Article
Computer Science, Interdisciplinary Applications
Domenico Spensieri, Edvin Ablad, Robert Bohlin, Johan S. Carlson, Rikard Soderberg
Summary: The focus of the research is on modeling delays in robot coordination to optimize the overall cycle time of assembly lines. An efficient heuristic algorithm is proposed through modeling and optimizing the model.
ROBOTICS AND COMPUTER-INTEGRATED MANUFACTURING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Luigi Cirillo, Arianna Rustici, Francesco Toni, Matteo Zoli, Fiorina Bartiromo, Laura Ludovica Gramegna, Domenico Cicala, Caterina Tonon, Ferdinando Caranci, Raffaele Lodi
Summary: Vessel Wall MRI (VW-MRI) is an emerging MR sequence used for the diagnosis and treatment of cerebrovascular diseases. Although there is no commercially available optimized VW-MRI sequence for intracranial imaging, this technique plays an important role in the management of cerebrovascular diseases.
Article
Engineering, Environmental
Mojtaba Sinaei Nobandegani, Liang Yu, Jonas Hedlund
Summary: Zeolite membrane processes showed significantly higher selectivity and permeance compared to polymeric membrane processes for biogas upgrading, resulting in lower cost and electricity consumption, as well as more compact design.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Business
John Ettlie, Ozer Muammer, Rajendran Murthy
Summary: This study evaluates an extension of the dynamic capabilities model in the global automotive sector, a rapidly changing and complex context. The results show a significant relationship between dynamic capabilities and R&D project success, with dynamic capabilities and resources playing independent and important roles in predicting sustainable R&D project success. Differences are observed between mature and emerging economies, with Chinese R&D focusing more on incremental improvements of existing products.
IEEE TRANSACTIONS ON ENGINEERING MANAGEMENT
(2023)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Engineering, Electrical & Electronic
Panagiotis Koulountzios, Tomasz Rymarczyk, Manuchehr Soleimani
Summary: A volumetric ultrasound tomography (UST) system and method are established for industrial process applications. The system captures axial variations and generates dynamical volumetric images using a ray-voxel intersection method and a time correlative total variation (TV) algorithm. Experimental results show the effectiveness of the system in both 3-D and 4-D imaging modes.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Chemistry, Multidisciplinary
Omar Sanchez Sanchez, Teresa Castelo-Grande, Paulo A. Augusto, Jose M. Compana, Domingos Barbosa
Summary: This study identifies the optimal values for obtaining the best shape and size of magnetic particles, and conducts a thorough industrial implementation study including production system design and technical and economic feasibility.
Article
Business
Samuel Adomako, Joseph Amankwah-Amoah, Albert Danso, Joseph Kwadwo Danquah, Zahid Hussain, Zaheer Khan
Summary: This paper explores the impact of R&D intensity on new product performance and highlights the mediating role of international R&D teams in this process. The findings suggest that utilizing international R&D teams can enhance new product performance, with a stronger effect when the internal knowledge creation process within the firm is more robust.
JOURNAL OF BUSINESS RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Ipek Suntar, Sumeyra Cetinkaya, Ulku Selcen Haydaroglu, Solomon Habtemariam
Summary: Decades of research have led to advancements in sustainable bioproduction of high-value natural products, with recent developments in biotechnological production of NPs driven by new methodologies and omics technologies. High-throughput technologies like NGS and CRISPR/Cas9 have revolutionized the field, allowing for higher yields and production of complex molecules.
BIOTECHNOLOGY ADVANCES
(2021)
Review
Chemistry, Physical
Burcin Cakir Erdener, Brian Sergi, Omar J. Guerra, Aurelio Lazaro Chueca, Kwabena Pambour, Carlo Brancucci, Bri-Mathias Hodge
Summary: There is increasing global interest in utilizing hydrogen for low-carbon energy systems, and blending it into existing natural gas pipelines is considered a promising strategy in the near-term. However, there are challenges related to the ability of current gas infrastructure to handle blended hydrogen levels. This review paper analyzes the operational perspective of integrating hydrogen into the gas grid and highlights areas that require further research.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Business, Finance
Chuanlin Shao, Yunqing Tao, Dong Chen, Yongwei Ye
Summary: Using the Chinese Integrated Circuit Industry Investment Fund established in 2014 as a quasi-natural experiment, this paper investigates the causal effect of national industrial investment funds on corporate R&D. The study finds that the establishment of these funds significantly increases corporate R&D, particularly for firms facing financing constraints, poor internal governance, and weak external supervision. Mechanism tests further show that this policy helps alleviate financial constraints and agency conflicts, leading to increased corporate R&D. Overall, these findings provide fresh insights into the positive effects of industrial policy.
FINANCE RESEARCH LETTERS
(2023)
Article
Psychology, Multidisciplinary
Yuan-ming Ren
Summary: This study demonstrates the importance of industrial investment fund involvement and government R&D subsidies in companies' technological innovation. The involvement of industrial investment funds can solve the funding difficulties faced by companies in technological innovation and promote their R&D investment. Government R&D subsidies can alleviate the pressure of R&D investment and promote higher levels of technological innovation in companies. For companies with industrial investment fund involvement, government R&D subsidies are conducive to promoting technological innovation.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Christine Gschwendtner, Simon R. Sinsel, Annegret Stephan
Summary: The adoption of electric vehicles plays a key role in decarbonization and the integration of electricity and transportation systems. Despite the growing number of "Vehicle-to-X" trials globally, there is a lack of in-depth understanding of trial implementations and expert experiences, which are crucial for technological development and deployment.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2021)
Article
Operations Research & Management Science
Ming-hui Wang, Nan-jing Huang
Summary: This paper extends the classic optimal research and development investment model into the regime-switching environment and formulates a robust model to obtain the maximal net value function of the R&D project. Although a closed-form solution is not found, a numerical simulation is conducted to further study the qualities of the solution to the model.
Article
Business
Yunhe Li, Xiaotian Tina Zhang
Summary: Using the World Bank's survey data on the Chinese business environment, we empirically demonstrate that industrial agglomeration plays a moderating role in mitigating the negative impact of rent-seeking in bank credit on firm R&D innovation. Our results indicate that rent-seeking in bank credit hampers firm R&D innovation, but this effect is counteracted by industrial agglomeration, even when accounting for endogenous issues. Additionally, our findings highlight that the moderating effect of industrial agglomeration on rent-seeking in bank credit is more significant for SMEs, non-state firms, and those facing severe financial constraints. These findings have implications for promoting firm R&D innovation in China's financially repressive environment.
JOURNAL OF BUSINESS RESEARCH
(2023)
Article
Polymer Science
G. Guidotti, M. Soccio, M. Gazzano, L. Fusaro, F. Boccafoschi, A. Munari, N. Lotti
Summary: A new high molecular weight aliphatic copolyester of PLLA with ABA triblock architecture was successfully synthesized via ring opening polymerization, with chain extension reaction performed to increase the polymer molecular weight. Annealing was found to be an efficient tool to control the crystalline phase and mechanical properties of the material.
Article
Cell Biology
Mara Gagliardi, Nausicaa Clemente, Romina Monzani, Luca Fusaro, Eleonora Ferrari, Valentina Saverio, Giovanna Grieco, Elzbieta Panczyszyn, Flavia Carton, Claudio Santoro, Sara Del Mare-Roumani, Sivan Amidror, Nissan Yissachar, Francesca Boccafoschi, Silvia Zucchelli, Marco Corazzari
Summary: Celiac disease is a complex immune-mediated chronic disease characterized by consistent inflammation of the gastrointestinal tract induced by gluten intake. The organ ex vivo culture system has shown effectiveness in studying disease pathogenesis, testing new treatments, and researching the impact of the microbiome and derived metabolites in a time- and cost-effective manner.
CELL DEATH DISCOVERY
(2021)
Article
Astronomy & Astrophysics
J. Gonzalez-Payo, M. Cortes-Contreras, N. Lodieu, E. Solano, Z. H. Zhang, M-C Galvez-Ortiz
Summary: This study aims to identify wide common proper motion companions to a sample of M and L metal-poor dwarfs to investigate the impact of metallicity on binary fraction and to improve the determination of their metallicity. Through the use of Virtual Observatory tools and large-scale public surveys, a multiplicity rate for sdMs of 1.0±2.0% was found for projected physical separations up to 743,000 au. The study also found four M-L systems, with a frequency of wide systems for sdM5-9.5 of 0.60±1.17% for projected physical separations larger than 1,360 au.
ASTRONOMY & ASTROPHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Cinzia Giannini, Liberato De Caro, Alberta Terzi, Luca Fusaro, Davide Altamura, Ana Diaz, Rocco Lassandro, Francesca Boccafoschi, Oliver Bunk
Summary: Diseases like diabetes can lead to high sugar concentrations in the body, promoting the formation of glycoconjugates such as glycated collagen. Glucose and galactose produce similar changes in collagen, while ribose is faster in glycation and has qualitatively different effects on collagen structure.
Article
Biology
Mara Gagliardi, Romina Monzani, Nausicaa Clemente, Luca Fusaro, Valentina Saverio, Giovanna Grieco, Elzbieta Panczyszyn, Nissan Yissachar, Francesca Boccafoschi, Marco Corazzari
Summary: Inflammatory Bowel Disease (IBD) is a complex, chronic, and dysregulated inflammatory condition with largely unknown etiology. The prognosis and disease progression are highly variable and unpredictable. IBD comprises various inflammatory conditions from Ulcerative Colitis (UC) to Crohn's Disease (CD). Effective clinical treatments for these pathologies are still lacking, emphasizing the urgent need for deeper understanding of the molecular mechanisms underlying IBD development and progression. The proposed ex vivo model using colon tissues from mice in a dynamic culture condition shows promise in efficiently studying the pathogenesis of IBD in a time- and cost-effective manner.
Article
Biochemistry & Molecular Biology
Fabio Bertani, Dalila Di Francesco, Maria Dolores Corrado, Maria Talmon, Luigia Grazia Fresu, Francesca Boccafoschi
Summary: Cardiovascular diseases, including ischemic heart disease and stroke, are the leading cause of global mortality, with almost all sharing a common feature of endothelial dysfunction. Research suggests that ECs stimulated at low shear stress may be involved in paracrine induction of peripheral endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Liberato De Caro, Alberta Terzi, Luca Fusaro, Davide Altamura, Francesca Boccafoschi, Oliver Bunk, Cinzia Giannini
Summary: Glycosylation is a significant process in biochemistry, involving the combination of glucose or other monosaccharides with molecules of different natures. In conditions like diabetes and aging, non-enzymatic glycation of proteins can lead to structural changes in collagen and hinder extracellular matrix degradation.
Article
Cell Biology
Maria Talmon, Erika Massara, Giulia Pruonto, Martina Quaregna, Francesca Boccafoschi, Beatrice Riva, Luigia Grazia Fresu
Summary: Muscular diseases have wide genetic diversity and Ca2+ signalling system is often disturbed. Differentiated skeletal muscle cells derived from USCs serve as an important and easily accessible model to study Ca2+ homeostasis, showing different characteristics and mechanisms compared to undifferentiated cells.
Article
Biochemistry & Molecular Biology
Dalila Di Francesco, Fabio Bertani, Luca Fusaro, Nausicaa Clemente, Flavia Carton, Maria Talmon, Luigia Grazia Fresu, Francesca Boccafoschi
Summary: Recent advancements in regenerative medicine have enhanced the development of biomaterials as multi-functional dressings. In this study, a bovine pericardium decellularized extracellular matrix (dECM) hydrogel was characterized and evaluated for its potential in wound healing. The results showed that the dECM hydrogel has a complex composition, is biocompatible, and has the ability to stimulate angiogenesis, drive cell polarization, promote fibroblast migration, and facilitate wound closure, demonstrating its great potential for regenerative applications.
Article
Astronomy & Astrophysics
J. Gonzalez-Payo, J. A. Caballero, M. Cortes-Contreras
Summary: Using the latest Gaia DR3 data, this study analyzes the widest pairs in the Washington Double Star (WDS) catalogue with angular separations greater than 1000 arcsec. Based on common proper motions, parallaxes, and radial velocities, the study confirms the membership of these pairs to stellar systems. Additionally, the study searches for additional closer companions to these ultrawide pairs and determines masses for each star, calculating the gravitational potential energy of the systems. The results show that out of the 155,159 pairs catalogued by WDS, only 94 remain as bona fide ultrawide pairs in the galactic field.
ASTRONOMY & ASTROPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Flavia Carton, Simona Casarella, Dalila Di Francesco, Emma Zanella, Annarita D'urso, Luca Di Nunno, Luca Fusaro, Diego Cotella, Maria Prat, Antonia Follenzi, Francesca Boccafoschi
Summary: Cells of the cardiovascular system are exposed to various mechanical forces that are crucial for cardiac development and functions. Focal adhesion (FA) complexes and actomyosin networks play vital roles in regulating cellular behaviors related to cytoskeleton dynamics, cell adhesion, migration, differentiation, and tissue organization. This study investigates the involvement of FA in cardiomyocyte differentiation, focusing on vinculin and focal adhesion kinase (FAK) family. The results show that differentiation conditions upregulate FAK-Tyr397 and vinculin, leading to their translocation to the cell membrane. Mechanical stretching also affects the cell shape and the length and number of vinculin-positive FAs, indicating the significant role of mechanotransductive pathways in cardiomyocyte differentiation and cytoskeleton rearrangement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Maria Talmon, Erika Massara, Martina Quaregna, Marta De Battisti, Francesca Boccafoschi, Giulia Lecchi, Federico Puppo, Michele A. Bettega Cajandab, Stefano Salamone, Enrica Bovio, Renzo Boldorini, Beatrice Riva, Federica Pollastro, Luigia G. Fresu
Summary: This study demonstrates, for the first time, the presence and functionality of a type 2 bitter receptor hTAS2R46 in human skeletal muscle cells. This finding suggests that bitter receptors may play an important role in the development, maintenance, and protection of muscle tissue functions.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dalila Di Francesco, Alexa Pigliafreddo, Simona Casarella, Luca Di Nunno, Diego Mantovani, Francesca Boccafoschi
Summary: The clinical demand for tissue-engineered vascular grafts is increasing, and there are many challenges to obtain functional small-diameter grafts. Advances in cell culture, biomaterials, manufacturing techniques, and tissue engineering methods have led to promising solutions for vascular graft production. The use of natural materials as scaffolds for vascular tissue engineering has gained attention and new strategies have been developed to overcome the drawbacks.