Zn, Cd and Hg complexes with unsymmetric thiourea derivatives; syntheses, free radical scavenging and enzyme inhibition essay

Unsymmetrical thiourea of general formula RR'C=S where R not equal R', were prepared by treating phenyi- sothiocayanate with iso-butylamine and tert-butylamine and respective thiourea derivatives, iso-butylphenylthiourea (1) and tert-butylphenylthiourea (2) were obtained. These ligands were treated with ZnCl2, CdCl2 and Hgl(2) and neutral complexes bis(isobutylphenylthiourea)dichlorozinc(II) 3, bis(tert-butylphenylthiourea)dichlorozinc(II) 4, bis(isobutylphenylthiourea)dichlorocadmium(II) 5, bis(tert-butylphenylthiourea)dichl orocadmium(II) 6, bis(isobutylphenylthiourea)diiodomercurry(II) 7, bis(tert-butylphenyl thiourea)diiodomercurry(II) 8 were obtained. All compounds were structurally characterized with the help of FT-IR and NMR (H-1 and C-13) spectroscopy. Compounds 2, 3, 5, 7 are crystalline and their structure was confirmed by SC-XRD. Complexes and their starting precursors were evaluated for their antioxidant and enzyme inhibition potentials. Some of the compounds exhibited excellent antioxidant potentials. Molecular docking studies were also carried out for compounds 1-8. (C) 2020 Elsevier B.V. All rights reserved.