Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis

A systems pharmacology workflow with experimental validation to assess the potential of anakinra for treatment of focal and segmental glomerulosclerosis

(2019) Michael Boehm et al.   PLoS One

C3 glomerulopathy — understanding a rare complement-driven renal disease

(2019) Richard J. H. Smith et al.   Nature Reviews Nephrology

A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier

(2019) Astgik Petrosyan et al.   Nature Communications

Recent advances of animal model of focal segmental glomerulosclerosis

(2018) Jae Won Yang et al.   Clinical and Experimental Nephrology

Efficacy and safety of interleukin-1 inhibitors in familial Mediterranean fever patients complicated with amyloidosis

(2018) Özkan Varan et al.   Modern Rheumatology

GIANT 2.0: genome-scale integrated analysis of gene networks in tissues

(2018) Aaron K Wong et al.   NUCLEIC ACIDS RESEARCH

Interleukin-17A participates in podocyte injury by inducing IL-1β secretion through ROS-NLRP3 inflammasome-caspase-1 pathway

(2018) J. Yan et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Beyond the Role of CD55 as a Complement Component

(2018) So Hee Dho et al.   Immune Network

TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement

(2017) Joong-Hyuk Sheen et al.   JOURNAL OF IMMUNOLOGY

The role of the complement system in diabetic nephropathy

(2017) Allan Flyvbjerg   Nature Reviews Nephrology

CD55 Deficiency and Protein-Losing Enteropathy

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis

(2017) Ahmet Ozen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss of CD55 in Eculizumab-Responsive Protein-Losing Enteropathy

(2017) Alina Kurolap et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum C3 and Renal Outcome in Patients with Primary Focal Segmental Glomerulosclerosis

(2017) Jian Liu et al.   Scientific Reports

Clinical Significance of IgM and C3 Glomerular Deposition in Primary Focal Segmental Glomerulosclerosis

(2016) Y.-m. Zhang et al.   Clinical Journal of the American Society of Nephrology

Sex Differences and Renal Protection: Keeping in Touch with Your Feminine Side

(2016) V. D. Garovic et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Of Inflammasomes and Alarmins: IL-1  and IL-1  in Kidney Disease

(2016) H.-J. Anders   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A previously unrecognized role of C3a in proteinuric progressive nephropathy

(2016) Marina Morigi et al.   Scientific Reports

Molecules Great and Small: The Complement System

(2015) D. R. Mathern et al.   Clinical Journal of the American Society of Nephrology

Critical role of serum response factor in podocyte epithelial–mesenchymal transition of diabetic nephropathy

(2015) Long Zhao et al.   Diabetes & Vascular Disease Research

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Complement Activation in Patients with Focal Segmental Glomerulosclerosis

(2015) Joshua M. Thurman et al.   PLoS One

The phospholipase D superfamily as therapeutic targets

(2015) Michael A. Frohman   TRENDS IN PHARMACOLOGICAL SCIENCES

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Complement as a multifaceted modulator of kidney transplant injury

(2014) Paolo Cravedi et al.   JOURNAL OF CLINICAL INVESTIGATION

C3a Receptor Antagonist Ameliorates Inflammatory and Fibrotic Signals in Type 2 Diabetic Nephropathy by Suppressing the Activation of TGF-β/smad3 and IKBα Pathway

(2014) Ling Li et al.   PLoS One

Recent Progress in the Pathophysiology and Treatment of FSGS Recurrence

(2013) P. Cravedi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Immune Cell-Derived C3a and C5a Costimulate Human T Cell Alloimmunity

(2013) P. Cravedi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

C3a modulates IL-1  secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

(2013) E. Asgari et al.   BLOOD

Defining cell-type specificity at the transcriptional level in human disease

(2013) Wenjun Ju et al.   GENOME RESEARCH

A Novel Source of Cultured Podocytes

(2013) Stefano Da Sacco et al.   PLoS One

Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies

(2012) Aude Servais et al.   KIDNEY INTERNATIONAL

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion

(2011) Sanjeev Sethi et al.   KIDNEY INTERNATIONAL

Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice

(2010) Natalia Papeta et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Amniotic Fluid as a Potential New Source of Organ Specific Precursor Cells for Future Regenerative Medicine Applications

(2010) Stefano Da Sacco et al.   JOURNAL OF UROLOGY

Primed CD8+T-Cell Responses to Allogeneic Endothelial Cells Are Controlled by Local Complement Activation

(2009) H. Raedler et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells

(2009) Lihua Bao et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of angiotensin II signaling on cytoskeleton of podocytes

(2008) Hsiang-Hao Hsu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

RAGE Mediates Podocyte Injury in Adriamycin-induced Glomerulosclerosis

(2008) J. Guo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nephrin AKTs on actin: The slit diaphragm–actin cytoskeleton signaling network expands

(2008) J. Schlondorff   KIDNEY INTERNATIONAL