Review
Biochemistry & Molecular Biology
Jorge Valencia-Ortega, Rebeca Gonzalez-Reynoso, Edgar G. Ramos-Martinez, Aldo Ferreira-Hermosillo, Maria I. Pena-Cano, Enrique Morales-avila, Renata Saucedo
Summary: Gestational diabetes mellitus (GDM) is a common metabolic disorder during pregnancy with significant impact on the health of both mother and newborn. Recent research has focused on the expression levels and circulating characteristics of adipokines in different tissues of GDM patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Long Cheng, Lu Shi, Changhao He, Chen Wang, Yinglan Lv, Huimin Li, Yongcheng An, Hongyu Dai, Yuhui Duan, Huilin Zhang, Yan Huang, Wanxin Fu, Yanyan Meng, Baosheng Zhao
Summary: The study found that rutin can activate thermogenesis in brown and white adipose tissue by increasing the concentration of short-chain fatty acids, thereby improving obesity and diabetes.
PHYTOTHERAPY RESEARCH
(2022)
Review
Nutrition & Dietetics
Karolline S. May, Laura J. den Hartigh
Summary: Obesity is a major risk factor for various pathological conditions, and an altered gut microbiota can contribute to the development of obesity and its associated metabolic complications. The interaction between gut microbiota and peripheral organs, such as adipose tissue, is still not fully understood. This review highlights the influence of circulating gut-derived short chain fatty acids (SCFAs) on adipose tissue metabolism and discusses their role as a prominent host energy source. Exploring the mechanisms by which SCFAs impact adipose tissue metabolism appears to be a promising approach to improve metabolic conditions related to obesity.
Article
Biochemistry & Molecular Biology
Susana Castelo Branco Ramos Nakandakari, Rafael Calais Gaspar, Gabriel Keine Kuga, Camila de Oliveira Ramos, Renan Fudoli Vieira, Thaiane da Silva Rios, Vitor Rosetto Munoz, Marcella Ramos Sant'ana, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Leandro Pereira Moura, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Dennys Esper Cintra
Summary: Long-term high-fat diet affects adipose tissue and leads to metabolic disorders. Short-term high-fat diet affects neuronal signaling pathways. Flaxseed oil containing omega-3 fatty acids protects against increased food intake and fasting glucose, but not inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Chao Cao, Han-Chow E. Koh, Stephan Van Vliet, Bruce W. Patterson, Dominic N. Reeds, Richard Laforest, Robert J. Gropler, Bettina Mittendorfer
Summary: This study found that enhanced FFA clearance in people with obesity is negatively correlated with muscle insulin sensitivity, and the stimulatory effect of insulin on FFA clearance is more significant in obese individuals.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Qi Hui Sam, Hua Ling, Wen Shan Yew, Zhaohong Tan, Sharada Ravikumar, Matthew Wook Chang, Louis Yi Ann Chai
Summary: Short chain fatty acids (SCFA) and medium chain fatty acids (MCFA) have divergent immunomodulatory propensities, with SCFA down-attenuating pro-inflammatory response through the TLR4 pathway, while MCFA augmenting inflammation through TLR2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qian Yang, Xiaxia Cai, Yandi Zhu, Zhuo Hu, Yuchen Wei, Qinyu Dang, Yadi Zhang, Xiaoyan Zhao, Xinyin Jiang, Huanling Yu
Summary: The supplementation of oat beta-glucan during gestation in gestational diabetes mellitus (GDM) dams improves fetal intestinal immune development, protecting against the effects of the disease.
Article
Agriculture, Multidisciplinary
Yu Wang, Aiqing Zhao, Haiping Du, Yueyue Liu, Bangran Qi, Xingbin Yang
Summary: The study indicates that theabrownin can enhance BAT activity and promote WAT browning by activating the AMPK-PGC la pathway and modulating SCFAs, thereby improving inflammatory disorder in HFD-fed mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Cell Biology
Dan Zhang, Yong-Ping Jian, Yu-Ning Zhang, Yao Li, Li-Ting Gu, Hui-Hui Sun, Ming-Di Liu, Hong-Lan Zhou, Yi-Shu Wang, Zhi-Xiang Xu
Summary: Short-chain fatty acids (SCFAs) are metabolites produced by bacterial fermentation of dietary fiber in the gut. They are absorbed by substrate transporters and play important roles in cellular metabolism. SCFAs are vital fuels for intestinal epithelial cells (IECs) and influence molecular processes such as blood glucose regulation and IEC function. They also affect intestinal motility, barrier function, and host metabolism, and play regulatory roles in local and peripheral metabolism. Major SCFAs like acetate, propionate, and butyrate are involved in immunity, apoptosis, inflammation, and lipid metabolism. This review highlights the diverse functional roles of SCFAs and their impact on intestines, metabolism, and diseases.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cardiac & Cardiovascular Systems
Debora Maria Soares de Souza, Maria Claudia Silva, Silvia Elvira Barros Farias, Ana Paula de J. Menezes, Cristiane Maria Milanezi, Karine de P. Lucio, Nivia Carolina N. Paiva, Paula Melo de Abreu, Daniela Caldeira Costa, Kelerson Mauro de Castro Pinto, Guilherme de Paula Costa, Joao Santana Silva, Andre Talvani
Summary: The study showed that tissue from mice subjected to a lard diet was more favorable for the growth of T. cruzi parasites, supporting the hypothesis of a relationship between the source of dietary lipids and parasite-induced immunopathology.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jorge Valencia-Ortega, Renata Saucedo, Martha A. Sanchez-Rodriguez, Jose G. Cruz-Duran, Edgar G. Ramos Martinez
Summary: Gestational diabetes mellitus is the most common metabolic complication in pregnancy, involving various factors in its pathophysiology. Studies have observed that alterations in DNA methylation patterns and certain microRNA levels are related to the disease characteristics, highlighting the need for further research in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Daniel Andersen, Henrik Munch Roager, Li Zhang, Janne Marie Moll, Henrik Lauritz Frandsen, Niels Banhos Danneskiold-Samsoe, Axel Kornerup Hansen, Karsten Kristiansen, Tine Rask Licht, Susanne Brix
Summary: Short-term feed deprivation induces significant metabolic and immune system changes in obese mice, highlighting the complex inter-tissue communication system affected by this manipulation.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jesus Fernandez-Felipe, Adrian Plaza, Gema Dominguez, Javier Perez-Castells, Victoria Cano, Francesco Cioni, Nuria Del Olmo, Mariano Ruiz-Gayo, Beatriz Merino
Summary: High-fat diets enriched with lauric acid do not increase leptin production and reduce the effect of leptin on kinase phosphorylation. Both high-fat diets affect adipocyte-size distribution and gene expression related to adipogenesis and inflammation. The composition of white adipose tissue is different between the two diets, which may impact the biophysical properties and signaling of leptin receptor.
Article
Chemistry, Medicinal
Jussara J. Simao, Maysa M. Cruz, Fernanda M. Abdala, Andressa Bolsoni-Lopes, Lucia Armelin-Correa, Maria Isabel C. Alonso-Vale
Summary: The study demonstrates that palmitoleic acid (n7) can alleviate or prevent low-grade chronic inflammation caused by obesity by inducing adipocyte differentiation and reducing the expression of inflammatory cytokines.
Article
Nutrition & Dietetics
Caitlyn Nguyen-Ngo, Anthony V. Perkins, Martha Lappas
Summary: Gestational diabetes mellitus (GDM) and maternal obesity have long-term detrimental impacts on the health of both mother and offspring. Increased inflammation and oxidative stress play key roles in the pathophysiology of these metabolic conditions. This study found that selenium supplementation may prevent inflammation and oxidative stress associated with GDM and maternal obesity.
Article
Developmental Biology
Padma Murthi, Ramona Sarkis, Ratana Lim, Caitlyn Nguyen-Ngo, Anita Pratt, Stella Liong, Martha Lappas
Article
Developmental Biology
Ratana Lim, Gillian Barker, Stella Liong, Caitlyn Nguyen-Ngo, Stephen Tong, Tu'uhevaha Kaitu'u-Lino, Martha Lappas
Article
Food Science & Technology
Caitlyn Nguyen-Ngo, Jane C. Willcox, Martha Lappas
MOLECULAR NUTRITION & FOOD RESEARCH
(2019)
Review
Endocrinology & Metabolism
Caitlyn Nguyen-Ngo, Nanthini Jayabalan, Carlos Salomon, Martha Lappas
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2019)
Article
Medicine, Research & Experimental
Ratana Lim, Caitlyn Nguyen-Ngo, Martha Lappas
Article
Medicine, Research & Experimental
Caitlyn Nguyen-Ngo, Carlos Salomon, Stephanie Quak, Andrew Lai, Jane C. Willcox, Martha Lappas
Review
Developmental Biology
Caitlyn Nguyen-Ngo, Nanthini Jayabalan, Polin Haghvirdizadeh, Carlos Salomon, Martha Lappas
Article
Developmental Biology
Caitlyn Nguyen-Ngo, Jane C. Willcox, Martha Lappas
Article
Developmental Biology
Caitlyn Nguyen-Ngo, Carlos Salomon, Andrew Lai, Jane C. Willcox, Martha Lappas
Review
Physiology
Caitlyn Nguyen-Ngo, Martha Lappas
CURRENT OPINION IN PHYSIOLOGY
(2020)
Article
Developmental Biology
Hope Eveline Carter Moylan, Caitlyn Nguyen-Ngo, Ratana Lim, Martha Lappas
MOLECULAR HUMAN REPRODUCTION
(2020)