Article
Chemistry, Multidisciplinary
George N. Samaan, Mckenzie K. Wyllie, Julian M. Cizmic, Lisa-Maria Needham, David Nobis, Katrina Ngo, Susan Andersen, Steven W. Magennis, Steven F. Lee, Byron W. Purse
Summary: A new tricyclic pyrimidine nucleoside analogue named ABN was designed and synthesized, which exhibited improved brightness and fluorescence properties in water, becoming the brightest and most red-shifted nucleobase analogue known in duplex DNA. Single-molecule fluorescence measurements of ABN showed excellent photostability with high count rates, offering robust and accessible single-molecule fluorescence detection capabilities.
Review
Gastroenterology & Hepatology
Daniel Segna, Yuly P. Mendoza, Naomi F. Lange, Susana G. Rodrigues, Annalisa Berzigotti
Summary: Non-invasive tests (NITs) and liver stiffness measurement (LSM) have been used for over 20 years in clinical practice to diagnose liver fibrosis in patients with compensated chronic liver disease. They have evolved to become important tools in stratifying the risk of portal hypertension and liver-related events. The Baveno VII consensus workshop provided novel recommendations on the use of well-established and novel NITs in the screening, diagnosis, and follow-up of portal hypertension.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Genetics & Heredity
Shuangjing Zhu, Mengtao Yang, Ting Wang, Zhen Ding
Summary: This study used Mendelian randomization (MR) analysis to explore the causal relationship between leukocyte telomere length and risk of liver disease. The findings suggest that individuals with longer telomeres may have a reduced risk of developing cirrhosis and a higher chance of developing benign liver tumors. However, there appears to be no direct link between telomere length and fatty liver, hepatic fibrosis, or liver cancer.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Dmitrii Shek, Dishen Chen, Scott A. Read, Golo Ahlenstiel
Summary: Liver cancer, predicted to be the third most lethal cancer worldwide by 2030, is primarily caused by obesity, chronic alcohol abuse or viral hepatitis, with alcohol and high fat diet promoting intestinal permeability. Understanding the mechanisms by which liver cancers initiate and progress is crucial, and organoid culture offers advantages for studying the role of the gut-liver axis in cancer initiation and progression.
Article
Oncology
Filomena Morisco, Alessandro Federico, Massimo Marignani, Mariarita Cannavo, Giuseppina Pontillo, Maria Guarino, Marcello Dallio, Paola Begini, Rosa G. Benigno, Flavia L. Lombardo, Tommaso Stroffolini
Summary: Baseline liver stiffness >= 20 kPa and HCV genotype different from 1 were independent predictors of liver decompensation, while only LSM >= 20 kPa was an independent predictor of HCC in HCV cirrhotic subjects achieving SVR after antiviral therapy with DAAs.
Article
Gastroenterology & Hepatology
Sakura Kirino, Nobuharu Tamaki, Masayuki Kurosaki, Kento Inada, Koji Yamashita, Shuhei Sekiguchi, Yuka Hayakawa, Leona Osawa, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Namiki Izumi
Summary: In chronic hepatitis B patients, the PAGE-B score can be used for HCC risk assessment, especially at different time points during NA treatment. The predictive ability of mPAGE-B and REACH-B at 2 years after NA treatment is not as good as PAGE-B.
JOURNAL OF VIRAL HEPATITIS
(2021)
Article
Biochemistry & Molecular Biology
Hui Shi, Ren Ishikawa, Choon Han Heh, Shigeki Sasaki, Yosuke Taniguchi
Summary: MTH1 is an enzyme that hydrolyzes oxidatively damaged nucleobase to prevent its mis-incorporation into genomic DNA. Research on new compounds has revealed the potential of strong inhibitory effects on MTH1 activity and interactions with its active site.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Monica Pons, Salvador Augustin, Bernhard Scheiner, Maeva Guillaume, Matteo Rosselli, Susana G. Rodrigues, Horia Stefanescu, Mang M. Ma, Mattias Mandorfer, Mayka Mergeay-Fabre, Bogdan Procopet, Philipp Schwabl, Arnulf Ferlitsch, Georg Semmler, Annalisa Berzigotti, Emmanuel Tsochatzis, Christophe Bureau, Thomas Reiberger, Jaime Bosch, Juan G. Abraldes, Joan Genesca
Summary: This study aimed to explore the prevalence of portal hypertension in different etiologies of patients with cACLD and develop classification rules based on LSM. The prevalence of portal hypertension was high in most etiologies except for NASH patients, especially obese ones. LSM >= 25 kPa was sufficient to diagnose CSPH in most etiologies, except for obese NASH patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, Research & Experimental
Aline Marcia Marques Braz, Fernanda Cristina Winckler, Larissa Sarri Binelli, Luis Guilherme Chimeno, Lia Beatriz Mantovani Lopes, Rodrigo Santos Lima, Rafael Plana Simoes, Rejane Maria Tommasini Grotto, Marjorie de Assis Golim, Giovanni Faria Silva
Summary: In cirrhotic patients with chronic hepatitis C, the most important biomarkers for predicting regression are TCD4+ lymphocytes. Non-regressors (NR) have lower levels of liver stiffness since baseline compared to regressors (R), while NK cells are increased in NR. The differences in the profile of circulating immune cells between R and NR allow for the development of a predictive model for regression of liver stiffness after SVR, although further validation in larger patient cohorts is needed.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Carly Jade Carter, Ahmed H. Mekkawy, David L. Morris
Summary: The prognosis of pancreatic cancer is poor with a very low 5-year survival rate, and research has shown that human nucleoside transporters play a crucial role in its development and chemoresistance mechanisms. This review summarizes the abnormal expression and function of these transporters in pancreatic cancer, as well as the importance of mucins associated with nucleoside transporters, current diagnostic techniques, and therapeutic treatments for pancreatic cancer.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Health Care Sciences & Services
Markus Kimmann, Jonel Trebicka
Summary: Acute-on-chronic liver failure (ACLF) is a severe complication in liver cirrhosis patients with high mortality. Identifying and treating the triggers of decompensation and ACLF, managing organ failures, and considering liver transplantation (LT) are crucial. However, there is no specific treatment for ACLF, and LT is often limited by contraindications. Bridging strategies and new therapeutic approaches are being explored. This review focuses on current management and potential future treatment options for ACLF.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Chemistry, Medicinal
Leandro S. de Mariz e Miranda
Summary: This viewpoint proposes that molecules inhibiting nucleotide biosynthesis may sensitize virus-infected cells to antiviral nucleosides, potentially leading to the development of new combination therapies.
ARCHIV DER PHARMAZIE
(2023)
Article
Oncology
Shunxi Wang, Long Chen, Wanqian Liu
Summary: Matrix stiffness can reduce ferroptosis and impair anti-tumor immunity by regulating the expression of ferroptosis-related genes. STEAP3 and PD-L2 can serve as independent factors to predict the clinical efficacy of sorafenib and potential diagnostic and treatment strategies for HCC patients.
CANCER CELL INTERNATIONAL
(2022)
Review
Surgery
Martin S. Schulz, Wenyi Gu, Andreas A. Schnitzbauer, Jonel Trebicka
Summary: Acute-on-chronic liver failure is a distinct syndrome characterized by severe inflammation, organ failure, and high mortality rates. Liver transplantation is a potentially life-saving treatment option due to the lack of specific therapies available.
TRANSPLANT INTERNATIONAL
(2022)
Article
Chemistry, Medicinal
Linjie Yan, Ruiyuan Cao, Hongjie Zhang, Yuexiang Li, Wei Li, Xiaoyuan Li, Shiyong Fan, Song Li, Wu Zhong
Summary: Phosphoamidate derivatives of nucleoside NITD008 were synthesized and evaluated for their antiviral activities against EV71 and EV-D68, with compounds 15f and 151 showing the most promising results. Compound 151 demonstrated the highest selectivity index against both viruses, indicating its potential as a candidate for antiviral drug development in treating EV71 and EV-D68 infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Gastroenterology & Hepatology
Alkistis Papatheodoridi, George Papatheodoridis
Summary: Hepatocellular carcinoma (HCC) is a major public health problem and is one of the leading causes of cancer-related deaths worldwide. Hepatitis B (HBV) and C (HCV) viruses have been identified as oncoviruses and are responsible for most cases of HCC, while the role of hepatitis D (HDV) virus in liver cancer development remains unclear. Coinfection of HDV/HBV is associated with more severe liver damage than HBV mono-infection, and recent studies suggest that HDV/HBV patients are at increased risk of developing HCC compared to those with HBV alone. This review summarizes the current literature on the impact of HDV in HCC development and discusses the potential interactions between HBV, HDV, and neighboring liver tissue in liver carcinogenesis.
LIVER INTERNATIONAL
(2023)
Letter
Gastroenterology & Hepatology
Margarita Papatheodoridi, Anna S. Lok, George V. Papatheodoridis
Article
Immunology
Sylvia M. Brakenhoff, Margo J. H. van Campenhout, Annemiek A. van der Eijk, Willem P. Brouwer, Florian van Bommel, Bettina E. Hansen, Thomas Berg, Harry L. A. Janssen, Robert A. de Man, Milan J. Sonneveld
Summary: The study aimed to investigate the relationship between off-treatment ALT flares and virological outcomes, as well as to explore whether serum levels of novel biomarkers at the end of treatment can predict flares. The results showed that ALT flares were associated with decreased sustained response rates, and higher levels of HBsAg, HBV RNA, and HBcrAg were associated with an increased risk of flares.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Review
Gastroenterology & Hepatology
Heiner Wedemeyer, Tammo L. Tergast, Jeffrey V. Lazarus, Homie Razavi, Kostas Bakoyannis, Ricardo Baptista-Leite, Marco Bartoli, Philip Bruggmann, Cristian-Silviu Busoi, Maria Buti, Manuel Carballo, Laurent Castera, Massimo Colombo, Rodrigo Sousa Coutinho, Yuval Dadon, Gamal Esmat, Rafael Esteban, Joan Colom Farran, Mark Gillyon-Powell, David Goldberg, Sharon Hutchinson, Harry L. A. Janssen, George Kalamitsis, Loreta A. Kondili, John S. Lambert, Rui Tato Marinho, Mojca Maticic, Aldo Patricello, Markus Peck-Radosavljevic, Stanislas Pol, Mario Poljak, Cora Pop, Tomislov Sokol, Vana Sypsa, Nurdan Tozun, Zobair Younossi, Alessio Aghemo, George V. Papatheodoridis, Angelos Hatzakis
Summary: In 2016, the Hepatitis B and C Public Policy Association (HepBCPPA) launched the HCV Elimination Manifesto, calling for the elimination of HCV in the EU by 2030. Although progress has been made, most countries are not on track to reach the elimination targets. The COVID-19 pandemic has also hindered efforts, resulting in a decrease in HCV diagnoses and treatment initiations. It is crucial to reinforce action and gain commitment from policymakers to achieve HCV elimination.
LIVER INTERNATIONAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Ebel, Manuel Florian Struck, Florian van Boemmel, Anne Bettina Beeskow, Holger Goessmann, Timm Denecke
Summary: The article provides an overview of the safety, feasibility, and effectiveness of percutaneous hepatic perfusion (CS-PHP) in the treatment of liver neoplasms. It highlights the promising potential of CS-PHP in uveal melanoma and cholangiocellular carcinoma, but insufficient data are available for other tumor entities. Due to the potential transient side effects and complications of CS-PHP, close interdisciplinary cooperation is necessary.
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2023)
Article
Gastroenterology & Hepatology
David Petroff, Ingmar Wolffram, Olaf Baetz, Katrin Jedrysiak, Jan Kramer, Thomas Berg, Johannes Wiegand
Summary: Risk-based screening is an efficient method for identifying undiagnosed HCV infections and should be evaluated in other countries with low HCV prevalence.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Huai Zhang, Rafael S. Rios, Jerome Boursier, Rodolphe Anty, Wah-Kheong Chan, Jacob George, Yusuf Yilmaz, Vincent Wai-Sun Wong, Jiangao Fan, Jean-Francois Dufour, George Papatheodoridis, Li Chen, Joern M. Schattenberg, Junping Shi, Liang Xu, Grace Lai-Hung Wong, Naomi F. Lange, Margarita Papatheodoridi, Yuqiang Mi, Yujie Zhou, Christopher D. Byrne, Giovanni Targher, Gong Feng, Minghua Zheng
Summary: This study aimed to investigate the utility of cytokeratin-18 (CK-18) M30 concentrations as a non-invasive diagnostic tool for non-alcoholic steatohepatitis (NASH). The results showed that there was a difference in CK-18 M30 levels between NASH and non-alcoholic fatty liver (NAFL) patients, but the sensitivity and positive predictive value were not ideal. Therefore, measurement of CK-18 M30 levels alone has limited value for non-invasively diagnosing NASH.
CHINESE MEDICAL JOURNAL
(2023)
Review
Surgery
Evangelos Cholongitas, Patrizia Burra, Georgia Vourli, George V. Papatheodoridis
Summary: The use of initial/early everolimus appears to be effective and has a satisfactory safety profile, making it a reasonable therapeutic option in liver transplantation.
CLINICAL TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Florian van Boemmel, Kerstin Stein, Renate Heyne, Joerg Petersen, Peter Buggisch, Christoph Berg, Stefan Zeuzem, Andreas Stallmach, Martin Sprinzl, Eckart Schott, Anita Pathil-Warth, Ulrike von Arnim, Verena Keitel, Juergen Lohmeyer, Karl-Georg Simon, Christian Trautwein, Andreas Trein, Dietrich Hueppe, Markus Cornberg, Frank Lammert, Patrick Ingiliz, Reinhart Zachoval, Holger Hinrichsen, Alexander Zipprich, Hartmuth Klinker, Julian Schulze zur Wiesch, Anett Schmiedeknecht, Oana Brosteanu, Thomas Berg
Summary: Stopping NUC treatment can achieve a higher rate of HBsAg loss compared to continued treatment, especially for patients with end of treatment HBsAg levels <1,000 IU/ml.
JOURNAL OF HEPATOLOGY
(2023)
Article
Microbiology
Nikolaos D. D. Karakousis, Lampros Chrysavgis, Alkistis Papatheodoridi, Aigli-Ioanna Legaki, Panagiotis Lembessis, Evangelos Cholongitas, Antonios Chatzigeorgiou, George Papatheodoridis
Summary: This study investigates the levels of circulating cf-DNA and 5-methyl-2'-deoxycytidine in HBeAg-negative patients with chronic hepatitis B (CHB). The results show that circulating cf-DNA concentration significantly increased after treatment initiation. There was also a trend in increasing levels of 5-methyl-2'-deoxycytidine after treatment initiation in CHB patients. These findings suggest that both cf-DNA and 5-methyl-2'-deoxycytidine may serve as useful biomarkers to monitor liver disease activity and response to antiviral treatment in HBeAg-negative chronic HBV patients.
Article
Gastroenterology & Hepatology
Milan J. Sonneveld, Shao-Ming Chiu, Jun Yong Park, Sylvia M. Brakenhoff, Apichat Kaewdech, Wai-Kay Seto, Yasuhito Tanaka, Ivana Carey, Margarita Papatheodoridi, Piero Colombatto, Florian van Boemmel, Thomas Berg, Fabien Zoulim, Sang Hoon Ahn, George N. Dalekos, Nicole S. Erler, Maurizia Brunetto, Heiner Wedemeyer, Markus Cornberg, Man-Fung Yuen, Kosh Agarwal, Andre Boonstra, Maria Buti, Teerha Piratvisuth, George Papatheodoridis, Chien-Hung Chen, Benjamin Maasoumy, Create Study Grp
Summary: This study investigated the association between pretreatment HBV DNA levels and outcomes after therapy cessation in patients with chronic hepatitis B. It was found that lower pretreatment HBV DNA levels were associated with a lower risk of clinical relapse and a higher chance of HBsAg loss after cessation of NUC therapy. These findings can help select patients for treatment withdrawal and guide intensity of off-treatment monitoring.
Article
Gastroenterology & Hepatology
Christopher Dietz-Fricke, Frank Tacke, Caroline Zollner, Munevver Demir, Hartmut H. Schmidt, Christoph Schramm, Katharina Willuweit, Christian M. Lange, Sabine Weber, Gerald Denk, Christoph P. Berg, Julia M. Grottenthaler, Uta Merle, Alexander Olkus, Stefan Zeuzem, Kathrin Sprinzl, Thomas Berg, Florian van Bommel, Johannes Wiegand, Toni Herta, Thomas Seufferlein, Eugen Zizer, Nektarios Dikopoulos, Robert Thimme, Christoph Neumann-Haefelin, Peter R. Galle, Martin Sprinzl, Ansgar W. Lohse, Julian Schulze zur Wiesch, Jan Kempski, Andreas Geier, Florian P. Reiter, Bernhard Schlevogt, Juliana Goediker, Wolf Peter Hofmann, Peter Buggisch, Julia Kahlhofer, Kerstin Port, Benjamin Maasoumy, Markus Cornberg, Heiner Wedemeyer, Katja Deterding
Summary: This study reported the safety and efficacy of bulevirtide in the treatment of chronic hepatitis D in a real-world setting in Germany. Among the 114 patients included, 87 cases showed virologic response and only a small proportion did not respond after 24 weeks of treatment. The treatment was well tolerated and showed signs of improvement in liver inflammation.
Article
Oncology
Manuel Florian Struck, Robert Werdehausen, Holger Kirsten, Holger Goessmann, Rhea Veelken, Florian van Boemmel, Sebastian Stehr, Timm Denecke, Sebastian Ebel
Summary: This retrospective analysis found that high perioperative infusion volumes and the omission of heparin reversal with protamine were associated with postoperative bleeding complications. High infusion volumes also contributed to a length of stay in the intensive care unit of more than one day. Our findings suggest a restrictive perioperative infusion regime and support the use of postoperative protamine for heparin reversal in chemosaturation procedures.
Article
Anesthesiology
Peter Kliem, Sebastian Ebel, Robert Werdehausen, Felix Girrbach, Denis Boesemann, Florian van Boemmel, Timm Denecke, Sebastian Stehr, Manuel F. Struck
Summary: Percutaneous hepatic melphalan perfusion (PHMP) is a last-line treatment for inoperable liver tumors. It selectively perfuses and saturates the liver with the chemotherapeutic agent melphalan while avoiding cytotoxic effects on the rest of the body. The procedure involves extracorporeal circulation and filtration of venous hepatic blood. Circulatory depression and coagulopathy are common during the procedure. This article reviews the anesthesiological and postprocedural management of patients undergoing PHMP, considering the challenges and special circumstances.
Article
Gastroenterology & Hepatology
Theodoros Voulgaris, Vassileios Lekakis, Jiannis Vlachogiannakos, Dimitrios Kamberoglou, Afroditi Orfanidou, George Papatheodoridis, George Karamanolis
Summary: In this study, we retrospectively assessed the efficacy of citalopram or amitriptyline versus no treatment in patients with functional chest pain (FCP). The results showed that both citalopram and amitriptyline are effective pharmacological options in the symptomatic relief of almost 50% of patients with well characterized FCP.
ANNALS OF GASTROENTEROLOGY
(2023)