A microfluidic platform enabling real-time control of dynamic biochemical stimuli to biological cells

Precise generation of dynamic biochemical signals by controlling the programmable pump in a Y‐shaped microfluidic chip with a “christmas tree” inlet

(2020) Jing‐Tong Na et al.   ELECTROPHORESIS

A sharp-edge-based acoustofluidic chemical signal generator

(2018) Po-Hsun Huang et al.   LAB ON A CHIP

Transmission of dynamic biochemical signals in the shallow microfluidic channel: nonlinear modulation of the pulsatile flow

(2018) Yong-Jiang Li et al.   Microfluidics and Nanofluidics

A microfluidic device with spatiotemporal wall shear stress and ATP signals to investigate the intracellular calcium dynamics in vascular endothelial cells

(2018) Zong-Zheng Chen et al.   Biomechanics and Modeling in Mechanobiology

Generation and precise control of dynamic biochemical gradients for cellular assays

(2017) Yasushi Saka et al.   PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS

Concentration gradient generation methods based on microfluidic systems

(2017) Xiang Wang et al.   RSC Advances

A review of chemical gradient systems for cell analysis

(2016) Himali Somaweera et al.   ANALYTICA CHIMICA ACTA

Perspectives in flow-based microfluidic gradient generators for characterizing bacterial chemotaxis

(2016) Christopher J. Wolfram et al.   Biomicrofluidics

A Y-Shaped Microfluidic Device to Study the Combined Effect of Wall Shear Stress and ATP Signals on Intracellular Calcium Dynamics in Vascular Endothelial Cells

(2016) Zong-Zheng Chen et al.   Micromachines

A spatiotemporally controllable chemical gradient generator via acoustically oscillating sharp-edge structures

(2015) Po-Hsun Huang et al.   LAB ON A CHIP

An automated programmable platform enabling multiplex dynamic stimuli delivery and cellular response monitoring for high-throughput suspension single-cell signaling studies

(2015) Luye He et al.   LAB ON A CHIP

A Generalizable, Tunable Microfluidic Platform for Delivering Fast Temporally Varying Chemical Signals to Probe Single-Cell Response Dynamics

(2014) Loice Chingozha et al.   ANALYTICAL CHEMISTRY

Generation of tunable and pulsatile concentration gradients via microfluidic network

(2014) Bingpu Zhou et al.   Microfluidics and Nanofluidics

Transport of Dynamic Biochemical Signals in Steady Flow in a Shallow Y-Shaped Microfluidic Channel: Effect of Transverse Diffusion and Longitudinal Dispersion

(2013) Yong-Jiang Li et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Temporal gradients in microfluidic systems to probe cellular dynamics: A review

(2012) Raghuram Dhumpa et al.   ANALYTICA CHIMICA ACTA

Exposure of BALB/3T3 fibroblast cells to temporal concentration profile of toxicant inside microfluidic device

(2011) Hyunjong Shin et al.   BioChip Journal

Stochastic Pulse Regulation in Bacterial Stress Response

(2011) J. C. W. Locke et al.   SCIENCE

Microfluidic System for Generation of Sinusoidal Glucose Waveforms for Entrainment of Islets of Langerhans

(2010) Xinyu Zhang et al.   ANALYTICAL CHEMISTRY

Chemical neurostimulation using pulse code modulation (PCM) microfluidic chips

(2010) Farouk Azizi et al.   JOURNAL OF NEUROSCIENCE METHODS

Microfluidic Perfusion System for Automated Delivery of Temporal Gradients to Islets of Langerhans

(2009) Xinyu Zhang et al.   ANALYTICAL CHEMISTRY

A millisecond micromixer via single-bubble-based acoustic streaming

(2009) Daniel Ahmed et al.   LAB ON A CHIP

Timing is everything: using fluidics to understand the role of temporal dynamics in cellular systems

(2009) Andreja Jovic et al.   Microfluidics and Nanofluidics

Frequency-specific flow control in microfluidic circuits with passive elastomeric features

(2009) Daniel C. Leslie et al.   Nature Physics

Dynamic analysis of MAPK signaling using a high-throughput microfluidic single-cell imaging platform

(2009) R. J. Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulsatile Stimulation Determines Timing and Specificity of NF- B-Dependent Transcription

(2009) L. Ashall et al.   SCIENCE

Biological rhythms: Clocks for all times

(2008) Albert Goldbeter   CURRENT BIOLOGY

Metabolic gene regulation in a dynamically changing environment

(2008) Matthew R. Bennett et al.   NATURE

Feedback Loops Shape Cellular Signals in Space and Time

(2008) O. Brandman et al.   SCIENCE

The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae

(2008) J. T. Mettetal et al.   SCIENCE

Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments

(2007) Kevin R. King et al.   LAB ON A CHIP

Biomolecular gradients in cell culture systems

(2007) Thomas M. Keenan et al.   LAB ON A CHIP