Article
Microbiology
Anjana Sasidharan, Dithi Banerjee, Christopher J. Harrison, Rangaraj Selvarangan
Summary: A study on pediatric central nervous system infections in the United States found that picornaviruses, such as EV and PeV-A, were the most common causes, with PeV-A3 being the dominant type. The detection of multiple EV and two PeV-A types in children's cerebrospinal fluid suggests routine testing and reporting of PeV-A, especially in infants under 6 months old. This could help reduce hospital stays and antibiotic usage in young children with acute febrile illnesses.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Virology
Raiana S. Machado, Francisco Gomes-Neto, Maria L. Aguiar-Oliveira, Fernanda M. Burlandy, Fernando N. Tavares, Edson E. da Silva, Ivanildo P. Sousa Jr
Summary: This study investigated the viral genetic diversity, molecular, and epidemiological aspects of CVB5 in Brazil, revealing the circulation of two CVB5 genogroups and important amino acid substitutions in residues known for their critical roles in viral host tropism.
Article
Immunology
Duc Long Phi, Xuan Duong Tran, Minh Manh To, Hai Yen Dang, Thi Dung Pham, Thi Thu Trang Vu, Trong Kiem Tran, Manh Dung Do, Thi Thuy Vu, Stephane Ranque, Laetitia Ninove, Sylvie Pillet, Philippe Colson, Bernard La Scola, Van Thuan Hoang, Philippe Gautret
Summary: From July to October 2020, there was a significant increase in the number of central nervous system infections in Thai Binh Pediatric Hospital, Viet Nam, with enteroviruses as the predominant pathogen. Older age and higher white blood cell count in the cerebrospinal fluid were significantly associated with CNS infections. Patients received empirical antimicrobial treatment, but there were no recorded deaths.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Virology
Lieke Brouwer, Giulia Moreni, Katja C. Wolthers, Dasja Pajkrt
Summary: Enteroviruses are highly prevalent worldwide, with Enterovirus B being the most detected species globally. Echo virus 30 is the most detected type, especially in studies conducted in Europe. Different Enterovirus types show distribution differences in different samples.
Article
Virology
Kyousuke Kobayashi, Hidekazu Nishimura, Katsumi Mizuta, Tomoha Nishizawa, Son T. Chu, Hiroshi Ichimura, Satoshi Koike
Summary: Research showed that different clades of EV-A71 viruses exhibit varying virulence levels in different regions and times. Experimental evaluation of circulating viruses using transgenic mice helps assess potential risks and enhances understanding of viral virulence dynamics.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Yoke Fun Chan, I-Ching Sam, Elena Nayan, Xiu Hui Tan, Thinesshwary Yogarajah
Summary: The seroepidemiology study of Enterovirus D68 in Kuala Lumpur, Malaysia reveals that older age groups have a higher seropositivity rate for EV-D68, especially post-September 2014. The low seropositivity rate observed in children aged 1-3 years suggests they are at risk for infection.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Genetics & Heredity
Hannah C. Howson-Wells, Theocharis Tsoleridis, Izzah Zainuddin, Alexander W. Tarr, William L. Irving, Jonathan K. Ball, Louise Berry, Gemma Clark, C. Patrick McClure
Summary: EV-D68 was detected in 58% of the EV-positive samples from 193 patients in the UK. The virus showed extensive genetic diversity, with two subclades B3 and D1, suggesting unrelated infections. B3 was more common in children and younger adults, while D1 was predominant in older adults. Most EV-D68 positive individuals presented with respiratory distress, including cough, shortness of breath, coryza, wheeze, supplemental oxygen required, and fever. AFM cases and ICU admissions were associated with EV-D68 subclade B3. However, statistical significance could not be assessed due to the infrequency of severe infection in the cohort.
MICROBIAL GENOMICS
(2022)
Article
Public, Environmental & Occupational Health
Li Ding, Ning Zhang, Bin Zhu, Jinlin Liu, Xue Wang, Feng Liu, Ying Mao
Summary: HFMD is a common intestinal infectious disease globally, with distinct regional differences in incidence rates within Shaanxi Province. High-incidence areas are mainly located in the central region, and the incidence rate of HFMD is positively associated with meteorological factors such as rainfall, temperature, and humidity.
Article
Virology
Meik Dilcher, Julia C. Howard, Simon C. Dalton, Trevor Anderson, Richard T. Clinghan, Anja M. Werno
Summary: This article describes a small outbreak of aseptic meningitis caused by echovirus E30 in a New Zealand hospital in 2017. The outbreak involved nine cases, with most patients showing lymphocytic predominance in their cerebrospinal fluid. The VP1 genotyping revealed that the outbreak strain was closely related to strains reported from the US, UK, Brazil, and Denmark. Further analysis suggested that the causative agent of this outbreak might be a mosaic triple-recombinant enterovirus composed of echovirus E6, echovirus E11, and echovirus E30 genome segments.
Article
Virology
Simon B. Larsson, Diana Vracar, Marie Karlsson, Johan Ringlander, Helene Norder
Summary: This study aimed to determine whether certain types of enteroviruses (EVs) were more likely to cause severe illness during the spread of upper respiratory infections. The findings showed that EV-D68 infections were associated with more severe disease manifestation, while other EV types were more evenly distributed among patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Liz J. Walker, Bruce R. Thorley, Anne Morris, Elizabeth J. Elliott, Nathan Saul, Philip N. Britton
Summary: Since 2012, both the United States and Australia have reported cases of acute flaccid myelitis (AFM) in children. Australia's AFP surveillance system is well-placed to identify future AFM cases, with a low incidence rate.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Virology
Jialu Xu, Zeyu Sun, Wei Li, Lifang Liu, Feng Gao, Dongli Pan
Summary: This study investigated the epidemiology and pathology of Enterovirus (EV) encephalitis in children in Hangzhou, China, revealing higher positivity rates in boys, peaks in cases from June to August, and elevated levels of 28 cytokines and chemokines in EV-positive samples. Age, sex, and seasonal preferences were identified, providing insights into the characteristics of EV encephalitis in children.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Or Kriger, Merav Weil, Ilana S. Fratty, Eyal Leshem, Itai Gueta, Danit Sofer, Sharon Amit
Summary: This study aimed to assess the clinical significance of EV-PCR-positive CSF and stool, and found that compared to the EV CSF+/Stool+ group, the EV CSF-/Stool+ group frequently had other pathogens detected and a higher stool Ct-value. Clinically, EV CSF-/Stool+ patients had lower body temperature and more symptoms of lethargy and convulsions.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Oncology
Wuqing Huang, Kristina Sundquist, Jan Sundquist, Jianguang Ji
Summary: Children of survivors with CNS tumor before the age of 20 did not show a significantly higher risk of overall somatic diseases compared to population controls. However, children with a paternal diagnosis of CNS tumor had a significantly increased risk of malignancies, infectious, and parasitic diseases.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Virology
Shi-Huan Tang, Ying Yuan, Zheng-Hua Xie, Man-Jun Chen, Xiao-Di Fan, Yong-Hui Guo, Meng-Hui Hong, Shao-Hua Tao, Nan Yu
Summary: The study revealed EV-D68 as the predominant enterovirus type in hospitalized children in Guangdong Province, mostly belonging to clade B3. Most cases presented with pneumonia and bronchial pneumonia, with wheezing being more common in EV-D68 cases. Development of diagnostic tools is necessary for monitoring EV-D68 infections in China.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Virology
Adriana Luchs, Audrey Cilli, Simone Guadagnucci Morillo, Cibele Daniel Ribeiro, Rita de Cassia Compagnoli Carmona, Maria do Carmo Sampaio Tavares Timenetsky
JOURNAL OF MEDICAL VIROLOGY
(2015)
Article
Infectious Diseases
Adriana Luchs, Audrey Cilli, Simone Guadagnucci Morillo, Rita de Cassia Compagnoli Carmona, Maria do Carmo Sampaio Tavares Timenetsky
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2015)
Article
Parasitology
Adriana Luchs, Audrey Cilli, Simone Guadagnucci Morillo, Debora de Souza Gregorio, Karen Aparecida Farias de Souza, Heloisa Rosa Vieira, Adeline de Mira Fernandes, Rita de Cassia Compagnoli Carmona, Maria do Carmo Sampaio Tavares Timenetsky
Article
Environmental Sciences
Simone Guadagnucci Morillo, Adriana Luchs, Audrey Cilli, Cibele Daniel Ribeiro, Rita de Cassia Compagnoli Carmona, Maria do Carmo Sampaio Tavares Timenetsky
FOOD AND ENVIRONMENTAL VIROLOGY
(2017)
Article
Geriatrics & Gerontology
Adriana Luchs, Geraldine Madalosso, Audrey Cilli, Simone Guadagnucci Morillo, Sandra Regina Martins, Karen Aparecida Farias de Souza, Gislene Mitsue Namiyama, Claudia Regina Goncalves, Rita de Cassia Compagnoli Carmona, Maria do Carmo Sampaio Tavares Timenetsky
Article
Infectious Diseases
Marcel Leite, Rita de Cassia Compagnoli Carmona, Emerson Carraro, Aripuana Sakurada Aranha Watanabe, Celso Francisco Hernandes Granato
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2017)
Article
Virology
Simone Guadagnucci Morillo, Adriana Luchs, Audrey Cilli, Rita de Cassia Compagnoli Carmona, Maria do Carmo S. T. Timenetsky
ARCHIVES OF VIROLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Adriana Luchs, Antonio Charlys da Costa, Audrey Cilli, Shirley Cavalcante Vasconcelos Komninakis, Rita de Cassia Compagnoli Carmona, Lais Boen, Simone Guadagnucci Morillo, Ester Cerdeira Sabino, Maria do Carmo Sampaio Tavares Timenetsky
JOURNAL OF GENERAL VIROLOGY
(2019)
Review
Immunology
Mateusz Hasso-Agopsowicz, Chandresh Nanji Ladva, Benjamin Lopman, Colin Sanderson, Adam L. Cohen, Jacqueline E. Tate, Ximena Riveros, Ana Maria Henao-Restrepo, Andrew Clark, M. Alkorta, C. Atchison, S. Banajeh, S. Becker-Dreps, M. Benhafid, N. Bhandari, L. Bodhidatta, T. Braeckman, J. Bwogi, R. de Cassia Compagnoli Carmona, G. Cilla, I. Contreras-Roldan, B. Coulson, N. A. Cunliffe, R. Dagan, N. Givon, J. I. Degiuseppe, S. Dhiman, Z. Dian, J. Diaz, S. Dutta, T. Krishnan, B. Manna, S. Fletcher-Lartey, C. Fu, D. Gendrel, K. S. Ghenghesh, G. Gonzalez Mago, S. De Grazia, K. Grimwood, M. Groome, A. Haque, U. Heininger, E. R. Houpt, M. Iturriza-Gomara, D. Hungerford, C. M. Jarquin, J. P. McCracken, I. L. Contreras, C. Cordon-Rosales, P. Kaiser-Labusch, G. Kang, S. Kar, N. Kiulia, K. Kotloff, R. Latipov, A. Linhares, M. Lorrot, M. Mandile, C. Mast, M. A. Mathew, F. Matinon-Torres, J. Matthijnssens, Z. Mladenova, M. Monini, M. Montes, A. Arana, M. Motamedifar, A. Najafi, T. Nelson, J. Nokes, F. Ntoumi, K. Numazaki, C. O'Reilly, T. J. Ochoa, N. A. Page, A. L. Page, C. Langendorf, A. T. Podkolzin, C. Quach, M. L. Racz, A. De Rougemont, G. M. Ruiz-Palacios, S. K. Saha, S. Saha, S. M. Satter, L. Soares, S. M. Sudarmo, K. Shigemura, T. Shirakawa, A. F. Athiyyah, B. Tagbo, P. Tarr, E. Klein, D. M. Denno, A. Turner, E. B. Uzoma, R. R. Vatosoa, E. A. Wandera, M. Wikswo, D. Payne, H. Yhu-Chering, T. Yoshikawa, K. Sugata, Q. Yuan, L. Liying, K. Zaman, X. -N. Zhou, S. -X. Zhang, W. Xu, Fatima Serhan, Tomoka Nakamura, Sebastien Antoni, Mary Agocs, Jillian Murray, Thomas Cherian, Jason M. Mwenda, Goitom Weldegebriel, Joseph N. M. Biey, Dah Cheikh, Nadia Teleb, Hossam Abdel Rahman, Hinda Ahmed, Danni Daniels, Dovile Videbaek, Annemarie Wasley, Simarjit Singh, Lucia de Oliveira, Gloria Rey-Benito, N. Jennifer Sanwogou, Jayantha Liyanage, Pushpa Ranjan Wijesinghe, Nyambat Batmunkh, Varja Grabovac, Kimberley Fox, Fem Julia Paladin, Nicholas Henschke
CLINICAL INFECTIOUS DISEASES
(2019)
Article
Public, Environmental & Occupational Health
C. L. Ciofi-Silva, C. Q. M. Bruna, R. C. C. Carmona, A. G. C. S. Almeida, F. C. P. Santos, N. M. Inada, V. S. Bagnato, K. U. Graziano
JOURNAL OF HOSPITAL INFECTION
(2019)
Article
Virology
Audrey Cilli, Adriana Luchs, Simone G. Morillo, Rita de Cassia C. Carmona, Fabiana C. P. dos Santos, Adriana Y. Maeda, Dieli Primo, Gabriela T. Pacheco, Ellen V. Souza, Roberta S. Medeiros, Maria do Carmo S. T. Timenetsky
Summary: The study revealed a prevalence of 3.7% of human sapoviruses (HuSaV) in Brazil, with a higher prevalence in children. Out of 13 outbreaks detected, 12 occurred in children under 3 years old and one in adults. The most prevalent genotypes found were GI.1 and GI.2, with two GIV.1 strains being the only ones reported in Brazil to date.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Virology
Rita C. C. Carmona, Braulio C. Machado, Fabricio C. Reis, Adriana M. V. Jorge, Audrey Cilli, Amanda M. N. Dias, Daniele R. Morais, Lucas Leme, Ana L. F. Yu, Marcela R. Silva, Telma R. M. P. Carvalhanas, Maria C. S. T. Timenetsky
Summary: This study investigated a large outbreak of Hand, foot, and mouth disease during the COVID-19 pandemic in 2021, and found the reemergence of CVA6 in HFMD. It highlights the importance of continued surveillance of circulating enterovirus types in the post-COVID pandemic era.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Adriana Luchs, Antonio Charlys da Costa, Audrey Cilli, Shirley Cavalcante Vasconcelos Komninakis, Rita de Cassia Compagnoli Carmona, Simone Guadagnucci Morillo, Ester Cerdeira Sabino, Maria do Carmo Sampaio Tavares Timenetsky
SCIENTIFIC REPORTS
(2019)
Article
Public, Environmental & Occupational Health
Norma H. Medina, Emilio Haro-Munoz, Alessandra Cristina Pellini, Braulio C. Machado, Denise H. Russo, Maria do Carmo Timenetsky, Rita de Cassia C. Carmona
REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH
(2016)