Article
Endocrinology & Metabolism
Kanchana Ngaosuwan, Desmond G. Johnston, Ian F. Godsland, Jeremy Cox, Azeem Majeed, Jennifer K. Quint, Nick Oliver, Stephen Robinson
Summary: Mortality risk is higher in adrenal insufficiency patients, especially in primary cases, with cardiovascular disease being the major cause of death, while infections are also significant contributors. Adrenal crisis plays a common role in mortality, urging early education for prompt treatment and prevention strategies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Giulia Carosi, Valentina Morelli, Giulia Del Sindaco, Andreea Liliana Serban, Arianna Cremaschi, Sofia Frigerio, Giulia Rodari, Eriselda Profka, Rita Indirli, Roberta Mungari, Veronica Resi, Emanuela Orsi, Emanuele Ferrante, Alessia Dolci, Claudia Giavoli, Maura Arosio, Giovanna Mantovani
Summary: A retrospective case-control study showed that AI patients who are adequately treated and trained displayed similar incidence of COVID-19 symptoms and disease severity as controls, with no patients requiring hospitalization or experiencing adrenal crisis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Amit Kumar, Maria Ghosh, Jubbin Jagan Jacob
Summary: The study found a high prevalence of adrenal insufficiency (AI) among in-patients with euvolemic hyponatremia (EuVHNa), driven primarily by exogenous steroid use and undiagnosed hypopituitarism.
ENDOCRINE CONNECTIONS
(2021)
Article
Endocrinology & Metabolism
Kanchana Ngaosuwan, Desmond G. Johnston, Ian F. Godsland, Jeremy Cox, Azeem Majeed, Jennifer K. Quint, Nick Oliver, Stephen Robinson
Summary: Cardiovascular disease is the leading cause of death in patients with adrenal insufficiency, with comorbidities playing a significant role in increasing cardiovascular events. Cerebrovascular events are noticeably increased in patients with secondary adrenal insufficiency and are associated with cranial irradiation therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Satoru Oshino, Youichi Saitoh, Manabu Kinoshita, Kosuke Mukai, Michio Otsuki, Haruhiko Kishima
Summary: The study revealed that in NFPAs causing sAI, factors such as Knosp grade and sex are more influential. sAI patients are usually male, and tumors that extend bilaterally with lower Knosp grades are common.
WORLD NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Lucyna Papierska, Michal Rabijewski, Bartosz Migda, Dorota Leszczynska, Karolina Nowak, Agnieszka Lebek-Szatanska, Piotr Glinicki, Wojciech Zgliczynski
Summary: The study aimed to determine whether a single measurement of ACTH is sufficient to confirm or rule out secondary adrenal insufficiency in the short Metyrapone test. The results showed that the readily available plasma ACTH assay cannot replace the measurement of 11-deoxycortisol concentrations for evaluating the results of the Metyrapone test.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Sophie A. Clarke, Maria Phylactou, Bijal Patel, Edouard G. Mills, Beatrice Muzi, Chioma Izzi-Engbeaya, Sirazum Choudhury, Bernard Khoo, Karim Meeran, Alexander N. Comninos, Ali Abbara, Tricia Tan, Waljit S. Dhillo
Summary: The study found that adrenal and thyroid function in COVID-19 survivors remained intact at least 3 months after acute illness, and persistent fatigue symptoms were not attributed to changes in these functions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Satoshi Washino, Hideki Takeshita, Masaharu Inoue, Makoto Kagawa, Takahiko Soma, Hodaka Yamada, Yukio Kageyama, Tomoaki Miyagawa, Satoru Kawakami
Summary: The combination therapy of nivolumab and ipilimumab in patients with renal cell carcinoma may result in a high prevalence of endocrine immune-related adverse events, which may be associated with non-endocrine immune-related adverse events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Rosemary Louise Rushworth, Nikki Gouvoussis, Thomas Goubar, Ann Maguire, Craig F. Munns, Kristen A. Neville, David J. Torpy
Summary: The study found that children with secondary adrenal insufficiency (SAI) who also had comorbid diabetes insipidus (DI) were associated with higher hospitalization rates, longer hospital stays, and lower pre-emergent stress dose use.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Joonatan Borchers, Outi Makitie, Jarmo Jaaskelainen, Saila Laakso
Summary: Hypokalemia is common and variable in APECED patients, with primary adrenal insufficiency (PAI) and kidney disease predisposing to hypokalemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Tuba Seven Menevse, Yasemin Kendir Demirkol, Busra Gurpinar Tosun, Elvan Bayramoglu, Melek Yildiz, Sezer Acar, Seda Erisen Karaca, Zerrin Orbak, Asan Onder, Elif Sobu, Ahmet Anik, Zeynep Atay, Fuat Bugrul, Ayse Derya Bulus, Korcan Demir, Durmus Dogan, Hamdi Cihan Emeksiz, Heves Kirmizibekmez, Nurhan Ozcan Murat, Akan Yaman, Serap Turan, Abdullah Bereket, Tulay Guran
Summary: The study found that steroid hormone profiles are highly sensitive for diagnosing non-CAH PAI of unknown etiology but are unlikely to provide a specific molecular diagnosis. Targeted-gene panel sequencing (TPS) is an optimal approach for molecular diagnosis in these patients with high efficacy, while little additional benefit is expected from whole-exome sequencing (WES).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Birgit Harbeck, Peter Kropp, Ilonka Kreitschmann-Andermahr
Summary: Patients with adrenal insufficiency (AI) receive glucocorticoid (GC) replacement therapy (GRT). However, temporary phases of hypo- and hypercortisolism are common, and prolonged phases of these can impair cognitive functioning. Little is known about the effects of dosage and duration of GC replacement therapy on cognitive functioning in AI patients. This Mini-Review provides an overview of current studies on GRT for AI and discusses their implications for clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Monica R. Gadelha, Niki Karavitaki, Jeffrey Fudin, Jeffrey J. Bettinger, Hershel Raff, Anat Ben-Shlomo
Summary: Opioids have a significant impact on hypothalamic-pituitary axes, potentially leading to various endocrine abnormalities. However, these clinical manifestations are often underestimated and poorly managed. There is a lack of comprehensive research on biochemical testing and treatment strategies for these opioid-induced endocrine effects.
Article
Endocrinology & Metabolism
Reem Al Argan, Abdulaziz Ramadhan, Ramanakumar Agnihotram, Jeffrey Chankowsky, Juan Rivera
Summary: Hypopituitarism is more likely to occur in large pituitary adenomas, with different hormonal deficiencies. In this study of NFPA patients, MRI characteristics were used to predict SAI and CHT. Factors such as age, sex, tumor size, invasiveness, and optic chiasma compression were associated with SAI/CHT.
ENDOCRINE CONNECTIONS
(2021)
Article
Medicine, General & Internal
Anis Grassa, Meriem Yazidi, Jihene Marrakchi, Chaima Bel Hadj Sliman, Ibtissem Oueslati, Melika Chihaoui
Summary: Pallister-Hall syndrome is a rare genetic disorder characterized by hypothalamic hamartoma and polydactyly, with endocrine manifestations being primarily associated with the hamartoma and rarely revealing the disease as a whole.
CLINICAL CASE REPORTS
(2022)
Article
Endocrinology & Metabolism
Stephanie Larose, Louis Bondaz, Livia M. Mermejo, Mathieu Latour, Odile Prosmanne, Isabelle Bourdeau, Andre Lacroix
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Matthieu St-Jean, Isabelle Bourdeau, Eric Therasse, Andre Lacroix
CLINICAL ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
John Newell-Price, Rosario Pivonello, Antoine Tabarin, Maria Fleseriu, Przemyslaw Witek, Monica R. Gadelha, Stephan Petersenn, Libuse Tauchmanova, Shoba Ravichandran, Pritam Gupta, Andre Lacroix, Beverly M. K. Biller
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Andre Lacroix, Feng Gu, Jochen Schopohl, Albert Kandra, Alberto M. Pedroncelli, Lixian Jin, Rosario Pivonello
Article
Endocrinology & Metabolism
A. Lacroix, M. D. Bronstein, J. Schopohl, T. Delibasi, R. Salvatori, Y. Li, A. Barkan, N. Suzaki, L. Tauchmanova, C-E Ortmann, S. Ravichandran, S. Petersenn, R. Pivonello
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2020)
Article
Endocrinology & Metabolism
Cedric Fontaine-Sylvestre, Laurent Letourneau-Guillon, Robert A. Moumdjian, France Berthelet, Andre Lacroix
Summary: This case report emphasizes the importance of monitoring ACTH and corticotroph tumor size in patients with persistent Cushing's disease, either under effective treatment with steroidogenesis inhibitors or after bilateral adrenalectomy.
Editorial Material
Medicine, General & Internal
Andre Lacroix
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Nada Younes, Matthieu St-Jean, Isabelle Bourdeau, Andre Lacroix
Summary: Endogenous Cushing's syndrome during pregnancy is rare, commonly caused by adrenal adenomas and pregnancy-induced CS. Diagnosis is challenging due to physiologic hypercortisolism in pregnancy. Careful interpretation of cortisol production tests and limited imaging options are required. Surgical resection of lesions before 24 weeks of gestation is the optimal treatment, with metabolic complications managed in mild cases.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Endocrinology & Metabolism
Frederic Castinetti, Andre Lacroix
Summary: The desmopressin test has been used for the diagnosis of Cushing syndrome for the past 30 years. Although it has some merits, such as confirming the source of ACTH excess and evaluating the effectiveness of tumor resection, there is a lack of consensus on the criteria for normal or abnormal response to desmopressin. Further research is needed to determine its usefulness.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Stefanie Parisien La Salle, Gilles Corbeil, Zaki El-Haffaf, Caroline Duranceau, Mathieu Latour, Pierre Karakiewicz, Andre Lacroix, Isabelle Bourdeau
Summary: This case reports the first instance of adrenal collision tumors in a patient with a germline pathogenic variant of the MEN1 gene associated with MEN1 loss of heterozygosity in both oncocytic ACC and adenoma, as well as a somatic KCNJ5 pathogenic variant leading to aldosterone-producing adenoma. This case provides new insights into adrenal tumorigenesis in MEN1 patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Jerome Bertherat, Isabelle Bourdeau, Lucas Bouys, Fanny Chasseloup, Peter Kamenicky, Andre Lacroix
Summary: Patients with primary bilateral macronodular adrenal hyperplasia (PBMAH) have bilateral benign adrenocortical macronodules and variable levels of cortisol excess. Genetic mutations in ARMC5 and KDM1A genes are associated with PBMAH and can be detected through genetic analysis. Detailed assessment of PBMAH is crucial for management decisions, and treatment options include adrenalectomy, medical treatment with cortisol synthesis inhibitors, or specific blockers of aberrant GPCR.
Editorial Material
Endocrinology & Metabolism
Adina F. F. Turcu, Andre Lacroix
Summary: This article highlights three major hurdles in understanding adrenal disorders in pregnant women: the overlap between pregnancy and adrenal pathology, the rare presentation of adrenal disorders during pregnancy, and the scarcity of human studies involving pregnant women. The lack of pregnancy-specific adrenal hormone calibrations makes the evaluation and management of adrenal disorders in pregnancy challenging. A collection of comprehensive articles by experts in adrenal physiology and pathology provides a valuable resource for healthcare providers at all stages and settings in addressing pregnancy-related adrenal pathology.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Endocrinology & Metabolism
Andre Lacroix
Summary: Thirty years ago, it was discovered that cortisol secretion in certain patients with adrenal disorders is stimulated by food intake due to abnormal adrenal response to increased glucose-dependent insulinotropic peptide (GIP). Ectopic GIP receptor (GIPR) expression was found in a limited number of cases, leading to the identification of various aberrant G-protein-coupled receptors involved in PBMAH or cortisol-secreting adenomas. In addition, ectopic GIPR was also found in other endocrine tumors. The elucidation of GIP-dependent diseases highlights the importance of personalized approaches to investigation and therapy for genetically determined conditions.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Nada Younes, Stephanie Larose, Isabelle Bourdeau, Eric Therasse, Andre Lacroix
Summary: Adrenal vein sampling (AVS) is recommended for subtyping primary aldosteronism (PA) to better guide individual management decisions. However, there is no consensus on AVS protocols, including sampling techniques, timing, and use of ACTH stimulation. Interpretation criteria for AVS also vary, leading to potential differences in clinical and biochemical outcomes. Recent pathological findings support the need for simultaneous bilateral sampling during AVS to properly evaluate selectivity, lateralization, and contralateral suppression.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2023)
Article
Endocrinology & Metabolism
Nada Younes, Eric Therasse, Isabelle Bourdeau, Andre Lacroix
Summary: This study evaluated the efficacy and safety of using high-dose dexamethasone premedication for AVS in patients with ICM allergy. The results showed that this method can diagnose the source of aldosterone excess in a safe and accurate manner.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)