Review
Chemistry, Physical
Yue Jiang, Xueting Pan, Tao Yu, Hai Wang
Summary: The existence of the blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system (CNS). Intranasal administration has emerged as an alternative method for delivering drugs to the brain by bypassing the BBB. This review focuses on the mechanisms, properties, and strategies of intranasal nanosystems for brain-targeted drug delivery. Despite promising results in animal models and clinical applications, significant challenges need to be overcome for the translation of these nanosystems into clinics. The future prospects of intranasal drug delivery nanosystems are discussed, aiming to provide insights and guidance for effective neurological disease treatment.
Article
Medicine, Research & Experimental
Xiaofan Jia, Yan Zhang, Ting Wang, Yuan Fu
Summary: A novel cell biology tool was developed to deliver recombinant proteins into mammalian cells with high efficiency and selectivity for ganglioside-rich cells. The method hijacked intracellular transport routes of cholera toxin and utilized split intein for protein delivery.
MOLECULAR PHARMACEUTICS
(2021)
Review
Food Science & Technology
Numa Piot, F. Gisou van der Goot, Oksana A. Sergeeva
Summary: AB toxins are bacterial two-component systems that utilize protein-based mechanisms to deliver toxins, providing insights into the development of bio-based drug delivery systems. With their intrinsic properties and modular characteristics, these toxins have great potential in therapy, allowing for the development of new therapeutic strategies and serving as promising tools in drug and drug delivery system development.
Review
Pharmacology & Pharmacy
Vimala N. Bharadwaj, Alexander Z. Tzabazis, Michael Klukinov, Neil A. Manering, David C. Yeomans
Summary: Chronic pain, a challenging condition in medicine, is associated with plastic changes in the nervous system. Polypeptides, highly selective molecules for nervous system receptors, have potential in pain therapeutics and have shown successful deposition in the nervous system through intranasal delivery. This non-invasive method has the potential to provide rapid and effective treatment for chronic pain.
Article
Chemistry, Multidisciplinary
Yuan Lu, Julie Tzu-Wen Wang, Na Li, Xiaoqin Zhu, Yongjun Li, Sukhi Bansal, Yonglin Wang, Khuloud T. Al-Jamal
Summary: This study developed EDV-loaded polymeric nanoparticles for nose-to-brain drug delivery, improving drug stability and bioavailability. The results showed that the nanoparticle formulation achieved higher and more sustained brain uptake of EDV compared to intravenous administration, offering hope for ALS treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Yaswanthi Yanamadala, Mahdi Y. Saleh, Afrika A. Williams, Yuri Lvov, Teresa A. Murray
Summary: The blood-brain barrier prevents most therapeutic drugs from entering the brain, but drugs loaded within halloysite nanotubes can overcome this barrier. Halloysite nanotubes, with their needle-like shape, were used as a nano-torpedo to deliver drugs across the blood-brain barrier when administered intranasally. By loading halloysite nanotubes with diazepam or xylazine and delivering them to mice intranasally, sedative effects were observed. This study confirms that halloysite can permeate the blood-brain barrier to deliver drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Raquel Talens-Visconti, Jesus Vicente de Julian-Ortiz, Ofelia Vila-Buso, Octavio Diez-Sales, Amparo Nacher
Summary: Alzheimer-type dementia (ATD) treatments are limited in their ability to cross the blood-brain barrier and can have adverse effects on the body. Intranasal administration provides a direct route to the brain through the nasal cavity. However, drug absorption and bioavailability can be hindered by nasal physiology, so technological strategies are needed to optimize the physicochemical properties of formulations. Among the strategies explored, lipid-based nanosystems, specifically nanostructured lipid carriers, show promise in preclinical studies with minimal toxicity and therapeutic efficacy. This review focuses on the use of nanostructured lipid carriers for intranasal administration in the treatment of ATD. Currently, no drugs for intranasal administration in ATD have received marketing approval, but three candidates (insulin, rivastigmine, and APH-1105) are being clinically investigated. Further studies with other candidates will help confirm the potential of intranasal administration in the treatment of ATD.
Article
Pharmacology & Pharmacy
Asya Petkova, Ilona Kubajewska, Alexandra Vaideanu, Andreas G. Schatzlein, Ijeoma F. Uchegbu
Summary: Gene delivery to the cerebral cortex can be achieved via intranasal administration of hyaluronidase-coated polyplexes (GCPH).
Article
Medicine, Research & Experimental
Madeleine S. A. Tan, Preeti Pandey, Rink-Jan Lohman, James R. Falconer, Dan J. Siskind, Harendra S. Parekh
Summary: This study aimed to develop and characterize a clozapine-loaded nanoemulsion sol-gel for intranasal delivery. The formulation showed desirable physicochemical properties and sustained drug release, with no severe ciliotoxicity on nasal mucosa.
MOLECULAR PHARMACEUTICS
(2022)
Article
Clinical Neurology
Qian Zhuang, Xiaoxiao Zheng, Shuxia Yao, Weihua Zhao, Benjamin Becker, Xiaolei Xu, Keith M. Kendrick
Summary: Oral administration of OXT produces similar effects on top-down social attention control and anxiety to intranasal administration.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Mokhtar Mapar, Mattias Sjoberg, Vladimir P. Zhdanov, Bjorn Agnarsson, Fredrik Hook
Summary: Recent innovations in microscopy techniques have allowed for label-free studies of single nanoscopic biological entities. One such technique, waveguide evanescent-field microscopy, offers a simple and sensitive way to image nanoparticles without using labels. In this study, the technique is extended by incorporating microfluidic liquid control and designing a transparent substrate for use with inverted microscopes. Analytical models are formulated to analyze scattering and fluorescence intensities, and these models are applied to study the binding of cholera-toxin B to individual vesicles with sub-nanometer precision.
BIOMEDICAL OPTICS EXPRESS
(2023)
Review
Pharmacology & Pharmacy
Zhiyu Jin, Yu Han, Danshen Zhang, Zhongqiu Li, Yongshuai Jing, Beibei Hu, Shiguo Sun
Summary: Depression is a growing mental disease in modern society, with low cure rates and high recurrence rates. The current treatment methods, primarily drug therapy combined with psychological and physical therapy, have limitations. Intranasal administration may provide a better option for the delivery of antidepressant medication.
Article
Pharmacology & Pharmacy
Elmira A. Vasilieva, Darya A. Kuznetsova, Farida G. Valeeva, Denis M. Kuznetsov, Andrey V. Zakharov, Syumbelya K. Amerhanova, Alexandra D. Voloshina, Irina V. Zueva, Konstantin A. Petrov, Lucia Ya. Zakharova
Summary: Chitosan-decorated liposomes were developed for the intranasal delivery of a reactivator for acetylcholinesterase in the brain as a therapy for poisoning from organophosphorus compounds. The polymer modification increased the encapsulation efficiency and stability of the liposomes. In vitro and in vivo experiments demonstrated the permeability of the chitosomes and their ability to reactivate brain AChE.
Review
Chemistry, Multidisciplinary
Xianying He, Jingru Yang, Meiqi Ji, Yu Chen, Yongheng Chen, Huantao Li, Huaqian Wang
Summary: Macromolecular drug delivery systems, especially using Cholera toxin (CT) as a delivery system, show great potential in retaining drug activity and inducing specific immunity. However, the toxicity of native CT restricts its practical application, and thus, research on CT-based proteins with reduced virulence and enhanced adjuvant activity is necessary.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Joana Gonsalves, Gilberto Alves, Carla Fonseca, Andreia Carona, Joana Bicker, Amilcar Falcao, Ana Fortuna
Summary: Lacosamide, known for its anticonvulsant properties, shows potential for increasing brain exposure and could be a valuable strategy for treating epilepsy and other neurological diseases through intranasal administration.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)