Article
Biochemistry & Molecular Biology
Cher Farrugia, Graham P. Stafford, Jan Potempa, Robert N. Wilkinson, Yan Chen, Craig Murdoch, Magdalena Widziolek
Summary: Studies have shown a clear association between periodontal disease and increased risk of cardiovascular disease. Pg directly mediates vascular damage by degrading PECAM-1 and VE-cadherin, providing a potential molecular mechanism for the contribution of Pg to cardiovascular disease.
Review
Cardiac & Cardiovascular Systems
Jerome Robert
Summary: Endothelial cells are crucial for vascular homeostasis and play a vital role in controlling blood flow, immune cell trafficking, and vascular growth and repair. Dysfunction of endothelial cells, characterized by impaired secretion of vasodilator molecules, increased reactive oxygen species, expression of adhesion molecules, and secretion of proinflammatory cytokines, leads to cardiovascular diseases. Sex hormones, such as estrogens, androgens, and progestogens, regulate endothelial functions. However, gender also influences endothelial cell physiology at the genetic level.
Review
Pharmacology & Pharmacy
George Bowley, Elizabeth Kugler, Rob Wilkinson, Allan Lawrie, Freek van Eeden, Tim J. A. Chico, Paul C. Evans, Emily S. Noel, Jovana Serbanovic-Canic
Summary: The use of zebrafish models in studying cardiovascular development and disease mechanisms has become increasingly popular. By comparing the anatomy and physiology of zebrafish and mammalian cardiovascular systems, researchers have found that zebrafish have unique advantages in simulating cardiac and vascular pathologies.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Jessica Kowalski, Lisa Deng, Chiara Suennen, Duygu Koca, David Meral, Christoph Bode, Lutz Hein, Achim Lother
Summary: The study showed that inhibiting MR in endothelial cells can mitigate hypoxia-induced pulmonary vascular remodeling, independent of MR in smooth muscle cells, fibroblasts, or macrophages. This provides a basis for future research on potential downstream mediators of MR involved in pulmonary hypertension.
Review
Nutrition & Dietetics
Hanxu Zhang, Shuang Zhou, Minxue Sun, Manqi Hua, Zhiyan Liu, Guangyan Mu, Zhe Wang, Qian Xiang, Yimin Cui
Summary: The review discusses the role of ferroptosis in endothelial cells in vascular diseases and explores potential therapeutic strategies for treating ferroptosis.
Review
Cell Biology
Alice Costa, Gianandrea Pasquinelli
Summary: Extensive evidence indicates that air pollution exposure is associated with an increased risk of cardiovascular disease development. Fine particulate matter, one of the main components of urban pollution, exerts adverse effects on the cardiovascular system through unknown mechanisms. This review provides an overview of the potential mechanisms by which air pollution hinders vascular repair by altering the functionality of stem cells and progenitor cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Chiara Simone Middel, Nadine Dietrich, Hans-Peter Hammes, Jens Kroll
Summary: The retinal trypsin digest protocol provides novel insights into the zebrafish retinal vascular architecture. Quantification of the different cell types shows that zebrafish have higher numbers of mural cells and an increased mural cell to endothelial cell ratio compared to mammalian retina.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Loan Bui, Shanique Edwards, Eva Hall, Laura Alderfer, Kellen Round, Madeline Owen, Pietro Sainaghi, Siyuan Zhang, Prakash D. Nallathamby, Laura S. Haneline, Donny Hanjaya-Putra
Summary: This study presents a strategy to improve the vasculogenic potential of vascular progenitor cells exposed to gestational diabetes mellitus by conjugating drug-loaded liposomal nanoparticles to the surface of the cells. The strategy successfully rejuvenates the cells and improves their therapeutic potential, offering a promising approach to address cardiovascular complications and advance tissue repair and regenerative medicine.
COMMUNICATIONS BIOLOGY
(2022)
Review
Physiology
Oindrila Paul, Payal Arora, Michael Mayer, Shampa Chatterjee
Summary: Inflammation is a protective response that can either lead to tissue healing or pathological processes. Periodontal disease initiated by bacteria triggers inflammatory responses that can result in tissue loss. Inflammation may also be associated with conditions like diabetes and cardiovascular disease.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Thaysa Ghiarone, Jorge A. Castorena-Gonzalez, Christopher A. Foote, Francisco I. Ramirez-Perez, Larissa Ferreira-Santos, Francisco J. Cabral-Amador, Roger de la Torre, Rama R. Ganga, Andrew A. Wheeler, Camila Manrique-Acevedo, Jaume Padilla, Luis A. Martinez-Lemus
Summary: This study investigates the involvement of ADAM17 in causing impaired insulin-induced vasodilation in type 2 diabetes (T2D). It provides evidence that ADAM17 activity is increased in the vasculature of T2D patients and supports the notion that ADAM17-mediated shedding of endothelial IRa ectodomains is a novel mechanism causing vascular insulin resistance. Targeting ADAM17 activity may be a potential therapeutic strategy to correct vascular insulin resistance in T2D.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Hematology
Arada Vinaiphat, Kalailingam Pazhanchamy, Gnanasekaran JebaMercy, SoFong Cam Ngan, Melvin Khee-Shing Leow, Hee Hwa Ho, Yong-Gui Gao, Kah Leong Lim, A. Mark Richards, Dominique P. V. de Kleijn, Christopher P. Chen, Raj N. Kalaria, Jian Liu, Deborah D. O'Leary, Neil E. McCarthy, Siu Kwan Sze
Summary: This study investigates the effects of high salt intake on endothelial cells and vascular structure. It shows that high salt diet decreases the expression of proteins in the endothelial glycocalyx and alters protein mediators in endothelial cells, leading to vascular pathology and increased cardiovascular risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jody Tori O. Cabrera, Ayako Makino
Summary: Cell death and the clearance of apoptotic cells are regulated by signaling molecules. Abnormal clearance of apoptotic cells is associated with various health complications and diseases. During this process, phagocytic cells and/or apoptotic cells release signals to promote engulfment of apoptotic cells. In addition to macrophages and dendritic cells, other cell types such as endothelial cells and fibroblasts can also engulf apoptotic cells, although at a slower rate. This review focuses on the macrophage efferocytosis of vascular cells and its relation to cardiovascular disease, emphasizing the importance of efferocytosis-related molecules in maintaining vascular homeostasis.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Medicine, General & Internal
D. van Lier, M. Kox, P. Pickkers
Summary: The article discusses the roles of DPP3 and ADM in the pathophysiology of sepsis and septic shock, as well as their associations with organ dysfunction and adverse outcomes. Research has shown that these two molecules represent distinct pathways involved in the development of septic shock.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Food Science & Technology
Kazuo Yamagata
Summary: Onion and quercetin found in onions can lower blood pressure, improve vascular dysfunction, and prevent cardiovascular disease through antioxidant, anti-inflammatory effects, inhibition of the renin-angiotensin system, and increased nitric oxide production.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Yvonne Alexander, Elena Osto, Arno Schmidt-Trucksass, Michael Shechter, Danijela Trifunovic, Dirk J. Duncker, Victor Aboyans, Magnus Back, Lina Badimon, Francesco Cosentino, Marco De Carlo, Maria Dorobantu, David G. Harrison, Tomasz J. Guzik, Imo Hoefer, Paul D. Morris, Giuseppe D. Norata, Rosa Suades, Stefano Taddei, Gemma Vilahur, Johannes Waltenberger, Christian Weber, Fiona Wilkinson, Marie-Luce Bochaton-Piallat, Paul C. Evans
Summary: Endothelial cells play a crucial role in cardiovascular health, and dysfunction can be caused by cardiovascular risk factors but restored once stimuli are removed. There are various methods to measure endothelial function, with each having its pros and cons. It is recommended to adopt a consensus methodology like flow-mediated dilatation and establish reference values for different populations. Future studies should explore the integration of endothelial function measurements with patient-specific epigenetic data and other biomarkers.
CARDIOVASCULAR RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Jake G. Edmans, Katharina H. Clitherow, Craig Murdoch, Paul V. Hatton, Sebastian G. Spain, Helen E. Colley
Article
Biochemistry & Molecular Biology
Cher Farrugia, Graham P. Stafford, Jan Potempa, Robert N. Wilkinson, Yan Chen, Craig Murdoch, Magdalena Widziolek
Summary: Studies have shown a clear association between periodontal disease and increased risk of cardiovascular disease. Pg directly mediates vascular damage by degrading PECAM-1 and VE-cadherin, providing a potential molecular mechanism for the contribution of Pg to cardiovascular disease.
Article
Dentistry, Oral Surgery & Medicine
Zulfahmi Said, Craig Murdoch, Jens Hansen, Lars Siim Madsen, Helen E. Colley
Summary: This study examined the potency and delivery of clobetasol-17-propionate from an electrospun mucoadhesive patch using cell monolayers and oral mucosal equivalents. OMEs were found to be more suitable than cell monolayers for evaluating toxicity and drug delivery, and the patch-delivered clobetasol-17-propionate showed efficacy in treating OLP.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hannah West, Fiona Roberts, Paul Sweeney, Simon Walker-Samuel, Joseph Leedale, Helen Colley, Craig Murdoch, Rebecca J. Shipley, Steven Webb
Summary: The study develops mathematical models to simulate the uptake of polymersomes in cancer cells and their performance in different experimental settings. Polymersomes are crucial for cancer therapy, with different internalization functions affecting the speed of drug delivery.
Article
Cell & Tissue Engineering
Bethany Ollington, Helen E. Colley, Craig Murdoch
Summary: Primary human macrophages were successfully incorporated into oral mucosal equivalents (OME) in this study, showing immunoresponsiveness to bacterial lipopolysaccharides by upregulation of proinflammatory markers. These advanced OME models will significantly help research in host-pathogen interaction, biomaterial toxicity, and drug delivery studies.
TISSUE ENGINEERING PART C-METHODS
(2021)
Review
Dentistry, Oral Surgery & Medicine
Asma El-Howati, Martin H. Thornhill, Helen E. Colley, Craig Murdoch
Summary: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa. The mechanisms of pathogenesis are still not fully understood, but evidence suggests a chronic, dysregulated immune response leading to increased expression of cytokines, chemokines, and adhesion molecules. CD8+ cytotoxic and CD4+ Th1 polarised T cells are the main lymphocytes involved, but recent evidence indicates the involvement of other T cell subsets.
Article
Dentistry, Oral Surgery & Medicine
Cher Farrugia, Graham P. Stafford, Ashley F. Gains, Antonia R. Cutts, Craig Murdoch
Summary: This study evaluates the impact of periodontal bacteria on endothelial infection and damage using single or mixed species infection. The results show that certain periodontal bacteria significantly reduce the abundance of PECAM-1 and cause mortality and morbidity in a zebrafish infection model. Polymicrobial infection highlights the virulence of certain strains with increased endothelial cell death and reduced PECAM-1 abundance.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Chemistry, Analytical
James P. Heath, Keith D. Hunter, Craig Murdoch, Dawn C. Walker
Summary: This study applied a multiscale modelling approach to simulate the electrical properties of oral tissue for the electrical impedance-based diagnosis of oral potential malignant disorder (OPMD). Finite element models of different cell types and a tissue scale model informed by histological analysis were used to distinguish different degrees of dysplasia and healthy tissue. However, significant keratinisation could cause OPMD tissue to exhibit larger than expected impedance values, potentially leading to misidentification as healthy tissue.
Article
Chemistry, Multidisciplinary
Jake G. Edmans, Bethany Ollington, Helen E. Colley, Martin E. Santocildes-Romero, Lars Siim Madsen, Paul Hatton, Sebastian G. Spain, Craig Murdoch
Summary: The study presented a new approach to deliver F(ab) biologics to the oral mucosa using electrospinning technology, offering a potential new therapeutic strategy for treating oral mucosal inflammatory diseases.
JOURNAL OF CONTROLLED RELEASE
(2022)
Meeting Abstract
Dermatology
I. Barragan Vazquez, S. Danby, V. M. Garcia Gonzalez, R. Lopez Almagro, H. E. Colley, C. Murdoch
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Sven E. Niklander, Craig Murdoch, Keith D. Hunter
Summary: The study of cancer biology has shifted focus to include the tumor microenvironment (TME), where chronic inflammation and IL-1 signaling play significant roles in cancer development. Targeting components of TME, such as IL-1, shows promise for potential clinical applications in cancer treatment.
FRONTIERS IN ORAL HEALTH
(2021)
Article
Dentistry, Oral Surgery & Medicine
M. P. McRae, A. R. Kerr, M. N. Janal, M. H. Thornhill, S. W. Redding, N. Vigneswaran, S. K. Kang, R. Niederman, N. J. Christodoulides, D. A. Trochesset, C. Murdoch, I Dapkins, J. Bouquot, S. S. Modak, G. W. Simmons, J. T. McDevitt
Summary: Oral cavity cancer has a low 5-year survival rate, but early detection can improve outcomes. Cytological features, including nuclear F-actin cell phenotypes, were used to classify oral epithelial dysplasia and squamous cell carcinoma. The study found that cytological features are valuable in predicting early and late-stage diseases, potentially enhancing screening and surveillance of oral potentially malignant disorders.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sarmad Al-Sahaf, Naeima B. Hendawi, Bethany Ollington, Robert Bolt, Penelope D. Ottewell, Keith D. Hunter, Craig Murdoch
Summary: The immune cell infiltration differs between HPV-positive and HPV-negative oropharyngeal cancer, with more neutrophils in HPV-negative tumors. IL-1 in HPV-negative tumors increases CXCL8 expression, leading to enhanced neutrophil recruitment, with this tumor-stromal response mediated by the IL-1/IL-1R axis.
FRONTIERS IN ORAL HEALTH
(2021)