Article
Endocrinology & Metabolism
Adina F. Turcu, Richard Auchus
Summary: Recent studies have shown that primary aldosteronism (PA) has a higher prevalence among hypertensive patients than previously assumed, with the most common subtypes being aldosterone-producing adenomas (APAs) and bilateral hyperaldosteronism (BHA). Screening and distinguishing between different subtypes can be costly, and it is important to assess the likelihood of benefit from imaging and adrenal vein sampling before embarking on these studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Fabrizio Buffolo, Jacopo Pieroni, Federico Ponzetto, Vittorio Forestiero, Denis Rossato, Paolo Fonio, Antonello Nonnato, Fabio Settanni, Paolo Mulatero, Giulio Mengozzi, Silvia Monticone
Summary: This study assessed the impact of asymmetrical cortisol secretion on the lateralization index during adrenal venous sampling, and the effectiveness of metanephrines as a normalization factor for aldosterone levels. The results showed that 18% of patients with primary aldosteronism had asymmetrical cortisol secretion, and the use of metanephrines as a normalization factor improved the accuracy of diagnosis compared to aldosterone to cortisol lateralization index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Masatoshi Ogata, Hironobu Umakoshi, Tazuru Fukumoto, Yayoi Matsuda, Maki Yokomoto-Umakoshi, Hiromi Nagata, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: The study suggests that a significant left adrenal vein absolute aldosterone gradient may indicate unilateral excess aldosterone, especially in patients with spontaneous hypokalemia or left unilateral disease on computed tomography. This finding can be a useful tool in diagnosing the left unilateral subtype of primary aldosteronism during adrenal vein sampling.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Gian Paolo Rossi, Giacomo Rossitto, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Leo Schultze Kool, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Margill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Vin Cent Wu, Zuzana Kratka, Teresa M. Seccia, Livia Lenzini
Summary: This study aimed to determine the rate of drug-resistant arterial hypertension in patients with primary aldosteronism (PA) and investigate the diagnostic performance of adrenal vein sampling (AVS). The results showed that resistant hypertension was common in PA patients, and AVS-guided adrenalectomy effectively resolved treatment-resistant hypertension.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Eleftheria Gkaniatsa, Augustinas Sakinis, Magnus Palmer, Andreas Muth, Penelope Trimpou, Oskar Ragnarsson
Summary: The study found that imaging studies inaccurately predicted laterality in a significant number of young patients with PA. In contrast to current clinical guidelines, the results support the use of AVS for subtype evaluation in young adults with PA, including patients 35 years or younger.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Gregory A. Kline, Alexander Ah-Chi Leung, Davis Sam, Alex Chin, Benny So
Summary: Repeat adrenal vein sampling (AVS) shows moderate correlation in biochemical results and diagnostic lateralization between the first and second procedures, indicating high repeatability and success rate in patients with primary aldosteronism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Peripheral Vascular Disease
Koshiro Nishimoto, Hironobu Umakoshi, Tsugio Seki, Masanori Yasuda, Ryuichiro Araki, Michio Otsuki, Takuyuki Katabami, Hirotaka Shibata, Yoshihiro Ogawa, Norio Wada, Masakatsu Sone, Shintaro Okamura, Shoichiro Izawa, Shozo Miyauchi, Takanobu Yoshimoto, Mika Tsuiki, Mitsuhide Naruse
Summary: The study found a relationship between PA pathology and adrenalectomy outcomes, with higher complete success rates in the large PA lesion group compared to the small lesion group. Serum potassium level was identified as an independent predictive factor for small PA lesions. These findings are significant for guiding clinical treatment of PA.
HYPERTENSION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Carmina Teresa Fuss, Katharina Brohm, Martin Fassnacht, Matthias Kroiss, Stefanie Hahner
Summary: Postural stimulation testing (PST) is a simple and noninvasive method for differentiating between unilateral and bilateral primary aldosteronism (PA). A study showed that when the aldosterone plasma concentration decreased by at least 28% after 4 hours in the upright position, PST had a specificity of 100% for identifying unilateral disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Seung Hun Lee, Jong Woo Kim, Hyun-Ki Yoon, Sang Wan Kim, Su Jin Kim, Kyu Eun Lee, Yu-Mi Lee, Tae-Yon Sung, Suck Joon Hong, Chan Soo Shin, Jung-Min Koh, Jung Hee Kim
Summary: The study analyzed the impact of AVS indices on postsurgical outcomes in PA patients. Results suggest that an LI value of >= 10 may be appropriate for achieving biochemical success, while CLR < 0.25 and ILR > 2 may be appropriate for achieving biochemical and clinical success.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Keith B. Quencer, Abhilasha Singh, Anu Sharma
Summary: Primary hyperaldosteronism (PA) is the most common secondary form of hypertension in middle-aged adults. Treatment options depend on the extent of aldosterone secretion, with unilateral cases treated surgically and bilateral cases treated medically. Adrenal vein sampling (AVS) is crucial in determining the appropriate treatment approach, but there is variability in AVS techniques and guidelines regarding its use in young patients with unilateral adrenal findings on imaging.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Peripheral Vascular Disease
Delin Ma, Xiaming Liu, Liwen Zeng, Penghui Yuan, Zheng Liu, Junhui Xie, Gang Yuan, Shaogang Wang, Xuefeng Yu, Yan Yang, Anhui Xu
Summary: The study showed that adrenal venous sampling (AVS) may be more beneficial in the surgical management of primary aldosteronism patients compared to computed tomography (CT), although there were no significant differences in postoperative outcomes between the two methods. AVS guided surgeries appeared to result in greater improvement and reduction in medications, indicating its potential advantages over CT in guiding surgical treatment.
JOURNAL OF HYPERTENSION
(2021)
Article
Endocrinology & Metabolism
Tazuru Fukumoto, Hironobu Umakoshi, Masatoshi Ogata, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Misato Motoya, Hiromi Nagata, Yui Nakano, Norifusa Iwahashi, Hiroki Kaneko, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: This study aimed to explore the role of two confirmatory tests in the subtype diagnosis of primary aldosteronism (PA). The results showed that patients with discordant results between confirmatory tests are highly likely to have a bilateral subtype on adrenal vein sampling (AVS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Mirko Parasiliti-Caprino, Fabio Bioletto, Filippo Ceccato, Chiara Lopez, Martina Bollati, Maria Chiara Di Carlo, Giacomo Voltan, Denis Rossato, Giuseppe Giraudo, Carla Scaroni, Ezio Ghigo, Mauro Maccario
Summary: This study evaluated the reliability of simple and corrected aldosterone indices for assessing the selectivity and lateralization of adrenal vein sampling (AVS) in patients with primary aldosteronism. The results showed that the aldosterone index had high accuracy in predicting selectivity and moderate accuracy in predicting ipsi/contralateral aldosterone hypersecretion. The study also found that the use of corrected aldosterone indices significantly improved the accuracy in predicting ipsi/contralateral disease. The comparative aldosterone index showed high accuracy in predicting unilateral primary aldosteronism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hikaru Hashimura, Jinbo Hu, Hiroki Kobayashi, Stella May Gwini, Jimmy Shen, Nicholas Y. N. Chee, James C. G. Doery, Winston Chong, Peter J. Fuller, Masanori Abe, Qifu Li, Jun Yang
Summary: The saline suppression test (SST) can confirm the diagnosis of primary aldosteronism (PA), while adrenal vein sampling (AVS) is used to subtype PA as unilateral or bilateral. A combination of plasma aldosterone concentration (PAC) <300 pmol/L and a reduction in aldosterone-to-renin ratio (ARR) following recumbent SST can accurately predict bilateral PA with high specificity. This criterion could reduce the need for AVS in a significant number of patients.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Hiba Obeid, Stanley M. Chen Cardenas, Shafaq Khairi, Adina F. Turcu
Summary: Primary aldosteronism (PA) is a common but underestimated secondary cause of hypertension, associated with increased cardiovascular and renal morbidity compared to primary hypertension. Early identification and targeted therapy are crucial in reducing the morbidity and mortality in a large hypertensive population. Unilateral adrenalectomy is the preferred treatment for lateralized PA, while medical therapy with mineralocorticoid receptor antagonists is offered to bilateral PA patients and those who are not surgical candidates. Novel therapies are being developed as alternative options for PA treatment. This review article discusses the individualized therapy for patients with PA.
ENDOCRINE PRACTICE
(2023)
Article
Environmental Sciences
Tomoko Suzuki, Koichi Miyaki, Akizumi Tsutsumi
Article
Endocrinology & Metabolism
Junji Kawashima, Eiichi Araki, Mitsuhide Naruse, Isao Kurihara, Katsutoshi Takahashi, Kouichi Tamura, Hiroki Kobayashi, Shintaro Okamura, Shozo Miyauchi, Koichi Yamamoto, Shoichiro Izawa, Tomoko Suzuki, Akiyo Tanabe
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Electrochemistry
Yudai Tsukada, Yoshiyuki Kuroda, Hideaki Niiro, Yuichi Fujii, Norikazu Fujimoto, Shigenori Mitsushima
ELECTROCHIMICA ACTA
(2020)
Article
Endocrinology & Metabolism
Hiroki Teragawa, Takeshi Morimoto, Yuichi Fujii, Tomohiro Ueda, Mio Sakuma, Michio Shimabukuro, Osamu Arasaki, Koichi Node, Takashi Nomiyama, Shinichiro Ueda
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2020)
Article
Infectious Diseases
Nlandu Roger Ngatu, Basilua Andre Muzembo, Nattadech Choomplang, Sakiko Kanbara, Roger Wumba, Mitsunori Ikeda, Etongola Papy Mbelambela, Sifa Marie-Joelle Muchanga, Tomoko Suzuki, Koji Wada, Hasan Al Mahfuz, Tomohiko Sugishita, Hiroyuki Miyazaki, Shunya Ikeda, Tomohiro Hirao
Summary: Malaria is a prevalent and deadly illness in sub-Saharan Africa, and this study aimed to assess the malaria burden in households in Kongo central province, DRC, and the impact of a community participatory WASH program. The research found high malaria prevalence among participants, but a 6-month WASH intervention significantly reduced household malaria incidence.
Article
Peripheral Vascular Disease
Kohei Saito, Isao Kurihara, Hiroshi Itoh, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Takashi Yoneda, Masakatsu Sone, Kenji Oki, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Koichi Yamamoto, Masanobu Yamada, Kohei Kamemura, Yuichi Fujii, Tomoko Suzuki, Akihiro Yasoda, Akiyo Tanabe, Mitsuhide Naruse
Summary: The study revealed significant changes in the clinical characteristics of primary aldosteronism subtypes APA and BAH from 2006 to 2018. APA patients tended to be diagnosed earlier and in milder forms, while BAH patients showed decreases in hypertension duration and hypokalemia prevalence.
JOURNAL OF HYPERTENSION
(2021)
Article
Environmental Sciences
Tomoko Suzuki, Koji Wada, Michiko Nakazato, Toshiyuki Ohtani, Yoko Yoshinaga, Basilua Andre Muzembo, Januka Khatiwada, Nattadech Choomplang, Ariuntuul Garidkhuu, Shunya Ikeda
Summary: Individuals with high levels of autistic traits are more likely to experience depressive symptoms, and this study found that they are also more vulnerable to different types of job stress. Workers with high autistic trait scores reported significantly more depressive symptoms for all job stress types, especially high job demand. Among workers with high autistic trait scores, those with active job stress reported more depressive symptoms than those with high strain job stress.
Article
Public, Environmental & Occupational Health
Yoko Muramatsu, Kuniyasu Takagi, Tomoko Suzuki, Bibha Dhungel, Akihiro Tsuchiya, Koji Wada
Summary: This study found that poor spousal health negatively affects the self-rated health of retired couples in Japan aged 65-70 after 1 year. Conversely, good spousal health is associated with a lower risk of declining health for respondents. The study highlights the importance of considering spousal health in assessing individual health outcomes.
SSM-POPULATION HEALTH
(2021)
Article
Endocrinology & Metabolism
Shoichiro Izawa, Kazuhisa Matsumoto, Kazuhiko Matsuzawa, Takuyuki Katabami, Takanobu Yoshimoto, Michio Otsuki, Masakatsu Sone, Yoshiyu Takeda, Shintaro Okamura, Takamasa Ichijo, Mika Tsuiki, Tomoko Suzuki, Mitsuhide Naruse, Akiyo Tanabe
Summary: The study found that the occurrence of OS/OP in patients with adrenal adenomas is positively associated with CE severity. However, the factors associated with OS/OP in patients with MACS differ between men and women.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Review
Environmental Sciences
Basilua Andre Muzembo, Ngangu Patrick Ntontolo, Nlandu Roger Ngatu, Januka Khatiwada, Tomoko Suzuki, Koji Wada, Kei Kitahara, Shunya Ikeda, Shin-Ichi Miyoshi
Summary: This study aimed to summarize the knowledge, misconceptions, beliefs, and practices related to Ebola that may hinder the control of Ebola outbreaks in Africa. The findings revealed widespread misconceptions, risk behaviors, and discrimination in African communities affected by Ebola. Efforts are needed to improve comprehensive knowledge on Ebola, address misconceptions, and change risk behaviors for future outbreak preparedness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Hiroki Teragawa, Takeshi Morimoto, Yuichi Fujii, Tomohiro Ueda, Mio Sakuma, Michio Shimabukuro, Osamu Arasaki, Koichi Node, Takashi Nomiyama, Shinichiro Ueda
Summary: This study investigated the effects of two types of DPP-4 inhibitors on renal function in patients with type 2 diabetes. The results showed that both drugs significantly reduced eGFR levels, but only SITA group had an elevation in UACR levels. The difference in eGFR was influenced by differences in HbA1c levels and BP, while the difference in UACR was influenced by differences in LDL-C levels and BP, which were reduced only in the ANA group.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Peripheral Vascular Disease
Motoko Nomura, Isao Kurihara, Hiroshi Itoh, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Takashi Yoneda, Masakatsu Sone, Kenji Oki, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Nobuya Inagaki, Koichi Yamamoto, Michio Otsuki, Daisuke Yabe, Shoichiro Izawa, Yutaka Takahashi, Tomoko Suzuki, Akihiro Yasoda, Akiyo Tanabe, Mitsuhide Naruse
Summary: A recent study suggests that patients with primary aldosteronism who remain renin suppressed during mineralocorticoid receptor antagonist treatment may have a higher risk of developing cardiovascular disease. The study found that patients with a high change in plasma renin activity after treatment had a significantly higher risk of cardiovascular disease compared to those with an intermediate change in renin activity. Age and body mass index were identified as independent risk factors for cardiovascular disease.
HYPERTENSION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Mitsuhide Naruse, Masanori Murakami, Takuyuki Katabami, Tomaz Kocjan, Mirko Parasiliti-Caprino, Marcus Quinkler, Matthieu St-Jean, Sam O'Toole, Filippo Ceccato, Ivana Kraljevic, Darko Kastelan, Mika Tsuiki, Jaap Deinum, Edelmiro Menendez Torre, Troy Puar, Athina Markou, George Piaditis, Kate Laycock, Norio Wada, Marianne Aardal Grytaas, Hiroki Kobayashi, Akiyo Tanabe, Chin Voon Tong, Nuria Valdes Gallego, Sven Gruber, Felix Beuschlein, Lydia Kuerzinger, Norlela Sukor, Elena A. B. Aisha Azizan, Oskar Ragnarsson, Michiel F. Nijhoff, Giuseppe Maiolino, Guido Di Dalmazi, Valentina Kalugina, Andre Lacroix, Raluca Maria Furnica, Tomoko Suzuki
Summary: This study investigated the diversity of approaches utilized for each diagnostic step in different expert centers regarding primary aldosteronism (PA). The results showed significant variations in blood sampling conditions, assay methods, screening and confirmatory tests among centers. This diversity may lead to inconsistent diagnosis of PA and limit comparison of evidence between centers. Standardization of the diagnostic process and revisiting the concept of mild PA are necessary.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Tomoko Suzuki, Koji Wada, Michiko Nakazato, Toshiyuki Ohtani, Michiko Yamazaki, Shunya Ikeda
Summary: This study investigated the associations between ADHD traits and sociodemographic characteristics among Japanese workers who were university graduates. The results showed that males had higher levels of ADHD traits than females, younger age was associated with higher levels of ADHD traits, workers with low incomes had higher levels of ADHD traits, more frequent consumption of midnight meals was associated with higher levels of ADHD traits, and insufficient sleep was also associated with higher levels of ADHD traits. These findings support the importance of assessing and preventing health deterioration related to ADHD traits.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
