Article
Environmental Sciences
Manikandan Rajendran, Selvaraj Barathi, Maryium Sajjad, Gadah Albasher, Jintae Lee
Summary: Arsenic remediation is a serious global issue. Carbon-encapsulated Fe nanoparticle composites (Fe/C CNPs) were synthesized and their adsorption behavior was investigated. The results suggest that Fe/C CNPs can be used for the remediation of arsenic-contaminated water.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Deva Nand Sharma, Anil Yadav
Summary: This paper presents a novel adsorbent, Chhotidudhi, for the removal of nickel ions from aqueous solutions. The adsorbent was characterized using FTIR, XRD, SEM, and TGA. The adsorbent showed strong bond with metals and had an amorphous structure with a porous morphology. At optimized conditions, the adsorption capacity for the adsorbent was 52.4 mg/g and 109.05 mg/g, with removal efficiencies of 81.6% and 93.8% for ETR and ETA, respectively. The experimental results fit well with Langmuir and pseudo-second-order reactions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Physical
Tariq A. Altalhi, Mohamed M. Ibrahim, Gaber A. M. Mersal, M. H. H. Mahmoud, Tushar Kumeria, Mohamed G. El-Desouky, Ashraf A. El-Bindary, Mohamed A. El-Bindary
Summary: In this study, mango seeds activated carbon (MSAC) nanoparticles were prepared with high biocompatibility for potential use as drug carriers. The experimental results showed that the nanocomposite significantly enhanced the adsorption performance of the anti-cancer drug DOX, indicating its potential in drug delivery applications.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Engineering, Chemical
Khlood S. Abou-Melha, Gamil A. A. Al-Hazmi, Ismail Althagafi, Reem Shah, Fathy Shaaban, Nashwa M. El-Metwaly, Ashraf A. El-Bindary
Summary: In this study, copper oxide (CuO) nanoparticles were successfully synthesized by thermal treatment of Cu(II) organometallic complex at temperatures up to 650 degrees C. The synthesized CuO nanoparticles were characterized using various spectroscopic techniques. Adsorption of acid red 57 onto CuO nanoparticles followed Langmuir isotherm, with a pseudo-second-order rate expression and chemisorption nature. Thermodynamic analysis revealed the endothermic and spontaneous nature of the adsorption process.
DESALINATION AND WATER TREATMENT
(2021)
Article
Engineering, Chemical
Bhaswati Devi, Netra Prova Baruah, Anasuya Bharadwaj, Arundhuti Devi
Summary: Elimination of excessive fluoride from the environment is a serious issue nowadays. In this study, a novel activated carbon supported tetrametallic oxide hybrid system was developed for fluoride removal. The adsorption performance of the system was investigated and it was found to follow Freundlich isotherm and pseudo-second order kinetics, indicating both physical and chemical adsorption mechanisms.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)
Article
Engineering, Environmental
Ataollah Babakhani, Majid Sartaj
Summary: This study successfully removed cadmium from aqueous solution using Cd(II)-imprinted chitosan hydrogel beads. The synthesis was confirmed through various analyses, and the adsorption process parameters and mechanisms were determined through batch adsorption tests and isotherm investigations.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Environmental Sciences
Fazal Haq, Arshad Farid, Naveed Ullah, Mehwish Kiran, Rizwan Ullah Khan, Tariq Aziz, Sahid Mehmood, Muhammad Haroon, Muhammad Mubashir, Awais Bokhari, Lai Fatt Chuah, Pau Loke Show
Summary: This study focused on the removal of methylene blue from aqueous solution using Car-St-g-PVP as a cost-effective and biodegradable adsorbent. The experimental results showed that the adsorption process followed pseudo 2nd order kinetics and Langmuir's adsorption isotherms, indicating a chemisorption mechanism. Thermodynamic studies revealed a spontaneous nature of the adsorption process, with increasing randomness and endothermic nature as indicated by positive entropy and enthalpy values. The separation factor (RL) was less than one, confirming the feasibility of the adsorption process. Overall, Car-St-g-PVP demonstrated high efficiency in removing methylene blue and could be a promising option for wastewater treatment.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Asha Singh, Dinesh Arora, Renu Bala, Anil Khokhar, Sunil Kumar
Summary: In this study, nanoparticles prepared from aquatic plants Salvinia molesta and Typha latifolia were loaded onto powdered form to create nanocomposite adsorbents for wastewater treatment. The adsorption capacity, optimal working conditions, and mechanisms of the novel adsorbents were evaluated.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Asma Nasrullah, Amir Sada Khan, A. H. Bhat, Israf Ud Din, Abrar Inayat, Nawshad Muhammad, Esraa M. Bakhsh, Sher Bahadar Khan
Summary: The study investigates the effects of short time ball milling on activated carbon synthesized from mangosteen peels waste, and its adsorption capability for methylene blue dye. Results showed that ball milling decreases particle size of activated carbon, increases adsorption efficiency, and is influenced by pH, contact time, and temperature.
Article
Chemistry, Physical
Ghaferah H. Al-Hazmi, Moamen S. Refat, Khaled F. Alshammari, Khadiza Tul Kubra, Ahmed Shahat
Summary: A simple synthesis method was used to prepare mesoporous alumina nanorods, which exhibited a high adsorption capacity for the anti-cancer medication DOX. The adsorption behavior of DOX on the alumina nanorods was evaluated under different conditions, and the Langmuir adsorption model was found to fit the data well. The adsorption kinetics followed a pseudo-second-order model, and the adsorption process was endothermic and spontaneous. The alumina nanorods also showed good adsorption performance for DOX in real water samples and could be used for wastewater treatment.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Engineering, Chemical
Lei Hu, Shunhui Tao, Junting Xian, Xiaodong Zhang, Yao Liu, Xiaojie Zheng, Xiaoqing Lin
Summary: In this study, three kinds of amide functional group modified hyper-cross-linked adsorption resin were synthesized and evaluated for their adsorption performance and selectivity towards 5-hydroxymethylfurfural (5-HMF). The poly (BDM-alt-DVB) resin showed the highest adsorption capacity and excellent selectivity, as well as good reusability. This study is significant for the separation of 5-HMF hydrolysate.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Engineering, Chemical
Ghaferah H. Al-Hazmi, Moamen S. Refat, Mohamed G. El-Desouky, Farouk K. M. Wali, Ashraf A. El-Bindary
Summary: Nickel oxide nanoparticles were synthesized and used for the adsorption of acid yellow 99 (AY99). The experimental results showed that NiO had a good adsorption effect on AY99, which could meet the requirements of practical applications.
DESALINATION AND WATER TREATMENT
(2022)
Article
Multidisciplinary Sciences
Shah Raj Ali, Abul Kalam, Abdullah G. Al-Sehemi, Zenab Khan, Sadaf Ansari, Naved Haider, Rajesh Kumar
Summary: Nanostructured iron-zirconium oxides (NIZOs) exhibit high adsorption efficiency towards Pb(2+) from aqueous solution, following Langmuir model. The adsorption process is spontaneous, exothermic, mediated by weak van der Waals forces, and conforms to pseudo-second-order kinetics.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2021)
Article
Chemistry, Physical
Hala A. Kiwaan, Farid Sh Mohamed, Ashraf A. El-Bindary, Naser A. El-Ghamaz, Heba R. Abo-Yassin, Mohamed A. El-Bindary
Summary: The study focused on the synthesis and characterization of metal organic frameworks, particularly the zeolitic imidazolate framework-7 (ZIF-7), and its adsorption behavior with dyes. The research analyzed the impact of various variables on batch processing, identified optimal test conditions, and investigated adsorption kinetics and thermodynamics. The study also explored the AC electrical conductivity of ZIF-7.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
N. Hassan, A. Shahat, I. M. El-Deen, M. A. M. El-Afify, M. A. El-Bindary
Summary: This research successfully prepared hexahedral NH2-MIL88(Fe) metal-organic framework using solvothermal technique, and studied its adsorption performance for cationic and anionic dyes in water. The results showed that NH2-MIL88(Fe) exhibited excellent adsorption for methylene blue (MB) and acid red 57 (AR57). By applying different adsorption and kinetic models, the detailed adsorption mechanism and thermodynamic characteristics of the adsorption reactions were analyzed.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
M. A. El-Bindary, M. G. El-Desouky, A. A. El-Bindary
Summary: Efficient date seed activated carbon was prepared through activation treatment using date seed powder. The activated carbon exhibited excellent iodine adsorption performance, surpassing commercial activated carbon. The adsorption conditions of malachite green from aqueous solutions were investigated, and the Langmuir isotherm was found to be suitable for the adsorption process. The adsorption was chemisorption, endothermic, and unpredictable.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Applied
Mohamed A. El-Bindary, Ashraf A. El-Bindary
Summary: Metal(II) chelates of Co2+, Ni2+, and Cu2+ can be produced from 2-(4-sulfadiazine)hydrazono dimedone (HL). These chelates have different structures and chemical properties, and they influence DNA linking activity, cancer cell inhibition, and antimicrobial effects.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Ola A. El-Gammal, Ashraf A. El-Bindary, Farid Sh Mohamed, Ghada N. Rezk, Mohamed A. El-Bindary
Summary: This study investigates the properties of a novel Schiff base and its complexes with Co(II), Ni(II), and Cu(II) metals using various analysis methods. The research covers structural characterization, thermodynamic properties, DNA binding, antioxidant activity, and antibacterial action. The potential of the compound in combating COVID-19 and prostate cancer is evaluated through its interaction with the SARS-CoV-2 main protease.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Gamil A. A. S. AlHazmi, Khlood G. AbouMelha, Mohamed A. El-Desouky, Ashraf El-Bindary
Summary: Zirconium metal organic framework (Zr-MOF) was synthesized by hydrothermal method, and various spectroscopic methods were used for sample characterization. The adsorption of doxorubicin (DOX) onto Zr-MOF was studied. The effects of DOX concentration, contact time, solution pH, and temperature were investigated. The surface properties of Zr-MOF were determined by scanning electron microscopy (SEM). The adsorption efficiency of Zr-MOF for DOX was found to be higher at pH 6. The equilibrium isotherms and kinetic data were described using different adsorption models. The docking interactions between DOX and lung cancer and liver cancer receptors were evaluated.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Applied
Mohamed A. El-Bindary, Mohamed G. El-Desouky, Ashraf A. El-Bindary
Summary: Metal-organic framework (MOF) hybrid materials, specifically Zr-MOF with encapsulated doxorubicin (DOX@Zr-MOF), have shown promising results in pH-responsive drug release and enhanced cytotoxicity against cancer cells. This simple one-pot approach could potentially serve as a multifunctional drug delivery vehicle for various applications, including cancer treatment. Further studies are needed to explore the potential of DOX@Zr-MOF in targeting specific cancer types and antimicrobial activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
M. G. El-Desouky, A. A. El-Bindary, M. A. M. El-Afify, N. Hassan
Summary: The global community is currently facing the COVID-19 pandemic, caused by the SARS-CoV-2 virus. Scientists are researching potential drug candidates by screening ligands and drugs for structure-based design and docking to the main viral protease. Additionally, complexes of Cu(II), Ni(II), Zn(II), and Mn(II) with a specific ligand were synthesized and characterized.
INORGANIC AND NANO-METAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ghaferah H. Al-Hazmi, Mohamed G. El-Desouky, Ashraf A. El-Bindary
Summary: Zinc oxide nanoparticles were produced at various calcination temperatures, with high surface area and small particle radius. The Williamson-Hall technique and size-strain approach were used to measure crystallite size and strain in ZnO nanoparticles. The experimental results, based on SEM and XRD, showed good agreement in crystal size of ZnO NPs prepared at different calcination temperatures.
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA
(2022)
Article
Chemistry, Applied
Mahmoud E. E. Awad, Amr M. M. Farrag, Ashraf A. A. El-Bindary, Mohamed A. A. El-Bindary, Hala A. A. Kiwaan
Summary: In this study, a simple technique for the production of TiO2-QDs-Kao photocatalyst was reported. The photocatalyst exhibited excellent degradation efficiency for RhB dye under visible light. The mechanism of photocatalytic degradation was based on the transport of electrons and holes. Additionally, the photocatalyst showed high stability and reusability.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Walied A. A. Mohamed, Waleed M. Saad, Farid Sh. Mohamed, Ashraf A. El-Bindary
Summary: Three types of titanium dioxide quantum dots (TQDs) samples were synthesized at low calcination temperatures using a modified precipitation method. The samples were characterized and evaluated for their photocatalytic activity and application in real industrial effluent treatment.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Multidisciplinary Sciences
Ghada N. Rezk, Ola A. El -Gammal, Salhah H. Alrefaee, Ismail Althagafi, Ashraf A. El-Bindary, Mohamed A. El-Bindary
Summary: A hydrazone ligand was successfully created by combining hydrazide with 2-Acetylpyridine. Copper (II) hydrazone complexes were synthesized using various copper (II) salts and studied using analytical techniques. The complexes exhibited tridentate behavior and octahedral geometries. Their properties were analyzed through computational calculations and experimental assays, revealing potential antimicrobial and antioxidant effects.
Article
Engineering, Chemical
Ghaferah H. Al-Hazmi, Moamen S. Refat, Mohamed G. El-Desouky, Farouk K. M. Wali, Ashraf A. El-Bindary
Summary: Nickel oxide nanoparticles were synthesized and used for the adsorption of acid yellow 99 (AY99). The experimental results showed that NiO had a good adsorption effect on AY99, which could meet the requirements of practical applications.
DESALINATION AND WATER TREATMENT
(2022)
Review
Engineering, Chemical
M. G. El-Desouky, M. A. G. Khalil, M. A. M. El-Afify, A. A. El-Bindary, M. A. El-Bindary
Summary: This article discusses the serious pollution problem of organic dyes in wastewater, compares several dye removal processes, and focuses on the latest developments in porous materials for organic dye adsorption. The article also explores the importance of dye wastewater treatment and various characteristics and treatment methods for dyes.
DESALINATION AND WATER TREATMENT
(2022)
Article
Chemistry, Applied
Ashraf A. El-Bindary, Mohamed G. El-Desouky, Maher A. M. El-Afify
Summary: This study aims to investigate the antiviral activity of a new compound and its metal complexes against the novel coronavirus, as well as the cytotoxic activity against breast cancer.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Article
Chemistry, Applied
Mohamed G. El-Desouky, A. Shahat, Ashraf A. El-Bindary, Mohamed A. El-Bindary
Summary: Mesoporous iron oxide nanospheres (MINs) have been synthesized successfully, showing high-efficiency adsorption capability. MINs have uniform spherical morphology with relatively large surface area and total pore volume, enabling effective adsorption of carbon dioxide. Various models have been used to assess the heterogeneous surface properties of MINs.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Article
Chemistry, Applied
Mohamed G. El-Desouky, Mohamed Abd El-Wahab, Ashraf A. El-Bindary
Summary: The electronic properties of polymers and polymers reacting with metal oxides can be studied using molecular modeling. The addition of metal oxides increases the reactivity of the nanocomposite and decreases the energy bandgap values.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
