of the biogenetically related types of diterpenoids was proposed. Compound 7 showed moderate inhibitory activity against Zika virus with an IC50 value of 2.5 mu M.
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