Article
Biochemistry & Molecular Biology
Marta Araujo-Castro, Miguel Paja Fano, Marga Gonzalez Boillos, Eider Pascual-Corrales, Ana Maria Garcia Cano, Paola Parra Ramirez, Patricia Martin Rojas-Marcos, Almudena Vicente Delgado, Anna Casteras, Albert Puig, Inigo Garcia Sanz, Patricia Diaz Guardiola, Cristina Robles Lazaro, Miguel Antonio Sampedro Nunez, Raquel Guerrero-Vazquez, Maria del Castillo Tous, Theodora Michalopoulou Alevras, Susana Tenes Rodrigo, Felicia A. Hanzu
Summary: The purpose of this study was to evaluate the diagnostic accuracy of the NP-59 adrenal scintigraphy for subtyping diagnosis of primary aldosteronism (PA), with the results of adrenal venous sampling (AVS) or adrenalectomy as the gold standard. The study found that NP-59 scintigraphy results combined with CT/MRI information may be useful for PA subtyping, but their diagnostic accuracy is only moderate.
Article
Endocrinology & Metabolism
Yuta Tezuka, Kae Ishii, Lili Zhao, Yuto Yamazaki, Ryo Morimoto, Hironobu Sasano, Aaron M. Udager, Fumitoshi Satoh, Adina F. Turcu
Summary: Dynamic HPA testing revealed significant differences in plasma steroid levels between patients with APA and BPA, with APA patients showing higher concentrations of specific steroids both at baseline and in response to ACTH stimulation. The discriminatory power of steroid measurements taken 15 minutes post-ACTH stimulation was particularly high, suggesting it could potentially replace adrenal vein sampling in some PA patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Linghui Kong, Xiaofeng Tang, Yuanyuan Kang, Lei Dong, Jianhua Tong, Jianzhong Xu, Ping-jin Gao, Ji-guang Wang, Weili Shen, Limin Zhu
Summary: The expression of NCC and pNCC in urinary extracellular vesicles (uEVs) varies in different subtypes and genotypes of primary aldosteronism (PA) and can be used to select candidates for adrenal venous sampling (AVS).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Adina F. Turcu, Richard Auchus
Summary: Recent studies have shown that primary aldosteronism (PA) has a higher prevalence among hypertensive patients than previously assumed, with the most common subtypes being aldosterone-producing adenomas (APAs) and bilateral hyperaldosteronism (BHA). Screening and distinguishing between different subtypes can be costly, and it is important to assess the likelihood of benefit from imaging and adrenal vein sampling before embarking on these studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Seung-Eun Lee, Sung Woon Park, Min Sun Choi, Gyuri Kim, Jee Hee Yoo, Jiyeon Ahn, Ji Eun Jun, Hong Suk Park, Dongho Hyun, Sung Ki Cho, Seong Eun Ko, Beom-Jun Kim, Jong Woo Kim, Hyun-Ki Yoon, Jung-Min Koh, Seung Hun Lee, Jae Hyeon Kim
Summary: AV/IVC index may assist in diagnosing PA subtype in the case of unilateral AVS failure according to the study findings.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Medicine, General & Internal
Barbora Kolosova, Petr Waldauf, Dan Wichterle, Jan Kvasnicka, Tomas Zelinka, Ondrej Petrak, Zuzana Kratka, Lubomira Forejtova, Jan Kavan, Jiri Widimsky, Robert Holaj
Summary: The study compared a new clinical prediction score for PA subtyping with previously published scores, finding certain scores had high reliability but low sensitivity in predicting bilateral PA, while others had high prediction probability and moderate sensitivity in predicting unilateral PA. Umakoshi's and Young's models also had 100% reliability for unilateral PA, but with lower sensitivity compared to previous models. None of the prediction tools demonstrated high diagnostic performance for predicting both unilateral and bilateral subtypes concurrently.
Article
Endocrinology & Metabolism
Tomaz Kocjan, Gaj Vidmar, Rok Vrckovnik, Milenko Stankovic
Summary: The use of suggested LAV/IVC index cut-offs did not predict lateralized PA with high accuracy as previously reported, suggesting limitations in its diagnostic utility.
ENDOKRYNOLOGIA POLSKA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Keith B. Quencer, Abhilasha Singh, Anu Sharma
Summary: Primary hyperaldosteronism (PA) is the most common secondary form of hypertension in middle-aged adults. Treatment options depend on the extent of aldosterone secretion, with unilateral cases treated surgically and bilateral cases treated medically. Adrenal vein sampling (AVS) is crucial in determining the appropriate treatment approach, but there is variability in AVS techniques and guidelines regarding its use in young patients with unilateral adrenal findings on imaging.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Endocrinology & Metabolism
Karin Zibar Tomsic, Tina Dusek, Anamarija Alduk, Nikola Knezevic, Vilim Molnar, Ivana Kraljevic, Tanja Skoric Polovina, Annemarie Balasko, Mirsala Solak, Nino Matas, Hrvoje Popovac, Sasa Kralik-Oguic, Darko Kastelan
Summary: Objective indices based on aldosterone/cortisol concentration in the adrenal vein and inferior vena cava can be used to determine the subtype of primary aldosteronism. The study provides cutoff values that can predict the aetiology of the disease and determine the location and involvement of the lesions.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Alexander Ah-Chi Leung, Davis Sam, Alex Chin, Benny So
Summary: Repeat adrenal vein sampling (AVS) shows moderate correlation in biochemical results and diagnostic lateralization between the first and second procedures, indicating high repeatability and success rate in patients with primary aldosteronism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Fabrizio Buffolo, Jacopo Pieroni, Federico Ponzetto, Vittorio Forestiero, Denis Rossato, Paolo Fonio, Antonello Nonnato, Fabio Settanni, Paolo Mulatero, Giulio Mengozzi, Silvia Monticone
Summary: This study assessed the impact of asymmetrical cortisol secretion on the lateralization index during adrenal venous sampling, and the effectiveness of metanephrines as a normalization factor for aldosterone levels. The results showed that 18% of patients with primary aldosteronism had asymmetrical cortisol secretion, and the use of metanephrines as a normalization factor improved the accuracy of diagnosis compared to aldosterone to cortisol lateralization index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hikaru Hashimura, Jinbo Hu, Hiroki Kobayashi, Stella May Gwini, Jimmy Shen, Nicholas Y. N. Chee, James C. G. Doery, Winston Chong, Peter J. Fuller, Masanori Abe, Qifu Li, Jun Yang
Summary: The saline suppression test (SST) can confirm the diagnosis of primary aldosteronism (PA), while adrenal vein sampling (AVS) is used to subtype PA as unilateral or bilateral. A combination of plasma aldosterone concentration (PAC) <300 pmol/L and a reduction in aldosterone-to-renin ratio (ARR) following recumbent SST can accurately predict bilateral PA with high specificity. This criterion could reduce the need for AVS in a significant number of patients.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tomaz Kocjan, Gaj Vidmar, Peter Popovic, Milenko Stankovic
Summary: Several clinical prediction tools have been proposed for subtyping primary aldosteronism, but their diagnostic performance did not meet the high standards reported in our study.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Davis Sam, Gregory A. Kline, Benny So, Janice L. Pasieka, Adrian Harvey, Alex Chin, Stefan J. Przybojewski, Alexander A. Leung
Summary: The study found that patients with unilateral PA and normal adrenal imaging had favorable outcomes following adrenalectomy, with a majority of patients showing complete or partial response in both biochemical and clinical outcomes. Therefore, patients with lateralizing disease should be considered for surgery even if their adrenal imaging appears normal.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Giulio Ceolotto, Giorgia Antonelli, Brasilina Caroccia, Michele Battistel, Giulio Barbiero, Mario Plebani, Gian Paolo Rossi
Summary: This study compared the selectivity index of androstenedione, metanephrine, and normetanephrine with cortisol in patients with primary aldosteronism, finding that androstenedione and metanephrine outperformed cortisol in verifying the success of adrenal vein sampling.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Zeng Guo, Marko Poglitsch, Diane Cowley, Oliver Domenig, Brett C. McWhinney, Jacobus P. J. Ungerer, Martin Wolley, Michael Stowasser
Review
Immunology
Samuel Chan, Eric Au, David W. Johnson, Carmel M. Hawley, Allison Tong, Elaine M. Pascoe, Jonathan C. Craig, Benedicte Sautenet, Emily A. Blumberg, Daniel Brennan, Scott B. Campbell, Christopher Cao, Ross S. Francis, Brooke Huuskes, Nicole M. Isbel, Greg Knoll, Camille N. Kotton, Nizam Mamode, Elmi Muller, Hai An Ha Phan, Helio Tedesco-Silva, David M. White, Martin J. Wolley, Andrea K. Viecelli
Summary: This study analyzed infection outcomes reported in 102 contemporary trials conducted in kidney transplant recipients. The results showed that outcomes were frequently reported by infection site and organism, but varied widely in terms of metrics, aggregation methods, and time points. Establishment of core outcomes for infection may improve the consistency, comparability, and usefulness of trial evidence.
Review
Endocrinology & Metabolism
Aihua Wu, Martin J. Wolley, Robert A. Fenton, Michael Stowasser
Summary: The thiazide-sensitive sodium chloride cotransporter (NCC) plays a major role in electrolyte balance and blood pressure regulation. The renal-K+ switch mechanism, which links dietary potassium intake to NCC activity, may offer new targets for blood pressure control. However, the lack of human data to confirm findings from animal models is a hurdle for full acceptance of this model. Urinary extracellular vesicles (uEVs) have potential as biomarkers for studying renal physiology and pathology. Challenges include the diverse origins and dynamic molecular composition of uEVs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Urology & Nephrology
Katharine Hegerty, Allison Jaure, Nicole Scholes-Robertson, Kirsten Howard, Angela Ju, Nicole Evangelidis, Martin Wolley, Amanda Baumgart, David W. Johnson, Carmel M. Hawley, Donna Reidlinger, Laura Hickey, Alyssa Welch, Yeoungjee Cho, Peter G. Kerr, Matthew A. Roberts, Jenny I. Shen, Jonathan Craig, Rathika Krishnasamy, Andrea K. Viecelli
Summary: This study aimed to explore patients' perspectives on incremental hemodialysis (HD) and their priorities and concerns regarding HD. The study found that patients with kidney failure preferred incremental initiation of HD to minimize disruption to daily living and improve quality of life. The top prioritized outcomes were quality of life, residual kidney function, and mortality.
KIDNEY INTERNATIONAL REPORTS
(2023)
Meeting Abstract
Peripheral Vascular Disease
Aihua Wu, Martin Wolley, Hannah Mayr, Diane Cowley, Bo Li, Paul Welling, Katrina Campbell, Robert Fenton, Michael Stowasser
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Aihua Wu, Martin Wolley, Hannah Mayr, Diane Cowley, Bo Li, Paul Welling, Katrina Campbell, Robert Fenton, Michael Stowasser
JOURNAL OF HYPERTENSION
(2022)
Article
Urology & Nephrology
Aihua Wu, Martin J. Wolley, Alexandra Matthews, Diane Cowley, Paul A. Welling, Robert A. Fenton, Michael Stowasser
Summary: This study found that acute oral potassium chloride supplementation can replenish plasma potassium in patients with primary aldosteronism (PA) and suppress the abundance and phosphorylation of sodium-chloride cotransporter (NCC), despite a significant rise in plasma aldosterone.
Article
Urology & Nephrology
Aihua Wu, Martin J. Wolley, Qi Wu, Diane Cowley, Johan Palmfeldt, Paul A. Welling, Robert A. Fenton, Michael Stowasser
Summary: Acute sodium chloride loading and volume expansion can reduce renal tubular reabsorption of sodium chloride and water in patients with hypertension. This modulation may be associated with changes in the sodium-chloride cotransporter (NCC), aquaporin-2 (AQP2), and urinary extracellular vesicle (uEV) proteins.
Meeting Abstract
Urology & Nephrology
A. Wu, M. Wolley, A. Douglas, D. Cowley, M. Stowasser
Meeting Abstract
Urology & Nephrology
G. Mylonas, M. Tunbridge, M. Wolley
Meeting Abstract
Peripheral Vascular Disease
Aihua Wu, Martin J. Wolley, Qi Wu, Diane Cowley, Richard D. Gordon, Robert A. Fenton, Michael Stowasser
JOURNAL OF HYPERTENSION
(2021)
Meeting Abstract
Peripheral Vascular Disease
Zeng Guo, Kazutaka Nanba, Brett C. Mcwhinney, Jacobus P. Ungerer, Martin Wolley, Richard D. Gordon, William E. Rainey, Michael Stowasser
JOURNAL OF HYPERTENSION
(2021)
Meeting Abstract
Peripheral Vascular Disease
Zeng Guo, Marko Poglitsch, Diane Cowley, Brett Mcwhinney, Jacobus Ungerer, Martin Wolley, Michael Stowasser
JOURNAL OF HYPERTENSION
(2021)
Meeting Abstract
Medicine, General & Internal
Samuel Chan, Eric Au, David Johnson, Carmel Hawley, Allison Tong, Elaine Pascoe, Jonathan Craig, Benedicte Sautenet, Emily Blumberg, Daniel Brennan, Scott Campbell, Christopher Cao, Ross Francis, Brooke Huuskes, Nicole Isbel, Greg Knoll, Camille Kotton, Nizam Mamode, Elmi Muller, Hai An Ha Phan, Helio Tedesco-Silva, David White, Martin Wolley, Andrea Viecelli
INTERNAL MEDICINE JOURNAL
(2021)
Article
Peripheral Vascular Disease
Aihua Wu, Martin J. Wolley, Qi Wu, Richard D. Gordon, Robert A. Fenton, Michael Stowasser
Summary: This study found significant changes in protein abundance in uEVs of PA patients undergoing fludrocortisone suppression testing, with a decrease in pendrin and an increase in ROMK. Co-administration of mineralocorticoid and KCl in PA patients may lead to these alterations.
JOURNAL OF HUMAN HYPERTENSION
(2021)