Article
Chemistry, Applied
Xiaodan Wang, Huiquan Zhu, Wenyuan Zhang, Yumeng Zhang, Pu Zhao, Shuwen Zhang, Xiaoyang Pang, Jacques Vervoort, Jing Lu, Jiaping Lv
Summary: In this study, the triglyceride and fatty acid composition of different types of milk samples and infant formulae were analyzed using UPLC-ESI-MS and GC techniques. The results showed that the triglyceride and fatty acid composition varied significantly among different milk samples. Furthermore, the fatty acid profiles of human milk and yak milk were unique, which has implications for optimizing dairy product composition.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Applied
Zhiqian Liu, Simone Rochfort
Summary: This study utilized a novel method to uncover the fine structure of milk phospholipids, revealing diverse distribution positions of unsaturated fatty acids and highlighting the complexity of milk lipid composition. The analysis identified predominant and minor isomers of C18:1 and C18:2 in phospholipid structures, providing new insights into the synthesis of phospholipids.
Article
Chemistry, Analytical
Oleksandr Kozlov, Eliska Horakova, Sara Rademacherova, David Malinak, Rudolf Andrys, Eliska Prchalova, Miroslav Lisa
Summary: A fast and selective method using chiral supercritical fluid chromatography-mass spectrometry (SFC-MS) was developed to study lipase selectivity in the hydrolysis of triacylglycerols (TGs). The method involved the synthesis of enantiomerically pure monoacylglycerol (MG) and diacylglycerol (DG) isomers and their separation using a chiral column and neat methanol as a mobile phase modifier. The results revealed different stereoselectivities for substrates in the lipase-catalyzed hydrolysis.
ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Xue-song Wang, Xiao Tan, Yan Zhang, Xia-xin Hu, Chuang Shen, Ying-ying Huang, Hui-ling Fu, Ruo-han Yu, Chun-tao He
Summary: This study investigated the hepatic metabolism of HBCD enantiomers using human HepG2 cells, revealing distinct metabolism patterns and identified metabolites. The findings shed light on the enantiomer-selective metabolism of HBCDs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Nutrition & Dietetics
Jinzhong Xu, Jiaying Lao, Qingxi Jiang, Wenhui Lin, Xiyi Chen, Chongrong Zhu, Shencong He, Wenbo Xie, Fan Wang, Bo Yang, Yanlong Liu
Summary: This study examined the association between milk intake and sleep disorders in a group of Chinese adults. The results showed that regular milk intake was not significantly associated with sleep disorders, but it was negatively associated with sleep disturbances. Increased milk intake was also associated with better sleep quality and fewer sleep disturbances. These associations were more pronounced in older adults and men.
Article
Biochemistry & Molecular Biology
Lihao Gu, Kazuhisa Maeda
Summary: It has been found that raspberry ketone is produced from rhododendrol in both mouse and human skin. The addition of nicotinamide adenine dinucleotide (NAD(+)), an oxidized form of a coenzyme of alcohol dehydrogenase, to human skin samples increased the conversion of rhododendrol to raspberry ketone. Chiral column analysis revealed a significant difference in the enantiomers of raspberry ketone in human skin, indicating that certain enantiomers are more susceptible to oxidation. These findings suggest that alcohol dehydrogenase in the skin plays a key role in the appearance of this oxidation product.
Review
Nutrition & Dietetics
Esben S. Sorensen, Brian Christensen
Summary: Osteopontin (OPN) is a multifunctional protein that is expressed in various cell types and found in most tissues and physiological secretions. It plays a role in immune system regulation, biomineralization, tissue development, bacterial interactions, and more. OPN is highly concentrated in milk and is believed to have developmental and physiological effects on infants. This article reviews and compares existing knowledge on the structure, function, and health implications of milk OPN.
Review
Food Science & Technology
Carlos Franco, Cristina Fente, Cristina Sanchez, Alexandre Lamas, Alberto Cepeda, Rosaura Leis, Patricia Regal
Summary: The functionality of breast milk in terms of immunity is well-known, however, many breastfed infants exhibit sensitization to potential allergens and clinical reactivity before the introduction of complementary feeding. The potential induction of early oral tolerance through allergen exposure in breast milk remains controversial. This scoping review critically appraised the content of cow's milk antigens in human milk to better understand their impact on allergic disease development.
Article
Nutrition & Dietetics
Laurentya Olga, Janna A. van Diepen, Maciej Chichlowski, Clive J. Petry, Jacques Vervoort, David B. Dunger, Guus A. M. Kortman, Gabriele Gross, Ken K. Ong
Summary: This study investigated the origins and determining factors of butyrate in human milk and its influence on infant weight gain. The results showed that higher concentrations of butyrate in human milk were associated with lower infant weight and adiposity, especially in younger infants. Furthermore, the study found an inverse correlation between butyrate concentration and milk intake volume, suggesting a potential mechanism involving appetite regulation and modulation of milk intake.
Article
Chemistry, Multidisciplinary
C. Palaric, S. Atwi-Ghaddar, Q. Gros, C. Hano, E. Lesellier
Summary: Supercritical fluid extraction with carbon dioxide is an effective and environmentally friendly method for extracting natural compounds from plants. This study focuses on the extraction of lipids and flavonolignans from milk thistle seeds using different solvents and conditions. The results provide insights into the optimal extraction parameters and methods.
JOURNAL OF CO2 UTILIZATION
(2023)
Article
Chemistry, Multidisciplinary
Shannon Thoonen, Hui Min Tay, Carol Hua
Summary: A fluorescent, chiral coordination polymer (CP) with a unique topology has been synthesized using a dipyridyl ligand derived from 1,1'-bi-2-naphthol (BINOL). High enantioselectivity ratios up to 2.61 were achieved in fluorescence sensing studies with chiral analytes.
CHEMICAL COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Amy Gates, Amy B. Hair, Ariel A. Salas, Amy B. Thompson, Brian K. Stansfield
Summary: This study compared the nutrient content of commercial pooled donor human milk (DHM) with that of early and mature preterm human milk. The results showed that DHM had significantly lower protein, sodium, chloride, potassium, and zinc content compared to preterm human milk. However, there were no statistical differences in calorie, carbohydrate, calcium, phosphorus, magnesium, and vitamin D content between DHM and preterm human milk. These findings have important implications for designing human milk-based feeding plans.
JOURNAL OF NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Washim Khan, Yan-Hong Wang, Narayan D. D. Chaurasiya, N. P. Dhammika Nanayakkara, H. M. Bandara Herath, Kerri A. A. Harrison, Gray Dale, Donald A. A. Stanford, Eric P. P. Dahl, James D. D. McChesney, Waseem Gul, Mahmoud A. A. ElSohly, David Jollow, Babu L. L. Tekwani, Larry A. A. Walker
Summary: Primaquine (PQ) is an effective antimalarial drug used to treat dormant Plasmodium vivax hypnozoites and P. falciparum mature gametocytes. This study compared the tolerability and metabolism of PQ enantiomers in human volunteers and found no significant differences in safety and tolerability in G6PDn subjects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Wenyuan Zhang, Jacques Vervoort, Jiancun Pan, Peng Gao, Huiquan Zhu, Xiaodan Wang, Yumeng Zhang, Baorong Chen, Ying Liu, Yuanyuan Li, Xiaoyang Pang, Shuwen Zhang, Shilong Jiang, Jing Lu, Jiaping Lyu
Summary: Human milk oligosaccharides (HMOs) play a vital role in the development of the infant's gut microbiome and immune function. This study measured 12 oligosaccharides in milk from Chinese donors and evaluated the impacts of various factors on the HMOs profiles. The results showed that the concentrations of 6 sialyllactose were the highest among the 12 oligosaccharides. HMOs concentrations varied depending on geographical location, environmental factors, maternal anthropometric factors, and dietary factors.
Article
Chemistry, Physical
Chong Ye, Yifan Sun, Yong Li, Xiangdong Zhang
Summary: We propose a single-shot nondestructive quantum sensing method for efficient detection of tiny amounts of chiral substances, especially at the single-molecule level. Our scheme involves two steps: first, the two enantiomers are prepared in different rotational states via microwave enantio-specific state transfer. Then, chiral discrimination is transferred to quantum hypothesis testing. By introducing a nondestructive quantum-state detection technique assisted with a microwave resonator, the molecular chirality is determined by the sign of the output signals.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
X. Kang, H. Liang, Y. Luo, Z. Li, F. He, X. Han, L. Zhang
Summary: The heat-inactivated MN-ZLW-002 can suppress adipocyte differentiation and lipid accumulation by regulating the immune response, possibly via the release of cytokines, especially TNF-alpha; it can also improve metabolism-related indicators in the early stage of HFD intervention and regulate the related pro-inflammatory immune response.
LETTERS IN APPLIED MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shiwei Chen, Haiyue Niu, Yifan Wu, Jialei Sun, Xue Han, Lanwei Zhang
Summary: Lactic acid inhibits the proliferation of Lactobacillus bulgaricus sp1.1 and arrests cell cycle progression at the intracellular biomass accumulation and cell division stages. pH 4.1 is the critical condition at which cell area and length are significantly reduced, and DNA replication initiation is prompted.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Youyou Lu, Zhe Zhang, Lingjun Tong, Xiaohong Zhou, Xi Liang, Huaxi Yi, Pimin Gong, Tongjie Liu, Lanwei Zhang, Liuqing Yang, Hanping Shi
Summary: Overall, this study revealed that Bifidobacterium animalis F1-7, Lactobacillus paraccasei F34-3, and Lactobacillus plantarum FWDG promoted 5-HT secretion in ECs of constipation mice through different pathways and were well colonized in the large intestine.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Plant Sciences
Zhe Zhang, Xi Liang, Lingjun Tong, Youyou Lv, Huaxi Yi, Pimin Gong, Xiaoying Tian, Qingyu Cui, Tongjie Liu, Lanwei Zhang
Summary: The study extracted main compounds of Inonotus obliquus using a high-pressure water extraction method, and found that its extract significantly alleviated blood glucose and insulin resistance in diabetic mice while improving lipid metabolism disorders. The underlying mechanisms involve the regulation of the PI3K/Akt and AMPK/ACC signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Yushan Bu, Hui Yang, Jianxun Li, Yinxue Liu, Tongjie Liu, Pimin Gong, Lanwei Zhang, Shumei Wang, Huaxi Yi
Summary: This study explored the biosynthesis mechanism of plantaricin Q7 using non-targeted metabolomics and identified differential metabolic pathways and metabolites, proposing a potential metabolic synthesis pathway. It also found critical metabolites that significantly simulate plantaricin Q7 biosynthesis, which could help enhance plantaricin Q7 yield through metabolic regulation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Lingjun Tong, Xinyi Zhang, Haining Hao, Qiqi Liu, Zihan Zhou, Xi Liang, Tongjie Liu, Pimin Gong, Lanwei Zhang, Zhengyuan Zhai, Yanling Hao, Huaxi Yi
Summary: Probiotic LGG-EVs show potential in attenuating colitis by inhibiting the TLR4-NF-kappa B-NLRP3 signaling pathway, reducing the release of pro-inflammatory cytokines, and reshaping gut microbiota. These findings suggest a promising therapeutic approach for colitis using oral gavage of LGG-EVs.
Article
Food Science & Technology
Yuehua Jiao, Han Yang, Nditange Shigwedha, Shuang Zhang, Fei Liu, Lanwei Zhang
Summary: This study investigated the effects of different culture conditions on Enterococcus faecalis LD33 and found that respiration-permissive conditions led to increased biomass, higher production of metabolites, and enhanced antimicrobial activities against certain bacteria. The strain also showed better adhesion capability and bile salt tolerance under respiration metabolism. However, its acid tolerance was weaker compared to fermentation conditions. The anti-cancer effect of the strain was not significantly different between the two growth modes, but the supernatant exhibited a higher inhibition effect on cancer cells.
Article
Food Science & Technology
Xi Liang, Zhe Zhang, Youyou Lv, Haiyan Lu, Tongjie Liu, Huaxi Yi, Maozhen Zhao, Lanwei Zhang, Pimin Gong
Summary: The study demonstrated that the combination of KO and Bif. animalis F1-7 significantly improved atherosclerosis by reducing plaque area and improving serum lipid and inflammatory factor levels. The synergistic effect of the two interventions could reduce lipid accumulation and improve inflammatory response through the regulation of the FXR/CYP7A1 and TLR4/MyD88 pathways.
Article
Food Science & Technology
Tongjie Liu, Yixin Shi, Yang Li, Huaxi Yi, Pimin Gong, Kai Lin, Zhe Zhang, Lanwei Zhang
Summary: The interaction between Saccharomyces cerevisiae and Fructilactobacillus sanfranciscensis during sourdough fermentation was studied. S. cerevisiae had no visible influence on F. sanfranciscensis, but the latter facilitated the growth of the former while affecting its volatile production. RNA-sequencing results showed significant changes in gene transcripts implicated in amino acid metabolism in F. sanfranciscensis by S. cerevisiae.
Article
Biotechnology & Applied Microbiology
Youyou Lu, Xi Liang, Yeting Wu, Ruiqi Wang, Tongjie Liu, Huaxi Yi, Zhuang Yu, Zhe Zhang, Pimin Gong, Lanwei Zhang
Summary: This study confirmed that B. animalis F1-7 can improve immunity by regulating immune response, achieved through promoting the expression of caspase-8/3 and Bak genes and proteins, and activating the FAS/CD95 pathway.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Nutrition & Dietetics
Yifan Wu, Gongsheng Zhang, Yucong Wang, Xin Wei, Huanhuan Liu, Lili Zhang, Lanwei Zhang
Summary: Allergic diseases are prevalent in infants worldwide and are closely related to maternal and infant flora composition and metabolism. The mother's flora, including breast milk, intestinal, and vaginal flora, affects the infant's immune system development during pregnancy and lactation. Changes in maternal flora composition and function are associated with infant allergic diseases. The infant's own flora, especially the intestinal flora, plays a role in the development and regulation of allergic diseases, and is affected by allergic diseases.
Article
Food Science & Technology
Youyou Lu, Xiaohong Zhou, Yeting Wu, Qingyu Cui, Xiaoying Tian, Huaxi Yi, Pimin Gong, Lanwei Zhang
Summary: This study explored the potential mechanism of Bifidobacterium animalis F1-7 in alleviating opioid-induced constipation (OIC) through non-targeted metabonomics, electrophysiological experiments, and molecular docking. The results showed that the metabolite 13,14-dihydro-15-keto PGE2, through the 5-HT pathway, participated in the alleviation of OIC by B. animalis F1-7.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Yinxue Liu, Yushan Bu, Jianxun Li, Yisuo Liu, Ao Liu, Pimin Gong, Tongjie Liu, Lanwei Zhang, Shumei Wang, Huaxi Yi
Summary: The study found that plantaricin Q7 exhibited significant inhibitory effects on both Listeria monocytogenes cells and its biofilm, suggesting its potential application as a natural and effective biological preservative for food storage.
FERMENTATION-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Youyou Lu, Zhuang Yu, Zhe Zhang, Xi Liang, Pimin Gong, Huaxi Yi, Liuqing Yang, Tongjie Liu, Hanping Shi, Lanwei Zhang
Summary: The combination of konjac glucomannan (KGM) and Bifidobacterium animalis F1-7 effectively promoted defaecation in mice, increased the fecal water content, shortened the defaecation time and improved the gastrointestinal transit rate. This mixture also influenced the levels of various components and proteins related to humoral transport pathways, demonstrating its effectiveness in improving intestinal motility and relieving constipation.
